Lijun Zhang

Shanghai University of Traditional Chinese Medicine

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Xianglan Lu

University of Oklahoma Health Sciences Center

Shibo Li

Shenzhen Institutes of Advanced Technology

Xianfu Wang

University of Electronic Science and Technology of China

Heyang Zhang

Beijing Shijitan Hospital

Naijin Zhang

China Medical University

Young Mi Kim

OU Health

Xiaoxue Wang

Northeast Agricultural University

Qianru Zhan

First Hospital of China Medical University

Meng Liu

First Affiliated Hospital of Zhengzhou University

Xinyue Huang

First Hospital of China Medical University

Cooperative Institutions

China Medical University

First Hospital of China Medical University

University of Oklahoma Health Sciences Center

Capital Medical University

Harbin Medical University

Gilead Sciences (United States)

Chinese Academy of Medical Sciences & Peking Union Medical College

Chinese Academy of Sciences

Shanghai Jiao Tong University

Sichuan University

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Cryptic and complex chromosomal rearrangements and the deletion of TP53 gene in a patient with leukemic mantle cell lymphoma

Cancer Genetics and Cytogenetics (2006)

Lijun Zhang Williams F. Kern Zongxing Yu John J. Mulvihill Shibo Li

Breakpoint

Chromosome engineering

Chromosomal Deletion

10.1016/j.cancergencyto.2006.04.002

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Citations (3)

Clinical study of heparin combined with aspirin in the treatment of thromboembolism and its effect on pregnancy outcomes

Minerva Medica (2021)

Lei Xu Yuan Zhang Zhen Wang Changhong Gao Qianqian Yu

10.23736/s0026-4806.20.07236-5

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The Role of E3 ubiquitin Ligase WWP2 and the Regulation of PARP1 by Ubiquitinated Degradation in Apoptosis of Acute Lymphoblastic Leukemia

Research Square (Research Square) (2022)

Lijun Zhang Xinxin Lu Xinyue Huang Haiqi Xu Saien Lu

Abstract Acute lymphoblastic leukemia (ALL) has been huge threaten for people health and finding effective target therapy is urgent and important. WWP2, as one of E3 ubiquitin ligase, is involved in many biological processes by specifically binding to substrates. PARP1 plays a role in cell apoptosis and is considered as a therapeutic target of certain cancers. In this study, we firstly tested WWP2 expression in patients and normal people and analyzed the relationship with clinicopathologic factors. We demonstrated WWP2 was involved in ALL apoptosis and knockout WWP2 alleviated ALL apoptosis induced by Dox in vitro and vivo. WWP2 negatively regulated and interacted with PARP1 in vitro and vivo and WWP2 mechanically degraded PARP1 through polyubiquitin-proteasome pathway. These findings suggested WWP2 played a role in ALL apoptosis and displayed a regulatory pathway of PARP1, which provide a new potential therapeutic target for the treatment of ALL.

PARP1

10.21203/rs.3.rs-1811189/v1

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Nucleotide Prodrug GS-5734 Is a Broad-Spectrum Filovirus Inhibitor That Provides Complete Therapeutic Protection Against the Development of Ebola Virus Disease (EVD) in Infected Non-human Primates

Open Forum Infectious Diseases (2015)

Travis K. Warren Robert Jordan Michale Lo Veronica Soloveva Adrian S. Ray

Broad spectrum

Ebolavirus

10.1093/ofid/ofv130.02

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Citations (59)

Association of High Levels of Free Light Chain and the Presence of Igh Translocations in Multiple Myeloma and Prognostic Implications.

Blood (2008)

Shaji Kumar Lijun Zhang Angela Dispenzieri Scott Van Wier Jerry A. Katzmann

Immunoglobulin heavy chain

Myeloma protein

10.1182/blood.v112.11.1677.1677

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Characterization of 1q Duplication by Array Comparative Genomic Hybridization in Acute Myeloid Leukemia Patients with t(8;16)(p11.2;p13.3)

Research Square (Research Square) (2020)

Meng Liu Yuan Ren Xianfu Wang Xianglan Lu Ming Li

Abstract Background: Acute myeloid leukemia (AML) is a complex hematological disease characterized by genetic and clinical heterogeneity. The identification and understanding of chromosomal abnormalities are important for the diagnosis and management of AML patients. Compared to recurrent chromosomal translocations in AML, t(8;16)(p11.2;p13.3) can be found in any age group, but is very rare and typically associated with poor prognosis. Methods: Cytogenetic studies were performed among 1,824 AML patients from our oncology database in the last 20 years by karyotype analysis. Fluorescence in situ hybridization (FISH) was used to further confirm the chromosomal translocation fusion. Array comparative genome hybridization (aCGH) was carried out to characterize the additional chromosomal segments in patients with t(8;16)(p11.2;p13.3). Results: Three patients with t(8;16)(p11.2;p13.3) were identified. One patient was pure t(8;16)(p11.2;p13.3), and the other two had an additional chromosomal anomaly of 1q duplication. Interestingly, the molecular size and position of this 1q duplication were similar in both patients, showing as 46.7 Mb and 49.9 Mb, respectively. Conclusion: 1q duplication is a recurrent event in AML patients with t(8;16)(p11.2;p13.3), indicating it could also play a role of an unfavorable prognostic factor.

