Prashant Kumar

Institute of Bioinformatics and Applied Biotechnology

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Kiranpreet Kaur

Government Medical College, Amritsar

Sanjay Johar

Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences

Sarla Hooda

Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences

Suresh Singhal

Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences

Virendra Singh

Banaras Hindu University

Mamta Bhardwaj

Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences

Teena Bansal

Pandit Bhagwat Dayal Sharma University of Health Sciences

Kundan Mittal

Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences

Kuldeep Dhama

Indian Veterinary Research Institute

Yashpal Singh Malik

Guru Angad Dev Veterinary and Animal Sciences University

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Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences

Institute of Medical Sciences

All India Institute of Medical Sciences

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Pandit Bhagwat Dayal Sharma University of Health Sciences

Banaras Hindu University

Christian Medical College & Hospital

Post Graduate Institute of Medical Education and Research

Chinese Academy of Sciences

Christian Medical College

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OSCE : Data interpretation

JOURNAL OF PEDIATRIC CRITICAL CARE (2018)

Kundan Mittal Prashant Kumar Rajesh Mishra Vinayak Patki

10.21304/2018.0504.00415

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DELIVERING INTENSIVE CARE TO COVID-19 PATIENTS WHILE PROTECTING THEMSELVES: CHALLENGES FACED BY FRONT LINE ANAESTHESIOLOGISTS

International Journal of Scientific Research (2021)

Monica Chhikara Prashant Kumar Priyanka Bansal Reena Mahajan Preeti Gehlaut

Background and Objectives: Frontline anaesthesiologist working in Covid 19 Intensive care units are the key to the management and containment of this infectious disease. Hence, their protection is of utmost importance in managing this epidemic. The equipment used for this purpose, pose technical difculties. This study is a survey of these challenges faced by anaesthesiologists. Material and Methods: This is a descriptive, cross sectional questionnaire based study which included 67 Anesthesiologist junior residents, senior residents and consultants. A valid Google form Questionnaire regarding technical difculties due to use of personal protective equipment was prepared and sent online to all participants. The responses were recorded and tabulated. Results: Physical fatigue due to PPE was experienced by 36(53.7%) residents and difculties in airway management by 66(98.5%) residents. Fogging of goggles was the major difculty (52.2%) during airway management. Intubation while using only PPE (71.6%) was a preferred method of intubation rather than using acrylic box (4.5%) or transparent sheet (23.9%). Apart from managing airway, other procedures like central venous cannulation was found to be always difcult (23.9%). Training program for managing pandemic was found to be helpful and 70.1% residents expressed the need for its conduct before every posting. Conclusion: Managing Covid 19 patients in a highly demanding area like intensive care units while using personal protective equipment has unveiled special challenges and concerns for frontline anaesthesiologists. Addressing them appropriately is the need of hour for the wellbeing of healthcare workers and effective patient management.

Personal Protective Equipment

Front line

Pandemic

10.36106/ijsr/0500715

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A study to evaluate the efficacy of topical quick penetrating solution of heparin in preventing thrombophlebitis

The Indian Anaesthetists Forum (2019)

Teena Bansal Prashant Kumar Garima Vashisht

Background and Aims: Superficial thrombophlebitis is the most common complication with intravenous cannulation which is characterized by cord-like painful veins and discoloration of skin over puncture site. The study was conducted to evaluate the efficacy of topical quick penetrating solution (QPS) of heparin to prevent superficial thrombophlebitis.Methods: This prospective randomized study included 200 patients who were divided into two groups. In Group I (control group), cannula site was observed using Phlebitis Assessment Grading Scale at 12, 24, 48, and 72 h. In Group II (heparin group), QPS of heparin was applied 12 hourly for up to 72 h, and cannula site was examined at the same time intervals as in Group I.Results: In Group I, at 12 h, score of 0 and 1 was observed in 96 and 4 patients, respectively, whereas all patients had a score of 0 in Group II (P = 0.044). At 24 h, the score was 0, 1, and 2 in 28, 60, and 12 patients, respectively, in Group I, whereas it was 0 and 1 in 96 and 4 patients in Group II (P = 0.001). At 48 h, the score was 1 and 2 in 36 and 64 patients in Group I, whereas it was 0 and 1 in 60 and 40 patients in Group II (P = 0.001), respectively. At 72 h, the score of 2, 3, and 4 was observed in 32, 44, and 24 patients in Group I, respectively, whereas the score of 0, 1, and 2 was observed in 36, 48, and 16 patients, respectively, in Group II (P = .001).Conclusion: Heparin QPS when applied prophylactically significantly decreased thrombophlebitis.

