Xiaomin Wang

Yan'an University

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Co-Authors

Wenxiu Zhao

Ningxia University

Zhenyu Yin

Tianjin Medical University General Hospital

Chengrong Xie

Zhongshan Hospital of Xiamen University

Xiaoqin Chi

Zhongshan Hospital of Xiamen University

You Song

Shenyang Pharmaceutical University

Tao Cheng

Institute of Hematology & Blood Diseases Hospital

Zhenyu Yin

Tianjin Medical University General Hospital

Jue Wang

Huazhong University of Science and Technology

Ding Ma

Tongji Hospital

Cong‐Yi Wang

Tongji Hospital

Cooperative Institutions

Xiamen University

Biogipuzkoa Health Research Institute

Istituti di Ricovero e Cura a Carattere Scientifico

Zhongshan Hospital of Xiamen University

Instituto de Salud Carlos III

University of Milan

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Charité - Universitätsmedizin Berlin

Chinese Academy of Medical Sciences & Peking Union Medical College

Huazhong University of Science and Technology

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On rough multi-granularity soft sets and its application in decision making

2022 34th Chinese Control and Decision Conference (CCDC) (2017)

Xiaomin Wang Chenxi Guo Piyu Li Jianbo Liu Jing Liu

In this paper we proposed the concept of optimistic rough multi-granularity soft set and pessimistic rough multi-granularity soft set. Basic properties of rough multi-granularity soft sets are presented. Furthermore, we compared the difference between rough multi-granularity soft sets and rough soft sets showed by some illustrative examples. Finally, an algorithm for decision making problem is proposed. We also give an example to illustrate the validity of this kind of method.

Granularity

Soft set

Granular Computing

10.1109/ccdc.2017.7979031

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Citations (1)

Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation

Nature Communications (2017)

Xueli Bian Hang-zi Chen Pengbo Yang Ying-ping Li Fen-na Zhang

Abstract Gluconeogenesis, an essential metabolic process for hepatocytes, is downregulated in hepatocellular carcinoma (HCC). Here we show that the nuclear receptor Nur77 is a tumour suppressor for HCC that regulates gluconeogenesis. Low Nur77 expression in clinical HCC samples correlates with poor prognosis, and a Nur77 deficiency in mice promotes HCC development. Nur77 interacts with phosphoenolpyruvate carboxykinase (PEPCK1), the rate-limiting enzyme in gluconeogenesis, to increase gluconeogenesis and suppress glycolysis, resulting in ATP depletion and cell growth arrest. However, PEPCK1 becomes labile after sumoylation and is degraded via ubiquitination, which is augmented by the p300 acetylation of ubiquitin-conjugating enzyme 9 (Ubc9). Although Nur77 attenuates sumoylation and stabilizes PEPCK1 via impairing p300 activity and preventing the Ubc9-PEPCK1 interaction, Nur77 is silenced in HCC samples due to Snail-mediated DNA methylation of the Nur77 promoter. Our study reveals a unique mechanism to suppress HCC by switching from glycolysis to gluconeogenesis through Nur77 antagonism of PEPCK1 degradation.

Gluconeogenesis

10.1038/ncomms14420

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Citations (115)

Novel tRNA-like transcripts from the NEAT1-MALAT1 genomic region critically influence human innate immunity and macrophage functions

Research Square (Research Square) (2022)

Martina Gast Vanasa Nageswaran Andreas W. Kuß Ana Tzvetkova Xiaomin Wang

Abstract The evolutionary conserved NEAT1-MALAT1 gene cluster generates large noncoding transcripts remaining nuclear, while tRNA-like transcripts (mascRNA, menRNA) enzymatically generated from these precursors translocate to the cytosol. NEAT1-/- and MALAT1-/- mice display massive atherosclerosis and vascular inflammation. Here, we identify the tRNA-like molecules as critical components of innate immunity. They appear as prototypes of a new class of noncoding RNAs distinct from others (miRNAs, siRNAs) by biosynthetic pathway and intracellular kinetics. CRISPR-generated human ΔmascRNA and ΔmenRNA monocytes/macrophages display defective innate immune sensing, loss of cytokine control, imbalance of growth/angiogenic factor expression impacting upon angiogenesis, and altered cell-cell interaction systems. Antiviral response, foam cell formation/oxLDL uptake, and M1/M2 polarization are defective in ΔmascRNA/ΔmenRNA macrophages, defining the tRNA-like molecules’ first described biological functions. menRNA and mascRNA represent novel components of innate immunity arising from the noncoding genome. Their NEAT1-MALAT1 region of origin appears as archetype of a functionally highly integrated RNA processing system.

