Hang Li

First Affiliated Hospital of Nanchang University

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Runping Fang

Shandong University

Lihong Ye

Nankai University

Leilei Li

Zhengzhou University

Yinghui Li

Shenzhen Center for Disease Control and Prevention

Juan Tao

Huazhong Agricultural University

Hongzhong Jin

Peking Union Medical College Hospital

Yicen Yan

National Clinical Research Center for Digestive Diseases

Li He

First Affiliated Hospital of Kunming Medical University

Xing‐Hua Gao

China Medical University

Wei Lai

Sun Yat-sen University

Cooperative Institutions

Medical University of South Carolina

218

American Academy of Dermatology

213

UConn Health

212

Peking University

163

Chinese Academy of Medical Sciences & Peking Union Medical College

Peking University First Hospital

Central South University

Wuhan University

Sichuan University

Huazhong University of Science and Technology

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Spleen size measured on enhanced mri for quantitatively staging liver fibrosis in minipigs

Journal of Magnetic Resonance Imaging (2013)

Xiaoli Chen Tian‐wu Chen Zhenlin Li Xiao Ming Zhang Nan Chen

Purpose: To investigate whether and how spleen size measured on magnetic resonance imaging (MRI) could be used to stage liver fibrosis. Materials and Methods: Sixteen minipigs were used to prospectively model liver fibrosis staged by biopsy. Abdominal gadolinium‐enhanced MRI was performed on the 0, 5th, 9th, 16th, and 21st weekend after beginning of the modeling. Splenic maximal width (W), thickness (T), length (L), and area (S) together with spleen volume (SV) and liver volume (LV) were measured on enhanced MRI and the ratio of SV to LV (SV/LV) was calculated. Spleen multidimensional indexes 1 and 2 were obtained by W × T × L and S × L, respectively. Statistical analyses were performed to determine which parameter could best stage the fibrosis. Results: W, T, L, S, SV, index 1 and 2, and SV/LV tended to increase with increasing stages of fibrosis ( r = 0.46–0.796, all P < 0.001), and might predict liver fibrosis stage ≥1, ≥2, ≥3, and 4 (area under receiver operating characteristic curve [AUC] = 0.697–1.0, all P < 0.05). Among the parameters, splenic index 1, SV, and SV/LV might be best for predicting stage ≥1 (AUC = 0.941), ≥2 or ≥3 (AUC = 0.875 or 0.978, respectively), and 4 (AUC = 1.0), respectively. Conclusion: Spleen size measured on MRI could be used for staging liver fibrosis. J. Magn. Reson. Imaging 2013;38:540–547. © 2013 Wiley Periodicals, Inc.

Hepatic fibrosis

10.1002/jmri.24007

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Citations (17)

HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-Myc

Cancer Research (2016)

Yinghui Li Zhen Wang Hui Shi Hang Li Leilei Li

Abstract c-Myc is regarded as a transcription factor, but the basis for its function remains unclear. Here, we define a long noncoding RNA (lncRNA)/protein complex that mediates the transcriptional activation by c-Myc in breast cancer cells. Among 388 c-Myc target genes in human MCF-7 breast cancer cells, we found that their promoters could be occupied by the oncoprotein HBXIP. We confirmed that the HBXIP expression correlated with expression of the c-Myc target genes cyclin A, eIF4E, and LDHA. RNAi-mediated silencing of HBXIP abolished c-Myc–mediated upregulation of these target genes. Mechanistically, HBXIP interacted directly with c-Myc through the leucine zippers and recruited the lncRNA Hotair along with the histone demethylase LSD1, for which Hotair serves as a scaffold. Silencing of HBXIP, Hotair, or LSD1 was sufficient to block c-Myc–enhanced cancer cell growth in vitro and in vivo. Taken together, our results support a model in which the HBXIP/Hotair/LSD1 complex serves as a critical effector of c-Myc in activating transcription of its target genes, illuminating long-standing questions on how c-Myc drives carcinogenesis. Cancer Res; 76(2); 293–304. ©2015 AACR.

HOTAIR

Demethylase

10.1158/0008-5472.can-14-3607

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Citations (119)

Full neuroendoscopic contralateral longitudinal fissure approach to resection of parafalcine meningioma via falx cerebri – Retractorless surgical technique: case report

Research Square (Research Square) (2022)

Ming Li Yu Zhao Hongming Ji Shengli Chen Gangli Zhang

Abstract Background: We reported one case of parafalcine meningioma, using a full neuroendoscopic contralateral longitudinal fissure approach to completely resect meningioma through the falx cerebri. Case presentation: This case was a 50-year-old female with a right anterior cerebral parafalcine meningioma. Her left limbs had decreased sensations of temperature, tactile and pain than the right side, muscle strength was grade IV, and Babinski sign was positive on the left. CT and MRI showed a mass on the right frontoparietal with edema.The patient was in supine position and the head was rotated 20 degrees to the opposite side. A neuronavigation was employed to perform a precise surface localization of parafalcine meningioma. Under neuroendoscopy, a contralateral craniotomy and a longitudinal fissure approach were followed by an incision of dura to expose arachnoid, then arachnoid was separated until falx cerebri along its surface. Neuronavigation was employed again to precisely locate the projection of meningioma in the contralateral falx cerebri. According to the position, firstly removed the invaded falx cerebri, blocked the blood supply of the meningioma, then completely resected the meningioma without retraction of normal brain tissue. Conclusion: This report explored a full neuroendoscopic contralateral longitudinal fissure approach to complete resect parafalcine meningioma via falx cerebri using retractorless surgical technique. This approach can reduce the retraction of normal brain tissue to enhance protection of brain function, while maximizing the total resection rate of parafalcine meningioma.

