Zhongqiu Guo

Chinese University of Hong Kong, Shenzhen

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Yuhua Chen

Shenzhen Second People's Hospital

Takemi Otsuki

Kawasaki Medical School

Ayako Ueki

Kawasaki Medical School

Ya‐Qin Tan

Wuhan University

Liao QingHui

Weatherford College

Haruko Sakaguchi

Kawasaki Medical School

Chuanhe Wang

China Medical University

yanrong chen

Chinese University of Hong Kong

Ge Wu

First Affiliated Hospital of Zhengzhou University

Yuki Hisano

Kawasaki Medical School Hospital

Cooperative Institutions

Tongji University

Chinese University of Hong Kong, Shenzhen

Kawasaki Medical School

Fudan University

Chinese Academy of Medical Sciences & Peking Union Medical College

Second Military Medical University

Changhai Hospital

Chinese University of Hong Kong

Longgang Central Hospital

Shanghai Tenth People's Hospital

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Thermal-force response analysis and applicability evaluation of strata energy shaft in Shanghai

IOP Conference Series Earth and Environmental Science (2024)

Jie Zhou Xin Wang Jie Xu Zhenguang Zhang Chao Ban

Abstract Energy underground structures, such as energy shafts and tunnels, are a class of energy-saving and environmentally-friendly underground structures. They can be used as shallow geothermal energy harvesting systems for heat exchanges with the ground. Theoretical research and practical applications of energy shafts are still in the initial stages, and related tests are still relatively few. This study used the Shanghai Taihe energy shaft test section as the research background. The results of the thermal force response test of the energy shaft was numerically analyzed using the COMSOL software and compared with that of Beijing Qinghuayuan energy tunnel for applicability evaluation and analysis. The results show that the Shanghai strata energy shaft has a better heat transfer capacity than the Beijing strata energy tunnel owing to the different geological environments and is more economical. Simultaneously, the temperature stress generated in the heat transfer process of the Shanghai Strata energy shaft was smaller than that of the Beijing strata energy tunnel, which is safer. Therefore, underground energy structures can be widely applied to the Shanghai strata, which can significantly improve economic applicability while ensuring safety.

10.1088/1755-1315/1333/1/012051

Cite

Citations (0)

Analysis of Freeze–Thaw Response and Pore Characteristics of Artificially Frozen Soft Soil under Combined Formation Seepage

Applied Sciences (2022)

Jie Zhou Zhongqiu Guo Chuanhe Wang Zeyao Li Huade Zhou

Artificial ground freezing (AGF) is a widely used method in coastal tunnel construction and reinforcement. With more and more underground construction in coastal areas, clay–sand combined formation, which is common in coastal areas, brings more challenges to AGF. In this paper, the frost–thaw characteristics of soft clay during AFG under the construction of combined formation seepage were studied by model test. It was found that the shape of the freezing curtain changed under the condition of seepage, and the water content of the upper soft soil layer decreased markedly after settlement. Subsequently the micro characteristics of melted soil by CT were also conducted for further mechanism analysis, and it was indicated that the distribution of CT number had obvious segmentation characteristics along the height. Finally, the 3D structure of melted clay was reconstructed, and a method was proposed to calculate freeze–thaw settlement through CT numbers.

Frost heaving

Ground freezing

Settlement (finance)

Frost (temperature)

10.3390/app122010687

Cite

Citations (3)

The occult insulinoma was localized using endoscopic ultrasound guidance:A case report

Authorea (Authorea) (2024)

yanrong chen Zhongqiu Guo Ronghuo Liu Yuhua chen

The case report aim to deepen primary care clinicians' understanding of insulinoma.We advocate for invasive EUS examination in patients exhibiting strong clinical and laboratory indicators of insulinoma, even when conventional imaging results are negative

Occult

Endoscopic Ultrasound

10.22541/au.172480587.73977680/v1

Cite

Citations (0)

Correlation between gene polymorphism of cytotoxic T lymphocyte associated antigen-4 and graves disease in Han people in the west of Guangdong.

