Rong Wang

University of Chinese Academy of Sciences

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Xurong Chen

Institute of Modern Physics

C. Han

Institute of Modern Physics

G. Ciullo

Istituto Nazionale di Fisica Nucleare, Sezione di Ferrara

M. Battaglieri

Istituto Nazionale di Fisica Nucleare

A. D’Angelo

University of Rome Tor Vergata

R. Paremuzyan

Thomas Jefferson National Accelerator Facility

M. Contalbrigo

Istituto Nazionale di Fisica Nucleare, Sezione di Genova

Y. Prok

University of Virginia

D. Sokhan

University of Glasgow

A. Celentano

Istituto Nazionale di Fisica Nucleare, Sezione di Genova

Cooperative Institutions

European Organization for Nuclear Research

1,264

Centro Brasileiro de Pesquisas Físicas

861

University of Chinese Academy of Sciences

778

Centre National de la Recherche Scientifique

704

Tsinghua University

695

Institute of High Energy Physics

579

Peking University

507

Central China Normal University

470

Institut National de Physique Nucléaire et de Physique des Particules

457

State Key Laboratory of Nuclear Physics and Technology

414

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Beam-target helicity asymmetry E in K0Λ and K0Σ0

Physical review. C (2018)

Dao H. Ho R. A. Schumacher A. D’Angelo A. Deur J. A. Fleming

We report the first measurements of the E beam-target helicity asymmetry for the →γ→n→K0Λ and K0Σ0 channels in the energy range 1.70≤W≤2.34 GeV. The CLAS system at Jefferson Lab uses a circularly polarized photon beam and a target consisting of longitudinally polarized solid molecular hydrogen deuteride with low background contamination for the measurements. The multivariate analysis method boosted decision trees is used to isolate the reactions of interest. Comparisons with predictions from the KaonMAID, SAID, and Bonn-Gatchina models are presented. These results will help separate the isospin I=0 and I=1 photocoupling transition amplitudes in pseudoscalar meson photoproduction.2 MoreReceived 16 May 2018DOI:https://doi.org/10.1103/PhysRevC.98.045205©2018 American Physical SocietyPhysics Subject Headings (PhySH)PolarizationPropertiesParticle propertiesPolarizationPropertiesAtomic PropertiesPolarizationResearch AreasPhotonuclear reactionsPhysical SystemsHyperonsKaonsStrange quarkPropertiesPolarizationTechniquesMachine learningOptical, coupled-channel & distorted wave modelsNuclear PhysicsParticles & Fields

Helicity

10.1103/physrevc.98.045205

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Citations (9)

Probing the core of the strong nuclear interaction

Nature (2020)

A. Schmidt M. J. Amaryan R. Weiss G. Asryan A. Hrnjic

Nuclear force

Atomic nucleus

Strong interaction

Momentum (technical analysis)

10.1038/s41586-020-2021-6

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Citations (28)

Multiparametric MRI Radiomics in Prostate Cancer for Predicting Ki-67 Expression and Gleason Score: a Multicenter Retrospective Study

Research Square (Research Square) (2023)

Chuan Zhou Yunfeng Zhang Sheng Guo Dong Wang Hao-Xuan Lv

Abstract Purpose Prostate cancers (PCas) with high Ki-67 expression and high Gleason Scores (GS) tend to have aggressive clinicopathological characteristics and a dismal prognosis. In order to predict the Ki-67 expression status and the GS in PCa, we sought to construct and verify MRI-based radiomics signatures. Methods and materials: We collected T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and apparent diffusion coefficient (ADC) images from 170 PCa patients at three institutions and extracted 321 original radiomic features from each image modality. We used support vector machine (SVM) and least absolute shrinkage and selection operator (LASSO) logistic regression to select the most informative radiomic features and built predictive models using up sampling and feature selection techniques. Using receiver operating characteristic (ROC) analysis, the discriminating power of this feature was determined. Subsequent decision curve analysis (DCA) assessed the clinical utility of the radiomic features. The Kaplan-Meier (KM) test revealed that the radiomics-predicted Ki-67 expression status and GS were prognostic factors for PCa survival. Result The hypothesized radiomics signature, which included 15 and 9 selected radiomics features, respectively, was significantly correlated with pathological Ki-67 and GS outcomes in both the training and validation datasets. Areas under the curve (AUC) for the developed model were 0.813 (95% CI:0.681,0.930) and 0.793 (95% CI:0.621, 0.929) for the training and validation datasets, respectively, demonstrating discrimination and calibration performance. The model's clinical usefulness was verified by means of DCA. In both the training and validation sets, high Ki-67 expression and high GS predicted by radiomics using SVM models were substantially linked with poor overall survival (OS). Conclusions Both Ki-67 expression status and high GS correlate with PCa patient survival outcomes; therefore, the ability of the SVM classifier-based model to estimate Ki-67 expression status and the Lasso classifier-based model to assess high GS may enhance clinical decision making.

