Xuesong Zhang

Hubei University of Chinese Medicine

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Wenqi Ai

Hubei University of Chinese Medicine

Li Liu

China Pharmaceutical University

Zhou Lan

Southern Medical University

Junzuo Zheng

Hubei University of Chinese Medicine

Yuman Xie

Hubei University of Chinese Medicine

Song Yu-guo

Beihua University

Huaqing Yang

Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University

Perez-Perez Guillermo

Claudio J. Conti

Universidad Carlos III de Madrid

Kuiyang Wang

Shanghai Jiao Tong University

Cooperative Institutions

The University of Texas MD Anderson Cancer Center

Chinese Academy of Medical Sciences & Peking Union Medical College

Chinese Academy of Sciences

Wenzhou Medical University

Dalian Medical University

Hebei Medical University

Hubei University of Chinese Medicine

Capital Medical University

Soochow University

Zhejiang University

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Xin-Fu-Kang Oral Liquid Mitigates Chronic Heart Failure through NR4A1-Dependent Regulation of Endoplasmic Reticulum-Mitochondrial Crosstalk in Cardiomyocytes

Phytomedicine (2025)

Xiaohan Zhang Xing Chang Ruoning Chai Xuesong Zhang Jiaran Li

Crosstalk

10.1016/j.phymed.2025.156467

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FGF1 protects against APAP-induced hepatotoxicity via suppression of oxidative and endoplasmic reticulum stress

Clinics and Research in Hepatology and Gastroenterology (2019)

Xiaofang Wang Xie Zhang Fan Wang Lingxia Pang Zeping Xu

Acetaminophen

Centrilobular necrosis

FGF1

10.1016/j.clinre.2019.03.006

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Citations (13)

Effect of nuclear factor kappa B on intercellular adhesion molecule-1 expression and neutrophil infiltration in lung injury induced by intestinal ischemia/reperfusion in rats

World Journal of Gastroenterology (2006)

Xiaofeng Tian Ji-Hong Yao Yinghua Li Xuesong Zhang Feng Bing-an

CONCLUSION:The activation of NF-κB plays an important role in the pathogenesis of lung injury induced by intestinal I/R through upregulating the neutrophil infiltration and lung ICAM-1 expression.PDTC as an inhibitor of NF-κB can prevent lung injury induced by intestinal I/R through inhibiting the activity of NF-κB.

Pyrrolidine dithiocarbamate

Malondialdehyde

Infiltration (HVAC)

Pathogenesis

10.3748/wjg.v12.i3.388

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Vascular Endothelial Growth Factor Protects CD200-Rich and CD34-Positive Hair Follicle Stem Cells Against Androgen-Induced Apoptosis Through the Phosphoinositide 3-Kinase/Akt Pathway in Patients With Androgenic Alopecia

Dermatologic Surgery (2019)

Xuesong Zhang Dongmei Zhou Tengfei Ma Qingquan Liu

BACKGROUND 5α-DHT can decrease the cell viability of the hair follicle stem cells (HFSCs) with CD34-positive and CD200-rich in bald scalp area of androgenic alopecia (AGA) patients and the apoptosis of HFSCs may be involved in the pathogenesis of AGA. The expression of Vascular endothelial growth factor (VEGF) turns to be weakened or disappeared in hair follicles of AGA patients. OBJECTIVE To investigate whether VEGF is involved in the apoptosis of HFSCs induced by 5α-DHT in the patients of AGA. METHODS By 5α-DHT, apoptosis of CD200-rich and CD34-positive HFSCs was induced and apoptotic rates up to 24 hours were assessed using flow cytometry. The expression grades of Bcl-2, Akt, caspase-3 and Bax were observed through Western blot analysis. RESULTS Vascular endothelial growth factor could cut 5α-DHT induced apoptosis down substantially in a concentration-dependent manner. The 5α-DHT induced decline in the rise of Bcl-2/Bax proportion and the increase in caspase-3 degrees were mostly reversed by using VEGF and the VEGF's anti-apoptotic actions were impeded through preventing the activation of phosphoinositide 3-kinase (PI3K)/Akt. CONCLUSION Vascular endothelial growth factor can protect CD200-rich and CD34-positive HFSCs from androgen induced apoptosis by means of the PI3K/Akt pathway.

