Wei Wu

Hubei University of Chinese Medicine

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Linfei Xiao

Heilongjiang University

Xuefeng Bai

Heilongjiang University

Wei Wang

University of Giessen

Xiaofang Su

Hainan University

Junxuan Lü

Pennsylvania State University

Peixin Jiang

The University of Texas MD Anderson Cancer Center

Su‐Ni Tang

University of Houston

Cheng Jiang

Chinese University of Hong Kong, Shenzhen

Celia R. Berkers

Utrecht University

Simone Lemeer

Utrecht University

Cooperative Institutions

Chinese Academy of Sciences

385

University of Chinese Academy of Sciences

166

Sun Yat-sen University

148

Zhejiang University

126

Sichuan University

121

Huazhong University of Science and Technology

120

Shanghai Jiao Tong University

116

Chinese Academy of Medical Sciences & Peking Union Medical College

111

Fudan University

110

Peking University

101

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Stereo- and Regioselective Pt(DVDS)/P(ⁱBuNCH₂CH₂)₃N-Catalyzed Hydrosilylation of Terminal Alkynes

Organometallics (2005)

H. Aneetha Wei Wu John G. Verkade

The catalyst system Pt(DVDS)/P(iBuNCH2CH2)3N (DVDS = [(H2CCH)Me2Si]2O), containing a bulky aminophosphine ligand, catalyzes the hydrosilylation of terminal alkynes possessing a variety of functional groups using Ph3SiH or Et3SiH. These reactions occur stereo- and regioselectively to give β-(E)-vinylsilanes with 97−99% selectivity in 76−98% yield. Using Pt2(DVDS)3, this selectivity ranged from 63 to 93%, except in one case, where the selectivities were the same for both catalyst systems.

Hydrosilylation

10.1021/om050034l

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Citations (73)

AA-SAS-IA三元重合体の合成とスケール防止性能評価【JST・京大機械翻訳】

Yingyong Huagong (2016)

Wei Wu Sun Hao Aishan Li Liu Pingping Zhang Xiaoyun

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Citations (0)

Synthesis of microscale and nanoscale ZSM-5 zeolites: effect of particle size and acidity of Zn modified ZSM-5 zeolites on aromatization performance

Catalysis Science & Technology (2017)

Xiaofang Su Zan Wang Xuefeng Bai Gaoliang Wang Wei Wu

Zn/NZ5 zeolite exhibits a higher BTX yield because of the higher mesoporosity and strong Lewis acid sites formed by [ZnOZn]²⁺species.

Aromatization

ZSM-5

Microscale chemistry

Particle (ecology)

10.1039/c7cy00435d

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Citations (137)

A highly regio- and stereoselective transition metal-catalyzed hydrosilylation of terminal alkynes under ambient conditions of air, water, and room temperature

Chemical Communications (2003)

Wei Wu Chao‐Jun Li

A highly efficient and stereoselective hydrosilylation of terminal alkynes was developed at room temperature in air and water.

Hydrosilylation

Open air

10.1039/b302259e

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Citations (62)

Author response: DNA-PK promotes DNA end resection at DNA double strand breaks in G0 cells

Faith C. Fowler Bo-Ruei Chen Nicholas Zolnerowich Wei Wu Raphael Pavani

Double strand

10.7554/elife.74700.sa2

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Table S1 from Role of P53-Senescence Induction in Suppression of LNCaP Prostate Cancer Growth by Cardiotonic Compound Bufalin

Yong Zhang Yinhui Dong Michael W. Melkus Shutao Yin Su‐Ni Tang

<p>Table S1 shows upregulated genes by 10 nM bufalin over vehicle control by over 50% or more in LNCaP cells exposed for 24 h. Expressed as fold over vehicle control set as unity.</p>

Bufalin

Senescence

10.1158/1535-7163.22504776

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Optical and Mechanical Nanostructured Coatings for Future Large-Scale Manufacturing

Springer eBooks (2012)

Shady Gawad Ana Valero Thomas Braschler David R. Holmes Philippe Renaud

10.1007/978-90-481-9751-4_246

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Mechanism of Enhanced Oral Absorption of a Nano-Drug Delivery System Loaded with Trimethyl Chitosan Derivatives

International Journal of Nanomedicine (2022)