Lasso

10.21203/rs.3.rs-2831937/v1

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Extraction of Proton Trace Anomaly Energy from Near-Threshold $ϕ$ and $J/ψ$ photo-productions

arXiv (Cornell University) (2021)

Wei Kou Rong Wang Xurong Chen

The trace anomalous energy contribution to the proton mass is a very important topic in non-perturbative QCD and hadron physics. In experiments, it is under the hot discussions on how to measure the trace anomalous energy.The QCD interpretation of proton trace anomaly is still not clear.To connect the theory with the experiment,we extract the trace anomaly by analyzing the near-threshold photo-production data of $ϕ$ and J/$ψ$ vector mesons. Based on the vector-meson-dominance model and QCD Van der Waals representation, we find that the percentage of trace anomaly in the proton mass ranges from $16\%$ to $24\%$, which is of similar order of magnitude as the 23$\%$ given by Lattice QCD. We also provide the approximate magnitudes of the systematic uncertainties of the extracted results from the model assumptions as well as the data fitting procedures. We give relative statistical uncertainties of 17.2$\%$, 17.7$\%$, 3.6$\%$, and 8.2$\%$, total relative systematic uncertainties of 21.4$\%$, 54.2$\%$, 37.2$\%$, and 25.7$\%$, for the analyses of the GlueX, LEPS, CLAS, and SAPHIR data, respectively. We argue that the near-threshold $Υ$ photo-production experiments are more beneficial for the measurement of trace anomaly in proton mass in the future.

TRACE (psycholinguistics)

Anomaly (physics)

10.48550/arxiv.2103.10017

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Citations (4)

Identification of new flavonoid compounds in dandelion Taraxacum mongolicum Hand.-Mazz. and evaluation of their antioxidant activities

Research Square (Research Square) (2022)

Rong Wang Weihua Li Cao Fang Xinxin Zheng Chao Liu

Abstract Due to the interest in the potential pharmacological application of dandelion, the chemical constituents and activities of Taraxacum mongolicum Hand.-Mazz were studied. Box-Behnken response surface methodology was employed to optimize the protocol for extraction of flavonoids from dandelion. The molecular structures of different flavonoid compounds were acquired and analyzed by liquid chromatography-mass spectrometry (LC-MS) and nuclear magnetic resonance (NMR) spectroscopy. Seven flavonoid compounds were isolated and purified, namely, hesperetin−5'-O-β-rhamnoglucoside (I), quercetin (II), hesperetin−7-glucuronide (III), kaempferol−3-glucoside (IV), baicalein (V), hyperseroside (VI) and rutin (VII), among which the flavonoid compounds II, III, V, VI were extracted for the first time from dandelion, whereas the compound I : hesperetin−5'-O-β-rhamnoglucoside, was identified as a new type of flavonoid that had never reported in the literature. The antioxidant activities of the extracted flavonoids were examined, and the determination of structure-related antioxidant activity could be interpreted based on DFT calculations. As such, we have not only illustrated the rich flavonoid contents in Taraxacum mongolicum Hand.-Mazz , but also revealed new types of flavonoids in dandelion in terms of structure and antioxidant properties.

Hesperetin

Taraxacum officinale

10.21203/rs.3.rs-1804045/v1

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Development of a new HRD algorithm which was highly associated with anthracycline-containing neoadjuvant chemotherapy.

