Li Liu

Yangzhou University

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Co-Authors

Zhongping Cheng

Tongji University

Ning Luo

The First Affiliated Hospital, Sun Yat-sen University

Lin Xie

Novo Nordisk (United States)

Cheng‐Wu Chi

Chinese Academy of Sciences

Xiao‐Xia Shao

Tongji University

Xiaodong Liu

China Pharmaceutical University

Guangji Wang

China Pharmaceutical University

Yunli Yu

Soochow University

Duo‐Duo Yuan

Chinese Academy of Sciences

Sen Yu

Simcere Pharmaceutical (China)

Cooperative Institutions

Tongji University

Chinese Academy of Sciences

Sun Yat-sen University

Chinese Academy of Medical Sciences & Peking Union Medical College

Shanghai Tenth People's Hospital

Nanjing Medical University

Southern Medical University

Peking University

China Pharmaceutical University

University of Chinese Academy of Sciences

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Neoantimycin F, a Streptomyces-Derived Natural Product Induces Mitochondria-Related Apoptotic Death in Human Non-Small Cell Lung Cancer Cells

Frontiers in Pharmacology (2019)

Liyun Liu Hongrui Zhu Wei Wu Yaoyao Shen Xiao Lin

Streptomyces-derived natural products have been become a major focus of anti-tumor drug discovery studies. Neoantimycin F (NAT-F), was isolated from Streptomyces conglobatus by our group. Here, we examined the anti-cancer activities and its underlying molecular mechanisms implicated in NAT-F-induced apoptosis of non-small cell lung cancer (NSCLC) cells. Our results showed that NAT-F exerted excellent growth-inhibitory activity against PC9 and H1299 cells in a concentration-dependent manner. NAT-F induced cell cycle arrest at S and G0/G1 phase in PC9 and H1299 cells, respectively. And further investigation revealed that the key proteins (including cyclinD1, cyclinE1, cyclinB1, CDK2, and CDK4) were involved in the cell regulation by NAT-F. Additionally, NAT-F significantly increased the production of reactive oxygen species (ROS), induced DNA damage, nuclear condensation, and cell apoptosis in both cell lines. Moreover, loss of the mitochondrial membrane potential (MMP) were markedly induced by NAT-F. Additional results revealed that NAT-F could up-regulate pro-apoptotic protein Bax and down-regulate anti-apoptotic protein Bcl-2, Mcl-1and Bcl-xL, resulting in cytochrome c release from mitochondria and sequential activation of caspase-9 and- 3 as well as the cleavage of poly (ADP-ribose) polymerase. Meanwhile, c-Jun N-terminal kinase (JNK), p38 MAPK (p38) and extracellular signal-regulated kinase (ERK) signaling pathway were also involved in anti-cancer activity of NAT-F in NSCLC cells. Taken together, these findings indicated that NAT-F possessed anti-proliferative effect and induced apoptosis in NSCLC cells in vitro and may be conducive to promote the development of novel anti-NSCLC agents.

Natural product

10.3389/fphar.2019.01042

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Citations (16)

[Effects of soybean isoflavones on the cell cycles, the cell apoptosis and the proliferation of spleen in radiated mice].

Li Liu Hong Jin Xianyuan Wang Zhiqin Xu Nan Wen-kao

AIM To study effect of soybean isoflavones (SI) on spleen in radiated mice. METHODS 90 male mice were randomly divided into control group, radiated group, radiated plus 0.5% dose SI group. After 2-week feeding, the mice received 4.0 Gy 137Cs gamma-radiation, the cell cycles, cell apoptosis and proliferation on the spleen and the spleen index were observed in radiated after 12 h, 24 h, 1 week and 2 weeks. RESULTS After the mice were radiated, the spleen were significantly atrophy, the rate of the cell apoptosis and the cell cycles of G0-G1 phase in splenocytes were significantly increased (P < 0.01), the cell cycles rate of S phase and the proliferation index were significantly decreased in spleen (P < 0.05). Compared with radiated group, the spleen atrophy and the rate of the cell cycles of G0-G1 phase were significantly decreased (P < 0.05), and the cell cycles of G2-M phase and the proliferation index were significantly increased (P < 0.05) in the mice supplied 0.5% soybean isoflavones. CONCLUSION The soybean isoflavones could significantly increase spleen radioprotective effect in mice.

