Ting Li

Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University

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Co-Authors

Shengwei Jin

Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University

Marc De Backer

UCB Pharma (Belgium)

Melissa Brock

UCB Pharma (United States)

Kiyohito Terada

National Epilepsy Center

Zhijian Sun

Tsinghua University

Chenchen Jiang

Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University

Binyu Ying

Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University

Linxin Xu

Tianjin Medical University

Manuel Toledo

Vall d'Hebron Hospital Universitari

Chengshui Chen

Wenzhou Medical University

Cooperative Institutions

Wenzhou Medical University

119

Peking University

Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University

Capital Medical University

Chinese Academy of Medical Sciences & Peking Union Medical College

Chinese Academy of Sciences

Sichuan University

Shanghai Jiao Tong University

Sun Yat-sen University

Fudan University

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Efficacy and safety of thrombopoietin receptor agonists in children and adults with persistent and chronic immune thrombocytopenia: a meta-analysis

Expert Opinion on Pharmacotherapy (2023)

Ting Li Qinqin Liu Ting Pu Jing Liu Aijun Zhang

In this paper, we systematically review the efficacy and safety of thrombopoietin receptor agonists (TPORAs) for treatment of persistent and chronic immune thrombocytopenia (ITP) in children and adults.We searched PubMed, MEDLINE, ScienceDirect, Scopus, EMbase and the Cochrane Library to collect randomized controlled trials (RCTs) of TPO-RAs which including avatrombopag hetrombopag eltrombopag and romiplostim treated persistent and chronic ITP from their earliest records to February 2022.We included 15 RCTs with a total of 1563 patients. There were ten trials of adults and five trials of children. The results of meta-analysis showed that in adult patients, patients treated with TPO-RAs had longer duration of platelet response, higher platelet response rate, lower use of rescue therapy, and lower incidence of bleeding events, and similar incidence of adverse events compared with placebo. Except for the incidence of any bleeding, the results in children were consistent with those in adults. The network meta-analysis of data on overall platelet response rates in adults showed that avatrombopag was more effective than eltrombopag and hetrombopag.TPO-RAs has better efficacy and higher safety in the treatment of ITP. And the overall response rate of avatrombopag in adults was higher than that in eltrombopag and hetrombopag.

Eltrombopag

Romiplostim

Thrombopoietin receptor

10.1080/14656566.2023.2198089

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Citations (7)

Setosphapyrone C and D accelerate macrophages cholesterol efflux by promoting LXRα/ABCA1 pathway

Archives of Pharmacal Research (2020)

Ting Li Jiayu Yin JI Yu-bin Ping Lin Yanjie Li

ABCG1

Liver X receptor

Scavenger Receptor

Efflux

Reverse cholesterol transport

10.1007/s12272-020-01255-w

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Citations (7)

Efficacy of traditional chinese medicine in a patient with forearm compartment syndrome after coronary angiography.

PubMed (2014)

Yuanshen Zhou Yi Su Ting Li Minzhou Zhang

Coronary angiography via the radial artery has been widely used in clinical practice. The radial access has the major advantages of fewer traumas, quicker recovery, better hemostasis and lower incidence of complications of puncturefor unnecessarily postoperative oppression. Although literature of forearm compartment syndrome (FCS) after angiography is scarce, however, the FCS could have disastrous clinical consequences and hence drew more attention. The use of bandages together with traditional Chinese medicine is an effective therapy in treating limb sprain in china society. However, it has not been reported in FCS after angiography. Here, we present a case of FCS after routine coronary angiography in a patient with acute heart failure, which was treated by external therapy of traditional Chinese medicine (TCM) using compression bandaging and the Xiao Zhong Zhi Tong plaster. FCS was caused by failure to puncture the artery and vessel injury caused by a catheter. The clinical diagnosis was based on the "5P syndrome", which standed for pain, paralysis, paresthesia, pallor and pulselessness. We showed that external therapy of TCM could help save time for subsequent surgical treatment and facilitate full recovery.

