Jinyao Chen

Sichuan University

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Co-Authors

Lishi Zhang

Sichuan University

Xiaomeng Li

Sichuan University

Jiao Huo

Chongqing Public Health Medical Center

Guo‐Bin Ren

East China University of Science and Technology

Mengmei Ni

Sichuan University

Ming‐Hui Qi

East China University of Science and Technology

Xuxi Chen

The University of Texas at Austin

Yiyi Chen

Zhejiang Gongshang University

Yunjie Liu

Chinese Academy of Sciences

Wuyang Yue

Second Affiliated Hospital of Zhejiang University

Cooperative Institutions

Sichuan University

145

New York University Press

Cambridge University Press

Peking University

Chinese Academy of Medical Sciences & Peking Union Medical College

Chinese Academy of Sciences

Sun Yat-sen University

China National Center for Food Safety Risk Assessment

Chongqing Medical University

Zhejiang University

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337P Is presence of molecular residual disease after pathologic complete response associated with relapse in inflammatory breast cancer?

Annals of Oncology (2024)

Jinyao Chen Salyna Meas Negar Koupaei Roland Bassett Vasiliki Sarli

Inflammatory breast cancer

Minimal Residual Disease

10.1016/j.annonc.2024.08.276

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Additional file 3 of A plant-based medicinal food inhibits the growth of human gastric carcinoma by reversing epithelial–mesenchymal transition via the canonical Wnt/β-catenin signaling pathway

Figshare (2021)

Xuxi Chen Wuyang Yue Lin Tian Na Li Yiyi Chen

Additional file 3.

Reversing

Gastric carcinoma

10.6084/m9.figshare.14561400

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Immunotoxicity of atrazine in Balb/c mice

Journal of Environmental Science and Health Part B (2013)

Jinyao Chen Yang Song Li S. Zhang

The present study was designed to investigate the immunotoxicity of atrazine (ATZ) in male Balb/c mice. ATZ (175, 87.5, and 43.75 mg/kg bw/day) was administered by gavage method for 28 days. The following indexes were determined in various groups of mice: body and organ weight; antibody aggregation of serum hemolysin; proliferative response of splenocytes to ConA; delayed-type hypersensitivity (DTH); natural killer cell activity; clearance of neutral red and nitric oxide (NO) release from peritoneal macrophages; apostosis and necrosis of splenocytes and thymocytes; cytokine production; and serum lysozyme. Results showed that cell-mediated, humoral immunity, and non-specific immune function in the high-dose ATZ group were suppressed; NO release and interferon-γ(IFN-γ)/interleukin-4 (IL-4) were also significantly decreased in the high-dose group. In the medium-dose group, the proliferation response and IFN-γ production was significantly decreased. In the low-dose group, the proliferation response was significantly decreased. Serum lysozyme was decreased in the ATZ-treated groups. The percentage of early apoptosis in thymocytes was increased significantly in high- and medium-dose ATZ groups. In conclusion, ATZ elicited an inhibitory effect on cell-mediated immunity, humoral immunity, and non-specific immune function of mice.

Splenocyte

Humoral immunity

Cellular immunity

10.1080/03601234.2013.777308

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Citations (33)

Low-dose florfenicol and copper combined exposure during early life induced health risks by affecting gut microbiota and metabolome in SD rats

Ecotoxicology and Environmental Safety (2022)

Zheng Ma Xue Gao Xiao Yang Lin Lin Xiangyi Wei

The potential health risks associated with simultaneous presence of residues of heavy metals and antibiotics in the environment and food have been of wide concern. However, the adverse health effects of combined heavy metal and antibiotic exposure at low doses remain unclear. In this study, the effects of combined exposure to florfenicol and copper at low doses during early life on toxicity, gut microbiota, drug resistance genes, and the fecal metabolome were investigated in Sprague-Dawley (SD) rats. The results showed that combined exposure induced inflammatory responses and visceral injury as well as faster weight gain compared with florfenicol or copper exposure alone. Alpha and beta diversity indices indicated that the composition of the gut microbiota and the abundance of bacteria related to energy intake and disease in the combined exposure group were significantly altered. The increase in resistance genes (floR, fexA) induced by florfenicol exposure was suppressed under combined exposure to florfenicol and copper. The fecal metabolome also demonstrated that metabolic pathways related to energy intake and liver injury were significantly affected in the combined exposure group. In conclusion, this study shows that combined exposure to florfenicol and copper during early life can pose a nonnegligible health risk even if the exposure concentration of florfenicol or copper is below the safe limit.

Florfenicol

Metabolome

Resistome

10.1016/j.ecoenv.2022.114120

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Citations (7)

CCDC 1906505: Experimental Crystal Structure Determination

The Cambridge Structural Database (2019)

Jinyao Chen Wenming Zhu Weijie Ji Bin Zhu Chunyang Guo

10.5517/ccdc.csd.cc21zw53

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SDラットにおける早期の銅曝露後の毒性,腸内細菌叢およびメタボローム効果【JST・京大機械翻訳】

Toxicology (2020)

Dai Juan Yang Xiao Yuan Ya Jia Youzhen Liu Guibing

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[Study on protective effect of Tianji soft capsule on blood lipids, internal antioxidant system and vascular endothelial system in hyperlipidemia rats].

PubMed (2011)

Haiying Ma Jinyao Chen Lishi Zhang

To study the protective effects of Tianji soft capsule (TJSC) on blood lipids, internal antioxidant system and vascular endothelial system in hyperlipidemia rats.Seventy two healthy male rats were divided into six groups. The rats in control group were administered with ordinary diet. The rats in model group were fed with high cholesterol/lipid diet to induce hyperlipidemia. The rats in TJSC and CoQ10 groups were fed with high cholesterol/lipid diet, and treated with TJSC at different doses of 83 (low-dose group, L), 250 (middle-dose group, M), 750 (high-dose group, H) mg/kg, and CoQ10 at the dose of 83 mg/kg, respectively. All animals were put to death after four weeks, effects on lipid level; antioxidant system and endothelial system were evaluated through detection of total cholesterol (TC), triglyceride (TG), very low density lipoprotein (VLDL), atherogenic index (AI), malondidehyde (MDA) and plasma endothelin (ET), HDL/TC ratio, activities of superoxide dismutase (SOD) and nitric oxide (NO).Compared with model group, serum TC, TG, VLDL, AI, MDA and ET reduced and the HDL/TC ratio increased, meanwhile activities of SOD and NO were enhanced.TJSC can regulate the lipid metabolism, enhance antioxidant system and protect the vascular endothelia system in hyperlipiemic rats.

Hyperlipidemia

High-density lipoprotein

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The mediation role of blood lipids on the path from air pollution exposure to MAFLD: A longitudinal cohort study

The Science of The Total Environment (2023)

Xinyu Han Bing Guo Lele Wang Kejun Chen Hanwen Zhou

Dyslipidemia

10.1016/j.scitotenv.2023.166347

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Citations (4)

CCDC 1870363: Experimental Crystal Structure Determination

The Cambridge Structural Database (2019)

Jinyao Chen Xiaoyu Wang Minghuang Hong Dongxu Yi Ming‐Hui Qi

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc20s89d

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Effects of atrazine on the proliferation and cytotoxicity of murine lymphocytes with the use of carboxyfluorescein succinimidyl ester-based flow cytometric approaches

Food and Chemical Toxicology (2014)

Jinyao Chen Jiao Huo Zhenchao Jia Yang Song Yan Li

Propidium iodide

Immunotoxicology

Rhodamine 123

10.1016/j.fct.2014.11.026

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Citations (20)