Lei Wang

Guangdong Pharmaceutical University

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Qing Zhu

People's Hospital of Xinjiang Uygur Autonomous Region

Anlong Xu

Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)

Chun-Ying Wu

National Yang Ming Chiao Tung University

Yeyan Zhu

Guangzhou University of Chinese Medicine

Aihua Lu

Sun Yat-sen University

Tianxin Yang

University of Utah

Jun‐Liang Liu

Sun Yat-sen University

Canhui Pi

Sun Yat-sen University

Shangwu Chen

Sun Yat-sen University

Weidong Wang

First Affiliated Hospital of Zhengzhou University

Cooperative Institutions

Sun Yat-sen University

151

Guangzhou University of Chinese Medicine

Chinese Academy of Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

Peking University

Fudan University

Shanghai Jiao Tong University

Nanjing Medical University

Capital Medical University

Guangzhou Medical University

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EP13.06-06 Exploratory Clinical Study of Anlotinib Combined with Concurrent Chemoradiotherapy in the Treatment of Small Cell Lung Cancer(SCLC)

Journal of Thoracic Oncology (2023)

Feifei Yang Ma Xing Rong Li Hongbo Zhao L. Ren

Chemoradiotherapy

10.1016/j.jtho.2023.09.1360

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Citations (0)

TGR5 Activation Ameliorated Hypertension Through Inhibiting Epithelial Sodium Channel (ENaC) Expression in the Kidney of Deoxycorticosterone Acetate (DOCA) Salt-Treated Mice

Journal of the American Society of Nephrology (2023)

Long Xu Xinyan Wu Suchun Li Wei Chen Lei Wang

Epithelial sodium channel

Desoxycorticosterone Acetate

10.1681/asn.20233411s1548c

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Restorative resection of radiation rectovaginal fistula can better relieve anorectal symptoms than colostomy only

World Journal of Surgical Oncology (2017)

Qinghua Zhong Zixu Yuan Tenghui Ma Huaiming Wang Qiyuan Qin

Radiation-induced rectovaginal fistula (RVF) is a severe and difficult complication after pelvic malignancy radiation. This study was to retrospectively compare the outcomes of restorative resection and colostomy only in remission of anorectal symptoms. We enrolled a cohort of 26 consecutive cases who developed RVF after pelvic radiation. Two main procedures for these patients in our institution were used: one was restorative resection and pull-through coloanal anastomosis with a prophylactic colostomy, and another was a simple colostomy without resection. Thus, we divided these patients into these two groups. Anorectal symptoms including rectal pain, bleeding, tenesmus, and perineal mucous discharge were recorded and scored prior to surgery and at postoperative multiple time points. The baseline was similar among the two groups. All patients acquired good efficacy with improved symptoms at postoperative 6, 12, and 24 months, when compared to baseline. In addition, the resection group showed a better remission of tenesmus (6 months 33.3 vs 0%; 12 months 66.7 vs 16.7%) and perineal mucous discharge (6 months 88.9 vs 6.7%; 12 months 77.8 vs 15.4%; 24 months 85.7 vs 25.0%). Furthermore, three (30%) patients in the resection group successfully reversed stomas while no stoma was closed in the simple colostomy group. Both restorative resection procedure and colostomy only can improve anorectal symptoms of radiation-induced RVF, but restorative resection can completely relieve anorectal symptoms in selected cases.

Rectovaginal Fistula

Surgical oncology

Colorectal Surgery

10.1186/s12957-017-1100-0

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Sodium Butyrate Protects against Renal Injury in DOCA Salt Hypertensive Rats

The FASEB Journal (2017)

Qing Zhu Lei Wang Linlin Zhang Aihua Lu Tianxin Yang

We previously found that infusion of sodium butyrate (NaBu) into the renal medullary suppressed angiotensin II‐induced hypertension and improved renal injury. The present study was to test whether systemic administration of NaBu protects the kidneys from damage in DOCA‐salt rats. Uninephrectomized male Sprague‐Dawley rats were treated with a subcutaneous DOCA pellet (200mg/rat) and 1% NaCl drinking water for 2 weeks. Sham rats were uninephrectomized and drank tap water. Animals received an oral gavage of NaBu (0.1g/kg) or vehicle once per day. Hypertension induced by DOCA‐salt was significantly attenuated in rats treated with NaBu. Urinary albumin excretion increased from 0.24 ± 0.05 mg/24h in sham rats to 12.01 ± 5.13 in DOCA‐salt rats, which was significantly reduced to 2.32 ± 0.94 in NaBu‐treated DOCA‐salt rats (p<0.05). Morphological examination showed that the glomerular damage indices were 1.04 ± 0.1, 2.87± 0.08 and 1.69 ± 0.12 in sham, DOCA salt‐treated, and NaBu‐treated DOCA‐salt rats, respectively. There was no difference in creatinine clearance rate in sham or NaBu‐treated DOCA‐salt rats compared with only DOCA‐salt rats. These results suggest that sodium butyrate may protect against renal injury in DOCA‐salt hypertension and that NaBu could serve as a novel therapeutic approach for the treatment of chronic renal injury. Support or Funding Information National Natural Science Foundation of China Grant No. 91439205, No. 31330037 and No. 81600322; Fundamental Research Funds of Sun Yat‐sen University 16ykpy47; Veterans Affairs Merit Review, and National Institutes of Health Grant DK094956.

