Hong Zhang

Anhui Agricultural University

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Hannah Y. Wen

Memorial Sloan Kettering Cancer Center

Britta Weigelt

Memorial Sloan Kettering Cancer Center

Jorge S. Reis‐Filho

Memorial Sloan Kettering Cancer Center

Fresia Pareja

Memorial Sloan Kettering Cancer Center

Edi Brogi

Memorial Sloan Kettering Cancer Center

Andrea Gazzo

Memorial Sloan Kettering Cancer Center

Pier Selenica

Memorial Sloan Kettering Cancer Center

Edaise M. da Silva

Memorial Sloan Kettering Cancer Center

Antonio Marra

European Institute of Oncology

Pedram Razavi

Memorial Sloan Kettering Cancer Center

Cooperative Institutions

Chinese Academy of Sciences

Fudan University

Sun Yat-sen University

Sichuan University

Peking University

Memorial Sloan Kettering Cancer Center

Chinese Academy of Medical Sciences & Peking Union Medical College

Shanghai Jiao Tong University

Huazhong University of Science and Technology

Capital Medical University

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TP53 and MYD88 Mutations As Detected By Liquid Biopsy in the Prediction of Progression-Free Survival in Patients with Diffuse Large B-Cell Lymphoma

Blood (2021)

Maher Albitar Andrew Ip Hong Zhang Andrew L. Pecora Jeffrey Justin Estella

Minimal Residual Disease

Liquid biopsy

Clinical Significance

Progression-free survival

10.1182/blood-2021-148122

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Neoadjuvant atezolizumab in combination with sequential nab-paclitaxel and anthracycline-based chemotherapy versus placebo and chemotherapy in patients with early-stage triple-negative breast cancer (IMpassion031): a randomised, double-blind, phase 3 trial

The Lancet (2020)

Elizabeth A. Mittendorf Hong Zhang Carlos H. Barrios Shigehira Saji Kyung Hae Jung

Atezolizumab

Nab-paclitaxel

Triple-negative breast cancer

10.1016/s0140-6736(20)31953-x

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Citations (828)

Supplementary Figure 3 from Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer

Douglass W. Tucker Christopher R. Getchell Eric T. McCarthy Anders Öhman Naoko Sasamoto

<p>Western blot analysis of A2780, IF quantification, immunoblot quantification in human and murine cell lines</p>

Reprogramming

Serous ovarian cancer

5-Hydroxymethylcytosine

10.1158/1078-0432.22460535.v1

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Genetic diagnosis strategy of hereditary non-polyposis colorectal cancer

World Journal of Gastroenterology (2009)

Jian-qiu Sheng Hong Zhang Min Ji Lei Fu Hong Mu

AIM:To study the characteristics of mismatch repair gene mutation of Chinese hereditary non-polyposis colorectal cancer (HNPCC) and hMLH1 gene promoter methylation, and to improve the screening strategy and explore the pertinent test methods. METHODS:A systematic analysis of 30 probands from HNPCC families in the north of China was performed by immunohistochemistry, microsatellite instability (MSI), gene mutation and methylation detection. RESULTS:High frequency microsatellite instability occurred in 25 probands (83.3%) of HNPCC family.Loss of hMLH1 and hMSH2 protein expression accounted for 88% of all microsatellite instability.Pathogenic muta-tion occurred in 14 samples and 3 novel mutational sites were discovered.Deletion of exons 1-6, 1-7 and 8 of hMSH2 was detected in 3 samples and no large fragment deletion was found in hMLH1.Of the 30 probands, hMLH1 gene promoter methylation occurred in 3 probands.The rate of gene micromutation detection combined with large fragment deletion detection was 46.7%-56.7%.The rate of the two methods in combination with methylation detection was 63.3%.CONCLUSION: Scientific and rational detection strategy can improve the detection rate of HNPCC.Based on traditional molecular genetics and combined with epigenetics, multiple detection methods can accurately diagnose HNPCC.

Microsatellite Instability

Proband

10.3748/wjg.15.983

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Overexpression of δ-catenin is associated with a malignant phenotype and poor prognosis in colorectal cancer

Molecular Medicine Reports (2015)

Hong Zhang SHUN‐DONG DAI Shuli Liu FANG-YUAN ZHANG Chaoliu Dai

Little is known regarding the expression or clinical significance of δ-catenin, a member of the catenin family, in colorectal cancer (CRC). The present study examined the expression of δ-catenin using immunohistochemistry in 110 cases of CRC, including 70 cases with complete follow‑up records and 40 cases with paired lymph node metastases. In addition, δ‑catenin mRNA and protein expression were compared in 30 pairs of matched CRC and normal colorectal tissues by reverse transcription quantitative polymerase chain reaction and western blot analysis. δ‑Catenin was weakly expressed or absent in the cytoplasm of normal intestinal epithelial cells, whereas positive δ‑catenin expression localized to the cytoplasm was observed in CRC cells. The rate of positive δ‑catenin expression in CRC (68.18%; 75/110) was significantly higher than that in normal colorectal tissues (36.7%; 11/30; P<0.001). In addition, δ‑catenin mRNA and protein expression were significantly increased in CRC tissues compared to those in their matched normal tissues (all P<0.05). The expression of δ‑catenin in stage III‑IV CRC was higher than that in stage I‑II CRC, and the expression of δ‑catenin in the tumors of patients with lymph node metastases was higher than that in patients without lymph node metastases. Kaplan‑Meier survival curves demonstrated that the survival time of patients with positive δ‑catenin expression was shorter than that of patients with negative δ‑catenin expression (P=0.005). Furthermore, Cox multivariate analysis indicated that the tumor, nodes and metastasis stage (P=0.02) and positive δ-catenin expression (P=0.033) were independent prognostic factors in CRC. The present study therefore indicated that δ-catenin may be a suitable independent prognostic factor for CRC.