Superficial thrombophlebitis

Grading scale

Group B

10.4103/theiaforum.theiaforum_73_18

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CRISPR/Cas System: A Revolutionary Technique Applied Potentially from Diagnosis to Therapeutics in COVID-19

ACTA SCIENTIFIC MICROBIOLOGY (2022)

Roshan Kumar Roy Ashish Srivastava Sonal Srivastava Taruna Gupta Tripti Singhal

The emergence of Coronavirus disease-2019 caused by SARS-CoV-2 has also bought new challenges to the researchers to develop novel therapeutic and diagnostic methods for the pathogen.The preventive vaccines are approved for the public but their role in the development of herd immunity is not clear due to the emergence of new variants of SARS-CoV-2.Therefore, the prime requirement to cope up with the current situation is to develop highly sensitive diagnostics and effective therapeutics to restrict the spread of SARS-CoV-2 among human population.CRISPR/Cas, a talk of the town, is one of the tools that has been used to develop sensitive, rapid and cost-effective diagnostics that may be made available even in the remote areas of the country.The ability of different Cas proteins viz.Cas9, Cas12, and Cas13 in binding and cleaving of dsDNA, ssDNA, and ssRNA, respectively, have been explored for these purposes.The Cas13 based Prophylactic Antiviral CRISPR in huMAN cells (PAC-MAN) and the Specific High-Sensitivity Enzymatic reporter unlocking (SHERLOCK) and Cas 12 based FALUDA technology have already been developed for diagnosis of COVID-19.This review summarizes the role of CRISPR/Cas based approaches for reliable, rapid, and ultrasensitive diagnostics development, and explore the possible therapeutic alternative for combating COVID-19.

2019-20 coronavirus outbreak

10.31080/asmi.2022.05.0985

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Big solution with small intervention

The Indian Journal of Medical Research (2020)

Prashant Kumar Jyoti Sharma

10.4103/ijmr.ijmr_2267_19

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Use of i-gel in magnetic resonance imaging

Acta anaesthesiologica Taiwanica (2014)

Kiranpreet Kaur Mamta Bhardwaj Prashant Kumar Jatin Lal Sanjay Johar

Artifact (error)

Endotracheal tube

10.1016/j.aat.2014.02.002

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Determinants of Use of Maternal Health Services in Rural Field Practice Area of Basaveshwara Medical College, Chitradurga: A Cross Sectional Study

Journal of Preventive Medicine and Holistic Health (2013)

M Kotresh Prashant Kumar

Background: Millions of women in developing countries experience life threatening and other serious health problems related to pregnancy or childbirth. The situation is even worse in developing countries like India due to inadequate access to essential maternal health services and their poor utilization. The present study was carried out to know the factors associated with the utilization of maternal health services. OBJECTIVES: To study the existing practices of utilization of maternal health care in rural area and to study the factors associated with health care seeking practices among post natal mothers. METHODOLOGY: A cross sectional study was taken up in PHC area of Yalagodu which is a rural field practice area of the Department of Community medicine for a period of one year. All mothers aged 15-45yrs residing in rural field practice area, who had delivered in last 1 year at the time of study constituted the study sample. Results and Conclusion: About 92% of the pregnancies were registered, of which 75% were registered in 1st trimester. About 62% of the respondents received full ANC. The prime factor responsible for not utilizing Full ANC was non consumption of recommended No. of IFA tablets (53%). The prime reason for noncompliance of IFA tablets was Acceptability (45%). Majority (93.5%) of the mothers had institutional delivery, acceptability (68.4%) and accessibility (44.4%). Postnatal services (53.3%) were the most neglected one. The most common reason for utilization was Acceptability (66.2%) and for non-utilization, lack of knowledge (93.7%). Key Words: Utilization, Availability, Accessibility, Acceptability.

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Critical Care for COVID-19 Affected Patients: Position Statement of the Indian Society of Critical Care Medicine

Indian Journal of Critical Care Medicine (2019)

Yatin Mehta Dhruva Chaudhry O C Abraham Jose Chacko Jigeeshu V. Divatia

The global pandemic involving severe acute respiratory syndrome-coronavirus-2 (SARS-COV-2) has stretched the limits of science.Ever since it emerged from the Wuhan province in China, it has spread across the world and has been fatal to about 4% of the victims.This position statement of the Indian Society of Critical Care Medicine represents the collective opinion of the experts chosen by the society.

