Liming Chen

Huazhong University of Science and Technology

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Ying Liu

Huazhong University of Science and Technology

Walter F. Boron

Case Western Reserve University

Liang Gao

Huazhong University of Science and Technology

Haobo Qiu

Huazhong University of Science and Technology

Chen Jiang

Guangdong Institute of Intelligent Manufacturing

Liwu Fu

Sun Yat-sen University Cancer Center

Yong‐ju Liang

Sun Yat-sen University

Zan Yang

Nanchang University

Sitong Liu

Peking University

Pan Su

First Affiliated Hospital of Henan University

Cooperative Institutions

Huazhong University of Science and Technology

118

Sun Yat-sen University

Peking University

Chinese Academy of Sciences

Zhejiang University

Chinese Academy of Medical Sciences & Peking Union Medical College

Shanghai Jiao Tong University

Sun Yat-sen University Cancer Center

Central South University

Sichuan University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

MAGNETIC AND ELECTRONIC TRANSPORT PROPERTIES OF NANOSTRUCTURED La0.67Ca0.33MnO3 FILMS

International Journal of Modern Physics B (2005)

P. G. LI Changping Chen Y Zhang Xinhai Fu Liming Chen

Nanostructured colossal magnetoresistive (CMR) films of La 0.67 Ca 0.33 MnO 3 (LCMO) were deposited by using pulsed electron deposition technique on anodized aluminum oxide membranes with pores of 50 nm in diameter. The magnetic and electronic transport properties were measured on Quantum Design physics properties measurement system (PPMS) and magnetic properties measurement system (MPMS). The resistance peak temperature ( T P ) is about 165 K and the Curie temperature ( T C ) is about 260 K. Large magnetoresistance was observed near T P in these nanostructured LCMO films. Linear I-V curves at different temperatures indicate no electronic tunneling effect. The large difference between T P and T C suggests that the nature of the resistance peak is different from that of bulk samples. The physics in these nanostructured films should be interesting to explore the mechanism of CMR effect.

Colossal Magnetoresistance

Anodizing

10.1142/s0217979205031262

Cite

Citations (4)

Structural requirements for the electrogenicity of the electrogenic Na‐HCO3 cotransporter NBCe1

The FASEB Journal (2008)

Liming Chen Walter F. Boron

Na/HCO 3 cotransporters, including the electrogenic NBCe1 and the electroneutral NBCn1, belong to SLC4 family. The NBCe1‐A splicing variant plays a key role in HCO 3 reabsorption by renal proximal tubules. NBCe1 and NBCn1 have 13 putative transmembrane (TM) segments and a large extracellular loop between TM5 and 6 (“the Loop”). Choi et al (J Physiol, 578:131, 2007) previously demonstrated that the electrogenecity of NBCe1‐A requires the interaction between TM1‐5 and TM6‐13, but does not require the cytoplasmic N terminus (Nt), the Loop, or the cytoplasmic C terminus (Ct). To understand better the structural basis of electrogenecity of NBCe1, we constructed a series of chimeras of human NBCe1‐A and NBCn1‐X (i.e., lacking cassette B in the Ct), starting with one consisting of Nt∼Loop of NBCe1‐A spliced to TM6∼Ct of NBCn1. We exposed Xenopus oocytes expressing chimeras or wild‐type NBCe1‐A to 1.5% CO 2 /10 mM HCO 3 (pH 7.5), and monitored pH i and V m . We found that this first chimera exhibits the Na conductance characteristic of NBCn1, but no HCO 3 transport. Restoring TM6‐7 of NBCe1‐A restored some electrogenic HCO 3 transport (i.e., CO 2 /HCO 3 elicited a slight hyperpolarization and pH i recovery). The chimera in which we restored TM6‐9 of NBCe1‐A functions as a typical NBCe1‐A. We conclude that the putative TM6‐9 of NBCe1 (vs NBCn1) is very important, but TM10‐13 of NBCe1 is not essential, for the electrogenecity of NBCe1‐A.

Hyperpolarization

10.1096/fasebj.22.1_supplement.759.13

Cite

Citations (1)

Redox state of NAD modulates the activation of Na-bicarbonate cotransporter NBCe1-B via IRBIT and L-IRBIT

Science China Life Sciences (2025)

Tianxiang Gui Ying Liu Minyue Fu Han Wu Su Pan

Bicarbonate

10.1007/s11427-024-2750-0

Cite

Citations (0)

P1‐338: Neuoroglobin attenuates tau hyperphosphorylation by regulation of glycogen synthase kinase‐3beta activity

Alzheimer s & Dementia (2010)

