The aim of this study was to investigate the feasibility and safety of vena cava filter (VCF) placement via percutaneous puncture of the great saphenous vein (GSV) in the prevention of pulmonary embolisms. Using ultrasound positioning, VCF placement via percutaneous puncture of the GSV was performed on 12 patients with deep vein thrombosis (DVT) in the lower extremities. Transcatheter thrombolysis was conducted simultaneously. The postoperative filter position, puncture wound recovery and fluency of the GSV were observed. All filters were successfully released, with accurate positioning. No hematoma was observed at the puncture point during the perioperative period. In certain patients, local petechiae appeared around the puncture point during the thrombolysis period, which did not require special treatment. Re-examination using ultrasound revealed unobstructed blood flow in the GSV. VCF placement via percutaneous puncture of the GSV is a new filter placement method. The feasibility and safety of this method for the prevention of pulmonary embolisms has been demonstrated in a small number of sample cases.
XieXie, which is called diarrhea in modern medicine, can be classified into this category of diarrhea symptoms caused by various diseases such as acute and chronic enteritis, intestinal tumors, etc. Traditional Chinese medicine pays attention to the overall principle and treats based on syndrome differentiation.This article will summarize the experience of Chief Physician Zhou Dayong in treating diarrhea from the aspect of dampness treatment.Master Zhou believes that the basic disease location of diarrhea lies in the spleen, stomach and large intestine, and is related to the liver and kidney.
Plant cell walls are largely composed of polysaccharide polymers, including cellulose, hemicelluloses (xyloglucan, xylan, mannan, and mixed-linkage β-1,3/1,4-glucan), and pectins. Among these cell wall polysaccharides, xyloglucan, xylan, mannan, and pectins are often
Vascular smooth muscle cell (VSMC) proliferation and migration has been proven to be a critical event in the development of varicosity. Variations in estrogen levels, a pathological event related to age and pregnancy, play a role in the pathogenesis of varicosity. Previous studies have reported a different response of VSMCs following estrogen stimulation. However, the exact mechanisms involved have not yet been elucidated. In the present study, we examined the responses of lesion and normal VSMCs treated with 10(-8) M 17β-estradiol (E2) for 24 h. A differential effect of exposure to E2 was observed in these cells. IQ-domain GTPase-activating protein 1 (IQGAP1), a scaffold protein, was overexpressed in the lesion VSMCs and was shown to modulate VSMC proliferation and migration in response to E2. Furthermore, the increased expression of IQGAP1 was found to be intimately associated with a high activity of estrogen receptor α (ERα), which has been implicated in the regulation of VSMC physiological function. Additionally, we found that two critical kinases, Akt and extracellular signal-regulated kinase (ERK), mediated the activation of ERα and VSMC proliferation. According to our results, we thus concluded that high levels of IQGAP1 in VSMCs regulate the physiological reaction of the cells in response to estrogen exposure, and that kinases are involved in the process by mediating ERα activation. In view of the essential role of IQGAP1 in the physiological function of VSMCs, targeting this molecule may prove to be a promising strategy for the treatment of varicosity.
This study was first time designed to investigate the effect of oxidation on protein digestion and transport properties in boiled sea cucumber body wall (BSCBW) via simulated digestion combine with everted-rat-gut-sac models. Boiling heat treatments led to protein oxidation in SCBW, manifested by increases in free radical intensity, thiobarbituric acid reactive substances, carbonyl groups, disulfide bonds, dityrosine bonds, advanced glycation end products, protein hydrophobicity and aggregation, declines in free sulfhydryl group, and secondary structure transition from α-helix to β-sheet. Boiling for 2 h caused the anti-digestion collagen unfolding, provided the action site for protease, and improved the protein digestion and transport levels. On the contrary, excessive oxidative modification of 4 h-BSCBW resulted in decreased protein digestion and transport levels. From the perspective of texture, digestion and transport properties, boiling for 2 h can obtain sea cucumber products with better edible and digestible properties, which is considered to be a better processing condition.
Based on the support characteristics of new phased array radar, the evaluation index system of maintenance support capability of new phased array radar is constructed. And combining AHP with GRG, the index weight in the index system is calculated. Combined with the theory of center of gravity of cloud, the cloud model of the evaluation of maintenance supporting capability for the new phased array radar is constructed. The cloud model is used to evaluate the maintenance support capability of a typical new phased array radar, and the effectiveness of the method is verified by an example.
The purpose of this study was to investigate the landing kinematics (LK) of pedestrians and cyclists and to provide an analysis of the influencing factors. A total of 112 pedestrian cases and 51 cyclist cases with video information were analysed. The results showed that the pedestrians' and cyclists' landing kinematics depends on the vehicle front-end shape and impact velocity. In this LK1, the pedestrian/cyclist body had a clear rotation speed during ground contact. In this case, 71% of the cyclists and 39% of the pedestrians were found head firstly contact to the ground. In the most frequent LK2, the pedestrian/cyclist was thrown upward-forward and then landed without rotational speed (46% of all pedestrian and 49% of all cyclist cases). Research on the relation between the vehicle front shape and the LK of pedestrians/cyclists can guide the safety design of a motor vehicle for reducing head injury risk.
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