Jie Li

Shanghai Jiao Tong University

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Changgang Sun

Weifang Chinese Medicine Hospital

Cun Liu

Shandong University of Traditional Chinese Medicine

Xiaoran Ma

Tianjin University

Chundi Gao

Weifang Medical University

Jing Zhuang

Heilongjiang University of Technology

Lijuan Liu

Weifang Chinese Medicine Hospital

Huayao Li

Weifang Medical University

Xue Wang

First Affiliated Hospital of Zhengzhou University

Lingyu Qi

Beijing University of Chinese Medicine

Chao Zhou

Qilu Hospital of Shandong University

Cooperative Institutions

Shandong University of Traditional Chinese Medicine

Chinese Academy of Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

Capital Medical University

Sun Yat-sen University

Shandong University

Huazhong University of Science and Technology

Harbin Medical University

Shanghai Jiao Tong University

Peking University

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Allocryptopine: A Review of Its Properties and Mechanism of Antiarrhythmic Effect

Current Protein and Peptide Science (2019)

Jie Li Bin Li Hailiang Huang Tao Han Yang Li

Abstract：Throughout the last decade, extensive efforts have been devoted to developing a percutaneous catheter ablation and implantable cardioverter-defibrillator technique for patients suffering from ventricular arrhythmia. Antiarrhythmic drug efficacy for preventing arrhythmias remains disappointing because of adverse cardiovascular effects. Allocryptopine is an isoquinoline alkaloid widely present in medicinal herbs. Studies have indicated that allocryptopine exhibits potential anti-arrhythmic actions in various animal models. The potential therapeutic benefit of allocryptopine in arrhythmia diseases is addressed in this study, focusing on multiple ion channel targets and reduced repolarization dispersion. The limitations of allocryptopine research are clear given a lack of parameters regarding toxicology and pharmacokinetics and clinical efficacy in patients with ventricular arrhythmias. Much remains to be revealed about the properties of allocryptopine.

Anti-Arrhythmia Agents

Isoquinoline

10.2174/1389203720666190807123609

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Nursing and Treatment of Combining TCM and Western Medicine to Gastric Paralysis Syndrome after Abdominal Operation

Zhejiang Zhongyi Xueyuan xuebao (2006)

Ying Zhang Jie Li Hangzhou

Western medicine

Integrative Medicine

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Back Cover

Clinical Implant Dentistry and Related Research (2019)

Lihua Yin Yaoren Chang Yuanhe You Chun Liu Jie Li

The cover image is based on the Original Article Biological responses of human bone mesenchymal stem cells to Ti and TiZr implant materials by Lihua Yin DDS, PhD et al., https://doi.org/10.1111/cid.12756.

10.1111/cid.12838

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ADRB1 was identified as a potential biomarker for breast cancer by the co-analysis of tumor mutational burden and immune infiltration

Aging (2020)

Wang Jia Xiaolu Zhang Jie Li Xiaoran Ma Fubin Feng

Breast cancer (BRCA) has traditionally been considered as having poor immunogenicity and is characterized by relatively low tumor mutational burden (TMB). Improving immunogenicity may improve the response to clinical immunotherapy of BRCA. However, the relationship between TMB, immune infiltration, and prognosis in BRCA remains unclear. We aimed to explore their interrelations and potential biomarkers. In this study, based on somatic mutation data of BRCA from The Cancer Genome Atlas (TCGA), patients were categorized into high and low TMB groups utilizing the TMB values. CIBERSOFT algorithm indicated significant infiltration of activated partial immune cells in high TMB group. Besides, ADRB1 had been identified as a prognosis-related immune gene in the mutant genes by the combination of the ImmPort database and the univariate Cox analysis. ADRB1 mutation was associated with lower TMB and manifested a satisfactory clinical prognosis. Various database applications (Gene Set Enrichment Analysis, Tumor IMmune Estimation Resource, Connectivity Map, KnockTF) supported the selection of treatment strategies targeting ADRB1. In conclusion, TMB was not an independent prognostic factor for BRCA and high TMB was more likely to activate a partial immune response. ADRB1 was identified as a potential biomarker and may provide new insights for co-therapy of BRCA.

