To review briefly the achievements of IE development in China since Chinese Industrial Engineering Institute has established for ten years with an eye on the future,this paper discusses some issues concerning continuously promoting IE development in China.
Objective: To study the features of microsatellite alterations and their association with clinicopathological characteristics of hepatocellular carcinoma (HCC). Methods: Ten high-polymorphic microsateliite markers were detected for loss of heterozygosity (LOH), microsateliite instability (MSI) and allelic imbalance (AI) in 56 HCC using MegaBACE 500 automatic DNA analysis system. Results: LOH was found in 43 of 56 HCC (76. 8%) on at least 1 locus, the top 2 loci were RIZ (76. 7%) and D4S426 (61. 0%). LOH on D4S426 was more frequent in Edmondson grade Ⅲ and Ⅳ tumors than in grade I and 11 tumors (P0. 01). LOH on D8S277 was more frequently found in HBsAg-positive carriers than in HBsAg-negative group (76. 7% vs 18. 2%, P0. 01). MSI was found in 32. 1% cases, the top 2 loci were BAT-26 (24. 3%) and D13S170 (21. 9%) MSI rates were significantly higher in cases with positive HBsAg than in those with negative HBsAg(P0. 01). AI was found in 35. 7% of all cases examined. Conclusion: Frequent microsateliite alterations exist in HCC. LOH, which represents tumor suppressor gene pathway, plays a more important role in hepatocarcinogenesis; MSI representing mismatch repair gene pathway ranks next.
In educating postgraduate students in aerospace medicine in our country, there are some deficiencies such as the course content lacking forward looking and systematicness, and students’ mastery of technology or skills lacking professional characteristics, innovation and divergent thinking. Based on the original foundations, the School of Aerospace Medicine, Fourth Military Medical University, has been constructing and improving the course system by modifying the course contents, reforming the practical teachings, expanding the academic communications, and managing the processes. Finally, they have achieved certain results.
Key words:
Aerospace medicine; Postgraduate students; Course system
With the continuous increase of the global population and the continuous development of the social economy, the annual global demand for oil resources has increased significantly. According to the survey results, heavy oil resources are very rich, accounting for about 70% of the world's total oil reserves, much larger than traditional crude oil, so the exploitation of heavy oil is particularly important. Due to the limited supply of conventional oil and soaring oil demand, China's oil security will face unprecedented challenges. Aquathermolysis process is one of the key and economical viscosity reduction technologies for successful recovery of heavy oil in the world. This paper briefly introduces the overview of heavy oil resources in China, the technical means of heavy oil exploitation and the development of heavy oil aquathermolysis technology, and introduces in detail the classification of aquathermolysis catalysts and the research on viscosity reduction mechanism of aquathermolysis. The most suitable catalysts contain strong active sites, which can break the heteroatomic bonds of resin and asphaltene in heavy oil and promote the increase of saturated hydrocarbon and aromatic hydrocarbon content. Finally, the problems and future development trends of heavy oil aquathermolysis technology are analyzed.
Infrared neural stimulation with the assistance of photothermal transducers holds great promise as a mini-invasive neural modulation modality. Optical nanoparticles with the absorption in the near-infrared (NIR) window have emerged as excellent photothermal transducers due to their good biocompatibility, surface modifiability, and tunable optical absorption. However, poor activation efficiency and limited stimulation depth are main predicaments encountered in the neural stimulation mediated by these nanoparticles. In this study, we prepared a targeted polydopamine (PDA)-coated gold (Au) nanoparticles with specific binding to thermo-sensitive ion channel as nanotransducers for second near-infrared (NIR-II) photo-stimulation of neurons in rats. The targeted Au nanoparticles were constructed via conjugation of anti-TRPV1 antibody with PEGylated PDA-coated Au nanoparticles and thus exhibited potent photothermal performance property in the second NIR (NIR-II) window and converted NIR-II light to heat to rapidly activate Ca2+ influx of neurons in vitro. Furthermore, wireless photothermal stimulation of neurons in living rat successfully evoke excitation in neurons in the targeted brain region as deep as 5 mm beneath cortex. This study thus demonstrates a remote-controlled strategy for neuromodulation using photothermal nanotransducers.
