Dandan Wang

Ministry of Agriculture and Rural Affairs

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Xiaobin Cui

Nanjing University

Jianming Hu

Shihezi University

Yunzhao Chen

Zhejiang Provincial People's Hospital

Lu Li

Ministry of Agriculture and Rural Affairs

Gezhi Xu

Eye & ENT Hospital of Fudan University

Tao Yuan

Ye Zheng

Chuanyue Wu

University of Pittsburgh

Ping Xu

Eye & ENT Hospital of Fudan University

Yaxuan Wang

Hebei Medical University

Cooperative Institutions

Chinese Academy of Medical Sciences & Peking Union Medical College

Shihezi University

Ministry of Agriculture and Rural Affairs

Sun Yat-sen University

Hebei Medical University

Central South University

Huazhong University of Science and Technology

Shanghai Jiao Tong University

Zhejiang University

Chinese Academy of Sciences

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Determination of the cervical cancer biomarker SCCA using CMK-3@UiO-66@AuNPs composite-modified glassy carbon electrodes

Microchemical Journal (2024)

Lixia Luo Jinglin Shui Yingying Gu Dandan Wang Jiangyang Qin

Nanomaterials

10.1016/j.microc.2024.110672

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Citations (4)

miR-185 Inhibits the Proliferation and Invasion of Non-Small Cell Lung Cancer by Targeting KLF7

Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics (2018)

Lili Zhao Yao Zhang Jiaoxia Liu Wei Yin Dan Jin

MicroRNAs (miRNAs) are short endogenous noncoding RNAs that frequently play vital roles in many cancer types. Herein we demonstrated that miR-185 was remarkably downregulated in NSCLC tissues compared with adjacent normal tissues. A lower level of miR-185 was associated with lymph node metastasis. Functional assays showed that upregulation of miR-185 inhibited the proliferation, colony formation, and invasion capacities of NSCLC cells in vitro. Furthermore, we found that miR-185 suppressed the epithelial‐mesenchymal transition (EMT) process. Bioinformatics analysis and luciferase reporter gene assays revealed that Kruppel-like factor 7 (KLF7) was the target of miR-185. Overexpression of miR-185 reduced the expression of KLF7 in NSCLC cells. Upregulation of KLF7 partly neutralized the inhibitory effects of miR-185 on the proliferation and invasion of NSCLC. Additionally, we confirmed that miR-185 suppressed the tumor growth of NSCLC A549 cells in vivo. Taken together, these results demonstrate that miR-185 acts as a suppressor by targeting KLF7 in NSCLC.

Competing Endogenous RNA

10.3727/096504018x15247341491655

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Citations (61)

Investigation on Ultrasound-Assisted Extraction and Separation of Enduracidin from Streptomyces sp. NJWGY3665

Applied Biochemistry and Biotechnology (2011)

Yonghong Hu Wenge Yang Wan Wen-qian Fei Shen Ziyu Lei

10.1007/s12010-011-9473-y

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Citations (5)

Data from Multikinase Inhibitor CT-707 Targets Liver Cancer by Interrupting the Hypoxia-Activated IGF-1R–YAP Axis

Hong Zhu Dandan Wang Tao Yuan Fangjie Yan Chenming Zeng

<div>Abstract<p>Given that Yes-associated protein (YAP) signaling acts as a critical survival input for hypoxic cancer cells in hepatocellular carcinoma (HCC), disruption of YAP function and the maintenance of hypoxia is an attractive way to treat HCC. Utilizing a cell-based YAP-TEAD luciferase reporter assay and functional analyses, we identified CT-707, a China-FDA approved multi-kinase inhibitor under clinical trial with remarkable inhibitory activity against YAP function. CT-707 exhibited prominent cytotoxicity under hypoxia on HCC cells, which was attributable to the inhibition of YAP signaling. CT-707 arrested tumor growth in HepG2, Bel-7402, and HCC patient-derived xenografts. Mechanistically, the inhibitory activity of CT-707 on YAP signaling was due to the interruption of hypoxia-activated IGF1R. Overall, these findings not only identify CT-707 as a promising hypoxia-targeting agent against HCC, but they also unveil IGF1R as a new modulator specifically regulating hypoxia-activated YAP signaling.</p><p><b>Significance:</b> CT-707 may represent a novel clinical approach for patients with HCC suffering poor drug response due to intratumor hypoxia. <i>Cancer Res; 78(14); 3995–4006. ©2018 AACR</i>.</p></div>

