Quan Wang

Nanjing University of Aeronautics and Astronautics

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Yingjiang Ye

Peking University People's Hospital

Kewei Jiang

Peking University People's Hospital

Kehu Yang

Lanzhou University

Jinhui Tian

Lanzhou University

Shan Wang

Hong Kong Polytechnic University

Xiran He

Guangdong Shunde Innovative Design Institute

Zhanlong Shen

Peking University People's Hospital

Xuezhang Duan

Chinese PLA General Hospital

Kelu Yang

KU Leuven

Bo Feng

Ruijin Hospital

Cooperative Institutions

Chinese Academy of Sciences

310

Chinese Academy of Medical Sciences & Peking Union Medical College

250

Shanghai Jiao Tong University

248

Sun Yat-sen University

247

Peking University

245

Capital Medical University

219

Sichuan University

209

Jilin University

197

Huazhong University of Science and Technology

189

Central South University

154

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Exploring the allosteric mechanism of protein tyrosine phosphatase 1B by molecular dynamics simulations

Journal of Biomolecular Structure and Dynamics (2019)

Quan Wang Xueqi Fu Qing‐Chuan Zheng

Quan Wanga, Xue-Qi Fua* & Qing-Chuan Zhengb*a Edmond H Fischer Signal Transduct Lab, College of Life Science, Jilin University, Changchun, People's Republic Of China; b Laboratory of Theoretical and Computational Chemistry, Institute of Theoretical Chemistry, International Joint Research Laboratory of Nano-Micro Architecture Chemistry, Jilin University, Changchun, People's Republic Of China

10.1080/07391102.2019.1682049

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Citations (7)

septic mice: potential role of interleukin-10 Heat shock response reduces intestinal permeability in

Quan Wang Per-Olof Hasselgren

Intestinal Permeability

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Lysophosphatidic Acid is a Biomarker for Peritoneal Carcinomatosis of Gastric Cancer and Correlates with Poor Prognosis

Genetic Testing and Molecular Biomarkers (2017)

Ruolan Zeng Bin Li Junhui Huang Meizuo Zhong Li Li

Background: Peritoneal carcinomatosis (PC) is an important cause of morbidity and mortality among patients with gastric cancer. Thus, it is important to identify an ideal biomarker for PC. Methods: Plasma and ascites samples were collected from gastric cancer patients with PC and a control group. Lysophosphatidic acid (LPA) levels were tested and analyzed. Results: The plasma LPA levels of gastric cancer patients with PC were significantly higher than those in gastric cancer patients after radical resection (p = 0.046) and healthy volunteers (p < 0.001). Besides, plasma LPA levels were statistically lower after chemotherapy in gastric cancer patients with PC (p = 0.028). Furthermore, the ascites LPA levels were significantly higher in gastric cancer patients with peritoneal carcinomatosis than those in liver cirrhosis patients (p < 0.001). Moreover, ascites LPA levels were statistically lower after intraperitoneal chemotherapy injection than before (p < 0.001). In addition, the plasma LPA levels were significantly associated with serum CA125 levels (p = 0.032) and TNM stage in gastric cancer patients (p = 0.009). Individuals with plasma LPA levels >20,000 ng/mL had significantly worse overall survival (OS) than those with plasma LPA levels <20,000 ng/mL group (p = 0.006). In addition the group with ascites LPA levels >24,000 ng/mL showed significantly worse progression-free survival (PFS) and OS (p < 0.001 in PFS and OS). Conclusions: This study demonstrated that LPA levels in plasma and ascites may be useful diagnostic biomarkers for PC of gastric cancer and that higher levels are associated with poor prognosis.

10.1089/gtmb.2017.0060

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hsa_circ_0000231 Promotes colorectal cancer cell growth through upregulation of CCND2 by IGF2BP3/miR-375 dual pathway

Cancer Cell International (2022)

