Pan Chen

Henan Agricultural University

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i-10 index

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Yanfeng He

Henan Agricultural University

Shucheng Huang

Henan Agricultural University

Aftab Shaukat

South China Agricultural University

Kaili Liu

Tianjin University

Fuchun Jian

Henan Agricultural University

Liu Cao

China Medical University

Luxi Lin

Fujian Medical University

Senyang Li

Henan Agricultural University

Tingting Xu

Binzhou Medical University

Xingrong Hou

Ministry of Education of the People's Republic of China

Cooperative Institutions

Central South University

Chinese Academy of Sciences

Zhejiang University

Chinese Academy of Medical Sciences & Peking Union Medical College

Henan Agricultural University

Hunan Cancer Hospital

Wenzhou Medical University

Shanghai Jiao Tong University

University of Chinese Academy of Sciences

Jilin University

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Gut microbiota as a target in the bone health of livestock and poultry: roles of short-chain fatty acids

Animal Diseases (2023)

Shucheng Huang Yanfeng He Pan Chen Kai‐Li Liu Aftab Shaukat

Abstract The regulation and maintenance of bone metabolic homeostasis are crucial for animal skeletal health. It has been established that structural alterations in the gut microbiota and ecological dysbiosis are closely associated with bone metabolic homeostasis. The gut microbiota and its metabolites, especially short-chain fatty acids (SCFAs), affect almost all organs, including the bone. In this process, SCFAs positively affect bone healing by acting directly on cells involved in bone repair after or by shaping appropriate anti-inflammatory and immunomodulatory responses. Additionally, SCFAs have the potential to maintain bone health in livestock and poultry because of their various biological functions in regulating bone metabolism, including immune function, calcium absorption, osteogenesis and osteolysis. This review primarily focuses on the role of SCFAs in the regulation of bone metabolism by gut microbiota and provides insight into studies related to bone health in livestock and poultry.

Bone remodeling

Osteolysis

Homeostasis

Dysbiosis

Bone Health

10.1186/s44149-023-00089-5

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Citations (9)

Anti-inflammatory agents design via the fragment hybrid strategy in the discovery of compound c1 for treating ALI and UC

European Journal of Medicinal Chemistry (2025)

Mi Guo Yu Zou Ke Dong Nan Huang Zhichao Chen

Fragment (logic)

10.1016/j.ejmech.2025.117431

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Citations (0)

Enhancement of growth and salt tolerance of tomato seedlings by a natural halotolerant actinobacterium Glutamicibacter halophytocola KLBMP 5180 isolated from a coastal halophyte

Plant and Soil (2019)

Youwei Xiong Yuan Gong Xuewei Li Pan Chen Xiuyun Ju

Halotolerance

Osmolyte

Plant Physiology

Biofertilizer

Ecotype

10.1007/s11104-019-04310-8

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Citations (66)

Design, synthesis and biological evaluation of imidazo[1,5-a]pyrazin-8(7H)-one derivatives as BRD9 inhibitors

Bioorganic & Medicinal Chemistry (2019)

Peiyuan Zheng Jian Zhang Hui Ma Xinrui Yuan Pan Chen

Structure–activity relationship

Docking (animal)

Lipophilicity

10.1016/j.bmc.2019.02.045

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Citations (9)

Machine learning guided discovery of superconducting calcium borocarbides

arXiv (Cornell University) (2023)

Chao Zhang Hui Tang Pan Chen Hong Jiang Huai-Jun Sun

Pursuit of superconductivity in light-element systems at ambient pressure is of great experimental and theoretical interest. In this work, we combine a machine learning (ML) method with first-principles calculations to efficiently search for the energetically favorable ternary Ca-B-C compounds. Three new layered borocarbides (stable CaBC5 and metastable Ca2BC11 and CaB3C3) are predicted to be phonon-mediated superconductors at ambient pressure. The hexagonal CaB3C3 possesses the highest Tc of 26.05 K among the three compounds. The σ-bonging bands around the Fermi level account for the large electron-phonon coupling (λ = 0.980) of hexagonal CaB3C3. The ML-guided approach opens up a way for greatly accelerating the discovery of new high-Tc superconductors.