10.1097/dss.0000000000002091

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Citations (20)

Study of factors related to peripartum cardiomyopathy

中国综合临床 (2010)

Guangyong Huang Xuesong Zhang

Objective To explore the risk factors of peripartum cardiomyopathy (PPCM). Methods A total of 82 PPCM and 100 normal delivery females were randomly recruited in the current study. Echocardiographic, cTNI,high sensitive C-reaction protein(hs-CRP) ,NT-proBNP were measured. Fifty-two patients were followed up for a mean of 6 months. Results The PPCM patients (29. 5 ± 6. 4) yrs were older than the controls (25. 2 ± 5. 8) yrs (P<0.01) . Compared to the controls, the PPCM patients showed higher blood pressure (146.9/98. 8 mm Hg v. s. 130. 2/80. 1 mm Hg, P < 0. 01) , higher proportion of cesarean section (65. 9% v. s. 51. 0% , P < 0. 05) and complicated infection(75. 6% v. s. 10. 0% ,P <0. 01). The level of leucocyte(11.0 × 109/L) ,cTNI(0. 17 μg/L), hs-CRP(28. 2 mg/L)and NT-proBNP(650. 1 ng/L) were significantly higher in the PPCM patients compared with control(8. 8 × 109/L,0. 06μg/L,6. 2 mg/L and 110. 5 ng/L,P <0. 01). Hs-CRP was positively related with NT-proBNP(r = 0. 67, P < 0. 01). After average of 6 months of treatment, left ventricular ejection fraction enhanced from 32. 2% to 50. 6%. NT-proBNP significantly declined from 650. 1 ng/L to 225.6 ng/L(P <0. 01). Multiple linear regression analysis showed that diastolic pressure (P < 0. 05), LVED (P < 0. 05) and hs-CRP (P < 0. 05) were the independent predictors for declined NT-proBNP. Conclusions Inflammatory plays an important role in the development of peripartum cardiomyopathy. Key words: Peripartum cardiomyopathy; Inflammatory

Peripartum Cardiomyopathy

10.3760/cma.j.issn.1008-6315.2010.06.031

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Efficacy of lipo-prostaglandin E_1 for treating hyperbilirubinemia

Zhongguo xin yao zazhi (2008)

Xuesong Zhang

Objective:To study the effect of lipo-prostaglandin E_1(lipo-PGE_1)on hyperbilirubinemia. Methods:This study was performed in multiple centers.The patients with hyperbilirubinemia were randomly divid- ed into 2 groups,and treated with either conventional regimen alone(control)or combined with lipo-PGE_1(10μg) for 14 days.The liver function was monitored before and after the treatments,and the total efficiency was analyzed. Results:The levels of ALT,AST and serum total bilirubin(TBil)were reduced in the patients of both groups (P0.05),while the improvement was significantly better in combination with lipo-PGE,(P0.05).The serum TBil was reduced more than control in combination with lipo-PGE_1(P0.05).The total effective rates were 83.34% and 48.48% in lipo-PGE_1 and control groups(P0.05),respectively.Conclusion:Lipo-PGE_1 im- proves liver function,and exerts a beneficial effect for treating hyperbilirubinemia.

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Polymorphisms of the Western CagA B-TPMs and their codons.

Xuesong Zhang T. M. Saksens Nicole Leah Traube Shawn Jindal Perez-Perez Guillermo

CagA

10.1371/journal.ppat.1004621.g001

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Clinical features of adverse reactions associated with telbivudine

World Journal of Gastroenterology (2008)