Hypoxia

10.1158/0008-5472.c.6509786

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Paenibacillus puernese sp. nov., a β-glucosidase-producing bacterium isolated from Pu’er tea

Archives of Microbiology (2015)

Dandan Wang Yeon-Ju Kim Van-An Hoang Ngoc‐Lan Nguyen Priyanka Singh

Paenibacillus

Strain (injury)

10.1007/s00203-015-1180-6

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Citations (7)

Enhancing storage stability, antihypertensive properties, flavor and functionality of fermented Milk through co-fermentation with Lactobacillus helveticus H11 adjunct culture

Food Chemistry (2024)

Lu Li Junxia Liu Dandan Wang Lai‐Yu Kwok Bohai Li

Lactobacillus helveticus

Adjunct

10.1016/j.foodchem.2024.142574

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Amylibacter cionae sp. nov., isolated from the sea squirt Ciona savignyi

INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY (2017)

Dandan Wang Yuxi Wei Qiu Cui Wenli Li

A Gram-stain-negative, non-motile, aerobic and rod-shaped bacterial strain, designated H-12T, was isolated from a sea squirt (Ciona savignyi) collected from Tsingtao Port, Jiaozhou Bay, China, and its taxonomic position was investigated. Strain H-12T grew optimally at 25-30 °C, at pH 7.0-8.0 and in the presence of 3.0-4.0 % (w/v) NaCl. The 16S rRNA gene sequence of strain H-12T exhibited the highest similarity to that of the type strain of Amylibacter marinus (95.3 %). A neighbour-joining phylogenetic tree based on 16S rRNA gene sequences revealed that strain H-12T clustered with the type strain of A. marinus. The predominant ubiquinone in strain H-12T was identified as Q-10. The major fatty acids of strain H-12T were C18 : 1ω7c and C18 : 1ω7c 11-methyl. The major polar lipids detected in strain H-12T were phosphatidylglycerol, phosphatidylcholine, phosphatidylethanolamine, one unidentified aminolipid, two unidentified phospholipids and five unidentified lipids. The DNA G+C content of strain H-12T was 52.7 mol%. On the basis of phylogenetic, chemotaxonomic and phenotypic properties, strain H-12T is considered to represent a novel species within the genus Amylibacter, for which the name Amylibacter cionae sp. nov. is proposed. The type strain is H-12T (=KCTC 52581T=CGMCC 1.15880T).

Strain (injury)

Phosphatidylglycerol

10.1099/ijsem.0.002140

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Citations (9)

[Interaction between balofloxacin and DNA and the influence of Mg2+ on the interaction].

Wenying Zhong Qi Huang Dandan Wang Kunyi Ni

AIM To study the binding mode of balofloxacin with DNA and evaluate the influence of Mg2+ on the binding between balofloxacin and DNA. METHODS Fluorescent spectroscopy was used to study the interaction of balofloxacin with DNA and to calculate the thermodynamic constants. UV-Vis spectra, DNA viscosity titration, competition experiment and the effect of dsDNA and ssDNA on the fluorescense intensity were used to identify the binding mode. RESULTS Balofloxacin interacted with CT-DNA with a quenching constant of (5.43 +/- 0.07) x 10(3) L x mol(-1). The interaction was exothermic with a Van't Hoff enthalply of - 8.03 kJ x mol(-1) x Mg2+ cation could enhance the quenching constant between balofloxacin and DNA. CONCLUSION Balofloxacin interacted with CT-DNA in the mode of groove binding and Mg2+ could mediate the binding of balofloxacin to DNA.

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Citations (1)

Data from Multikinase Inhibitor CT-707 Targets Liver Cancer by Interrupting the Hypoxia-Activated IGF-1R–YAP Axis

Hong Zhu Dandan Wang Tao Yuan Fangjie Yan Chenming Zeng

Hypoxia

10.1158/0008-5472.c.6509786.v1

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Citations (0)

Sample description for mRNA expression and public SRA accessions.xlsx