Abstract Objectives Comorbidity prediction models have been demonstrated to offer more comprehensive and accurate predictions of death risk compared to single indices. However, their application in China has been limited, particularly among maintenance hemodialysis (MHD) patients. Therefore, the objective of this study was to evaluate the utility of comorbidity index models in predicting mortality risk among Chinese MHD patients. Methodology The MHD patients in the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine were taken as the subjects. Claims‐based disease‐specific refinements matching translation to ICD‐10 and flexibility (CDMF‐CCI) model and Liu model were selected as the candidate models for this verification research. Univariate and multivariate Cox regression calculations were used to analyze the independent predictive effect of the models on survival rate. Results Annually, nearly 500 patients undergo hemodialysis treatment. From January 2019 to June 2022, a total of 199 patients succumbed, with a mean age of 65.2 years. During these 4 years, the mortality rates were 13.04%, 9.68%, 11.69%, and 6.39%, respectively. The leading causes of death were sudden demise (82 patients, 41.2%), cardiovascular disease (48 patients, 24.1%), pulmonary infection (33 patients, 16.5%), and stroke (19 patients, 9.5%). When compared to individual indices, the CDMF‐CCI model displayed more accurate and predictive results, with an HR of 1.190 ( P = 0.037). Conversely, the Liu model failed to identify high‐risk individuals. Conclusion The MHD patients face a significant risk of mortality. When compared to univariate parameters and the Liu model, the CDMF‐CCI model exhibits superior predictive accuracy for mortality in MHD patients.
We successfully prepared high quality Li-doped ZnO ceramic targets with 70mm in diameter and 10~15mm in depth by solid-state reactions. The paper studied the influence of different concentration of Li2CO3 on the electrical properties of ZnO ceramic target. By comparing and analyzing the IR( insulative resistivity ) and tgδ(dielectric loss), the optimum concentration of Li2CO3 doped in ZnO ceramic target was obtained(2.2%mol ratio). And the optimum process for preparing ZnO-Li22% ceramic target was also realized through the investigation of physics and electrics of ZnO ceramic under the different sintering temperatures and molding pressure treatments. By using Li22%-doped ZnO ceramic as the target, the ZnO films with highly c-axis (002) preferred orientation were grown by RF magnetron sputtering on Si(100), glass and Pt(111)/Ti/SiO2/Si(100) substrates respectively.
Egg lecithin differs from soy lecithin in its phospholipid profile and fatty acid composition. The current study was designed to test whether egg lecithin or soy lecithin decreased the plasma cholesterol concentration in hamsters that are used as a model for humans. Male golden Syrian hamsters were assigned randomly to eight dietary treatments lasting 4 weeks (n=10 per treatment) that contained 0.12% (wt/wt) of cholesterol and varied amount of supplemental lipids. The diet groups were: control with no supplemental lipid, 0.05%, 0.5%, and 5% (wt/wt) of egg lecithin or soy lecithin, respectively, and 5% (wt/wt) of soybean oil. Dietary soy lecithin decreased the plasma cholesterol concentration compared with control in a dosage- and time-dependent manner. The 5% soy lecithin treatment greatly decreased the final plasma total cholesterol and LDL-cholesterol compared with the control (p<0.0001). In addition, the 5% soy lecithin supplementation caused greater decrease in plasma total cholesterol than did the 5% soybean oil treatment (p<0.05), indicating effects beyond the fatty acid composition. The cholesterol absorption measured on day 24, however, was lower in the control group compared with all other treatments (p<0.05). Overall, dietary soy lecithin but not egg lecithin decreased the plasma cholesterol concentration in hamsters via a mechanism other than decreasing cholesterol absorption.
The purpose of this study is to explore the influence of volleyball teaching in colleges and universities on students’ physical and mental health, and to systematically analyze it by multi-modal evaluation method. 300 college students were randomly divided into experimental group and control group. The experimental group received personalized intervention based on multimodal evaluation system during 16 weeks of volleyball teaching, covering multi-dimensional monitoring and feedback of physiological, psychological and technical performance. Through heart rate, body fat rate, heart rate variability (HRV), GHQ-12 scale, technical score and self-efficacy, the students’ physical quality, mental health, technical proficiency and self-efficacy were comprehensively evaluated. The results show that the multimodal intervention strategy is effective in improving physical health and mental health, and the experimental group is superior to the control group in heart rate, body fat rate, vital capacity, HRV, GHQ-12 score, technical proficiency and self-efficacy. The real-time monitoring and feedback of multimodal assessment in teaching optimizes the intervention effect and provides a scientific basis for the optimization of physical education courses in colleges and universities.
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