Splenocyte

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Citations (4)

STATIONARY OSCILLATION OF IMPULSIVE SYSTEM

International Journal of Bifurcation and Chaos (2006)

Li Liu Jitao Sun

This letter introduces two new concepts of S-stability and stationary oscillation for impulsive differential system. Based on the concept of S-stable, we present the relationship of S-stability and stationary oscillation for an impulsive system. Some criterions of stationary oscillation for the impulsive system are established. A numerical example is presented to illustrate the efficiency of the proposed result.

Oscillation (cell signaling)

10.1142/s0218127406016707

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Citations (8)

Effect of HuperzineA on neurophathologic change of mouse exposed by isocarbophos and phoxim

Journal of hygiene research (2006)

Guangyun Xie Li Liu Jian Wang Wen-jin Zhao

OBJECTIVE In order to assessment the Huperzine A (HupA) on CNS of mice exposed by phoxim and isocarbophos. METHODS One group was given tween-80 or peanut oil as control. One group was given phoxim or isocarbophos alone as phoxim or isocarbophos group. The other group was given HupA 2h before phoxim or isocarbophos exposure as HupA protective group. Twenty-four hours after exposure, the whole body perfusion in situ technique was performed for tissue fixation. The whole brain was removed and adjacent coronal sections was obtained. The sections of brain were stained with hematoxylin and eosin (HE) and toluidine blue. Under optic microscope images were collected and analysed. RESULTS The extensive lesions including cortex oedema, pyramidal cell oedema, and nissal body numbers reduced were observed in phoxim or isocarbophos group. The animals of HupA protective group were observed cortex oedema, pyramidal cell oedema, but the lesional degree was lighter obviously than phoxim or isocarbophos group. CONCLUSION It was suggested that the HupA could have the protective effect of neuropathologic changes exposed by phoxim and isocarbophos.

Phoxim

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Berberine suppresses intestinal disaccharidases with beneficial metabolic effects in diabetic states, evidences from in vivo and in vitro study

Naunyn-Schmiedeberg s Archives of Pharmacology (2010)

Li Liu Yunli Yu Jiansong Yang Li Yang Yao‐Wu Liu

Disaccharidase

Acarbose

Sucrase

Maltase

Alpha-glucosidase

10.1007/s00210-010-0502-0

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Citations (62)

Correction to Versicoamides F–H, Prenylated Indole Alkaloids from Aspergillus tennesseensis

Organic Letters (2017)

Li Liu Long Wang Bao Li Jinwei Ren Buddha Bahadur Basnet

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to Versicoamides F–H, Prenylated Indole Alkaloids from Aspergillus tennesseensisLi Liu, Long Wang, Li Bao, Jinwei Ren, Buddha Bahadur Basnet, Ruixing Liu, Luwei He, Junjie Han, Wen-Bing Yin, and Hongwei Liu*Cite this: Org. Lett. 2017, 19, 6, 1494–1495Publication Date (Web):March 3, 2017Publication History Received27 February 2017Published online3 March 2017Published inissue 17 March 2017https://pubs.acs.org/doi/10.1021/acs.orglett.7b00593https://doi.org/10.1021/acs.orglett.7b00593correctionACS PublicationsCopyright © 2017 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1130Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (493 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts

10.1021/acs.orglett.7b00593

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Citations (2)

Hyperpigmentation in palms associated with lung adenocarcinoma resolving after chemotherapy

The Clinical Respiratory Journal (2014)

Fengying Wu Chunxia Su Li Liu Jianfang Xu

Hyperpigmentation is a kind of paraneoplastic syndrome associated with lung cancer. Diffuse hyperpigmentation was reported and generally resulted from overproduction of melanocyte-stimulating hormone or adrenocorticotropic hormone. However, localized hyperpigmentation is rare for lung cancer.Here, we report a 56-year-old lung adenocarcinoma patient who developed hyperpigmentation in two palms about 3 months preceding the diagnosis and resolved gradually with the shrink of the primary tumours in lung after chemotherapy.Localized hyperpigmentation suggests that another mechanism might be involved.The case reminds us that any skin disorders without obvious causes in heavy smokers should be alerted as a sign of lung cancer and sometimes could be used as a marker of response to the treatment.