Xiandai shengwu yixue jinzhan (2010)

Xiaoming Chen Zhongqiu Guo Fei Zhou Meifen Wu Ge Wu

Objective:To investigate association between the polymorphic(AT)n repeats in the 3 untranslated region of exon-4 of cytotoxic T lymphocyte associated antigen-4 [CTLA-4(AT) n] and Graves'disease in western Guangdong Han population.Methods:The CTLA-4(AT) n polymorphisms were genotyped via PCR-RFLP in 102 GD patients and 100 healthy controls.Results:Seventeen alleles were observed in the population,with sizes ranging from 84 to 128bp.There was no significant difference when compared with controls in the distribution of the genotypes(P 0.05).This investigation indicated that the gene of CTLA-4(AT) n was not susceptible gene for Graves disease.Conclusion:This study suggests that CTLA-4(AT) n gene may not be susceptible gene to Graves disease for the western Guangdong Han population.

Source

Cite

Citations (0)

Multiple endocrine neoplasia 2A with RET mutation p.Cys611Tyr

Medicine (2021)

Yan Li Ya‐Qin Tan Zhi-Xiang Tang Liao QingHui Zhongqiu Guo

Abstract Rationale: Multiple endocrine neoplasia 2A (MEN2A) is a rare autosomal-dominant genetic syndrome, frequently misdiagnosed or neglected clinically, resulting in delayed therapy to patients. Patient concerns: A 47-year-old Chinese male patient underwent laparoscopic right adrenal tumorectomy, and postoperative pathology confirmed the tumor as pheochromocytoma (PHEO). He was readmitted to the department of endocrinology and metabolism due to constant increase in carcinoembryonic antigen (CEA) at 5 months after the operation. Diagnosis: The patient was confirmed with medullary thyroid carcinoma (MTC), multiple neck lymph node metastasis, and pituitary microadenoma. The p.Cys611Tyr (c.1832G>A, C611Y) mutation was detected. Therefore, he was diagnosed with MEN2A. Interventions: He underwent total thyroidectomy. The gene-sequencing analysis of his family was conducted, and the C611Y mutation was detected in his daughter. Outcomes: The level of carcinoembryonic antigen decreased significantly after thyroidectomy in this patient. Long-term follow-up management was conducted. Elevated serum calcitonin and bilateral thyroid nodules were found in his 13-year-old daughter. Thus, MEN2A was highly suspected and she was suggested to undergo total thyroidectomy. Conclusion Patients with MEN2A should be screened regularly and managed by a multidisciplinary team.

Carcinoembryonic antigen

10.1097/md.0000000000026230

Cite

Citations (1)

Perturbation of secretory Ig A in saliva and its daily variation by academic stress

Environmental Health and Preventive Medicine (2002)

Zhongqiu Guo Takemi Otsuki Yasuhisa Ishi Aya Inagaki Youichiro Kawakami

Immunoglobulin A

Secretory IgA

Psychological stress

10.1007/bf02897981

Cite

Citations (6)

Reduced Expression of the Survivin Gene in PBMC from Silicosis Patients

Kawasaki medical journal (2001)

Zhongqiu Guo Takemi Otsuki Toshiyuki Shimizu Shiho Tachiyama Haruko Sakaguchi

Silicosis

Survivin

Source

Cite

Citations (5)

Clinical value of 18F-FDG PET/CT for the prognosis of colorectal cancer

Zhonghua heyixue yu fenzi yingxiang zazhi (2018)