Journal of Clinical Oncology (2022)

Wenming Cao Jiani Pan Xiaojia Wang Feng Lou Mingwei Li

e13575 Background: Homologous recombination deficiency (HRD) can be resulted from dysfunction of BRCA and is associated with sensitivity to platinum, PARP inhibitor and other DNA-damaging drugs. The results from a neoadjuvant trial showed that pathological complete response (pCR) was not significantly higher with cisplatin than with doxorubicin-cyclophosphamide in BRCA1/2-mutated breast cancers (BC). It suggests that BC with HRD might benefit from anthracycline-containing regiment. There are many commercial HRD detection assays, including the FoundationFocus CDx BRCA LOH and myChoice CDx, but there is still no uniform standard in China. Methods: A total of 96 in-house BC samples and 6 HRD positive standard cells (Cat No. CBP90023) were analyzed by whole-genome sequencing (WGS). Besides, 122 BCs from the TCGA database were down-sampled to ̃1X WGS. We constructed a new algorithm for HRD score based on WGS at low coverage as input data to estimate large-scale copy number alteration (LCNA) events on the genome. The sensitivity and specificity were compared between our algorithm and the ShallowHRD. A clinical cohort of 50 BCs (15 cases carrying BRCA mutation) was used to assess the association between HRD status and anthracyclines-containing neoadjuvant treatment outcomes. Results: A 100kb-window was defined as the optimal size by using 41 in-house cases and the TCGA dataset. The threshold of HRD was determined as the number of 10 LCNAs by using 55 in-house BCs with BRCA mutation, with the goal of achieving 95% sensitivity. The sensitivity and specificity of our algorithm were both 100%, while those of the ShallowHRD were 40% and 100%, respectively, by testing standard samples with positive HRD. Meanwhile, similar results were also observed that the sensitivity of our algorithm was far superior to ShallowHRD (87% vs 13%) in the clinical cohort. The association between HRD status and BRCA mutations was compared between our algorithm and the ShallowHRD by 120 BC WGS samples (20 cases carrying BRCA mutation) from the TCGA database. The results showed that BRCA status was significantly associated with HRD status by our algorithm and ShallowHRD (P = 0.00838 and P = 0.00284, respectively). However, our algorithm had a higher positive concordance rate than the ShallowHRD algorithm (70% vs 60%). In the clinical cohort of neoadjuvant treatment, HRD group was more likely to respond to anthracycline-containing chemotherapy than non-HRD group, with outcomes of pCR (OR = 9.5, 95% CI: 1.11–81.5, p = 0.04) and residual cancer burden score of 0 or 1 (RCB0/1) (OR = 10.29, 95% CI: 2.02–52.36, p = 0.005). Among 35 patients lacking BRCA mutations, HRD group tended to have RCB0/1 responses compared to non-HRD group (OR = 6.0, 95% CI: 1.00–35.91, p = 0.05). Conclusions: Here, we developed a new stable algorithm for HRD score. It’s a promising assay for clinical application to predict sensitivity of DNA-damaging drugs.

BRCA Mutation

10.1200/jco.2022.40.16_suppl.e13575

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Physics with Positron Beams at Jefferson Lab 12 GeV

arXiv (Cornell University) (2019)

Andrei Afanasev Ibrahim Albayrak Salina Ali Moskov Amaryan A. D’Angelo

Positron beams, both polarized and unpolarized, are identified as essential ingredients for the experimental program at the next generation of lepton accelerators. In the context of the Hadronic Physics program at the Jefferson Laboratory (JLab), positron beams are complementary, even essential, tools for a precise understanding of the electromagnetic structure of the nucleon, in both the elastic and the deep-inelastic regimes. For instance, elastic scattering of (un)polarized electrons and positrons off the nucleon allows for a model independent determination of the electromagnetic form factors of the nucleon. Also, the deeply virtual Compton scattering of (un)polarized electrons and positrons allows us to separate unambiguously the different contributions to the cross section of the lepto-production of photons, enabling an accurate determination of the nucleon Generalized Parton Distributions (GPDs), and providing an access to its Gravitational Form Factors. Furthermore, positron beams offer the possibility of alternative tests of the Standard Model through the search of a dark photon or the precise measurement of electroweak couplings. This letter proposes to develop an experimental positron program at JLab to perform unique high impact measurements with respect to the two-photon exchange problem, the determination of the proton and the neutron GPDs, and the search for the $A^{\prime}$ dark photon.