Renal Injury

Sodium butyrate

10.1096/fasebj.31.1_supplement.855.14

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Sodium butyrate suppresses Angiotensin II‐induced hypertension by inhibition of renal (pro)renin receptor and intrarenal RAS

The FASEB Journal (2017)

Lei Wang Qing Zhu Aihua Lu Linlin Zhang Chuangmin Xu

Background Butyrate, one of Short‐chain fatty acids, is end product produced from the fermentation of complex carbohydrates by the gut microbiota. Recently, sodium butyrate (NaBu) is found to play protective roles in a number of chronic diseases. However, it is still unclear whether NaBu processes a therapeutic potential in hypertension. The present study was aimed to investigate the role of NaBu in Ang II‐induced hypertension and further explore the underlying mechanism. Methods Ang II (200 ng/min) was infused in uninephrectomized Sprague‐Dawley rats plus intramedullary infusion of NaBu (1μg/kg·min) or not for 14 days. Blood pressure were monitored by the telemetry system. The renal tissues and serum samples as well as the last 24‐hour urine samples were collected to examine renal injury and regulation of (pro)renin receptor (PRR) and renin. Results Intramedullary infusion of NaBu in Sprague‐Dawley rats lowered the Ang II‐induced mean arterial pressure from 128.8 ± 6.2 mmHg to 108.0 ± 3.9 mmHg (P<0.01). This was paralleled with improvement of Ang II‐induced renal injury, including urinary albumin (μg/24h: Ctrl 270.7±49.2 vs AngII 1012.0±219.2 vs AngII‐NaBu 449.4±73.3, P<0.05), glomerulosclerosis (GDI: Ctrl 1.48±0.08 vs AngII 2.70±0.06 vs AngII‐NaBu 1.68±0.08, P<0.01), and renal fibrosis (α‐SMA protein: Ctrl 1.00±0.06 vs AngII 1.38±0.05 vs AngII‐NaBu 0.64±0.05, P<0.01), as well as the expression of inflammatory mediators TNF‐α and IL‐6. The renal protein expression of (pro)renin receptor, urinary excretion of soluble (pro)renin receptor and renin were all increased by AngII infusion but decreased by NaBu treatment. In cultured IMCD cells, NaBu treatment attenuated AngII‐induced expression of PRR and renin. Conclusion These results demonstrated NaBu exerts antihypertensive action likely via suppressing PRR‐mediated intrarenal RAS. Support or Funding Information This work was supported by National Natural Science Foundation of China Grant No. 91439205, No. 31330037 and No. 81600322; Fundamental Research Funds of Sun Yat‐sen University 16ykpy47; Veterans Affairs Merit Review, and National Institutes of Health Grant DK094956. T. Yang is Research Career Scientist in the Department of Veterans Affairs.

Glomerulosclerosis

Sodium butyrate

10.1096/fasebj.31.1_supplement.855.11

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Overweightness, obesity and arterial stiffness in healthy subjects: a systematic review and meta-analysis of literature studies

Postgraduate Medicine (2016)

Ping Li Lei Wang Chao Liu

The relationship between overweightness, obesity and arterial stiffness remains unclear. We performed a meta-analysis evaluating the impact of obesity/overweightness on arterial stiffness in healthy subjects.Literature searches were conducted using databases (eg, MEDLINE, EMBASE) and citations cross-referenced. Studies evaluating the relationship between obesity/overweightness and cfPWV, baPWV, and AIx were systematically searched. A total of 10 studies (1,124 obese/overweight subjects, 1,884 controls) were included.Compared to controls, obese/overweight subjects showed a significantly higher cfPWV (SMD 0.50 m/s; 95%CI 0.15, 0.86; P = 0.005), baPWV (SMD 0.41 m/s; 95% CI 0.08, 0.74; P = 0.014), and AIx (SMD 1.02；95%CI 0.16, 1.87; P < 0.0001). When analyzing 'high quality' studies, the difference in arterial stiffness among obese/overweight subjects and controls remain (SMD 0.73 m/s; 95%CI 0.16, 1.30; P = 0.013).Arterial stiffness, a recognized marker of cardio vascular risk, is increased in obese/overweight subjects without overt cardiovascular diseases.

