Shiyu Wang

Key Laboratory of Nuclear Radiation and Nuclear Energy Technology

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Peng Huang

Shanghai Jiao Tong University

Guihua Zeng

Shanghai Jiao Tong University

Tao Wang

Shanghai Jiao Tong University

Hongxin Ma

PLA Air Force Aviation University

Wan-Su Bao

State Key Laboratory of Cryptology

Yanan Wang

Shanghai Jiao Tong University

Yuan Liu

Guangzhou University of Chinese Medicine

Weiqi Liu

Shanghai Institute of Materia Medica

Dongyun Bai

Shanghai Jiao Tong University

Sufang Wu

Shanghai Jiao Tong University

Cooperative Institutions

University of Science and Technology of China

Shanghai Jiao Tong University

Chinese Academy of Sciences

Hefei National Center for Physical Sciences at Nanoscale

Beijing Academy of Quantum Information Sciences

Peking University

Tongji University

Tsinghua University

Sichuan University

Shanghai East Hospital

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LSD1 sustains estrogen-driven endometrial carcinoma cell proliferation through the PI3K/AKT pathway via di-demethylating H3K9 of cyclin D1

International Journal of Oncology (2017)

Chunqin Chen Yanan Wang Shiyu Wang Yuan Liu Jiawen Zhang

A recent study reported that histone lysine specific demethylase 1 (LSD1, KDM1A) is overexpressed in endometrioid endometrial carcinoma (EEC) and associated with tumor progression as well as poor prognosis. However, the physiological function and mechanism of LSD1 in endometrial cancer (EC) remains largely unknown. In this study, we demonstrate that β-estradiol (E2) treatment increased LSD1 expression via the GPR30/PI3K/AKT pathway in endometrial cancer cells. Both siGPR30 and the PI3K inhibitor LY294002 block this effect. RNAi-mediated silencing of LSD1 abolished estrogen-driven endometrial cancer cell (ECC) proliferation, and induced G1 cell arrest and apoptosis. Mechanistically, we find that LSD1 silencing results in PI3K/AKT signal inactivation, but without the elevation of PTEN expression as expected. This is because the inhibition of LSD1 induces dimethylation of lysine 9 on histone H3 (H3K9m2) accumulation at the promoter region of cyclin D1. Interfering with cyclin D1 leads to PI3K/AKT signal suppression. Re-overexpression of cyclin D1 in LSD1-knockdown ECCs reverses the LSD1 inhibitory action. Our finding connects estrogen signaling with epigenetic regulation in EEC and provides novel experimental support for LSD1 as a potential target for endometrial cancer therapeutics.

10.3892/ijo.2017.3849

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Citations (26)

Fast multiplexed superconducting qubit readout with intrinsic Purcell filtering

arXiv (Cornell University) (2024)

Peter Spring Luka Milanovic Yoshiki Sunada Shiyu Wang Arjan F. van Loo

Fast and accurate qubit measurement remains a critical challenge on the path to fault-tolerant quantum computing. In superconducting quantum circuits, fast qubit measurement has been achieved using a dispersively coupled resonator with a large external linewidth. This necessitates the use of a Purcell filter that protects the qubit from relaxation through the readout channel. Here we show that a readout resonator and filter resonator, coupled to each other both capacitively and inductively, can produce a compact notch-filter circuit that effectively eliminates the Purcell decay channel through destructive interference. By utilizing linewidths as large as 42 MHz, we perform 56-ns simultaneous readout of four qubits and benchmark an average assignment fidelity of 99.77%, with the highest qubit assignment fidelity exceeding 99.9%. These results demonstrate a significant advancement in speed and fidelity for multiplexed superconducting qubit readout.

Flux qubit

10.48550/arxiv.2409.04967

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Halogen-bond induced unusual polyhalogen anions formation in hydrogen-bonded frameworks to secure iodine sequestration

Nano Research (2024)

Yi Xie Pengling Huang Qiang Gao Shiyu Wang Jianchen Wang

Halogen bond

10.1007/s12274-024-6606-5

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miR-98-5p contributes to cisplatin resistance in epithelial ovarian cancer by suppressing miR-152 biogenesis via targeting Dicer1

Cell Death and Disease (2018)

Yanan Wang Wei Bao Yuan Liu Shiyu Wang Shengjie Xu

Abstract Epithelial ovarian cancer (EOC) is a highly lethal gynecological malignancy, and cisplatin resistance is usually correlated with the poor prognosis of EOC. Increasing evidence indicates that the dysregulation of miRNAs is related to chemotherapy sensitivity. In this study, we revealed that miR-98-5p, a member of the let-7 family, was enriched in cisplatin-resistant EOC cells compared with cisplatin-sensitive cells, and could promote cisplatin resistance in EOC cells. Further studies showed that miR-98-5p could directly target the 3′-UTR of Dicer1 and suppress its expression, causing global miRNA downregulation. By miRNA array and qRT-PCR verification, we identified miR-152 as the vital downstream target of the miR-98-5p/Dicer1 axis in EOC cells. Moreover, we demonstrated that the ectopic expression of miR-152 reversed cisplatin resistance both in vitro and in vivo by targeting RAD51, a central member in homologous recombination. Importantly, miR-98-5p expression, as determined by in situ hybridization in tumor tissues, was associated with poor outcome of EOC patients. Together, these findings suggest the essential role of the miR-98-5p/Dicer1/miR-152 pathway in regulating cisplatin resistance of EOC cells and provide a potential target for EOC therapy.

