Ting Wang

Beijing Proteome Research Center

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Ning Wang

Shanghai Innovative Research Center of Traditional Chinese Medicine

Ann M. Bode

Royal Belfast Hospital for Sick Children

Xiaomeng Xie

Zhengzhou University

Yuanyuan Zhang

China Agricultural University

Feifei Liu

Shandong University

Zigang Dong

China-US (Henan) Hormel Cancer Institute

Yuanyuan Zhen

Qilu Hospital of Shandong University

Xueyin Zu

West China Hospital of Sichuan University

Hanyong Chen

Hormel (United States)

Kangdong Liu

Zhengzhou University

Cooperative Institutions

Chinese Academy of Sciences

182

Sichuan University

Chinese Academy of Medical Sciences & Peking Union Medical College

Shanghai Jiao Tong University

Anhui Medical University

Central South University

University of Chinese Academy of Sciences

Sun Yat-sen University

Peking University

Fudan University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Design, Synthesis, and Biological Evaluation of Novel DNA Gyrase-Inhibiting Spiropyrimidinetriones as Potent Antibiotics for Treatment of Infections Caused by Multidrug-Resistant Gram-Positive Bacteria

Journal of Medicinal Chemistry (2019)

Chenghui Shi Yinyong Zhang Ting Wang Wenchao Lu Shu‐Hua Zhang

Spiropyrimidinetriones are a novel class of antibacterial agents that target the bacterial type II topoisomerase via a new mode of action. Compound ETX0914 is thus far the only drug from this class that is being evaluated in clinical trials. To improve the antibacterial activity and pharmacokinetic properties of ETX0914, we carried out systematic structural modification of this compound, and a number of compounds with increased potency were obtained. The most promising compound 33e, with incorporation of a spirocyclopropane at the oxazolidinone 5 position reduced metabolism, exhibited excellent antibacterial activity against Gram-positive pathogens and a good pharmacokinetic profile combined with high aqueous solubility. In addition, compound 33e exhibited good selectivity for Staphylococcus aureus gyrase over human Topo IIα. In a murine model of systemic methicillin-resistant S. aureus infection, 33e exhibited superior in vivo efficacy (ED50 = 3.87 mg/kg) compared to ETX0914 (ED50 = 11.51 mg/kg).

Topoisomerase IV

Mode of Action

10.1021/acs.jmedchem.8b01750

Cite

Citations (30)

Multifunctional particle-constituted microneedle arrays as cutaneous or mucosal vaccine adjuvant-delivery systems

Human Vaccines & Immunotherapeutics (2016)

Xueting Wang Ning Wang Ning Li Yuanyuan Zhen Ting Wang

To overcome drawbacks of current injection vaccines, such as causing needle phobia, needing health professionals for inoculation, and generating dangerous sharps wastes, researchers have designed novel vaccines that are combined with various microneedle arrays (MAs), in particular, with the multifunctional particle-constructed MAs (MPMAs). MPMAs prove able to enhance vaccine stability through incorporating vaccine ingredients in the carrier, and can be painlessly inoculated by minimally trained workers or by self-administration, leaving behind no metal needle pollution while eliciting robust systemic and mucosal immunity to antigens, thanks to delivering vaccines to cutaneous or mucosal compartments enriched in professional antigen-presenting cells (APCs). Especially, MPMAs can be easily integrated with functional molecules fulfilling targeting vaccine delivery or controlling immune response toward a Th1 or Th2 pathway to generate desired immunity against pathogens. Herein, we introduce the latest research and development of various MPMAs which are a novel but promising vaccine adjuvant delivery system (VADS).

10.1080/21645515.2016.1158368

Cite

Citations (15)

Superficial performance and pore structure of palygorskite treated by hydrochloric acid

Journal of Central South University of Technology (2006)

Yixin Liu Wei-wei Dai Ting Wang Yong Tao

Palygorskite

Hydrochloric acid

Microcrystalline

Specific surface area

10.1007/s11771-006-0066-9

Cite

Citations (10)

Liposomes used as a vaccine adjuvant-delivery system: From basics to clinical immunization

Journal of Controlled Release (2019)

Ning Wang Minnan Chen Ting Wang

10.1016/j.jconrel.2019.04.025

Cite

Citations (242)

Immunization - Vaccine Adjuvant Delivery System and Strategies

IntechOpen eBooks (2018)

Ning Wang Ting Wang

Immunization plays a key role in maintaining human health and each year, saves millions of lives from lethal pathogens and other fatal diseases in the most economical way, thanks to the advanced development of model vaccines. Subunit vaccines are regarded as a safer product than the whole microbe based-conventional vaccines and can be entrapped in various nanocarriers to form a vaccine adjuvant-delivery system (VADS) able to further boost their immunostimulatory activity. In this book, six groups of authors introduce immunization advances in VADSs designed for infection prophylaxis and cancer immunotherapy, problems and their resolution in both human and poultry immunization, and also, the mathematical model for assay of the basic immunization problem (BIP) understood from a finance point of view.