Wei Zhang Bo Wang Yilin Lin Yang Yang Zhen Zhang

Abstract Background Circular RNAs (circRNAs) have emerged as vital regulators of the initiation and progression of diverse kinds of human cancers. In this study, we explored the role of hsa_circ_0000231 and its downstream pathway in CRC. Methods The expression profile of circRNAs in 5 pairs of CRC tissues and adjacent normal tissues were analyzed by Microarray. Quantitative real-time PCR and in situ hybridization and Base Scope Assay were used to determine the level and prognostic values of hsa_circ_0000231 . Then, functional experiments in vitro and in vivo were performed to investigate the effects of hsa_circ_0000231 on cell proliferation. Mechanistically, fluorescent in situ hybridization, dual luciferase reporter assay, RNA pull-down and RNA immunoprecipitation experiments were performed to confirm the interaction between hsa_circ_0000231 and IGF2BP3 or has_ miR-375 . Results We acquired data through circRNA microarray profiles, showing that the expression of hsa_circ_0000231 was upregulated in CRC primary tissues compared to adjacent normal tissues, which was indicated poor prognosis of patients with CRC. Functional analysis indicated that inhibition of hsa_circ_0000231 in CRC cell lines could suppress CRC cell proliferation as well as tumorigenesis in vitro and in vivo. The mechanistic analysis showed that hsa_circ_0000231 might, on the one hand, act as a competing endogenous RNA of miR-375 to promote cyclin D2 ( CCND2 ) and, on the other hand, bind to the IGF2BP3 protein to prevent CCND2 degradation. Conclusions The findings suggested that hsa_circ_0000231 facilitated CRC progression by sponging miR-375 or binding to IGF2BP3 to modulate CCND2 , implying that hsa_circ_0000231 might be a potential new diagnostic and therapeutic biomarker of CRC.

Competing Endogenous RNA

Tissue microarray

10.1186/s12935-022-02455-8

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Proximal versus distal adductor canal blocks for knee surgery: A protocol for a systematic review and meta-analysis of randomised controlled trials

Quan Wang Yijun Zhang Jingyu Du Xiangjin Lin Quan Wang

Review question: Currently, there remains a paucity of literature about the efficiency of proximal adductor canal block (PACB) versus distal adductor canal block (DACB) for pain management after knee surgery.The purpose of this study is to perform a relatively credible and overall assessment to compare the efficiency of PACB versus DACB for early postoperative pain treatment after knee surgery.Methods: The following electronic databases will be searched: PubMed, Scopus, EMBASE, and Cochrane Library databases.There will be English language restriction.We developed a search strategy using a combination of keywords and medical subject headings (MeSH)/EMTREE terms, and the following expressions will be used: (knee arthroplasty or arthroscopic knee surgery) and (adductor canal block or saphenous nerve block or peripheral nerve block) and (proximal or distal or femoral triangle or adductor canal) and (blind or random).The reference lists of the included studies will also be checked for additional studies that are not identified in the database search.The flow diagram of the study selection is shown in Figure 1.This study will be reported in line with Assessing the Methodological Quality of Systematic Reviews guidelines.Ethical approval is not necessary because the present meta-analysis will be performed based on previously published studies.

Adductor canal

10.37766/inplasy2020.3.0004

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Applications of Lgr5-Positive Cochlear Progenitors (LCPs) to the Study of Hair Cell Differentiation

Frontiers in Cell and Developmental Biology (2019)

Danielle R. Lenz Niliksha Gunewardene Dunia Abdul‐Aziz Quan Wang Tyler M. Gibson

The mouse cochlea contains approximately 15,000 hair cells. Its dimensions and location, and the small number of hair cells, make mechanistic, developmental and cellular replacement studies difficult. We recently published a protocol to expand and differentiate murine neonatal cochlear progenitor cells into 3D organoids that recapitulate developmental pathways and can generate large numbers of hair cells with intact stereociliary bundles, molecular markers of the native cells and mechanotransduction channel activity, as indicated by FM1-43 uptake. Here, we elaborate on the method and application of these Lgr5-positive cochlear progenitors, termed LCPs, to the study of inner ear development and differentiation. We demonstrate the use of these cells for testing several drug candidates, gene silencing and overexpression, as well as genomic modification using CRISPR/Cas9. We thus establish LCPs as a valuable in vitro tool for the analysis of progenitor cell manipulation and hair cell differentiation.

Mechanotransduction

10.3389/fcell.2019.00014

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Citations (33)

Clinical features of multiple gastrointestinal stromal tumors: A pooling analysis combined with evidence and gap map

World Journal of Gastroenterology (2020)