MALAT1

10.21203/rs.3.rs-1540419/v2

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Citations (1)

Tunable T₁ and T₂ contrast abilities of manganese-engineered iron oxide nanoparticles through size control

Nanoscale (2014)

Guoming Huang Hui Li Jiahe Chen Zhenghuan Zhao Lijiao Yang

In this paper, we demonstrate the tunable T1 and T2 contrast abilities of engineered iron oxide nanoparticles with high performance for liver contrast-enhanced magnetic resonance imaging (MRI) in mice. To enhance the diagnostic accuracy of MRI, large numbers of contrast agents with T1 or T2 contrast ability have been widely explored. The comprehensive investigation of high-performance MRI contrast agents with controllable T1 and T2 contrast abilities is of high importance in the field of molecular imaging. In this study, we synthesized uniform manganese-doped iron oxide (MnIO) nanoparticles with controllable size from 5 to 12 nm and comprehensively investigated their MRI contrast abilities. We revealed that the MRI contrast effects of MnIO nanoparticles are highly size-dependent. By controlling the size of MnIO nanoparticles, we can achieve T1-dominated, T2-dominated, and T1-T2 dual-mode MRI contrast agents with much higher contrast enhancement than the corresponding conventional iron oxide nanoparticles.

Iron oxide nanoparticles

Contrast effect

Contrast Enhancement

10.1039/c4nr02680b

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Citations (142)

Relationship between the genotype of EGF 61 * G/G and the genetic susceptibility to pancreatic head cancer

Zhonghua shiyan waike zazhi (2009)

Guoyang Wu Peiming Bai Xiaomin Wang

Objective To understand the effect of EGF on the development of pancreatic head cancer by investigating the EGF 61 * G/A gene functional polymorphism. Methods PCR-RFLP was em-ployed to study the EGF 61 * G/A genotypes in pancreatic head cancer patients and healthy controls. Re-suits The frequency of EGF 61 * G/G genotype and G allele was significantly higher in patients with pancreatic head cancer than in healthy controls (genotype X2 = 6.042, P ＜ 0.05, OR = 2. 618,95% CI =1. 195-5. 738 ;allele X2 = 6. 007, P ＜ 0. 05, OR = 1. 696,95% CI = 1. 110-2. 592). Conclusion EGF 61 * G/G genotype and G allele are significantly related to the development of pancreatic head cancer. Key words: Pancreatic head carcinoma; Genetic polymorphism; Epidermal growth factor

Pancreatic head

10.3760/cma.j.issn.1001-9030.2009.10.043

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Citations (0)

Improved RP-HPLC method to determine neferine in dog plasma and its application to pharmacokinetics

Journal of Chromatography B (2007)

Libo Zhao Xiaomin Wang Jian Wu Yongsheng Jia Wenquan Wang

10.1016/j.jchromb.2007.07.043

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Citations (11)

[The spectral characteristics and chlorophyll content at winter wheat growth stages].

PubMed (2010)