Pallor

Source

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Prompting drainage tube placement following fracture internal fixation or not: A prospective cohort study

Zhonghua chuangshang guke zazhi (2018)

Xu Sun Ting Li Zhijian Sun Zhiqiang Gao Yong‐gang Su

Objective To investigate the effects of drainage tube placement after fracture internal fixation. Methods A prospective cohort study was conducted of the 235 patients who were to undergo open reduction and internal fixation for tibia fracture, distal radial fracture or ankle joint fracture at Department of Orthopaedic Trauma, Beijing Jishuitan Hospital from March to August, 2016. Of them, 123 were assigned into an experimental group who were subjected to adequate hemostasis after releasing the tourniquet without drainage following surgery while 112 into a control group who were subjected to conventional hemostasis without relaxing the tourniquet and placement of drainage tubes. The 2 groups were compared in terms of post-operative hospital stay, wound condition, body temperature 3 days postoperatively, counts of hemoglobins, white blood cells and neutrophils, and postoperative visual analogue scale (VAS). Results High fever was not observed in all the patients postoperatively. There were no significant differences between the 2 groups in post-operative hospital stay[(3.3±1.6) d versus (3.7±1.7) d], wound reddening, wound swelling, hemoglobins, white blood cells, neutrophils, or VAS scores postoperatively (P>0.05). Conclusion Drainage tube placement is not routinely necessary after internal fixation of simple fractures if surgical invasion is limited and hemostasis is adequate after intraoperative release of the tourniquet. Key words: Fractures, bone; Fracture fixation, internal; Postoperative period; Drainage

10.3760/cma.j.issn.1671-7600.2018.06.001

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Citations (1)

Study on Lipid Metabolism and Related Risk Factors in Endometrial Polyps

Clinical Laboratory (2023)

Jian Ren Qi Zhou Ziwen Jiang Ting Li Hao Yan

The object of the study was to explore the risk factors for endometrial polyps (EP) by analyzing the clinical characteristics and laboratory findings.From January 2019 to June 2020, clinical data from 183 patients treated with gynecological hysteroscopic surgery were collected. Among them were 118 EP cases which were included into the study group. They were divided into four groups by age: Group 1: < 30 years old (9, 7.6%), Group 2: ≥ 30 < 40 years old (62, 52.5%), Group 3: ≥ 40 < 50 years of age (39, 33.1%), Group 4: ≥ 50 years of age (8, 6.8%). The remaining 65 patients with uterine adhesion were used as controls.Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), hemoglobin (HGB), and uterine volume between the two groups were statistically significant. TC, LDL-C, and uterine volume were identified as independent risk factors for EP, with TC being the most significant. In patients < 40 years of age, HGB, LDL-C, and uterine volume were significantly different, with LDL-C and uterine volume acting as independent risk factors and uterine volume being more significant. There were differences in the overall distribution of blood flow signal ratio in the EP age groups. Menarche occurred significantly earlier in Groups 1, 2, and 3 than in groups 4. Uterine volume was significantly smaller in Group 1 than Group 3. LDL-C and uterine volume had better prediction values for EP. When the uterine volume was 61.65 cm3, the sensitivity was 58.6%, and the specificity was 93.5%.In clinical practice, attention should be paid to the cholesterol metabolism in EP patients.

Menarche

Endometrial Polyp

High-density lipoprotein

10.7754/clin.lab.2022.220415

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Bromhexine Hydrochloride Tablets for the Treatment of Moderate COVID‐19: An Open‐Label Randomized Controlled Pilot Study

Clinical and Translational Science (2020)

Ting Li Laifang Sun Wenwu Zhang Chanfan Zheng Chenchen Jiang

This open‐label randomized controlled pilot study aimed to test the study feasibility of bromhexine hydrochloride (BRH) tablets for the treatment of mild or moderate coronavirus disease 2019 (COVID‐19) and to explore its clinical efficacy and safety. Patients with mild or moderate COVID‐19 were randomly divided into the BRH group or the control group at a 2:1 ratio. Routine treatment according to China’s Novel Coronavirus Pneumonia Diagnosis and Treatment Plan was performed in both groups, whereas patients in the BRH group were additionally given oral BRH (32 mg t.i.d.) for 14 consecutive days. The efficacy and safety of BRH were evaluated. A total of 18 patients with moderate COVID‐19 were randomized into the BRH group ( n = 12) or the control group ( n = 6). There were suggestions of BRH advantage over placebo in improved chest computed tomography, need for oxygen therapy, and discharge rate within 20 days. However, none of these findings were statistically significant. BRH tablets may potentially have a beneficial effect in patients with COVID‐19, especially for those with lung or hepatic injury. A further definitive large‐scale clinical trial is feasible and necessary.

