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Chuangyu Qu

Fudan University

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Danfeng Xu

First Affiliated Hospital of Guangzhou University of Chinese Medicine

Lei Yin

East China University of Science and Technology

Youhua Zhu

Nantong University

Cunzhou Wang

Second Military Medical University

Xingang Cui

XinHua Hospital

Jizhong Ren

Second Military Medical University

Min Zhi-lian

Wannan Medical College

Cunzhou Wang

Second Military Medical University

Yacheng Yao

Second Military Medical University

Xingang Cui

Shandong First Medical University

Cooperative Institutions

Second Military Medical University

Shanghai Changzheng Hospital

Shanghai Jiao Tong University

Shanghai University of Traditional Chinese Medicine

Central South University

Changhai Hospital

Longhua Hospital Shanghai University of Traditional Chinese Medicine

Eastern Hepatobiliary Surgery Hospital

Huazhong University of Science and Technology

Fudan University

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Low-frequency electrotherapy for female patients with detrusor underactivity due to neuromuscular deficiency

International Urogynecology Journal (2012)

Danfeng Xu Zhang Shen Cunzhou Wang Jun Li Chuangyu Qu

The aim of the study was to assess the efficacy of low-frequency electrotherapy (LFE) for female patients with early-stage detrusor underactivity (DUA) due to neuromuscular deficiency. A total of 102 female patients were divided randomly into four groups: LFE-NC (normal compliance), LFE-LC (low compliance), CON (control)-NC and CON-LC. Patients in the LFE-NC and LFE-LC groups received LFE, and those in the CON-NC and CON-LC groups received conservative treatment. Urodynamic evaluation was performed before and after treatment. After treatment, 82 % of the LFE-NC regained detrusor contractility, whereas only 2 (8 %) of the CON-NC had normal detrusor contraction. None of LFE-LC or CON-LC regained detrusor contractility (p < 0.01). The per cent of LFE-NC who relied on catheterization for bladder emptying decreased by 43 % (p < 0.01). Those in the LFE-LC, CON-NC and CON-LC groups decreased by only 4, 12 or 0 % (p > 0.05). LFE was more effective for DUA patients with normal compliance; these patients benefited from LFE, but DUA patients with low compliance did not.

Contractility

Electrotherapy

10.1007/s00192-012-1714-2

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Editorial Comment to Retropubic tissue fixation system tensioned mini‐sling carried out under local anesthesia cures stress urinary incontinence and intrinsic sphincter deficiency: 1‐year data

International Journal of Urology (2017)

Stress incontinence

10.1111/iju.13374

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Dysfunctional voiding confirmed by transdermal perineal electromyography, and its effective treatment with baclofen in women with lower urinary tract symptoms: a randomized double‐blind placebo‐controlled crossover trial

BJU International (2007)

Danfeng Xu Chuangyu Qu Hong Meng Jizhong Ren Youhua Zhu

To assess the activity of baclofen, a potent gamma-aminobutyric acid-ergic agonist, against dysfunctional voiding (DV) and lower urinary tract symptoms (LUTS) in a clinical trial, as DV is a leading cause of LUTS in women, but there is no effective treatment.We conducted a randomized double-blind placebo-controlled crossover trial in 60 women with DV and LUTS between January 2003 and January 2006; patients were randomly assigned either baclofen 10 mg three times daily, then matching placebo for 4 weeks, or matching placebo then baclofen 10 mg three times daily for 4 weeks, separated by a 2-week washout period. Voiding diaries and multichannel urodynamics (at baseline, 4 and 10 weeks) were used to record the changes of voids/24 h and urodynamic variables. The primary efficacy endpoint was the change in voids/24 h, and the TL value (log[T/L]), a new electromyographic variables showing the extent of DV. Efficacy outcomes at 4 and 10 weeks were compared with the baseline data, using a crossover-designed analysis of variance model.The efficacy analysis of the treatment showed that baclofen was associated with significantly fewer voids/24 h than placebo (mean difference from baseline 5.53 vs 2.70; P = 0.001) and a significant increase in TL (mean difference from baseline -1.78 vs 0.01, P = 0.001). No significant adverse events were reported.A 4-week course of baclofen significantly reduced the number of voids/24 h and increased the TL value in women with DV confirmed by transdermal perineal electromyography. These encouraging results suggest that baclofen could be used for treating DV in women.