Hong Sun Minzan Li Yong Zhao Yan-E Zhang Xiaomin Wang

The canopy spectral reflectance and chlorophyll content of winter wheat were measured and analyzed in the whole growing season. The characteristics of canopy spectral reflectance indicated that the canopy spectral reflectance changed signifi cantly at different stages. It decreased first and increased later with growth progress in the visible region (400-750 nm) after jointing stage, then the reflectance was lowest at booting stage. In near-infrared region (750-1000 nm) the spectral reflectance climbed sharply. The canopy reflectance was declined at booting stage and rose to the highest point at flowering stage. It dropped to minimum level subsequently at milk-ripe stage. However, the spectral reflectance characteristics at jointing stage and booting stage were used to detect the chlorophyll content. High correlation was observed between the canopy spectral reflectance and chlorophyll content. The positive correlation of canopy spectral reflectance with chlorophyll content was found at jointing stage and booting stage. Because the plant spectral reflectance was effected by chlorophyll greatly in visible region, the correlation coefficient reached 0.89 at 552 nm in booting stage. On the contrary, there was a negative correlation at flowering stage. Meanwhile, the red edge inflection point as one of the most important spectral parameters was analyzed at winter wheat growth stages based on the first derivative of reflectance spectra. The relation between the red edge inflection point and chlorophyll content was observed in each plot and the analysis results illustrated that the red edge inflection points could help detect the chlorophyll content at jointing stage and booting stage. The linear model of chlorophyll content with red edge inflection points was built at jointing stage (R2 = 0.92). High correlation was found between thered edge inflection point and chlorophyll content at booting stage. It was showed that the binomial model (R2 = 0.91) was better than linear model (R2 = 0.73). It was indicated that using spectral analysis to detect the winter wheat chlorophyll content non-destructively was feasible. The obtained conclusions also provided theoretical basis for further researches on measuring methods of chlorophyll content in the field.

Red edge

Inflection point

Source

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Citations (24)

Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription

Proceedings of the National Academy of Sciences (2013)

Bin Xu Shan-Hua Li Rong Zheng Shu-Bin Gao Lihong Ding

Significance Epigenetic changes commonly occur in hepatocellular carcinoma (HCC) and are associated with aberrant gene expression. Most studies have focused on epigenetic gene-silencing events; therefore, the mechanism that promotes gene activation in HCC is not well established. We identify an epigenetic activation mechanism whereby menin promotes Yes-associated protein (Yap1) transcription, which is associated with a poor prognosis for HCC patients. Substantial overexpression of the menin–mixed-lineage leukemia complex is associated with increased histone 3 lysine 4 trimethylation at certain loci of the tumor promoter in HCC. Heterozygous ablation of multiple endocrine neoplasia type 1 ( Men1) in mice reduces diethylnitrosamine-induced development of HCC. Our findings reveal that menin plays an important epigenetic role in up-regulating Yap1 transcription, leading to liver tumorigenesis.

MEN1

YAP1

H3K4me3

Liver Cancer

10.1073/pnas.1312022110

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Citations (69)

Real-Time Monitoring in Vivo Behaviors of Theranostic Nanoparticles by Contrast-Enhanced T₁ Imaging

Analytical Chemistry (2015)

Xianglong Zhu Xiaoqin Chi Jiahe Chen Lirong Wang Xiaomin Wang

The innovative applications of engineered nanoparticles (NPs) in medicine, such as diagnosis and therapy, have attracted considerable attention. It is highly important to predict the interactions between engineered NPs and the complex biological system as well as the impacts on the subsequent behaviors in living subjects. Herein, we report the use of T1 contrast-enhanced magnetic resonance imaging (MRI) to monitor the in vivo behaviors of NPs in a real-time manner. We chose ultrasmall Pd nanosheets (SPNSs) as the object of NPs because of their promise in theranostics and fitness for diverse surface chemistry. SPNSs were modified with different surface coating ligands (e.g., polyethylene glycol, zwitterionic ligands, polyethylenimine) and functionalized with Gd-chelates to render T1 contrast-enhanced capability. MRI real-time monitoring recorded the location and accumulation of SPNSs in small animals and revealed the prominent roles of surface coating ligands in pharmacokinetics. These results highlighted the significance of selecting proper surface coating for particular biomedical assignment. Moreover, we demonstrated a powerful and noninvasive means to predict and detect the behaviors of NPs in living subjects, which may be helpful for rational design and screening of engineered NPs in biomedical applications.

Biodistribution

Polyethylenimine

Rational design

Surface Modification

Contrast Enhancement

MRI contrast agent

10.1021/acs.analchem.5b02095

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Citations (25)

[The electroporation effects of high power pulse microwave and electromagnetic pulse irradiation on the membranes of cardiomyocyte cells and the mechanism therein involved].

PubMed (2005)

Hua Deng Dewen Wang Ruiyun Peng Shuiming Wang Jiankui Chen