Open label

10.1111/cts.12881

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Citations (41)

Perioperative Protocol of Ankle Fracture and Distal Radius Fracture Based on Enhanced Recovery after Surgery Program: A Multicenter Prospective Clinical Controlled study

Pain Research and Management (2022)

Ting Li Zhijian Sun Yan Zhou Weitong Sun Pengcheng Wang

The enhanced recovery after surgery (ERAS) program is aimed to shorten patients' recovery process and improve clinical outcomes. This study aimed to compare the outcomes between the ERAS program and the traditional pathway among patients with ankle fracture and distal radius fracture.This is a multicenter prospective clinical controlled study consisting of 323 consecutive adults with ankle fracture from 12 centers and 323 consecutive adults with distal radial fracture from 13 centers scheduled for open reduction and internal fixation between January 2017 and December 2018. According to the perioperative protocol, patients were divided into two groups: the ERAS group and the traditional group. The primary outcome was the patients' satisfaction of the whole treatment on discharge and at 6 months postoperatively. The secondary outcomes include delapsed time between admission and surgery, length of hospital stay, postoperative complications, functional score, and the MOS item short form health survey-36.Data describing 772 patients with ankle fracture and 658 patients with distal radius fracture were collected, of which 323 patients with ankle fracture and 323 patients with distal radial fracture were included for analysis. The patients in the ERAS group showed higher satisfaction levels on discharge and at 6 months postoperatively than in the traditional group (P < 0.001). In the subgroup analysis, patients with distal radial fracture in the ERAS group were more satisfied with the treatment (P=0.001). Furthermore, patients with ankle fracture had less time in bed (P < 0.001) and shorter hospital stay (P < 0.001) and patients with distal radial fracture received surgery quickly after being admitted into the ward in the ERAS group than in the traditional group (P=0.001).Perioperative protocol based on the ERAS program was associated with high satisfaction levels, less time in bed, and short hospital stay without increased complication rate and decreased functional outcomes.

10.1155/2022/3458056

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Citations (5)

Incidence of 12‐month postoperative cognitive decline following regional vs. general anaesthesia in older patients undergoing hip fracture surgery: follow‐up of the RAGA trial

Anaesthesia (2025)

Ting Li Jun Li Chenchen Jiang Liyong Yuan Jinze Wu

Summary Introduction Data regarding the incidence of 12‐month postoperative cognitive decline following regional or general anaesthesia in older patients undergoing hip fracture surgery remain observational. Compared with general anaesthesia, we hypothesised that regional anaesthesia would decrease the incidence of 12‐month postoperative cognitive decline. Methods This is substudy of a multicentre randomised trial of regional anaesthesia with no sedation vs. general anaesthesia with 12‐month follow‐up, conducted in nine university hospitals in south‐eastern China. Patients aged ≥ 65 y with hip fractures requiring surgery were eligible for inclusion. The prespecified 1‐year primary outcome was the incidence of postoperative cognitive decline at 12 months post‐randomisation. Secondary outcomes included major or mild postoperative cognitive decline; changes in Mini‐Mental State Examination; newly developed dementia; affective status; and health‐related quality of life. Results We recruited 950 patients between October 2014 and September 2018 (n = 474 general and n = 476 regional), with the last participant interviewed in November 2019. A total of 293 patients (139 general vs. 154 regional) were included in the primary analysis of the 12‐month outcome. Median (IQR [range]) age of patients was 78 (71–82 [65–96]) y and 217 (74.1%) were female. The incidence of cognitive decline at 12 months was 29.7% vs. 25.4% of patients allocated to general vs. regional anaesthesia, respectively (unadjusted OR 1.2 (95%CI 0.7–2.1), p = 0.43, Bayes factor = 0.28). Major cognitive decline developed in 8.6% vs. 8.5% of patients allocated to general vs. regional anaesthesia, respectively (unadjusted OR 1.0 (95%CI 0.4–2.4)). Discussion The incidence of 12‐month postoperative cognitive decline was not significantly different in patients having general or regional anaesthesia for hip fracture surgery.