Chen Li Kelu Yang Quan Wang Jinhui Tian Li Yang

Background Multiple gastrointestinal stromal tumors (MGISTs) are a very rare type of gastrointestinal stromal tumor (GIST) and are usually observed in syndrome. Aim The paper aimed to describe the clinical and oncological features of MGISTs and to offer evidence for the diagnosis and treatment. Methods Data of consecutive patients with MGISTs who were diagnosed at Peking University People's Hospital (PKUPH) from 2008 to 2019 were retrospectively evaluated. Further, a literature search was conducted by retrieving data from PubMed, EMBASE, and the Cochrane library databases from inception up to November 30, 2019. Results In all, 12 patients were diagnosed with MGISTs at PKUPH, and 43 published records were ultimately included following the literature review. Combined analysis of the whole individual patient data showed that female (59.30%), young (14.45%), and syndromic GIST (63.95%) patients comprised a large proportion of the total patient population. Tumors were mainly located in the small intestine (58.92%), and both CD117 and CD34 were generally positive. After a mean 78.32-mo follow-up, the estimated median overall survival duration (11.5 years) was similar to single GISTs, but recurrence-free survival was relatively poorer. Conclusion The clinical and oncological features are potentially different between MGISTs and single GIST. Further studies are needed to explore appropriate surgical approach and adjuvant therapy.

Pooling

10.3748/wjg.v26.i47.7550

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Construction of ceRNA regulatory networks for active pulmonary tuberculosis

Scientific Reports (2024)

Qifeng Li Xin Tao Zhigang Liu Quan Wang Lanhong Ma

Delayed diagnosis in patients with pulmonary tuberculosis (PTB) often leads to serious public health problems. High throughput sequencing was used to determine the expression levels of lncRNAs, mRNAs, and miRNAs in the lesions and adjacent health lung tissues of patients with PTB. Their differential expression profiles between the two groups were compared, and 146 DElncRs, 447 DEmRs, and 29 DEmiRs were obtained between lesions and adjacent health tissues in patients with PTB. Enrichment analysis for mRNAs showed that they were mainly involved in Th1, Th2, and Th17 cell differentiation. The lncRNAs, mRNAs with target relationship with miRNAs were predicted respectively, and correlation analysis was performed. The ceRNA regulatory network was obtained by comparing with the differentially expressed transcripts (DElncRs, DEmRs, DEmiRs), then 2 lncRNAs mediated ceRNA networks were established. The expression of genes within the network was verified by quantitative real-time PCR (qRT-PCR). Flow cytometric analysis revealed that the proportion of Th1 cells and Th17 cells was lower in PTB than in controls, while the proportion of Th2 cells increased. Our results provide rich transcriptome data for a deeper investigation of PTB. The ceRNA regulatory network we obtained may be instructive for the diagnosis and treatment of PTB.

Competing Endogenous RNA

Gene regulatory network

10.1038/s41598-024-61451-2

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ECRG4 Represses Cell Proliferation and Invasiveness via NFIC/OGN/NF-κB Signaling Pathway in Bladder Cancer

Frontiers in Genetics (2020)

Xin Liang Jian-gang Gao Quan Wang Sichuan Hou Changli Wu

Bladder cancer (BCa) is a malignant tumour in the urinary system with high cancer-related mortality globally. However, the molecular mechanisms of numerous genes dysregulated in BCa are still unclear. Herein, we showed that Esophageal cancer-related gene-4 (ECRG4), which is downregulated in the BCa tissues and cell lines, has a positive association with Osteoglycin (OGN). Further functional experimental studies suggested that both the ECRG4 and the OGN inhibited cell proliferation, migration, and invasion in the BCa cells. Moreover, the ECRG4 acted as a tumour repressor and promoted the expression of the OGN via the upregulation of nuclear factor 1 C-type (NFIC), which could bind to the OGN promoter region and regulate its transcription. Bioinformatics analysis showed that the NFIC was downregulated in the BCa tissues and had a positive correlation with the ECRG4 or OGN. The ECRG4 could positively regulate the protein level of NFIC in the BCa cells. Also, we first demonstrated that ECRG4 inhibited the NF-κB signalling pathway via the upregulation of the OGN in the BCa cells. Overall, these findings provide the evidence that the ECRG4 and OGN both functioned as tumour repressors, and overexpression of the ECRG4 inhibited the NF-κB signalling pathway via promoting the NFIC/OGN signalling in the BCa cells. Our results revealed the molecular regulatory mechanisms of the ECRG4-mediated repression of the NFIC/OGN/NF-κB signalling pathway in BCa and provided potential biomarkers or therapeutic targets for BCa.

10.3389/fgene.2020.00846

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miR-130a targets CiGadd45bb to modulate the inflammatory response to bacterial infection in Ctenopharyngodon idella kidney (CIK) cells

Fish & Shellfish Immunology (2023)

Yuan Fang Shengzhen Jin Xiaoyan Xu Yubang Shen Quan Wang

Grass carp

Proinflammatory cytokine

10.1016/j.fsi.2023.108633

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