10.48550/arxiv.2303.09342

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Citations (0)

Effects of Radix dichroae extract supplementation on growth performance, oocysts output and gut microbiota in growing lambs with coccidiosis

Veterinary Research Communications (2023)

Pan Chen Shijie Li Lijun Zheng Zhanming Wang Yanfeng He

Radix (gastropod)

Feed additive

10.1007/s11259-023-10209-8

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Citations (7)

Progress of the Correlation Between Lipoprotein Associated Phospholipase A2 and Coronary Heart Disease

Chinese Journal of Arteriosclerosis (2014)

Pan Chen

Lipoprotein associated phospholipase A2( Lp-PLA2) is an enzyme produced by inflammatory cells and attached to low density lipoprotein( LDL). Lp-PLA2 hydrolyzes the oxidized LDL and releases inflammatory meditor to promote atherosclerosis. There is a significant association between the single nucleotide polymorphisms in the PLA2G7 gene and coronary heart disease. Lp-PLA2 is a novel inflammatory biomarker and has close relationship with the propensity of atherosclerosis. Lp-PLA2 has received attention gradually as an independent risk predictor and may be a new therapeutic target of coronary heart disease. This paper reviewed the recent research in the correlation between Lp-PLA2 and coronary heart disease.

Lipoprotein-associated phospholipase A2

Coronary atherosclerosis

Source

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Genetic characteristics and growth patterns of the hybrid grouper derived from the hybridization of Epinephelus fuscoguttatus (female) × Epinephelus polyphekadion (male)

Journal of Fish Biology (2022)

Liu Cao Pan Chen Xingrong Hou Jun Ma Ning Yang

Hybridization is one of the primary methods used to cultivate farmed grouper species. The hybrid grouper derived from crossing Epinephelus fuscoguttatus (♀) and E. polyphekadion (♂) exhibits growth superiority over its parents. The genetic characteristics and growth patterns of the hybrid grouper have not yet been defined. This study confirms the ploidy level of the hybrid grouper (2n = 48) using chromosome count analysis and flow cytometry. The 5S rDNA family was used to evaluate genetic diversity. Only one 5S class (~400 bp) was detected in the hybrid grouper, which could be used to distinguish between two different types based on nucleotide sequences, likely representing homologous unit classes from the female and male parental species. Growth patterns of 5-8-month-old hybrid groupers were also monitored. In this phase, a positive allometric growth pattern in body mass with total length was found. Body height and body mass were significantly correlated based on correlation and path coefficient, suggesting that body height could serve as an excellent index to increase body mass. These results aid our understanding of the genetic evolution of the hybrid grouper and inform the development of improved rearing techniques.

Epinephelus

Serranidae

Allometry

Genetic distance

10.1111/jfb.15263

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Citations (5)

Magnetohydrodynamic pressure drop in a quickly changing magnetic field

Fusion Engineering and Design (1995)

Zeng Yu Xu J.M Chen J.P. Qian W. H. Jiang Pan Chen

Dimensionless quantity

Pressure gradient

10.1016/0920-3796(95)90183-3

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Citations (4)

Leg disorders in broiler chickens: a review of current knowledge

Animal Biotechnology (2023)

Kaili Liu Yanfeng He Bowen Xu Luxi Lin Pan Chen

Ensuring improved leg health is an important prerequisite for broilers to achieve optimal production performance and welfare status. Broiler leg disease is characterized by leg muscle weakness, leg bone deformation, joint cysts, arthritis, femoral head necrosis, and other symptoms that result in lameness or paralysis. These conditions significantly affect movement, feeding and broiler growth performance. Nowadays, the high incidence of leg abnormalities in broiler chickens has become an important issue that hampers the development of broiler farming. Therefore, it is imperative to prevent leg diseases and improve the health of broiler legs. This review mainly discusses the current prevalence of broiler leg diseases and describes the risk factors, diagnosis, and prevention of leg diseases to provide a scientific basis for addressing broiler leg health problems.

10.1080/10495398.2023.2270000

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Citations (14)