Infiltration (HVAC)

10.18632/aging.104204

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The preliminary results of high intensity focused ultrasound (HIFU) treatment for advanced pancreatic cancer

Zhonghua putong waike zazhi (2014)

Shuijun Zhang Tianliang Song Yang Wu Jie Li Wenzhi Guo

Objective To study the efficacy and safety of high intensity focused ultrasound (HIFU) treatment for advanced pancreatic cancer.Methods In this study,25 patients with advanced pancreatic cancer received high-intensity focused ultrasound (HIFU) treatment.Liver and kidney function,CA19-9 levels,tumor size changes,pain relief,survival rate before and after treatment were evaluated.Results The blood routine test,liver and kidney function,blood amylase did not alter significantly after HIFU treatment in all patients.The CA19-9 level of 12 patients decreased.The appetite of 15 patients improved,5 patients with body weight gain after HIFU treatment.Pain was relieved after HIFU treatment in 18 cases,pain relief rate was 72％ (18/25).In 15 cases tumor ablation volume ＞ 90％ after HIFU treatment,5 patients with tumor ablation volume ＞ 50％,tumor ablation effective rate was 80％ (20/25).There were no major complications such as acute pancreatitis,gastrointestinal injury after HIFU treatment.After HIFU treatment,the median survival period was 8 months,1 year survival rate was 30％.Conclusions High-intensity focused ultrasound is a safe and effective method of palliative treatment for advanced inoperable pancreatic cancer. Key words: Pancreatic neoplasms; High intensity focused ultrasound ablation; Palliative care

High-intensity focused ultrasound

10.3760/cma.j.issn.1007-631x.2014.09.007

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[Material base on Chinese medical theory of 'Fei and Dachang being interior-exteriorly correlated'].

Chinese journal of integrated traditional and Western medicine (2011)

Jie Li Xin Cheng Yuhua Jia

Abstract By reviewing pertinent literatures, we found that there existed some defects in studying material base on Chinese medical theory of Fei and Dachang being interior-exteriorly related, such as the low efficacy of research methods; the neglect of intestinal and respiratory microhabitat and Chinese medical functional condition; and the unconformity of research design with evidence-based medicinal requirements. Thereby, the authors offered that the researches method of initiating merely from sole material or line linkage path should be rejected. The new research strategy should be established based on the feature of the lung and large intestine network connective structure, cutting-in from correlative changes in the two terminals (respiratory system and intestinal tissue), and the intermedial key knot of connection (blood serum), screen out in high throughput the relevant materials adopting microecological, proteomic and metabonomic techniques, and catch hold of the knots of network as much as possible. Based on these to perfect the researches on coordinating mechanism of the network, and to establish a new strategy for future researching.

Linkage (software)

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Exploring the Mechanism of Danshen against Myelofibrosis by Network Pharmacology and Molecular Docking

Evidence-based Complementary and Alternative Medicine (2018)

Jie Li Xiaoran Ma Cun Liu Huayao Li Jing Zhuang

Danshen (Salvia miltiorrhiza Bunge), a natural powerful drug for various conditions treatment, has traditionally been used in Asian countries for centuries as anticancer agent, anti‐inflammatory agent, and antioxidant. More recently, it is explored in combination with other herbs for skeletal diseases therapy; bone‐targeting compounds with pharmacological activities have been isolated from various sources of traditional Chinese medicine (TCM), including Danshen. In this case, some evidence supports that Danshen may treat myelofibrosis (MF) by exerting its antitumor effect. To study the specific mechanism of Danshen in the treatment of MF, we used bioinformatics databases to determine its active ingredients. Then, identification of target proteins related to MF was made using a network pharmacology analysis platform. In our results, 20 key active compounds and 457 key targets of Danshen were identified. In‐depth network analysis of the top diseases, functions, and pathways suggested that a common underlying mechanism linked Danshen involvement with MF. Finally, 5 potential targets were confirmed by the analysis; these 5 targets, as well as 20 previously identified compounds, were subjected to molecular docking experiments. The results indicated that cryptotanshinone of Danshen may affect MF by acting on the key genes in the JAK‐STAT signalling pathway and the TGF‐ β signalling pathway.

Docking (animal)

10.1155/2018/8363295

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A newly identified lncRNA MAR1 acts as a miR‐487b sponge to promote skeletal muscle differentiation and regeneration

Journal of Cachexia Sarcopenia and Muscle (2018)