Skin hyperpigmentation

Pigmentation disorder

10.1111/crj.12226

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Citations (1)

Sohlh1 and Lhx8 are prominent biomarkers to estimate the primordial follicle pool in mice

Research Square (Research Square) (2022)

Li Liu Biting Liu Lian Wang Caixia Li Yang Zhou

Abstract Efficient evaluation of the primordial follicle pool (PFP) of mammalian models is an essential subject in biomedical research relating to ovarian physiology and pathogenesis. Our recent study has identified a gene signature including Sohlh1 , Nobox , Lhx8 , Tbpl2 , Stk31 , Padi6 , and Vrtn strongly correlated with ovarian reserve by using bioinformatics analysis. Aimed to investigate the validity of these candidate biomarkers for evaluating the PFP, we utilized an OR comparison model to decode the relationship between the numbers of PFP and candidate biomarkers in the present study. Our results suggest that these biomarkers Sohlh1, Nobox, Lhx8, Tbpl2, Stk31, Padi6 , and Vrtn possess independent potential to evaluate the number of the PFP. And the combination of Sohlh1 and Lhx8 can be used as the optimal biomarkers for rapid assessment of the PFP in the murine ovary. Our findings provide a new perspective for evaluating the PFP of the ovary in animal studies and the clinic.

10.21203/rs.3.rs-2047326/v1

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Embryotoxicity and genotoxicity evaluation of sediments from Yangtze River estuary using zebrafish (Danio rerio) embryos

Environmental Science and Pollution Research (2015)

Qian Li Ling Chen Li Liu Lingling Wu

Danio

Yangtze river

10.1007/s11356-015-5737-3

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Citations (15)

Characterization of novel M‐superfamily conotoxins with new disulfide linkage

FEBS Journal (2006)

Yu‐Hong Han Qi Wang Hui Jiang Li Liu Cai Xiao

The M‐superfamily with the typical Cys framework (–CC–C–C–CC–) is one of the seven major superfamilies of conotoxins found in the venom of cone snails. Based on the number of residues in the last Cys loop (between C4 and C5), M‐superfamily conotoxins can be provisionally categorized into four branches (M‐1, M‐2, M‐3, M‐4) [Corpuz GP, Jacobsen RB, Jimenez EC, Watkins M, Walker C, Colledge C, Garrett JE, McDougal O, Li W, Gray WR, et al. (2005) Biochemistry 44 , 8176–8186]. Here we report the purification of seven M‐superfamily conotoxins from Conus marmoreus (five are novel and two are known as mr3a and mr3b) and one known M‐1 toxin tx3a from Conus textile . In addition, six novel cDNA sequences of M‐superfamily conotoxins have been identified from C. marmoreus , Conus leopardus and Conus quercinus . Most of the above novel conotoxins belong to M‐1 and M‐2 and only one to M‐3. The disulfide analyses of two M ‐1 conotoxins, mr3e and tx3a, revealed that they possess a new disulfide bond arrangement (C1–C5, C2–C4, C3–C6) which is different from those of the M‐4 branch (C1–C4, C2–C5, C3–C6) and M‐2 branch (C1–C6, C2–C4, C3–C5). This newly characterized disulfide connectivity was confirmed by comparing the HPLC profiles of native mr3e and its two regioselectively folded isoforms. This is the first report of three different patterns of disulfide connectivity in conotoxins with the same cysteine framework.

Conotoxin

Linkage (software)

Disulfide Linkage

Characterization

10.1111/j.1742-4658.2006.05493.x

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Citations (50)