Cognitive Decline

Hip Fracture

Postoperative cognitive dysfunction

10.1111/anae.16545

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Case report of cerebral edema with decerebrate rigidity monitored by fNIRS (Conference Presentation)

Chenyang Gao Ting Li

Cerebral edema, as an acute head injury, has been of great interest over decades in clinical neurosurgery research. Many patients exhibited extensor motor abnormalities in the acute phase because their cerebral lose control of brainstem and spinal cord. These phenomenon, which is called "decerebrate rigidity", showed up spontaneously or when their bodies were stimulated by external forces. Neuro imaging methods provide a new perspective in cerebral edema with decerebrate rigidity. Functional near infrared spectroscopy (fNIRS), as a novel optical detection method, has been widely used in monitoring changes of cerebral cortex blood oxygen concentration. Here, we utilized a self-made fNIRS detecting instrument with 4 channels fixed in forehead to monitor cerebral hemodynamic changes of patients with cerebral edema. The instrument has three waveforms (735nm, 805nm and 850nm) to detect concentration changes of oxygenated hemoglobin (HbO, deoxy hemoglobin (Hb), and blood volume (HbT). During the monitoring period, we captured two typical decerebrate rigidity in a patient (caused by external stimulation). At the beginning of decerebrate rigidity, Hb and HbT increased rapidly along with HbO decreased. The stage of this change lasts about 3s. Then the three hemodynamic parameters keep stable for about 6s. Finally, the three hemodynamic parameters return to the initial stage slowly (about 10s). The change amplitude of decerebrate rigidity caused by external stimulation were significantly higher than spontaneous situation. The results indicate that decerebrate rigidity caused acute hypoxia and congestion in patients' cerebral cortex.

Presentation (obstetrics)

Rigidity (electromagnetism)

Cerebral edema

10.1117/12.2512412

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Correlation between the degree of abdominal obesity and the risk of stones in patients with type 2 diabetes mellitus: a cross-sectional study

Chin J Diabetes Mellitus (2020)

Yuanpeng Nie Xixiang Tang Haicheng Li Mei Li Ting Li

探究2型糖尿病患者腹型肥胖程度与胆囊结石、泌尿系结石患病率的相关性。选取2016年1月至2018年12月在中山大学附属第三医院内分泌与代谢病学科住院的2 477例2型糖尿病（T2DM）患者。每例受试者均接受体格检查、生化检测、腹部B超检查。总人群按照腰臀比的四分位数分为4组，使用方差分析各组间基线资料差异。χ2检验分析各组间胆囊结石及泌尿系结石患病率的差异，Logistic回归分析法分析2型糖尿病患者结石患病的危险因素。结果显示，在胆囊结石组中，随着腰臀比四分位数的增加，患病率由2.4%（15/625）增加至12.5%（77/618）。胆囊结石患病率多因素Logistic回归分析表明，在胆囊结石组，T2DM患者中位于腰臀比第4四分位数的患者相比第1四分位数的患者，其患胆囊结石的风险显著增加（OR=3.78，95%CI 1.16~12.30，P=0.027）。在肾结石组，随着腰臀比四分位数的增加，患病率由2.4%增加至6.8%。在校正除体质指数外其他可能混杂因素后，T2DM患者中位于腰臀比第4四分位数的患者相比第1四分位数的患者，其患肾结石风险显著增加（OR=5.34，95%CI 1.14~25.01，P=0.033）。但进一步校正体质指数后，其结果无统计学意义（P>0.05）。说明，T2DM患者腹型肥胖程度与胆囊结石患病风险增加存在显著相关。

Abdominal obesity

Cross-sectional study

Degree (music)

10.3760/cma.j.cn115791-20191223-00481

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