Shanshan Liu

Wuhan University

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Bio-organic fertilizers stimulate indigenous soil Pseudomonas populations to enhance plant disease suppression

Microbiome (2020)

Chengyuan Tao Rong Li Wu Xiong Zongzhuan Shen Shanshan Liu

Abstract Background Plant diseases caused by fungal pathogen result in a substantial economic impact on the global food and fruit industry. Application of organic fertilizers supplemented with biocontrol microorganisms ( i.e. bioorganic fertilizers) has been shown to improve resistance against plant pathogens at least in part due to impacts on the structure and function of the resident soil microbiome. However, it remains unclear whether such improvements are driven by the specific action of microbial inoculants, microbial populations naturally resident to the organic fertilizer or the physical-chemical properties of the compost substrate. The aim of this study was to seek the ecological mechanisms involved in the disease suppressive activity of bio-organic fertilizers. Results To disentangle the mechanism of bio-organic fertilizer action, we conducted an experiment tracking Fusarium wilt disease of banana and changes in soil microbial communities over three growth seasons in response to the following four treatments: bio-organic fertilizer (containing Bacillus amyloliquefaciens W19), organic fertilizer, sterilized organic fertilizer and sterilized organic fertilizer supplemented with B . amyloliquefaciens W19. We found that sterilized bioorganic fertilizer to which Bacillus was re-inoculated provided a similar degree of disease suppression as the non-sterilized bioorganic fertilizer across cropping seasons. We further observed that disease suppression in these treatments is linked to impacts on the resident soil microbial communities, specifically by leading to increases in specific Pseudomonas spp.. Observed correlations between Bacillus amendment and indigenous Pseudomonas spp. that might underlie pathogen suppression were further studied in laboratory and pot experiments. These studies revealed that specific bacterial taxa synergistically increase biofilm formation and likely acted as a plant-beneficial consortium against the pathogen. Conclusion Together we demonstrate that the action of bioorganic fertilizer is a product of the biocontrol inoculum within the organic amendment and its impact on the resident soil microbiome. This knowledge should help in the design of more efficient biofertilizers designed to promote soil function.

Bacillus amyloliquefaciens

Organic fertilizer

Beneficial organism

Biofertilizer

Plant disease

Chlamydospore

10.1186/s40168-020-00892-z

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Citations (265)

Development of a lateral flow immunoassay for rapid quantitation of carbendazim in agricultural products

Microchemical Journal (2022)

Huimin Deng Cai Xian-Jie Yuan Ji Yan Ding Fei Yang

Hapten

Residue (chemistry)

10.1016/j.microc.2022.107495

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Citations (15)

Abietane Diterpenoids from Clerodendrum bungei

Journal of Natural Products (2008)

Shanshan Liu Huilin Zhu Shuwei Zhang Xiao Hui Zhang Qiang Yu

Five new naturally occurring abietane diterpenoids (1-5) along with three known diterpenoids (6-8) were isolated from an acetone-soluble extract of the roots of Clerodendrum bungei. The structures of the new compounds were elucidated on the basis of spectroscopic analysis and chemical methods. In addition, all compounds were evaluated for cytotoxic activity against the cultured B16 (murine melanoma), HGC-27 (human gastric), and HEK-293 (human epithelial kidney) cell lines. Uncinatone (7) exhibited moderate cytotoxicity, inhibited cell proliferation, and induced cell-cycle G(2)/M phase arrest.

Abietane

Verbenaceae

Folk medicine

10.1021/np0703489

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Citations (38)

ChemInform Abstract: A Study on the Substituent Effects of Norbornadiene Derivatives in Iridium‐Catalyzed Asymmetric [2 + 2] Cycloaddition Reactions.

ChemInform (2013)

Jun Hu Qingjing Yang Yu Lu Jianbin Xu Shanshan Liu

Abstract Employing a series of norbornadiene derivatives as substrates, the effects of various substituents on the Ir‐catalyzed [2 + 2] cycloaddition reactions with arylacetylenes are studied.

10.1002/chin.201331027

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Citations (0)

Chemical Constituents from Clerodendrum bungei and Their Cytotoxic Activities

Helvetica Chimica Acta (2009)