Comparative genomic hybridization

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10.21203/rs.3.rs-24639/v1

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Two rare cases of acute myeloid leukemia with t(8;16)(p11.2;p13.3) and 1q duplication: case presentation and literature review

Molecular Cytogenetics (2020)

Meng Liu Yuan Ren Xianfu Wang Xianglan Lu Ming Li

Acute myeloid leukemia (AML) is a complex hematological disease characterized by genetic and clinical heterogeneity. The identification and understanding of chromosomal abnormalities are important for the diagnosis and management of AML patients. Compared with recurrent chromosomal translocations in AML, t(8;16)(p11.2;p13.3) can be found in any age group but is very rare and typically associated with poor prognosis.Conventional cytogenetic studies were performed among 1,824 AML patients recorded in our oncology database over the last 20 years. Fluorescence in situ hybridization (FISH) was carried out to detect the translocation fusion. Array comparative genome hybridization (aCGH) was carried out to further characterize the duplication of chromosomes.We identified three AML patients with t(8;16)(p11.2;p13.3) by chromosome analysis. Two of the three patients, who harbored an additional 1q duplication, were detected by FISH and aCGH. aCGH characterized a 46.7 Mb and 49.9 Mb gain in chromosome 1 at band q32.1q44 separately in these two patients. One patient achieved complete remission (CR) but relapsed 3 months later. The other patient never experienced CR and died 2 years after diagnosis.A 1q duplication was detected in two of three AML patients with t(8;16)(p11.2;p13.3), suggesting that 1q duplication can be a recurrent event in AML patients with t(8;16). In concert with the findings of previous studies on similar patients, our work suggests that 1q duplication may also be an unfavorable prognostic factor of the disease.

Comparative genomic hybridization

10.1186/s13039-020-00507-0

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Citations (8)

Two rare cases of acute myeloid leukemia with t(8;16)(p11.2;p13.3) and 1q duplication: case presentation and literature review

Research Square (Research Square) (2020)

Meng Liu Yuan Ren Xianfu Wang Xianglan Lu Ming Li

Abstract Background : Acute myeloid leukemia (AML) is a complex hematological disease characterized by genetic and clinical heterogeneity. The identification and understanding of chromosomal abnormalities are important for the diagnosis and management of AML patients. Compared with recurrent chromosomal translocations in AML, t(8;16)(p11.2;p13.3) can be found in any age group but is very rare and typically associated with poor prognosis. Methods : Conventional cytogenetic studies were performed among 1,824 AML patients recorded in our oncology database over the last 20 years. Fluorescence in situ hybridization (FISH) was carried out to detect the translocation fusion. Array comparative genome hybridization (aCGH) was carried out to further characterize the duplication of chromosomes. Results : We identified three AML patients with t(8;16)(p11.2;p13.3) by chromosome analysis. Two of the three patients, who harbored an additional 1q duplication, were detected by FISH and aCGH. aCGH characterized a 46.7 Mb and 49.9 Mb gain in chromosome 1 at band q32.1q44 separately in these two patients. One patient achieved complete remission (CR) but relapsed three months later. The other patient never experienced CR and died two years after diagnosis. Conclusion : A 1q duplication was detected in two of three AML patients with t(8;16)(p11.2;p13.3), suggesting that 1q duplication can be a recurrent event in AML patients with t(8;16). In concert with the findings of previous studies on similar patients, our work suggests that 1q duplication may also be an unfavorable prognostic factor of the disease.

Comparative genomic hybridization

Breakpoint

10.21203/rs.3.rs-24639/v3

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Individualized prediction of conditional survival for colorectal signet-ring cell carcinoma patients

Annals of Medicine and Surgery (2024)

Jiani Gu Lijun Zhang Yan‐Jin Zhang Xia Chen Ting Gu

Conditional survival (CS) considers the time already survived after surgery and may provide additional survival information. The authors sought to construct and validate novel conditional survival nomograms for the prediction of conditional overall survival (OS) and cancer-specific survival (CSS) of colorectal signet-ring cell carcinoma (SRCC) patients.

Nomogram

Rectal carcinoma

10.1097/ms9.0000000000001982

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Investigating the mechanism of ferroptosis induction by Sappanone A in Hepatocellular carcinoma: NRF2/xCT/GPX4 axis

European Journal of Pharmacology (2024)

Yizhuo Xing Hongxuan YANG Chun-Lan Dai Ziyang Qiu Ying‐Yun Guan

Viability assay

10.1016/j.ejphar.2024.176965

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Citations (1)