Falx cerebri

Neuronavigation

10.21203/rs.3.rs-1597356/v1

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Letter: The History and Evolution of Dermatologic Surgery in China

Dermatologic Surgery (2008)

Hang Li

Hang

10.1111/j.1524-4725.2008.34231.x

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Prediction of Hospital Discharge Outcome from Changes in Cerebrospinal Fluid/serum Albumin Quotient and Cerebrospinal Fluid Lactate Dehydrogenase in Patients with Cryptococcal meningitis

Future Microbiology (2021)

Yue Huang Jun Zou Keming Zhang Hang Li Dongying Hu

Aim: This study aims to provide reliable prognostic factors for patients with cryptococcal meningitis (CM). Patients & methods: Clinical characteristics and laboratory findings of CM patients were retrospectively reviewed. Results: Sixty-three patients with CM were enrolled and 38/63 were confirmed to be HIV serology positive. Among clinical characteristics, headache, nausea and/or vomiting, and fever were the most common symptoms. Among cerebrospinal fluid (CSF) parameters, changes in leukocyte count, lactate dehydrogenase and chloride were significantly associated with the outcome. An increased CSF/serum albumin quotient (QAlb) was indicative of an unfavorable outcome in HIV-negative patients. Conclusion: CSF lactate dehydrogenase and QAlb may improve the prediction of outcomes in patients with CM.

CSF albumin

Serum Albumin

10.2217/fmb-2021-0272

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Prediction of Hospital Discharge Outcome From Changes in Albumin Quotient and Cerebrospinal Fluid Lactate Dehydrogenase in Patients With Cryptococcal Meningitis

Research Square (Research Square) (2021)

Yue Huang Jun Zou Keming Zhang Hang Li Dongying Hu

Abstract Background Cryptococcal meningitis (CM) is a life-threatening infection of the central nervous system that occurs in healthy individuals and immunocompromised patients, and reliable prognostic parameters are needed urgently. This study analyzed the clinical characteristics and laboratory findings of CM patients from two tertiary care hospitals in China between 2015 and 2019, aiming to provide reliable prognostic factors for patients with CM. Methods Clinical characteristics and laboratory findings of CM patients were retrospectively reviewed. The unfavorable outcome was defined as no improvement or worsening symptoms and signs or persistent positive results for CSF culture or death after starting treatment. The significant differences in clinical characteristics and symptoms between the patients with favorable and unfavorable outcomes were descriptively analyzed. For comparison of mean values of laboratory results between the patients with favorable and unfavorable outcomes, the t test was performed. Results 63 patients with CM were enrolled in this study and 67% were men. 38/63 patients were confirmed to be HIV serology positive. The mean onset age of all patients was 49±15 (20– 77) years. For clinical characteristics, headache, nausea and/or vomiting, and fever were the most common symptoms. Older age and disturbance of consciousness tended to poor prognosis. Changes in serum antioxidant parameters were significantly associated with clinical outcome. For CSF parameters, there were significant correlations between changes in leukocyte count, lactate dehydrogenase and chloride, and outcomes in different groups. For HIV-infected patients, increased CD4 + T cell counts suggested good prognosis. Increased CSF/serum albumin quotient (Qalb) was indicative of unfavorable outcome in HIV-negative patients. Conclusions In summary, CSF lactate dehydrogenase and albumin quotient may improve prediction of outcome in patients with CM. We recommend incorporation of Qalb value analysis and pay attention to change of CSF LDH during hospitalization.

Etiology

Serum Albumin

CSF albumin

10.21203/rs.3.rs-789545/v1

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A case of cutaneous Merkel cell carcinoma complicated by pulmonary adenocarcinoma

Chinese Journal of Dermatology (2020)

Pingping Lin Hang Li

摘要：患者女，56岁，因左前臂无痛性肿物迅速增大5个月余至北京大学第一医院就诊。5个月前患者左前臂出现一绿豆大小皮色肿物，无不适，3个月前迅速增长至核桃大小，表面渐呈紫红色，当地医院考虑为囊肿（直径2.0 cm），予单纯肿物切除，术后病理回报神经内分泌癌……

Pulmonary adenocarcinoma

Merkel cell

10.35541/cjd.20190472

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Restoration of long bone defects of infected tibia with induced membrane technique

Zhonghua chuangshang guke zazhi (2018)

