Li Zhao

Beijing Sport University

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i-10 index

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Ping Ping Li

Chinese Academy of Medical Sciences & Peking Union Medical College

Zhi Gang Liu

Wuxi Institute of Technology

Yaqing Wang

University of Chinese Academy of Sciences

Zhiheng Xu

Institute of Genetics and Developmental Biology

Tao Wang

Chinese Academy of Sciences

Qian Zhang

Huazhong University of Science and Technology

I. L. Kim

Laikang Yu

Beijing Sport University

Lei Shi

Chinese Academy of Sciences

Jianan Zhou

Southwest Jiaotong University

Cooperative Institutions

Chinese Academy of Sciences

Institute of Genetics and Developmental Biology

University of Chinese Academy of Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

University of Hong Kong

Jiangsu University

Purdue University West Lafayette

Peking Union Medical College Hospital

Harbin Institute of Technology

Center for Excellence in Brain Science and Intelligence Technology

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Mea6/cTAGE5 Cooperates with TRAPPC12 to Regulate PTN Secretion and White Matter Development

Tiantian Ma Yaqing Wang Laikang Yu Tao Wang Pengyu Sun

Mutations of TRAPPC12 are associated with progressive childhood encephalopathy including abnormal white matter. However, the underlying pathogenesis is still unclear. Here, we found that Trappc12 deficiency in CG4 and oligodendrocyte progenitor cells (OPCs) affects their differentiation and maturation. In addition, TRAPPC12 interacts with Mea6/cTAGE5, and Mea6/cTAGE5 ablation in OPCs affects their proliferation and differentiation, leading to marked hypomyelination, compromised synaptic functionality, and aberrant behaviors in mice. We reveal that TRAPPC12 is associated with COPII components at ER exit site, and Mea6/cTAGE5 cKO disrupts the trafficking pathway by affecting the distribution and/or expression of TRAPPC12, SEC13, SEC31A, and SAR1. Moreover, we observed marked disturbances in the secretion of pleiotrophin (PTN) in Mea6-deficient OPCs. Notably, exogenous PTN supplementation ameliorated the differentiation deficits of these OPCs. Collectively, our findings indicate that the association between TRAPPC12 and MEA6 is important for cargo trafficking and white matter development.

White (mutation)

10.2139/ssrn.4529647

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Study on Substrate Humidity, EC and Salinity <i>In Situ</i> Detection Technology

Applied Mechanics and Materials (2010)

Qing Yuan Sheng Ping Ping Li Xi Liang Zhang Zhi Gang Liu Li Zhao

Considering the greater character differences between matrix and soil, and the great disparity in physicochemical properties of various substrate, now there is no special equipment to test matrix moisture, electrical conductivity (EC) and salinity of medium .On the basis of analyzing physicochemical properties of various substrate, the relationship between output voltage and water content is studied through piezoelectric type soil moisture probe trial. With "voltage-current" four-terminal method, multi-parameter integrated sensor testing medium moisture and electrical conductivities developed, and through the solution calibration EC measuring model is established. Then relationships among matrix water content, electrical conductivity and salinity are analyzed, and salinity testing model is established. A portable low-cost in-situ multi-parameter detection apparatus, testing substrate humidity, EC and salinities, developed by adopting MCU SPCE06A. Experimental results indicate that detection accuracy of the equipment can meet the need of soilless culture production, and it has greater application and dissemination value.

Matrix (chemical analysis)

10.4028/www.scientific.net/amm.43.361

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Using High Fidelity Vehicle Trajectory Data for Safety Analyses: A Case Study

Transportation Research Board 97th Annual MeetingTransportation Research Board (2018)

Li Zhao Laurence R. Rilett Jianan Zhou

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SWATShare- A Platform for Collaborative Hydrology Research and Education with Cyber-enabled Sharing, Running and Visualization of SWAT Models

AGU Fall Meeting Abstracts (2014)

Adnan Rajib Venkatesh Merwade Chao Song Li Zhao I. L. Kim

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A Voice Dispatching System Design for Coal Mine Industry Based on TD-SCDMA Special Network

Li Zhao Rui Li Qian Zhang

The advantages and the specific dispatching services of the voice dispatching system based on TD-SCDMA special network is introduced in this paper, including conference call, monitor, record, group call, transfer call, forced release, forced insert, substitute call, hold call, night service, and so on, which is dependent on the detailed introduction of the architecture and functions of TD-SCDMA special network. Voice dispatching system is described in detail including the structure and function, special emphasis is placed on mechanisms and other key technologies such as the voice mixing techniques, voice synchronization, and voice dithering eliminating mechanism. Voice dispatching system based on TD-SCDMA special network is with these properties of good real-time, high reliability, simple operation, which also can enhance the ability of emergent command when a disaster happens, reduce the loss of property and life, protect the safety of production by leaps and bounds for the mine industry.

Emphasis (telecommunications)

File transfer

10.1109/icmult.2010.5629663

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Digital Simulation Study of SINS of a Small Tactical Missile

Tactical Missile Technology (2009)

Li Zhao

The small tactical missile SINS digital simulation software is designed,based on the establishment of the rigid body trajectory math model,the inertial device simulation model,the SINS math model and the error treatment model.The simulation software provides simulation tool for the study of SINS error.The precision of SINS math model and the arithmetic is verified,and the influence of inertial device error on system is studied.

Missile Guidance

Simulation software

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