Surgical oncology

Beta-catenin

10.3892/mmr.2015.3918

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The effect of electroacupuncture on the protein expression levels of Cyt-C, Caspase-3 and Caspase-9 in the bladder tissue of rats with neurogenic bladder after suprasacral spinal cord injury

World Journal of Acupuncture - Moxibustion (2017)

Ming Xu Hong Zhang Xiuting Yin Jisheng Liu Jian Zhang

10.1016/s1003-5257(17)30140-x

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In vitro observation on albendazole sulfoxide and its enantiomers against Echinococcus granulosus protoscolex

Gen-shu Bao Hong Zhang Tao Jing Hua Qiao Jing Wang

Objective To investigate in vitro anti-hydatid efficacy on Echinococcus granulosus protoscolex(EgPSC) by using albendazole sulfoxide(ASOX) and its two enantiomeric antipodes, L-ASOX and D-ASOX.Methods Eg protoscoleces were divided into eight groups and cultured in the DMEM culture media under two concentrations(50 μg/ml and 100 μg/ml) of ASOX, L-ASOX and D-ASOX respectively.The appropriate controls included(i) a culture containing an equal amount of DMSO and(ii) a culture medium alone.The mortality of EgPSC in each group was daily counted until 100% EgPSC death in some groups.Results Significant difference of EgPSC mortality was found among the three drugs with various concentrations compared to control group(P0.01), and a significant difference between L-ASOX group and D-ASOX group(P0.05).There were no statistical difference between ASOX group and D-ASOX group(P0.05), but between ASOX group and L-ASOX group(P0.05).On the 9th day of culture, the mortality of protoscleces with the concentration of 50 μg/ml was 93.6%, 56.2% and 99.0% in ASOX, L-ASOX and D-ASOX groups respectively, and those under the concentration of 100 μg/ml were 100%, 74.5% and 100% respectively.The mortality was 19.1% and 22.5% respectively in the control and solvent groups.Conclusion ASOX, L-ASOX and D-ASOX demonstrate significant effect of anti-Eg protoscolex in vitro.D-ASOX shows stronger effect than L-ASOX.

Albendazole

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Tiamulin inhibits breast cancer growth and pulmonary metastasis by decreasing the activity of CD73

BMC Cancer (2017)

Yang Xu Shimin Pei Huanan Wang Yipeng Jin Fang Yu

Metastasis is the leading cause of death in breast cancer patients. CD73, also known as ecto-5'-nucleotidase, plays a critical role in cancer development including metastasis. The existing researches indicate that overexpression of CD73 promotes growth and metastasis of breast cancer. Therefore, CD73 inhibitor can offer a promising treatment for breast cancer. Here, we determined whether tiamulin, which was found to inhibit CD73, was able to suppress breast cancer development and explored the related mechanisms.We firstly measured the effect of tiamulin hydrogen fumarate (THF) on CD73 using high performance liquid chromatography (HPLC). Then, we investigated cell proliferation, migration and invasion in MDA-MB-231 human breast cancer cell line and 4 T1 mouse breast cancer cell line treated with THF by migration assay, invasion assay and activity assay. Besides, we examined the effect of THF on syngeneic mammary tumors of mice by immunohistochemistry.Our data demonstrated that THF inhibited CD73 by decreasing the activity instead of the expression of CD73. In vitro, THF inhibited the proliferation, migration and invasion of MDA-MB-231 and 4 T1 cells by suppressing CD73 activity. In vivo, animal experiments showed that THF treatment resulted in significant reduction in syngeneic tumor growth, microvascular density and lung metastasis rate.Our results indicate that THF inhibits growth and metastasis of breast cancer by blocking the activity of CD73, which may offer a promising treatment for breast cancer therapy.

Surgical oncology

10.1186/s12885-017-3250-4

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Corrigendum: Correlation of Bromodomain Protein BRD4 Expression With Epithelial–Mesenchymal Transition and Disease Severity in Chronic Rhinosinusitis With Nasal Polyps

Frontiers in Medicine (2020)

Xuanchen Zhou Zhaoyang Cui Yiqing Liu Zhiyong Yue Fengyang Xie

Xuanchen Zhou1,2, Zhaoyang Cui 1, Yiqing Liu1, Zhiyong Yue1, Fengyang Xie1, Ling Ding1,Shuai Xu1, Jie Han1,2 and Hong Zhang3*1. Department of Otorhinolaryngology Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, 2. Department of Otorhinolaryngology Head and Neck Surgery, Shandong Provincial HospitalAffiliated to Shandong University, Jinan, China, 3.Health Management Center, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China

Nasal Polyps

Chronic Rhinosinusitis

10.3389/fmed.2020.604072

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[Screening the tumor associated gene in human hepatocellular carcinoma by gene chip.].

PubMed (2009)

Hong Zhang Jie-Fei Huang Dongfeng Huang Ting-yan Hua Qun Wei

为寻找肝癌早期诊断标志物,本研究用基因芯片技术检测了肝细胞癌(HCC)和正常肝组织中基因群的表达情况,初步筛选出相关的基因群,并对其中的肿瘤相关基因进行验证,以进一步了解这些基因对肝癌诊断的价值。

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