Nanocarriers

10.5772/intechopen.74198

Cite

Citations (9)

In vivo pharmacokinetics, biodistribution and antitumor effect of amphiphilic poly(l-amino acids) micelles loaded with a novel all-trans retinoic acid derivative

European Journal of Pharmaceutical Sciences (2013)

Jihui Tang Xin-Qun Wang Ting Wang Feihu Chen Jianping Zhou

Biodistribution

10.1016/j.ejps.2013.09.016

Cite

Citations (7)

Mannose derivative and lipid A dually decorated cationic liposomes as an effective cold chain free oral mucosal vaccine adjuvant-delivery system

European Journal of Pharmaceutics and Biopharmaceutics (2014)

Ning Wang Ting Wang Mei‐Ling Zhang Ruonan Chen Ruowen Niu

10.1016/j.ejpb.2014.04.007

Cite

Citations (81)

Cucumber (Cucumis sativus L.) Nitric Oxide Synthase Associated Gene1 (CsNOA1) Plays a Role in Chilling Stress

Frontiers in Plant Science (2016)

Xingwang Liu Bin Liu Shudan Xue Yanlinq Cai Wenzhu Qi

Nitric oxide (NO) is a gaseous signaling molecule in plants, transducing information as a result of exposure to low temperatures. However, the underlying molecular mechanism linking NO with chilling stress is not well understood. Here, we functionally characterized the cucumber (Cucumis sativus) nitric oxide synthase-associated gene, NITRIC OXIDE ASSOCIATED 1(CsNOA1). Expression analysis of CsNOA1, using quantitative real-time PCR, in situ hybridization and a promoter::β-glucuronidase (GUS) reporter assay, revealed that it is expressed mainly in the root and shoot apical meristem (SAM), and that expression is up-regulated by low temperatures. A CsNOA1-GFP fusion protein was found to be localized to the mitochondria, and ectopic expression of CsNOA1 in the A. thaliana noa1 mutant partially rescued the normal phenotype. Transgenic cucumber plants revealed that the gene is required by seedlings to tolerate chilling stress: constitutive over-expression of CsNOA1 led to a greater accumulation of soluble sugars, starch, and an up-regulation of Cold-regulatory C-repeat binding factor3 (CBF3) expression. Conversely, suppression of CsNOA1 expression resulted in the opposite phenotype and a reduced NO content compared to wild type plants. Additionally, analyses using inhibitors suggested that NO can be synthesized via a CsNOA1 dependent pathway that is independent of the nitrate reductase (NR) pathway.

Cucumis

Ectopic expression

10.3389/fpls.2016.01652

Cite

Citations (23)

Segmental Analysis of R/S-Methamphetamine and R/S-Amphetamine in Abusers’ Head Hair

Journal of Analytical Toxicology (2019)

Ting Wang Baohua Shen Hejian Wu Jun Gu Min Shen

In this study, the relationships between the concentrations of R/S-methamphetamine (MA) and its metabolite R/S-amphetamine (AP), the AP/MA ratio in hair samples, and MA dependence were investigated by performing segmental hair analysis in MA users. Authentic hair samples collected from 10 chronic MA abusers were cut into 1-cm sections (a total of 120 segments). The concentrations of MA and AM enantiomers were quantitatively measured by the LC-MS-MS method. The S-MA concentrations ranged from 1.17 to 256.41 ng/mg and the S-AP concentrations ranged from 0.11 to 23.31 ng/mg in the 120 segments. S-MA and S-AP were the most common analytes identified in hair; no R-MA or R-AP was found. The S-AP/S-MA ratios ranged from 0.03 to 0.32, indicating that the subjects primarily consumed S-MA rather than R-MA or AP. The S-AP/S-MA ratios in the long hair of all chronic MA abusers showed some variation, but there was an overall trend of gradual increase from the distal to the proximal end. This trend was independent of the drug concentrations. Therefore, we could conclude that the AP/MA ratios increased with the duration of MA abuse, and a higher AP/MA ratio suggested high MA dependence. There was no chiral conversion of MA or AP in the hair matrix. The segmental hair analysis showed that all subjects continuously used S-MA, and some users showed an increase in drug dose or the frequency of use.

Methamphetamine

10.1093/jat/bkz089

Cite

Citations (7)

TABLE OF CONTENTS FOR VOLUME 23 ATOMIZATION AND SPRAYS

Atomization and Sprays (2013)

Cristiano Schetini de Azevedo Januário de Andrade Filippo Costa Mohd Zaid Akop Yoshio Zama

Table (database)

10.1615/atomizspr.v23.i12.60

Cite

Citations (0)