Zong‐Kang Zhang Jie Li Daogang Guan Chao Liang Zhenjian Zhuo

Abstract Background Skeletal muscle atrophy induced by either aging (sarcopenia) or mechanical unloading is associated with serious health consequences. Long non‐coding RNAs (lncRNAs) are implicated as important regulators in numerous physiological and pathological processes. Methods Microarray analysis was performed to identify the differentially expressed lncRNAs in skeletal muscle between adult and aged mice. The most decreased lncRNA in aged skeletal muscle was identified. The C2C12 mouse myoblast cells were used to assess the biological function of the lncRNA in vitro . The target microRNA of lncRNA and the target protein of microRNA were predicted by bioinformatics analysis and validated in vitro . Furthermore, the biology function of the lncRNA in vivo was investigated by local overexpression or knockdown the lncRNA in skeletal muscle. The therapeutic effect of the lncRNA overexpression in age‐related or mechanical unloading‐induced muscle atrophy was also evaluated. Results We identified a novel lncRNA (muscle anabolic regulator 1, MAR1) which was highly expressed in mice skeletal muscle and positively correlated with muscle differentiation and growth in vitro and in vivo . We predicted and validated that microRNA‐487b (miR‐487b) was a direct target of MAR1. We also predicted and validated that Wnt5a, an important regulator during myogenesis, was a target of miR‐487b in C2C12 cells. Our findings further demonstrated that enforced MAR1 expression in myoblasts led to derepression of Wnt5a. Moreover, MAR1 promoted skeletal muscle mass/strength and Wnt5a protein level in mice. Enforced MAR1 expression in mice attenuated muscle atrophy induced by either aging or unloading. Conclusions The newly identified lncRNA MAR1 acts as a miR‐487b sponge to regulate Wnt5a protein, resulting in promoting muscle differentiation and regeneration. MAR1 could be a novel therapeutic target for treating muscle atrophy induced by either aging or mechanical unloading.

C2C12

Muscle Atrophy

10.1002/jcsm.12281

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Predict the role of lncRNA in kidney aging based on RNA sequencing

BMC Genomics (2022)

Jie Li Fanfan Gao Limin Wei Lei Chen Ning Qu

Long noncoding RNAs (lncRNAs) are involved in physiological and pathological processes. However, no studies have been conducted on the relationship between lncRNAs and renal aging.First, we evaluated the histopathology of young (3-month-old) and old (24-month-old) C57BL/6J mouse kidneys. Masson trichrome staining and PAS staining showed interstitial collagen deposition and fibrosis, mesangial matrix expansion, a thicker basement membrane and renal interstitial fibrosis in old mouse kidneys. Senescence-associated β-galactosidase (SA-β-gal)-positive areas in the kidneys of old mice were significantly elevated compared to those of young mice. Then, we analyzed the differential expression of lncRNAs and mRNAs in the kidneys of young and old mouse kidneys by RNA-seq analysis. 42 known and 179 novel differentially expressed lncRNAs and 702 differential mRNAs were detected in the mouse kidney. Next, we focused on the differentially expressed mRNAs and lncRNAs by RNA-seq. GO and KEGG analyses were performed based on differentially expressed mRNAs between young and old mouse kidneys. Transregulation based on RIsearch and the correlation coefficient of mRNA-lncRNA were also calculated. The mRNA-lncRNA network was constructed by choosing a Spearman correlation coefficient > 0.9 or <-0.9. GO and KEGG pathway enrichment analyses revealed that differentially expressed mRNAs participated in aging-related pathways. A total of 10 lncRNAs and trans-regulated mRNAs were constructed. Finally, we validated the role of lncRNA Gm43360 by CCK-8, flow cytometry, western blot and SA-β-gal staining. The expression level of Adra1a was positively correlated and Csnk1a1 was negatively correlated with lncRNA Gm43360. The cell counting kit-8 (CCK-8) results showed that lncRNA Gm43360 promoted cell viability. LncRNA Gm43360 increased the percentage of S phase cells and decreased the percentage of G1 phase cells compared with the negative control. LncRNA Gm43360 decreased the expression of p53, p21 and SA-β-gal.LncRNA Gm43360 may play a protective role in kidney aging.

KEGG

10.1186/s12864-022-08479-8

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Research progress of phenolic compounds regulating IL‐6 to exert antitumor effects

Phytotherapy Research (2021)

Tingting Xia Jie Li Xin Ren Cun Liu Changgang Sun

Cytokine therapy, which activates the host immune system, has become an important and novel therapeutic approach to treat various cancers. Recent studies have shown that IL‐6 is an important cytokine that regulates the homeostasis in vivo. However, excessive IL‐6 plays a pathological role in a variety of acute and chronic inflammatory diseases, especially in cancer. IL‐6 can transmit signals through JAK/STAT, RAS /MAPK, PI3K/ Akt, NF‐κB, and other pathways to promote cancer progression. Phenolic compounds can effectively regulate the level of IL‐6 in tumor cells and improve the tumor microenvironment. This article focuses on the phenolic compounds through the regulation of IL‐6, participate in the prevention of cancer, inhibit the proliferation of cancer cells, reduce angiogenesis, improve therapeutic efficacy, and reduce side effects and other aspects. This will help to further advance research on cytokine therapy to reduce the burden of cancer and improve patient prognosis. However, current studies are mostly limited to animal and cellular experiments, and high‐quality clinical studies are needed to further determine their antitumor efficacy in humans.

10.1002/ptr.7258

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Citations (18)