Lijun Xie Hang Li Zhijun Pan Weixu Li Qiang Zheng

Objective To evaluate the induced membrane technique (Masquelet technique) used for restoration of long bone defects of infected tibia. Methods This retrospective study evaluated 44 patients with long bone defect of infected tibia who had been treated at Department of Orthopedics, The Second Affiliated Hospital by the induced membrane technique between January 2004 and January 2017. They were 31 males and 13 females, aged from 18 to 71 years (mean, 43.7 years). Of them, 17 were complicated with diabetes, 13 with primary hypertension, and 12 with more than two basic diseases. Their bone defects ranged from 6 to 17 cm (average, 11 cm). Their postoperative fracture healing and complications were observed. Results This cohort received from 2 to 5 operations on average (average, 3.7 operations). All the patents obtained bony union after 9 to 13 months (average, 11.3 months). Their follow-ups ranged from 16 months to 11 years (average, 3.1 years). Nineteen complications related to the surgery occurred in 15 cases. Skin healing problem after implantation of bone cement was found in 5 cases which called for operative intervention, infection relapsed in 8 patients after the first phase of cement implantation which necessitated further surgical debridement for successful management, local haematoma appeared after bone grafting in one case of 17 cm bone defect, implant failure occurred in one case, leg length discrepancy larger than 2 cm was observed in 3 cases, and a discharging sinus developed in one case 2 years after successful healing of a tibial defect. Conclusions The induced membrane technique appears to be a good alternative management for large tibial defects secondary to infection. The technique should be considered in the surgeon's armamentarium and patients conditions as it is effective and associated with a low rate of complications. Key words: Tibia; Infection; Bone reconstruction; Bone defects; Induced membrane

Bone grafting

Debridement (dental)

10.3760/cma.j.issn.1671-7600.2018.10.007

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[Change of ambulatory blood pressure-related parameters for different levels of renal function in resistant hypertension].

PubMed (2015)

Yu Kong Hang Li Zhenqiu Yu Yang Geng

To explore the predictive values of ambulatory blood pressure-related parameters for moderate renal impairment in resistant hypertension (RH).The clinical data were retrospectively analyzed for 401 hospitalized patients with hypertension at our hospital from October 2010 to October 2013. They were divided into RH (n = 263) and non-RH (n = 138). The modified estimating equation of glomerular filtration rate (GFR) for Chinese patients was used to assess renal functions. The standardization of moderate renal impairment was when GFR below 60 ml · min⁻¹ · 1.73 m⁻². The ambulatory blood pressure-related parameters were obtained by 24 h ambulatory blood pressure monitoring. The important prediction of these parameters for moderate renal impairment was accessed by receiver operating characteristic (ROC) curve. And the related risk factors for renal function impairment were tested by multiple stepwise Logistic regression analysis.Ambulatory arterial stiffness index (AASI), 24 h mean pulse pressure (24 hPP), sleeptime relative systolic blood pressure (SBP) decline and 24 h systolic blood pressure (24 hSBP) had important predictive values for moderate renal impairment in RH. GFR was significantly lower in those with AASI ≥ 0.485, 24 hPP ≥ 47.5 mmHg, sleeptime relative SBP decline ≤ -1.75% and 24 hSBP ≥ 130.5 mmHg (P < 0.05). Area under curve of ROC curve of AASI, 24 hPP, sleeptime relative SBP decline and 24 hSBP were 0.804, 0.644, 0.602 and 0.623 respectively. Multiple Logistic regression analysis showed that AASI (OR 1 268.5, P = 0.000), low density lipoprotein (OR 0.7, P = 0.01) and sleeptime relative SBP decline (OR 1.3, P = 0.01) were independent risk factors for GFR < 60 ml · min⁻¹ · 1.73 m⁻² in RH.AASI, 24 hPP, sleeptime relative SBP decline and 24 hSBP are the most significant ambulatory blood pressure-related parameters in predicting renal impairment in resistant hypertension.

Stepwise regression

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Cerebrospinal fluid microscopy as an index for predicting the prognosis of cryptococcal meningitis patients with and without HIV

Future Microbiology (2020)

Keming Zhang Hang Li Lei Zhang Wanqing Liao Liyan Ling

Aim: To evaluate the clinical data and quantitative cerebrospinal fluid for associations with the outcome of cryptococcal meningitis (CM) patients in the hospital. Patients & methods: We retrospectively analyzed a total of 139 CM patients comprising 108 without HIV and 31 with HIV admitted in a Jiang Xi hospital. Resμlts: We found that CM patients with the high fungal burden (≥10 yeasts/μl) (26.3%) had a worse prognosis than those with the low fungal burden (<10 yeasts/μl). (4.9%) (p = 0.0007 <0.05). Conclusion: In CM patients, a fungal burden of 10 yeasts/μl in the first cerebrospinal fluid test may be used as an indicator of patient prognosis, and we can personalize patients' treatment based on the fungal burden to improve prognosis.

Cryptococcal meningitis

10.2217/fmb-2020-0086

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Citations (4)