Zhongqiu Guo Tao Wang

18F-flurodeoxyglucose(FDG) PET/CT plays an important role in early diagnosis, clinical staging, therapeutic efficacy evaluation, and recurrence monitoring of colorectal cancer (CRC). More and more scholars have focused on the value of PET/CT in CRC prognosis, intending to find out whether PET/CT can predict the survival outcomes (disease-free survival, progression-free survival and overall survival) of CRC patients after radical resection, in liver metastasis stage or in multiple metastases stage. This review summarizes the clinical value of 18F-FDG PET/CT for the prognosis of CRC. Key words: Colorectal neoplasms; Prognosis; Positron-emission tomography; Tomography, X-ray computed; Deoxyglucose

PET-CT

Standardized uptake value

10.3760/cma.j.issn.2095-2848.2018.04.017

Cite

Citations (0)

Study on the association between the polymorphism of MCP-1 rs1024611 and the genetic susceptibility of type 2 diabetes with sepsis

Medicine (2022)

Yan Li Junbing He Yiming Shao Lanchun Chen Ming Li

Monocyte chemoattractant protein-1 (MCP-1) rs1024611 (-2518 A > G) polymorphism are associated with inflammatory diseases. In this study, we investigate the relationship between MCP-1 rs1024611 polymorphism and genetic susceptibility of type 2 diabetes mellitus (T2DM) with sepsis. Two hundred eighty-five patients with T2DM are divided into the diabetes with sepsis group (combined group, 113 cases) and the diabetes group (172 cases). Blood samples and corresponding clinical data were collected. MCP-1 rs1024611 polymorphism in blood samples was detected by pyrosequencing. Meanwhile, the expressions of MCP-1, tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, and IL-6 in blood samples were detected by real-time quantitative polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. The relationship between different genotypes of MCP-1 rs1024611 polymorphic locus and T2DM with sepsis was analyzed by combining with the clinical data of the patients. The frequencies of rs1024611 AG/GG genotypes and G allele in T2DM with sepsis group were significantly higher than those in T2DM patients without sepsis (P = .004 for AG/GG vs AA genotypes; P = .037 for G allele vs A allele). Subgroup analysis showed that the rs1024611 G allele frequency in the septic shock group was significantly higher than the general sepsis group (P = .02). The expressions of MCP-1 and TNF-α in GG genotypes in T2DM with sepsis group were significantly higher than AA or GA genotypes (P < .05). This study preliminarily showed that the rs1024611 A > G polymorphism within the promoter region of MCP-1 gene can upregulate the expression of MCP-1 gene and proinflammatory cytokine TNF-α, which ultimately contributed to the predisposition and progression of T2DM with sepsis.

10.1097/md.0000000000029903

Cite

Citations (3)

The Occult Insulinoma Was Localized Using Endoscopic Ultrasound Guidance: A Case Report

Clinical Case Reports (2025)

Zhongqiu Guo yanrong chen Ronghuo Liu Yuhua Chen

ABSTRACT Insulinomas are the primary etiology of endogenous hyperinsulinemic hypoglycemia, which often manifest with Whipple’s triad and neuroglycopenic symptoms. Given the diverse clinical manifestation and subtle onset of insulinomas generally in a small size, detecting a minority of these generally small tumors can be challenging. We reported a case of a 44‐year‐old female patient with recurrent hypoglycemia accompanied by hyperinsulinemia, and the conventional imaging revealed no abnormality. With the aid of endoscopic ultrasound‐guided fine‐needle aspiration biopsy (EUS‐FNAB), the insulinoma was precisely diagnosed and localized, and successfully excised via operation. The patient’s hyperinsulinemia and hypoglycemic episodes were relieved significantly after surgery. The application of EUS‐FNAB notably enhances the diagnostic accuracy for occult insulinomas, thereby informing appropriate surgical management. Herein, we advocate for invasive EUS examination in patients exhibiting strong clinical and laboratory indicators of insulinoma, even when conventional imaging results are negative.

Occult

Endoscopic Ultrasound

Hyperinsulinemia

Hyperinsulinemic hypoglycemia

Endoscopic ultrasonography

Etiology

10.1002/ccr3.9634

Cite

Citations (0)