Liming Chen Ling‐Qiang Zhu Jian‐Zhi Wang

Neuroglobin (Ngb) is a recently discovered globin that is predominantly expressed in the brain. Ngb has been shown to act as a neuroprotective factor and signaling transduction molecular. Alzheimer's disease (AD) characterized pathologically with tau hyperphosphorylation and glycogen synthase kinase-3β (GSK-3β) is a major tau kinase. Therefore, an attractive hypothesis is that Ngb might act as signaling transduction molecular to regulate activity of GSK-3β. Wortmannin (wort) and GF-109203X (GFX) or transfection of GSK-3β plasmid for HEK293/tau cell to mimic AD-like tau hyperphosphorylation induced by GSK-3 activation. Ngb-EGFP-N1 or PEGFP-N1 plasmid was also transfected into HEK293/tau cell. Western blotting and immunofluorescence were applied to assay the level of tau hyperphosphorylation, the expression of total GSK-3β and phospho-GSK-3β at Ser9, total Protein kinase B (Akt) and phosphor-Akt at Ser 473 and at Thr 308. Immunoprecipitation technique test the interaction of between Ngb and GSK-3β. Ngb attenuates the level of tau hyperphosphorylation at multiple sites, increases the level of phosphor-GSK3β at Ser9 site and phosphor-Akt at Ser473 or Thr308 site in Hek393/tau/Ngb cell. And total Gsk3β and Akt are not changed. Immunoprecipitation data shows Ngb is not binding with Gsk3β. Ngb act as a guanine nucleotide dissociation inhibitor (GDI), can induce PI3/Akt pathway, then activate Gsk3β of a major of tau kinase. Ngb may as a new drug target to treat Alzheimer disease in future.

Hyperphosphorylation

GSK3B

Wortmannin

10.1016/j.jalz.2010.05.891

Cite

Citations (0)

Overexpression of Survivin and XIAP in MDR cancer cells unrelated to P-glycoprotein

Oncology Reports (2007)

Zhi Shi Yong‐ju Liang Zhe‐Sheng Chen Xiaohong Wang Yan Ding

XIAP

Survivin

Inhibitor of apoptosis

P-glycoprotein

10.3892/or.17.4.969

Cite

Citations (50)

A screening-based gradient-enhanced Kriging modeling method for high-dimensional problems

Applied Mathematical Modelling (2018)

Liming Chen Haobo Qiu Liang Gao Chen Jiang Zan Yang

10.1016/j.apm.2018.11.048

Cite

Citations (42)

Application of integrated traditional chinese and western medicine in treatment of systemic sclerosis: A case report

EXPLORE (2022)

Xiaohan Wang Jiaqian Zhang Qi Kong Wen-Zhen Tu Liming Chen

Demographics

Clinical Practice

10.1016/j.explore.2022.06.001

Cite

Citations (2)

Effects of optional structural elements, including two alternative amino termini and a new splicing cassette IV, on the function of the sodium–bicarbonate cotransporter NBCn1 (SLC4A7)

The Journal of Physiology (2013)

Ying Liu Xue Qin Deng‐Ke Wang Yi‐Min Guo Harindarpal S. Gill

The SLC4A7 gene encodes the electroneutral sodium/HCO3 cotransporter NBCn1, which plays important physiological and pathophysiological roles in many cell types. Previous work identified six NBCn1 variants differing in the sequence of the extreme N terminus--MEAD in rat only, MERF in human only--as well as in the optional inclusion of cassettes I, II, and III. Earlier work also left open the question of whether optional structural elements (OSEs) affect surface abundance or intrinsic (per-molecule) transport activity. Here, we demonstrate for the first time that SLC4A7 from one species can express both MEAD- and MERF-NBCn1. We also identify a novel cassette IV of 20 aa, and extend by 10 the number of full-length NBCn1 variants. The alternative N termini and four cassettes could theoretically produce 32 major variants. Moreover, we identify a group of cDNAs predicted to encode just the cytosolic N-terminal domain (Nt) of NBCn1. A combination of electrophysiology and biotinylation shows that the OSEs can affect surface abundance and intrinsic HCO3(-) transport activity of NBCn1, as expressed in Xenopus oocytes. Specifically, MEAD tends to increase whereas novel cassette IV reduces surface abundance. Cassettes II, III and novel cassette IV all appear to increase the intrinsic activity of NBCn1.

10.1113/jphysiol.2013.258673

Cite

Citations (17)

Vimentin Promotes Astrocyte Activation After Chronic Constriction Injury

Journal of Molecular Neuroscience (2017)

Pengfei Xue Liming Chen Xiongsong Lu Jinlong Zhang Guofeng Bao

10.1007/s12031-017-0961-6

Cite

Citations (11)

A Novel Surrogate-assisted Differential Evolution for Expensive Optimization Problems with both Equality and Inequality Constraints

2022 IEEE Congress on Evolutionary Computation (CEC) (2019)

Zan Yang Haobo Qiu Liang Gao Chen Jiang Liming Chen

Surrogates have recently shown excellent abilities in assisting evolutionary algorithms for solving computationally expensive constrained optimization problems (ECOPs). However, the effectiveness of such surrogate-assisted evolutionary algorithms has only been verified on ECOPs with inequality constraints. In this paper, a Novel Surrogate-Assisted Differential Evolution (NSADE) algorithm is proposed for solving ECOPs with equality and inequality constraints, in which a trial vector generation mechanism and two surrogate-assisted local search phases are carried out iteratively. The trial vector generation mechanism based on information exchange between the historical elite solution set and current population is utilized to balance exploiting potential areas and exploring unknown areas. Then the expectation improvement-based local search is used to not only guide the current population to move towards feasible region but also alleviate the inaccuracy of the surrogate on the constraint boundary. Finally, a solution identification-based local search is utilized to further optimize two different types of historical elite solutions. Empirical studies on fifteen widely used benchmark problems demonstrate that the proposed NSADE can effectively obtain high-quality feasible solutions on ECOPs with equality constraints under a limited computational budget.

Benchmark (surveying)

Differential Evolution

Feasible region

Surrogate model

Constrained optimization

10.1109/cec.2019.8790113

Cite

Citations (6)