Crossover study

Baclofen

10.1111/j.1464-410x.2007.06987.x

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Citations (34)

Impact of tension-free vaginal tape procedure on dysfunctional voiding in women with stress urinary incontinence: Original Article: Clinical Investigation

Danfeng Xu Chuangyu Qu Jizhong Ren Haihong Jiang Yacheng Yao

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Comprehensive urodynamics: Being devoted to clinical urologic practice

World Journal of Clinical Urology (2014)

Clinical Practice

10.5410/wjcu.v3.i2.96

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Impact of tension‐free vaginal tape procedure on dysfunctional voiding in women with stress urinary incontinence

International Journal of Urology (2010)

Danfeng Xu Chuangyu Qu Jizhong Ren Haihong Jiang Ya‐Cheng Yao

To determine the prevalence of dysfunctional voiding (DV) in female stress urinary incontinence (SUI) and its modification after tension-free vaginal tape (TVT) procedure.Three hundred and sixty women with SUI were enrolled and underwent urodynamics from 2002 to 2008. DV was determined when non-neurogenic detrusor-sphincter dyssynergia occurred during voluntary voiding. It was further quantitatively analyzed using the tense/loose value, a parameter derived from external anal sphincter electromyogram. The distribution of other urodynamic variables was also evaluated. One hundred and fifty patients underwent the TVT procedure and forty of them were studied with urodynamics after surgery during follow up.Overall, DV was diagnosed in ninety-nine patients, with a prevalence of 27.5%. The functional profile length in SUI women with DV was significantly shorter than that in SUI women without DV (3.13 +/- 0.76 vs 3.32 +/- 0.65, P = 0.017). After the TVT procedure, the recovery of SUI between cases with and without DV showed no significant difference. The rate of DV state change after the surgery, namely from with to without DV or from without to with DV, significantly differed between the female patients with and without DV (66.7% vs 3.6%, P < 0.05) during follow up. The DV improved after the surgery in SUI women with DV.DV might represent a coexistent finding in women with SUI. The main difference of women with SUI and DV, as compared with those without DV, is a shortened functional profile length. In such cases, TVT procedure can improve DV along with the treatment of SUI.

Dyssynergia

Urethral sphincter

10.1111/j.1442-2042.2010.02467.x

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Citations (8)

Is vaginal mucosal graft the excellent substitute material for urethral reconstruction in female-to-male transsexuals?

World Journal of Urology (2015)

Yingfan Zhang Cai-Yue Liu Chuangyu Qu Lixuan Lu Antang Liu

Phalloplasty

10.1007/s00345-015-1562-z

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Citations (34)

Urodynamic Pattern Distribution Among Aged Male Patients With Lower Urinary Tract Symptoms Suggestive of Bladder Outlet Obstruction

Danfeng Xu Xingang Cui Chuangyu Qu Lei Yin Cunzhou Wang

Urethral sphincter

10.1016/j.urology.2013.10.033

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Urodynanic features of female patients with non-neurogenic lower urinary tract symptoms

Neurourology and Urodynamics (2012)

Cunzhou Wang Chuangyu Qu Jie Chen Lei Yin Danfeng Xu

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Immediate effect of electropuncture on urodynamic parameters in post-prostatectomy incontinence: a case report

Acupuncture in Medicine (2022)

Huimin Zheng Junhao Cai Chuangyu Qu Ping Yin Wenguang Hou

Urodynamic studies

10.1177/09645284221107695

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Citations (1)