Ectopic expression

10.1038/s41419-018-0390-7

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Citations (90)

Dynamic polarization control for free-space continuous-variable quantum key distribution

Optics Letters (2020)

Shiyu Wang Peng Huang Tao Wang Guihua Zeng

Free-space quantum key distribution (QKD) is attractive for the establishment of future global-scale quantum networks. However, it can be quite difficult for dynamic polarization control required in continuous-variable QKD systems to work properly in the presence of channel fading. Here we propose a dynamic polarization control scheme and verify its validity via simulations and an experiment performed over a 150 m free-space channel. The results indicate the capability of the scheme to effectively control the states of polarization for free-space continuous-variable quantum communication.

Quantum key distribution

Free space

Continuous variable

Free-Space Optical Communication

10.1364/ol.404589

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Carrier-phase estimation for simultaneous quantum key distribution and classical communication using a real local oscillator

Physical review. A/Physical review, A (2019)

Tao Wang Peng Huang Shiyu Wang Guihua Zeng

The simultaneous quantum and classical communication (SQCC) protocol is an appealing protocol since it allows continuous-variable quantum key distribution (CV-QKD) and classical communication to be implemented simultaneously by using the same communication infrastructure and on a single wavelength. However, the main challenge of the SQCC protocol is its low tolerance of phase noise, limiting the transmission distance under the real local oscillator (LO) design. To eliminate the phase drift without the aid of the reference signal, the classical carrier phase estimation (CPE) algorithm in the field of coherent optical communication is employed for phase recovery and data extraction. Besides, the power of the residual phase noise in classical communication and the power of the excess phase noise in CV-QKD are derived, including the effects of the employed laser linewidth, the transversal filter length, and the classical signal power. On this basis, the performances of the SQCC protocol under the trusted and the untrusted phase noise model are discussed, respectively. Our work confirms the feasibility of the CPE algorithm in the SQCC protocol and demonstrates the conditions required for this protocol to operate on a coherent optical communication system.

Quantum key distribution

Quantum noise

10.1103/physreva.99.022318

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Citations (15)

High key rate continuous-variable quantum key distribution with a real local oscillator

Optics Express (2018)

Tao Wang Peng Huang Yingming Zhou Weiqi Liu Hongxin Ma

Continuous-variable quantum key distribution (CVQKD) with a real local oscillator (LO) has been extensively studied recently due to its security and simplicity. In this paper, we propose a novel implementation of a high-key-rate CVQKD with a real LO. Particularly, with the help of the simultaneously generated reference pulse, the phase drift of the signal is tracked in real time and then compensated. By utilizing the time and polarization multiplexing techniques to isolate the reference pulse and controlling the intensity of it, not only the contamination from it is suppressed, but also a high accuracy of the phase compensation can be guaranteed. Besides, we employ homodyne detection on the signal to ensure the high quantum efficiency and heterodyne detection on the reference pulse to acquire the complete phase information of it. In order to suppress the excess noise, a theoretical noise model for our scheme is established. According to this model, the impact of the modulation variance and the intensity of the reference pulse are both analysed theoretically and then optimized according to the experimental data. By measuring the excess noise in the 25km optical fiber transmission system, a 3.14Mbps key rate in the asymptotic regime proves to be achievable. This work verifies the feasibility of the high-key-rate CVQKD with a real LO within the metropolitan area.

Quantum key distribution

Heterodyne detection

10.1364/oe.26.002794

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Citations (115)

Radiofrequency ablation versus percutaneous ethanol injection for hepatocellular carcinoma: a meta-analysis of randomized controlled trials

World Journal of Surgical Oncology (2015)

Biao Yang Rui-yu Zan Shiyu Wang Xianglian Li Mao‐Ling Wei

Radiofrequency ablation (RFA) and percutaneous ethanol injection (PEI) are treatment methods for patients with early-stage hepatocellular carcinoma (HCC) who are not suitable for surgery. Although some reports indicate that RFA is better than PEI, results from previous reviews and analyses are inconsistent. Therefore, this meta-analysis was performed to more thoroughly evaluate the effects of these treatments in patients with HCC.

Percutaneous ethanol injection

Surgical oncology

Subgroup analysis

10.1186/s12957-015-0516-7

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Citations (51)

Long-distance continuous-variable measurement-device-independent quantum key distribution with discrete modulation

Physical review. A/Physical review, A (2019)

Hongxin Ma Peng Huang Dongyun Bai Tao Wang Shiyu Wang

We propose a long-distance continuous-variable measurement-device-independent quantum key distribution (CV-MDI-QKD) protocol with discrete modulation. This kind of discrete-modulated schemes have good compatibility with efficient error correction code, which lead to higher reconciliation efficiency even at low signal-to-noise ratio (SNR). Security analysis shows that the proposed protocol is secure against arbitrary collective attacks in the asymptotic limit with proper use of decoy states. And with the using of discrete modulation, the proposed CV-MDI-QKD protocol has simpler implementation and outperform previous protocols in terms of achievable maximal transmission distance, which precisely solve the bottleneck of the original Gaussian-modulated CV-MDI-QKD protocol.

Quantum key distribution

Continuous variable

Modulation (music)

10.1103/physreva.99.022322

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Citations (57)

人脐带间充质干细胞通过 IGF1R-CHK2-p53 信号轴减轻 2 型糖尿病雄性大鼠糖尿病肾病

Journal of Zhejiang University SCIENCE B (2024)

Hao Zhang Xinshu Wang Bo Hu Peicheng Li Yierfan Abuduaini

Oil Red O

10.1631/jzus.b2300182

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Citations (1)