Dark photon

Virtual particle

10.48550/arxiv.1906.09419

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Citations (3)

Looking for quark saturation in proton and nuclei

International Journal of Modern Physics E (2017)

Wei Zhu Rong Wang Jianhong Ruan

The quark saturation behavior at low [Formula: see text] is shown in a numeric solution of the DGLAP equation with parton recombination corrections, which resembles the widely discussed JIMWLK saturation of gluons. Our calculation suggests that the partonic saturation can be interpreted as a dynamical balance between the splitting and the fusion processes of partons, without any other condensation mechanisms added. The nuclear shadowing saturation at small [Formula: see text] resulted from the proposed quark saturation is also discussed.

DGLAP

Saturation (graph theory)

10.1142/s0218301317500094

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Citations (2)

High‐speed counter‐current chromatography assisted preparative isolation of phenolic compounds from the flowers of Chrysanthemum morifolium cv. Fubaiju

Journal of Separation Science (2023)

Xiaowei Dong Hongping Huang Rong Wang Luo Shi-yu Yahui Mi

Chrysanthemum morifolium cv. Fubaiju is rich in phenolic compounds with various benefits such as anti‐inflammatory, antioxidant, and cardiovascular protection. In this study, 12 phenolic compounds, including five flavonoid glycosides and seven quinic acid derivatives, were successfully separated from the flowers of Chrysanthemum morifolium cv. Fubaiju by high‐speed counter‐current chromatography and preparative high‐performance liquid chromatography. Ethyl acetate‐ n ‐butanol–acetonitrile–water–acetic acid (5:0.5:2.5:5:0.25, v/v/v/v/v) was selected as solvent system to separate six fractions from the flowers of Chrysanthemum morifolium cv. Fubaiju, and 20% aqueous acetonitrile (containing 0.1% formic acid) was chosen to be the elution solvent in preparative high‐performance liquid chromatography for purifying the fractions above. Luteolin‐7‐ O ‐ β ‐D‐glucoside ( 1 ), luteolin‐7‐ O ‐ β ‐D‐glucuronide ( 2 ), apigenin‐7‐ O ‐ β ‐D‐glucoside ( 3 ), luteolin‐7‐ O ‐ β ‐D‐rutinoside ( 4 ), diosmetin‐7‐ O ‐ β ‐D‐glucoside ( 5 ), chlorogenic acid ( 6 ), 1,5‐dicaffeoylquinic acid ( 7 ), 1,4‐dicaffeoylquinic acid ( 8 ), 3,4‐dicaffeoylquinic acid ( 9 ), 3,4‐dicaffeoyl‐epi‐quinic acid ( 10 ), 3,5‐dicaffeoylquinic acid ( 11 ), and 4,5‐dicaffeoylquinic acid ( 12 ) were isolated with purities all above 95%, respectively. In addition, all isolates were evaluated for their protective effects on H 2 O 2 ‐induced oxidative damage in adult retinal pigment epithelial cells.

Chrysanthemum morifolium

Chlorogenic Acid

Quinic acid

Vanillic acid

Phenolic acid

10.1002/jssc.202300172

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Citations (5)

Mass of a short-range correlated nucleon *

Chinese Physics C (2020)

Rong Wang Xurong Chen Taofeng Wang

The nucleon properties and structure should be modified by short-range correlations (SRC) among nucleons. By analyzing SRC ratio data, we extract the mass of nucleon in the SRC pair and the expected number of pn-SRC pairs in deuterium, under the assumption that the SRC nucleon mass is universal in different nuclei. The nucleon mass of a two-nucleon SRC pair is $m_{\text{SRC}}=852\pm 18$ MeV, and the number of pn-SRC pairs in deuterium is $n^{\text{d}}_{\text{SRC}}=0.021\pm 0.005$. The mass deficit of the strongly overlapping nucleon can be explained by the trace anomaly contribution to the mass in QCD or alternatively by the vacuum energy in the MIT bag model.

Anomaly (physics)

10.1088/1674-1137/abccab

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Citations (3)