Sun Liang

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AFMに基づくPCLナノ繊維動力学実験とサイズ効果研究【JST・京大機械翻訳】

Gongcheng Lixue (2009)

Sun Liang Wang Jun Han Ping-chou

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Longitudinal Resonance Method for Measuring Mechanical Parameters of Viscoelastic Materials

Noise and Vibration Control (2012)

Sun Liang

Based on virtual instrument measuring system,mechanical parameters of the viscoelastic material are measured in longitudinal vibration.One end of the bar is excited by a periodic sinusoidal signal with vibrator,while the other end is allowed to move freely.After which,the amount of acceleration of these two ends are measured using the transducer.At resonant frequency,Young's modulus and loss factor can be calculated using the amplitude of acceleration ratio between the driven end and the free end.Besides this,the sampled signals are averaged in several times,which can improve SNR highly.The measuring results agree well with that of commercial viscoelastic instrument.

Vibrator (electronic)

Bar (unit)

Loss factor

SIGNAL (programming language)

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Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42

Nature Communications (2023)

Tao Ma Lei Wang Anping Chai Chao Liu Wenqiang Cui

ClC-2 transports chloride ions across plasma membranes and plays critical roles in cellular homeostasis. Its dysfunction is involved in diseases including leukodystrophy and primary aldosteronism. AK-42 was recently reported as a specific inhibitor of ClC-2. However, experimental structures are still missing to decipher its inhibition mechanism. Here, we present cryo-EM structures of apo ClC-2 and its complex with AK-42, both at 3.5 Å resolution. Residues S162, E205 and Y553 are involved in chloride binding and contribute to the ion selectivity. The side-chain of the gating glutamate E205 occupies the putative central chloride-binding site, indicating that our structure represents a closed state. Structural analysis, molecular dynamics and electrophysiological recordings identify key residues to interact with AK-42. Several AK-42 interacting residues are present in ClC-2 but not in other ClCs, providing a possible explanation for AK-42 specificity. Taken together, our results experimentally reveal the potential inhibition mechanism of ClC-2 inhibitor AK-42.

Chloride channel

10.1038/s41467-023-39218-6

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ZNGEP_2結晶の合成と成長【JST・京大機械翻訳】

Rengong Jingti Xuebao (2009)

Yang Chunhui Meng Wang Xia Shi-xing Sun Liang Chongqiang Zhu

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汎用UAV着艦のための相対運動のモデル化と制御【Powered by NICT】

IEEE Conference Proceedings (2016)

Zhu Ming Zhenghao Jin Zewei Zheng Sun Liang

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安徽省阜陽市栃州区2005-2017年法定報告伝染病流行の特徴分析【JST・京大機械翻訳】

Xiandai Yiyaoweisheng (2019)

Guo Qing Cui Zhongmin Jian Liu Yang Yong Sun Liang

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On the three branches of theory of city form

Shanxi Architecture (2004)

Sun Liang

This paper introduces the three branches of theory of city form from the book Good City Form by Kevin Lynch, and proposes some opinions. In order to have a city form theory.

Urban theory

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キシレンの検出のためのPdドープWO_3H_2Oナノ材料を用いた改良型ガス検知性能【Powered by NICT】

Sensors and Actuators B Chemical (2017)

Feng Li Qixuan Qin Nan Zhang Chen Chuan Sun Liang

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銅-ポリウレタン複合材料の静的および熱伝達特性を研究した。【JST・京大機械翻訳】

Rejiagong Gongyi (2016)