Tingting Wang

Northeast Forestry University

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Jingqing Zhang

Beijing Academy of Agricultural and Forestry Sciences

Cailing Zhong

Guangdong Provincial Hospital of Traditional Chinese Medicine

Yong Zhao

Chongqing Medical University

Shanshan Yu

Quzhou City People's Hospital

Jiayun Xu

Hangzhou Normal University

Peng Li

Hebei Medical University

Bing Feng

Chinese Academy of Medical Sciences & Peking Union Medical College

Yaping Li

Shanghai Institute of Materia Medica

Fangyuan Zhou

Huazhong University of Science and Technology

Yaqin Tang

Chongqing University of Technology

Cooperative Institutions

Chinese Academy of Sciences

197

Chongqing Medical University

133

Central South University

Chinese Academy of Medical Sciences & Peking Union Medical College

Zhejiang University

Shanghai Jiao Tong University

Sun Yat-sen University

Jilin University

Peking University

University of Chinese Academy of Sciences

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Study of Deformation Law of Casing Local Lateral Collapse Based on the Principle of Virtual Work

Energies (2019)

Wanchun Zhao Jing Ge P.G. Ranjith Yuwei Li Zhenlong Song

In view of the water swelling of mudstone and the creep induction function of formations in the process of oilfield water injection, the casing incurs collapse deformation under local lateral load. In this study, according to the actual collapse deformation characteristics of the casing in the second section of the Qing formation of the Songliao Basin in China, the yield surfaces of the casing collapse deformation are considered as plane plastic areas (half rhombus) with symmetric parabola shaped boundaries, and a mechanical model for the local lateral collapse deformation of casing is presented based on the principle of virtual work. Four types of casing, 4½″J55, 5½″J55, 4½″N80 and 5½″N80, are selected as examples. The relation of the casing intensity, the absolute reduction of intensity and the relative reduction ratio of intensity change with casing wall thickness, yield stress, radial maximum deformation, and deformation length are calculated and analyzed. The results show that the casing intensity of the casing is reduced under local lateral load, which is lower than the design standard value of the American Petroleum Association specification (API SPEC) 5CT. The relative reduction ratio declines linearly with the wall thickness of the casing wall as the yield stress increases, and increases linearly with increasing maximum deformation. In addition, the local lateral bearing capacity of the casing reaches the minimum value when the plastic deformation length reaches the critical value or the deformation quantity is less than the critical value. The conclusions provide scientific guidance for preventing casing failure accidents caused by deformation.

Intensity

10.3390/en12193717

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Citations (5)

Enhanced gene delivery of low molecular weight PEI by flower-like ZnO microparticles

Materials Science and Engineering C (2016)

Ming Chen Yaqin Tang Tingting Wang Qipeng Long Zi‐Ying Zeng

Polyethylenimine

10.1016/j.msec.2016.06.095

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Citations (15)

Management of intrauterine adhesions using human amniotic mesenchymal stromal cells to promote endometrial regeneration and repair through Notch signalling

Journal of Cellular and Molecular Medicine (2021)

Jie Yu Wenwen Zhang Jiayue Huang Yating Gou Congcong Sun

Abstract Intrauterine adhesions (IUAs) severely hamper women's reproductive functions. Human amniotic mesenchymal stromal cell (hAMSC) transplantation is effective in treating IUAs. Here, we examined the function of Notch signalling in IUA treatment with hAMSC transplantation. Forty‐five Sprague‐Dawley female rats were randomly divided into the sham operation, IUA, IUA + E2, IUA + hAMSCs and IUA + hAMSCs + E2 groups. After IUA induction in the rats, hAMSCs promoted endometrial regeneration and repair via differentiation into endometrial epithelial cells. In all groups, the expression of key proteins in Notch signalling was detected in the uterus by immunohistochemistry. The results indicated Notch signalling activation in the hAMSCs and hAMSCs + E2 groups. We could also induce hAMSC differentiation to generate endometrial epithelial cells in vitro. Furthermore, the inhibition of Notch signalling using the AdR‐dnNotch1 vector suppressed hAMSC differentiation (assessed by epithelial and mesenchymal marker levels), whereas its activation using the AdR‐Jagged1 vector increased differentiation. The above findings indicate Notch signalling mediates the differentiation of hAMSCs into endometrial epithelial cells, thus promoting endometrial regeneration and repair; Notch signalling could have an important function in IUA treatment.

Amniotic epithelial cells

10.1111/jcmm.17023

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Citations (13)

A Novel Toolpath for Robotic Adaptive Grinding of Extremely Thin Blade Edge Based on Dwell Time Model

IEEE/ASME Transactions on Mechatronics (2022)

Chong Lv Lai Zou Yun Huang Heng Li Tingting Wang

High precision and high efficiency in robotic grinding of aero-engine extremely thin blade edges is a challenging problem. In this article, a novel toolpath planning method is proposed based on the derived dwell time calculation model and the developed interpolation algorithm. The dwell time of each cutter contact point is solved based on the matrix method by consideration of the revised material removal model and machining allowance distribution. To optimize the previous interpolation algorithm based on geometric intersection, an arc length and Taylor binary expansion optimization are proposed to plan cutter contact points according to the dwell time and the curvature changes of blade edges. Subsequently, the tool orientation is corrected based on a double-vector controlling method to avoid the processing interference. Simulation results show that the proposed interpolation algorithm has improved the path coverage by 17.6%, and its computational efficiency is 34 times higher than that in previous algorithm. The comparative robotic grinding experiment results show that the proposed toolpath has improved the surface profile accuracy of blade edge to 0.042 mm, and its machining accuracy is 14.3–46.2% higher than that of other methods.