10.1080/00325481.2017.1268903

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Citations (51)

Aloe emodin relieves Ang II-induced endothelial junction dysfunction via promoting ubiquitination mediated NLRP3 inflammasome inactivation

Journal of Leukocyte Biology (2020)

Yi Zhang Ziqing Song Shan Huang Li Zhu Tianyi Liu

Abstract Recent studies have revealed that aloe emodin (AE), a natural compound from the root and rhizome of Rheum palmatum L., exhibits significant pharmacologic activities. However, the pharmacologic relevance of the compound, particularly for cardiovascular disease, remains largely unknown. Here, we hypothesized that AE could improve endothelial junction dysfunction through inhibiting the activation of NOD-like receptor family pyrin domain containing-3 (NLRP3) inflammasome regulated by NLRP3 ubiquitination, and ultimately prevent cardiovascular disease. In vivo, we used confocal microscopy to study the expression of tight junction proteins zonula occludens-1/2 (ZO-1/2) and the formation of NLRP3 inflammasome in coronary arteries of hypertension. And the experimental serum was used to detect the activation of NLRP3 inflammasome by ELISA assay. We found that AE could restore the expression of the endothelial connective proteins ZO-1/2 and decrease the release of high mobility group box1 (HMGB1), and also inhibited the formation and activation of NLRP3 inflammasome. Similarly, in vitro, our findings demonstrated that AE could restore the expression of the tight junction proteins ZO-1/2 and decrease monolayer cell permeability that related to endothelial function after stimulation by angiotensin II (Ang II) in microvascular endothelial cells (MECs). We also demonstrated that AE could inhibit Ang II-induced NLRP3 inflammasome formation and activation, which were regulated by NLRP3 ubiquitination in MECs, as shown by fluorescence confocal microscopy and Western blot. Together with these changes, we revealed a new protection mechanism of AE that inhibited NLRP3 inflammasome activation and decreased the release of HMGB1 by promoting NLRP3 ubiquitination. Our findings implicated that AE exhibited immense potential and specific therapeutic value in hypertension-related cardiovascular disease in the early stage and the development of innovative drugs.

Aloe emodin

Endothelial Dysfunction

Pyrin domain

10.1002/jlb.3ma0520-582r

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Citations (19)

Rationale and Design of Sodium Tanshinone IIA Sulfonate in Left Ventricular Remodeling Secondary to Acute Myocardial Infarction (STAMP-REMODELING) Trial: A Randomized Controlled Study

Cardiovascular Drugs and Therapy (2015)

Shuai Mao Xiaotong Li Lei Wang Phillip C. Yang Minzhou Zhang

Ventricular remodeling

Clinical endpoint

Surrogate endpoint

10.1007/s10557-015-6625-2

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Citations (17)

The Shigesada–Kawasaki–Teramoto cross-diffusion system beyond detailed balance

Journal of Differential Equations (2023)

Xiuqing Chen Ansgar Jüngel Lei Wang

The existence of global weak solutions to the cross-diffusion model of Shigesada, Kawasaki, and Teramoto for an arbitrary number of species is proved. The model consists of strongly coupled parabolic equations for the population densities in a bounded domain with no-flux boundary conditions, and it describes the dynamics of the segregation of the population species. The diffusion matrix is neither symmetric nor positive semidefinite. A new logarithmic entropy allows for an improved condition on the coefficients of heavily nonsymmetric diffusion matrices, without imposing the detailed-balance condition that is often assumed in the literature. Furthermore, the large-time convergence of the solutions to the constant steady state is proved by using the relative entropy associated to the logarithmic entropy.

Population model

Constant (computer programming)

Detailed balance

10.1016/j.jde.2023.02.048

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Sodium butyrate suppresses angiotensin II-induced hypertension by inhibition of renal (pro)renin receptor and intrarenal renin–angiotensin system

Journal of Hypertension (2017)

Lei Wang Qing Zhu Aihua Lu Xiaofen Liu Linlin Zhang

Objectives: Butyrate, a short-chain fatty acid, is the end product of the fermentation of complex carbohydrates by the gut microbiota. Recently, sodium butyrate (NaBu) has been found to play a protective role in a number of chronic diseases. However, it is still unclear whether NaBu has a therapeutic potential in hypertension. The present study was aimed to investigate the role of NaBu in angiotensin II (Ang II)-induced hypertension and to further explore the underlying mechanism. Methods: Ang II was infused into uninephrectomized Sprague-Dawley rats with or without intramedullary infusion of NaBu for 14 days. Mean arterial blood pressure was recorded by the telemetry system. Renal tissues, serum samples, and 24-h urine samples were collected to examine renal injury and the regulation of the (pro)renin receptor (PRR) and renin. Results: Intramedullary infusion of NaBu in Sprague-Dawley rats lowered the Ang II-induced mean arterial pressure from 129 ± 6 mmHg to 108 ± 4 mmHg (P < 0.01). This corresponded with an improvement in Ang II-induced renal injury, including urinary albumin, glomerulosclerosis, and renal fibrosis, as well as the expression of inflammatory mediators tumor necrosis factor α, interleukin 6. The renal expression of PRR, angiotensinogen, angiotensin I-converting enzyme and the urinary excretion of soluble PRR, renin, and angiotensinogen were all increased by Ang II infusion but decreased by NaBu treatment. In cultured innermedullary collecting duct cells, NaBu treatment attenuated Ang II-induced expression of PRR and renin. Conclusion: These results demonstrate that NaBu exerts an antihypertensive action, likely by suppressing the PRR-mediated intrarenal renin–angiotensin system.

Plasma renin activity

10.1097/hjh.0000000000001378

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Citations (156)