A comparative study was performed of the content of heavy metals in wheat and corn in an area of soil heavy metal pollution and a control area in a certain gold mining area in the Xiaoqingling Mountains. The study shows that: the cumulative contents of Hg,Pb and Cd in wheat seeds in the polluted area are obviously higher than those in the soil control area; there is almost no difference in contents of Cr,As,Cu and Zn between the polluted area and control area; and the above-standard rates of Hg,Pb,Cd,Zn and Cu in wheat are 86.67%,60%,33.33%,6.67% and 20% respectively. In comparison with the control area,the Pb,Cd and Cr contents in corn in the polluted area are markedly high but do not exceed the set standards,only mercury being above the standard,with an above-standard rate of 15.15%. Wheat is easier to absorb heavy metals than corn at the same sampling site. There is a good correlation between the content of heavy metals in wheat and the degree of heavy metal pollution in soils. In contrast with 1990,the cumulative effects of Hg and Cd in wheat are very prominent. The heavy metal pollution of soils in gold mining area has caused serious pollution of wheat.
Tenofovir amibufenamide (TMF) has potent antiviral efficacy in a randomized clinical study. This study aimed to reveal the effectiveness and safety of TMF in real-world, and compared TMF to tenofovir alafedimide (TAF) in patients with chronic hepatitis B(CHB).
Methods
This was a retrospective study. TMF-treated CHB patients were divided into a treatment-naïve (TN) group and a treatment-experienced (TE) group. And TAF-treated patients were enrolled using the propensity score matching method(PSM). We assessed the virological response (VR, HBV DNA<100IU/mL) rates, renal function and blood lipids changes during 24 weeks of treatment.
Results
The VR rates at week 24 were 93%(50/54) in the TN group and 95%(61/64) in TE group (IDDF2023-ABS-0143 Figure 1(A) The antiviral effects and safety profiles of TMF in VR rates during 24 weeks of treatment betweentreatment-naïve (TN) and treatment-experienced (TE) groups). The ratios of alanine transaminase (ALT) normalization was 89%(25/28) in TN group and 71%(10/14) in TE group(p=0.306) (IDDF2023-ABS-0143 Figure 1(B) Ratios of ALT normalization during 24 weeks of treatment betweentreatment-naïve (TN) and treatment-experienced (TE) groups). Additionally, no matter in TN group or TE group, serum creatine decreased[-4.44±13.55μmol/L vs -4.14±9.33μmol/L, p=0.886], estimated glomerular filtration rate (eGFR) increased[7.01±12.49ml/min/1.73m2 vs. 5.50±8.16ml/min/1.73m2, p=0.430] (IDDF2023-ABS-0143 Figure 1(C) Mean changes of eGFR during 24 weeks of treatment betweentreatment-naïve (TN) and treatment-experienced (TE) groups), and low-density lipoprotein cholesterol(LDL-C) levels increased[0.09±0.71mmol/L vs. 0.27±0.68mmol/L, p=0.152]( IDDF2023-ABS-0143 Figure 1(D) LDL-C Levels during 24 weeks of treatment betweentreatment-naïve (TN) and treatment-experienced (TE) groups), but total cholesterol/high-density lipoprotein cholesterol (TC/HDL-C) values decreased continuously from 3.26±1.05 to 2.49±0.72 in TN group and from 3.31±0.99 to 2.88±0.77 in TE group. After PSM, we further compared VR rates between TMF and TAF cohorts. The VR rates among TN patients were higher in the TMF cohort[92%(35/38) vs. 74%(28/38), (p=0.033)](IDDF2023-ABS-0143 Figure 1(E) The VR rates between TMF and TAF after PSM among treatment-naïve patients). The VR rates among TE patients showed no statistical difference between TMF and TAF cohorts, but eGFR increased in the TMF cohort but decreased in the TAF cohort[5.43±8.30 ml/min/1.73m2 vs -3.01±6.35ml/min/1.73m2, p=0.000)] (IDDF2023-ABS-0143 Figure 1(F) Changes in eGFR between TMF and TAF after PSM among treatment-naïve patients).
Conclusions
TMF had profound antiviral effectiveness and no adverse effects on renal function and blood lipid. Additionally, TMF was more efficient than TAF in inhibiting viral replication.
Monoindolylmaleimides have been identified as potent glycogen synthase kinase-3β inhibitors.In this paper, a convenient methodology for the preparation of some new monoindolylmaleimides was developed by microwave assisted condensation of substituted monochloromaleimides with N-containing heterocycles followed by ammonolysis in good overall yield (up to 80 %).The products were characterized by 1 H NMR and ESI-MS.
Organic–inorganic hybrid perovskite materials have had remarkable success in photovoltaics due to their superior optoelectronic properties and compositional abundance. Most advances focus on the improvement of the heterojunction, in which nonperovskite materials are employed at the pertaining interfaces. Herein we demonstrate the modification of perovskite absorber by incorporation of CsPbBr3 nanocrystals, which is congeneric to the absorber in terms of crystal structure and stoichiometry. It led to significant enhancement in photovoltaic performance in the corresponding devices, which was mainly attributed to the improved carrier dynamics over the resultant heterojunction. Therefore, a different strategy is suggested for further improvement of the perovskite heterojunction by using congeneric materials.
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