Position statement

Statement (logic)

Pandemic

Position (finance)

2019-20 coronavirus outbreak

10.5005/jp-journals-10071-23395

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Regional anaesthesia—Still a comfortable choice in morbidly obese parturient

Colombian Journal of Anesthesiology (2013)

Teena Bansal Prashant Kumar Sarla Hooda

Obesity has been identified as a significant risk factor for anaesthesia related morbidity/mortality in obstetrics. Obesity compounds most of the physiological changes in pregnancy. The obese parturients are at increased risk of having either concurrent medical problems or superimposed antenatal diseases including preeclampsia and gestational diabetes. These patients need thorough preoperative assessment, meticulous preparation and preparation for difficult airway as incidence of failed intubation is many times higher in these patients. Regional anaesthesia whenever possible is the best choice in this group of patients. La obesidad se ha identificado como un factor importante de riesgo de morbimortalidad relacionada con anestesia en obstetricia. La obesidad acentúa la mayoría de los cambios fisiológicos del embarazo. Las parturientas obesas tienen un mayor riesgo de presentar problemas médicos concomitantes o enfermedades prenatales, entre ellas la preeclampsia y la diabetes gestacional. Estas pacientes requieren valoración preoperatoria minuciosa, una preparación meticulosa y alistamiento para una vía aérea difícil, puesto que la incidencia de intubación fallida es mucho más alta en ellas. Siempre que sea posible, la anestesia regionales la mejor alternativa en este grupo de pacientes.

10.1016/j.rcae.2013.08.001

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Effect of plant growth promoting fungal inoculant on the growth of arachis hypogea (L.) and it’s role on the induction of systemic resistance against rhizoctonia solani.

Asian Journal of Biological Sciences (2011)

J Sudha Lakshmi T. Kuberan J. Anburaj C. Sundaravadivelan Prashant Kumar

Beneficial plant microbe interactions in the rhizosphere are primary determinants of plant health and soil fertility. Plant growth promoting fungi have great effect towards the growth of plant crops. Soil borne pathogenic fungi cause heavy crop losses all over the world. As the use of chemicals for disease control and fertilization causes environmental problems, there is a need for alternative control measures. The most important and economically cultivated plant pea-nut was selected to test the growth promotion by antagonistic microorganisms with or with our pathogen Rhizoctonia solani . This necessitates a study on Plant Growth Promoting Fungi (PGPF) as adequate work has gone on rhizobacteria. The present investigation was conducted to study the effect of PGPF on the growth of Arachis hypogea (L.) and its role of induction of systemic resistance against Rhizoctonia solani. Forty five rhizosphere fungal isolates were obtained from 12 different cultivated field crops and were screened for their potential to promote growth in Arachis hypogea (L.). The isolate (Cc 2 ) obtained from Cucumis sativus (L.). Duch.ex. poir was identified as the potential plant growth promoting fungus. The effect of soil inoculation with the selected isolate Cc 2 on the growth of healthy plants of Arachis hypogea (L.) and those challenged with Rhizoctonia solani was studied by pot culture experiment. The overall vegetative growth of plant (Root and Shoot development, Dry matter accumulation) and reproductive growth (Pod and Seed development) were studied. The fungal inoculants improved effectively the growth both in plants challenged and unchallenged with Rhizoctonia solani. The soil inoculation of Cc 2 has improved the chlorophyll, carotenoid, anthocyanins ,total soluble sugar and protein content compare to the untreated plants (T 0 ) and plants infected by Rhizoctonia solani (T 1 ). The phenol and proline contents were found to be higher in plants challenged with Rhizoctonia solani. Growth hormone production ability of the selected isolate was determined. Results revealed that the selected isolate could produce Indole Acetic Acid and Gibberellic Acid. The in vitro study by dual culture method revealed that there was a negative interaction (Antibiosis) between the plant growth promoting fungal inoculant (Cc 2 ) and the pathogen Rhizoctonia solani. It could be concluded that the selected isolate Cc 2 proved to be a potential fungus in promoting plant growth and yield in Arachis hypogea (L.) and in inducing systemic resistance in Arachis hypogea (L.) against Rhizoctonia solani. Finally Cc 2 was identified as

Arachis

Rhizoctonia

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