Ying Zhao Shiyuan Lin Ruiyue Fang Yaling Shi Wei Wu

In the previous study, nanoparticles coated with trimethyl chitosan (TMC) derivatives (PPTT-NPs) could promote the oral bioavailability of panax notoginseng saponins (PNS). Herein, we chose PPTT-NPs as a model drug to study the property and mechanism of intestinal absorption in vitro and in vivo.The stability of PPTT-NPs was evaluated using simulated gastric fluid and simulated intestinal fluid. The uptake and transport of PPTT-NPs were investigated in Caco-2 and Caco-2&HT29 co-culture cells. The biosafety, intestinal permeability, adhesion, and absorption mechanism of PPTT-NPs were investigated using SD rats in vivo. The live imaging and biodistribution of PPTT-NPs were observed by IVIS. Furthermore, the effects on CYP3A4 of PPTT-NPs were investigated using testosterone as the probe substrate.The results of the stability assay showed that PPTT-NPs had a strong tolerance to the pH and digestive enzymes in the gastrointestinal environment. In vitro cell experiments showed that the uptake of drugs exhibited a time-dependent. When the ratio of TMC-VB12 and TMC-Cys was 1:3, the uptake capacity of PPTT-NPs was the highest. PPTT-NPs could enhance the paracellular transport of drugs by reversibly opening a tight junction. Animal experiments demonstrated that PPTT-NPs have good biological safety. PPTT-NPs had good adhesion and permeability to small intestinal mucosa. Meanwhile, PPTT-NPs needed energy and various protein to participate in the uptake of drugs. The live imaging of NPs illustrated that PPTT-NPs could prolong the residence time in the intestine. Moreover, TMC-VB12 and TMC-Cys could reduce the metabolism of drugs by inhibiting CYP3A4 to a certain extent.The results show that TMC-VB12 and TMC-Cys are effective in the transport of PPTT-NPs. PPTT-NPs can increase the intestinal adhesion of drugs and exert high permeation by intestinal enterocytes which demonstrate significant and efficient potential for oral delivery of the BCS III drugs.

10.2147/ijn.s358832

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Citations (8)

Synthesis of SAPO-41 Molecular Sieves with Different SiO2/Al2O3 Ratios and their Catalytic Performance of n-Decane Hydroisomerization

IOP Conference Series Materials Science and Engineering (2020)

Han Wang Chunmu Guo Jinying Meng Ting Li Le Luo

Using di-n-propylamine (DPA) as a template, SAPO-41 molecular sieves with SiO2/Al2O3 ratios (n) of 0.3, 0.5, and 0.7 were synthesized. Their structure, morphology and acidity were characterized by XRD, N2 physical adsorption, SEM, and Py-IR. All the synthesized samples have characteristic diffraction peaks corresponding to the AFO topological structure, which means that samples are pure phase SAPO-41 molecular sieve. The samples exhibited a highly ordered prismatic morphology with regular arrangement of individual grains, wrapped in flakes, and possessed complete channel structure. With the increase of n, the specific surface area and the amount of B acid showed a downward trend after increasing. Hydroisomerization reaction results of n-decane over SAPO-41 loaded with 0.5wt% Pd (Pd/SAPO-41(n)) showed that the higher the amount of B acid, the higher the conversion of n-decane,and high specific surface area and moderate B acid are favorable for yield of isomerization products. When the conversion of n-decane catalyzed by Pd/S41(0.3)-P was 88.9%, the yield of hydroisomerization products reached 83.3%.

Decane

Morphology

Brønsted–Lowry acid–base theory

10.1088/1757-899x/758/1/012080

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Citations (1)

Selective Hydrogenation on a Highly Active Single-Atom Catalyst of Palladium Dispersed on Ceria Nanorods by Defect Engineering

ACS Applied Materials & Interfaces (2020)

Zhijun Li Xiuli Dong Mingyang Zhang Leipeng Leng Wenxing Chen

Single-atom catalysis represents a new frontier that integrates the merits of homogeneous and heterogeneous catalysis to afford exceptional atom efficiency, activity, and selectivity for a range of catalytic systems. Herein we describe a simple defect engineering strategy to construct an atomically dispersed palladium catalyst (Pdδ+, 0 < δ < 2) by anchoring the palladium atoms on oxygen vacancies created in CeO2 nanorods. This was confirmed by spherical aberration correction electron microscopy and extended X-ray absorption fine structure measurement. The as-prepared catalyst showed exceptional catalytic performance in the hydrogenation of styrene (99% conversion, TOF of 2410 h–1), cinnamaldehyde (99% conversion, 99% selectivity, TOF of 968 h–1), as well as oxidation of triethoxysilane (99% conversion, 79 selectivity, TOF of 10 000 h–1). This single-atom palladium catalyst can be reused at least five times with negligible activity decay. The palladium atoms retained their dispersion on the support at the atomic level after thermal stability testing in Ar at 773 K. Most importantly, this synthetic method can be scaled up while maintaining catalytic performance. We anticipate that this method will expedite access to single-atom catalysts with high activity and excellent resistance to sintering, significantly impacting the performance of this class of catalysts.

Nanorod

10.1021/acsami.0c17009

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Citations (46)