Shanshan Liu Tong Zhou Shuwei Zhang Li‐Jiang Xuan

Abstract magnified image A new phenylethanoid glycoside, two new cyclohexylethanoids, one new phenolic glycoside, and a new farnesane‐type sesquiterpenoid, namely 2‐phenylethyl 3‐ O ‐(6‐deoxy‐ α ‐ L ‐mannopyranosyl)‐ β ‐ D ‐glucopyranoside ( 1 ), 6″‐ O ‐[( E )‐caffeoyl] rengyoside B ( 2 ), clerodenone A ( 3 ), 2‐({6‐ O ‐[(4‐hydroxy‐3‐methoxyphenyl)carbonyl]‐ β ‐ D ‐glucopyranosyl}oxy)‐2‐methylbutanoic acid ( 4 ), 2‐{(2 S ,5 R )‐5‐[(1 E )‐4‐hydroxy‐4‐methylhexa‐1,5‐dien‐1‐yl]‐5‐methyltetrahydrofuran‐2‐yl}propan‐2‐yl β ‐ D ‐glucopyranoside ( 5 ), together with 16 known compounds, were isolated from the roots of Clerodendrum bungei. All structures were elucidated by spectroscopic methods. The new compounds showed modest in vitro inhibition of the proliferation of the HeLa human cervical carcinoma cell line (CCL‐2), with IC 50 values in the range of 3.5–8.7 μ M , adriamycin being used as positive control, with an IC 50 value of 0.026±0.001 μ M .

HeLa

Phenylethanoid

10.1002/hlca.200800392

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Citations (32)

MnBr2 catalyzed regiospecific oxidative Mizoroki-Heck type reaction

Chinese Chemical Letters (2021)

Xiang Chen Zhihong Zhu Shanshan Liu Yi‐Hung Chen Xiao Shen

Heck Reaction

10.1016/j.cclet.2021.10.083

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Citations (23)

Acute myeloid leukemia with T lymphoblastic lymphoma: a case report and literature review

Journal of International Medical Research (2021)

Yan Gao Xianqi Feng Shanshan Liu Yu-Jie Xu Chunxia Mao

Acute myeloid leukemia (AML) with T lymphoblastic lymphoma (T-LBL) is a hematologic tumor of two origins, myeloid and lymphoblastic, and is relatively rare in the same patient. We report a rare case of AML with T-LBL. After the patient was diagnosed, he received standard chemotherapy, which decreased the primitive bone marrow cell percentage from 84% to 5%; however, the enlarged superficial lymph nodes showed no obvious change in size. Immunohistochemistry revealed the following: cluster of differentiation (CD)3 (+), CD5 (+), CD7 (+), transmission disequilibrium test (TDT) (+), myeloperoxidase (MPO) (−), and lysozyme (Lys) (−). The lymph node morphology and immunohistochemical results indicated T-LBL. Therefore, the final diagnosis was AML with T-LBL, with both diseases occurring independently and concurrently.

Lymphoblastic lymphoma

Myeloid sarcoma

CD5

Immunophenotyping

10.1177/03000605211016138

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Citations (1)

Diversity-oriented functionalization of 2-pyridones and uracils

Nature Communications (2021)

Yongjia Shang Chenggui Wu Qianwen Gao Chang Liu Lisha Li

Abstract Heterocycles 2-pyridone and uracil are privileged pharmacophores. Diversity-oriented synthesis of their derivatives is in urgent need in medicinal chemistry. Herein, we report a palladium/norbornene cooperative catalysis enabled dual-functionalization of iodinated 2-pyridones and uracils. The success of this research depends on the use of two unique norbornene derivatives as the mediator. Readily available alkyl halides/tosylates and aryl bromides are utilized as ortho -alkylating and -arylating reagents, respectively. Widely accessible ipso -terminating reagents, including H/DCO 2 Na, boronic acid/ester, terminal alkene and alkyne are compatible with this protocol. Thus, a large number of valuable 2-pyridone derivatives, including deuterium/CD 3 -labeled 2-pyridones, bicyclic 2-pyridones, 2-pyridone-fenofibrate conjugate, axially chiral 2-pyridone (97% ee ), as well as uracil and thymine derivatives, can be quickly prepared in a predictable manner (79 examples reported), which will be very useful in new drug discovery.

Norbornene

Uracil

Bioorthogonal Chemistry

Surface Modification

10.1038/s41467-021-23058-3

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Citations (30)

Supramolecular vesicle engineering by regulating the assembly of shape-persistent aromatic-hydrazone macrocycles

Organic Chemistry Frontiers (2022)

He Deng Guanfei Gong Siheng Lv Yi Chen Qi Zhao

The size of supramolecular vesicles is manipulated by regulating the assembly of macrocycles with different mono- or bi-pyridinium salts.

Hydrazone

Supramolecular assembly

10.1039/d2qo01691e

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Citations (1)

ChemInform Abstract: Enantioselective α‐Tosyloxylation of Ketones Catalyzed by Spirobiindane Scaffold Based Chiral Iodoarenes.

ChemInform (2012)

Jun Yu Jian Cui Xuesen Hou Shanshan Liu Wen‐Chao Gao

Abstract A series of enantiomerically pure spirobiindane is prepared and investigated as catalysts in the tosyloxylation reaction of ketone (I) using MCPBA as a stoichiometric oxidant.

Stoichiometry

10.1002/chin.201225080

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Citations (0)