Xuesong Zhang Rui Jin Shibin Zhang Tao Ming-ling

AIM:To analyze the clinical features and risk factors of adverse reactions associated with telbivudine.METHODS: C l i n i c a l d a t a w e r e c o l l e c t e d f r o m cases that presented with serious adverse reactions to telbivudine.We analyzed general information and medicine status, clinical features, results of examination, and misdiagnosis.RESULTS: Out of 105 patients who were treated with telbivudine for hepatitis B in an outpatient department from January, 2007 to January, 2008, five presented with serious adverse drug reactions.Most of these five patients had used other nucleoside analogues in the past.Four were treated with a combination of telbivudine and interferon or another nucleoside analogue, while the other received an increased dose of telbivudine.The main adverse reactions were myalgia and general weakness.This was accompanied by cardiac arrhythmia in one patient, and nervous symptoms in three.Serum creatine kinase was elevated.The rate of misdiagnosis was high.CONCLUSION: The adverse reactions were related to telbivudine, but the biological mechanism of the reactions is not yet clear.Combination therapy with interferon or another nucleoside analogue and a high dose may increase the risk of adverse reactions.

Telbivudine

Adverse drug reaction

10.3748/wjg.14.3549

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Citations (35)

Effects of spironolactone on cardiac function and plasma level of brain natriuretic peptide in patients with chronic heart failure

Xinxueguan kangfu yixue zazhi (2010)

Xuesong Zhang

Objective:To investigate the changes of cardiac function and plasma brain natriuretic peptide(BNP) level in patients with chronic heart failure(CHF) after spironolactone treatment.Methods:A total of 64 CHF patients were randomly divided into two groups,spironolactone group(n=32) and normal control group(n=32).Patients in spironolactone group were given spironolactone 20mg,2 times/d for three months beside conventional therapy.Plasma BNP level,left ventricular end-diastolic dimension(LVEDd) and left ventricular ejection fraction(LVEF) were evaluated before and after treatment.Results:After 3-month treatment,the overall effective rate of spironolactone group was significantly higher than that of normal control group(90.6% vs.81.3%,P0.05).Plasma BNP level,LVEDd and LVEF of the two groups were significantly improved compared with those of before treatment(P0.01all).In spironolactone group,plasma BNP concentration decreased from(839±67)ng/L to(359±51)ng/L(P0.01),LVEF increased from(36±1.2)% to(49±5.9)%(P0.01) and LVEDd decreased from(66.01±3.7)mm to(59.1±2.4)mm(P0.05),all these were significantly better than those of normal control group(P0.05).Conclusion:Based on conventional therapy,spironolactone can significantly improve cardiac function and decrease plasma brain natriuretic peptide in patients with chronic heart failure.

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Atractylenolide I alleviates ischemia/reperfusion injury by preserving mitochondrial function and inhibiting caspase-3 activity

Journal of International Medical Research (2021)

Caiqin Sun Xuesong Zhang Fei Yu Chen Liu Fangbin Hu

Myocardial ischemia/reperfusion (I/R) injury causes various severe heart diseases, including myocardial infarction. This study aimed to determine the therapeutic effect of atractylenolide I (ATR-I), which is an active ingredient isolated from Atractylodes macrocephala, on myocardial I/R injury.Male Sprague-Dawley rats were randomly allocated to the five following groups (nine rats/group): control, I/R, and I/R + ATR-I preconditioning (10, 50, and 250 µg). The effects of ATR-I on rats with I/R injury were verified in cardiomyocytes with hypoxia/reoxygenation. Production of reactive oxygen species was determined. The proliferative ability of cardiomyocytes was detected using the bromodeoxyuridine assay. Mitochondrial membrane potential was measured using flow cytometry. Cellular apoptosis was assessed by flow cytometry and the terminal dUTP-digoxigenin nick end labeling assay.I/R and hypoxia/reoxygenation injury increased mitochondrial dysfunction and activated caspase-3 and Bax/B cell lymphoma 2 expression in vitro and in vivo. ATR-I pretreatment dose-dependently significantly attenuated myocardial apoptosis and suppressed oxidative stress as reflected by increased mitochondrial DNA copy number and superoxide dismutase activity, and decreased reactive oxygen species and Ca2+ content.ATR-I protects against I/R injury by protecting mitochondrial function and inhibiting activation of caspase-3.

10.1177/0300060521993315

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Citations (10)