A phosphine-mediated γ-umpolung/Wittig/γ-umpolung reaction between phthalimidomalonates and allenoates/but-2-ynoate furnishes highly functionalized pyrroloisoindolinone derivatives in synthetically useful yields.

Domino

Domino Effect

10.1039/c6qo00775a

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Total alkaloid fraction of Leonurus japonicus Houtt. Promotes angiogenesis and wound healing through SRC/MEK/ERK signaling pathway

Journal of Ethnopharmacology (2022)

Xiaoqin Shi Gan Chen Jiaqi Tan Zhuo Li Si-Min Chen

MTT assay

10.1016/j.jep.2022.115396

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Citations (15)

Retraction Note to: CXCR4 Signaling Induced Epithelial-Mesenchymal Transition by PI3K/AKT and ERK Pathways in Glioblastoma

Molecular Neurobiology (2017)

Baoyu Lv Xiangshan Yang Shunzeng Lv Lei Wang Kaixi Fan

10.1007/s12035-017-0464-z

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Citations (20)

Can Hedysari Radix replace Astragali Radix in Danggui Buxue Tang, a Chinese herbal decoction for woman aliment?

Phytomedicine (2013)

Li Zhang Roy Chi-Yan Choi Janis Ya-Xian Zhan Jianping Chen Wilson Kin-Wai Luk

Calycosin

Radix (gastropod)

Decoction

Angelica sinensis

Flos

10.1016/j.phymed.2013.04.016

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Citations (22)

Indirect determination of superoxide anion radical in the plant of red sage based on vanillin-8-aminoquinoline with fluorescence

Analytica Chimica Acta (2003)

Bo Tang Li Zhang Ji-Xi Hu Ping Li Hui Zhang

Superoxide radical

Linear range

10.1016/j.aca.2003.09.052

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Citations (22)

The natural compound neobractatin inhibits cell proliferation mainly by regulating the RNA binding protein CELF6

Food & Function (2022)

Zhaoqing Zheng Jiaqi Tan Juan Zhang Man Wu Gan Chen

The fruits of Garcinia bracteata can be eaten raw or processed into spices, which are considered to possess nutritional and medicinal value. Neobractatin (NBT) is a natural compound isolated from Garcinia bracteate. This study showed that NBT showed antitumor effect by upregulation of CELF6. CELF6, an RNA-binding protein of the CELF family, is involved in cancer cell proliferation. However, the role of CELF6 in human cervical cancer remains unknown. Here, we showed that CELF6 overexpression significantly suppressed HeLa cell proliferation. Mechanistically, the RNA immunoprecipitation sequencing (RIP-seq) results suggested that CELF6 physically targeted the cyclin D1 transcript, affecting protein stability. Overexpression of CELF6 increased the degradation of cyclin D1. Consistent results were obtained for the effect of NBT, which increased the expression of CELF6 at both the mRNA and protein levels. An in vivo study further confirmed the regulatory effect of NBT on CELF6 and cyclin D1 levels in a HeLa xenograft model. Similar effects of NBT on CELF6 were also shown in K562 cells in vitro and in vivo. In conclusion, our findings identified CELF6 as a tumor suppressor and a novel therapeutic target in cervical cancer. The upregulation of CELF6 expression by NBT and its antiproliferative effect on HeLa cells indicated that NBT from G. bracteata might be a small-molecule compound targeting CELF6.

HeLa

Immunoprecipitation

Cyclin B1

10.1039/d1fo03542h

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Citations (6)