Interpolation

Dwell time

Cutter location

Milling cutter

10.1109/tmech.2022.3156804

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Citations (30)

Optimal design of blade in pump as turbine based on multidisciplinary feasible method

Science Progress (2020)

Senchun Miao Zhang Hong-biao Tingting Wang Xiaohui Wang Fengxia Shi

In order to make the pump as turbine (PAT) run efficiently and safely, a multidisciplinary optimization design method for PAT blade, which gives consideration to both the hydraulic and intensity performances, is proposed based on multidisciplinary feasibility (MDF) optimization strategy. This method includes blade parametric design, Latin Hypercube Sampling (LHS) experimental design, CFD technology, FEA technology, GA-BP neural network and NSGA-II algorithm. Specifically, a parameterized PAT blade with cubic non-uniform B-spline curve is adopted, and the control point of blade geometry is taken as the design variable. The LHS experimental design method obtains the sample points of training GA-BP neural network in the design space of variables. The hydraulic performance of each sample point (including the hydraulic pressure load on the blade surface) and the strength performance analysis of blades are completed by CFD and FEA technology respectively. In order to save calculation time of the whole optimization design, the multi-disciplinary performance analysis of each sample in the optimization process is completed by single-coupling method. Then, GA-BP neural network is trained. Finally, the multi-disciplinary optimization design problem of PAT blade is solved by the optimization technology combining GA-BP neural network and NSGA-II algorithm. Based on this optimization method, the PAT blade is optimized and improved. The efficiency of the optimized PAT is improved by 1.71% and the maximum static stress on the blade is reduced by 7.98%, which shows that this method is feasible.

Latin Hypercube Sampling

Multidisciplinary design optimization

10.1177/0036850420982105

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Citations (17)

Biomimetic lipidic nanovectors for effective asparaginase supramolecule delivery

Nanomedicine Nanotechnology Biology and Medicine (2022)

Yan Wu Shengli Wan Yun Chen Jingchuan Fan Yao Li

10.1016/j.nano.2022.102518

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Citations (3)

Exosome is an important novel way of acupuncture information transmission

World Journal of Traditional Chinese Medicine (2020)

Bo Chen Yi Guo Ningcen Li Mingyue Li Zhong-Xi Lü

As a physical stimulation of the body surface, the process of transmitting acupuncture information from acupoints to target organs through meridians and collaterals is complex, and network regulation is the most basic mode of acupuncture. Exosomes are membrane vesicles formed by various types of cells and secreted to the extracellular matrix through a series of regulation. We speculate that exosomes and their carriers, as important carriers of communication among neurons, endocrine cells, and immune cells, may play an important role in the process of acupuncture information transmission. Exosome in the acupoint area is an important interactive form of transformation from physical information to chemical information. Circulating exosome is an important means of delivery for acupuncture to play an important role in the network regulation. The structure and information molecules of exosomes are the important material bases for acupuncture effect. Through experimental research, it was found that acupuncture can regulate the release of exosome and may have a certain relationship with acupuncture effect. Therefore, exosome may play an important role in the process of acupuncture information transmission, which is an important new way of acupuncture information transmission.

Exosome

Information transmission

10.4103/wjtcm.wjtcm_57_20

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Citations (3)

A novel evodiamine amino derivative as a PI3K/AKT signaling pathway modulator that induces apoptosis in small cell lung cancer cells

European Journal of Pharmacology (2021)

Tingting Wang Di Qi Xueyuan Hu Na Li Xue Zhang

Evodiamine

10.1016/j.ejphar.2021.174215

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Citations (12)

Characteristics and application of immune-regulating and antiviral Chinese materia medica/ 免疫调节抗病毒中药的特性与应用

Ran Chen Tingting Wang Kailing Li Rui-Feng Shang Jie Song

Recently, the epidemic of novel coronavirus pneumonia (COVID-19) in China and other countries in the world is serious. There are at present no effective treatments for COVID-19. The safety and effectiveness of western anti-coronavirus drugs are under investigation. In many places in China, traditional Chinese medicine (TCM) has been used to treat COVID-19 with a high clinical cure rate. The treatment economics of TCM is good. The immune-regulating and antiviral TCM can enhance human immunity and exert an antiviral effect. They have been widely used in the anti-COVID-19 treatment. We consulted the database of CNKI, Wanfang, VIP and PubMed for screening the immune-regulating and antiviral TCMs (Glycyrrhizae Radix et Rhizoma, Pogostemonis Herba, Lonicerae Japonicae Flos, Scutellariae Radix, Forsythiae Fructus, Magnoliae Officinalis Cortex, Bupleuri Radix, Isatidis Radix, Rhei Radix et Rhizoma, Astragali Radix, and Houttuyniae Herba). This article summarizes the physicochemical and pharmacokinetic characteristics, and the clinical application of the effective components of immune-regulating and antiviral TCM in the prescriptions and Chinese patent medicines, in order to provide a better reference for the clinical application of TCM.

Radix (gastropod)

Flos

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Motion Planning for SLAM Based on Frontier Exploration

International Conference on Mechatronics and Automation (2007)

Tao Tong Yalou Huang Fengchi Sun Tingting Wang

This paper proposes a novel motion planning approach for SLAM in out-door large unknown environment. This approach uses the frontier based exploration strategy to find frontier points, and select the best one as the destination point of the robot. Navigating to the destination point will minimize the system uncertainty and improve the efficiency of exploration. The last part of this paper compares the proposed approach with traditional random SLAM from the point of efficiency and accuracy to validate its advantage.

Frontier

10.1109/icma.2007.4303879

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Citations (23)