<div>Abstract<p>Because of profound effects observed in carcinogenesis, prostaglandins (PG), prostaglandin-endoperoxide synthases, and PG receptors are implicated in cancer development and progression. Understanding the molecular mechanisms of PG actions has potential clinical relevance for cancer prevention and therapy. This review focuses on the current status of PG signaling pathways in modulating cancer progression and aims to provide insights into the mechanistic actions of PGs and their receptors in influencing tumor progression. We also examine several small molecules identified as having anticancer activity that target prostaglandin receptors. The literature suggests that targeting PG pathways could provide opportunities for cancer prevention and therapy.</p></div>
CRF_BC recombinants, including CRF07_BC and CRF08_BC, were considered the predominant subtypes in China. Since the discovery of HIV-1 circulating recombinant form CRF 85_BC in Southwest China in 2016, this BC recombinant forms had been reported in different regions of China. However, the history and magnitude of CRF85_BC transmission were still to be investigated.We conducted the most recent molecular epidemiology of HIV-1 among newly reported HIV-1 infected patients in Sichuan in 2019 by sequencing and phylogenetic analysis of 1291 pol sequences. Then, we used maximum likelihood approach and the Bayesian Markov chain Monte Carlo (MCMC) sampling of pol sequences to reconstruct the phylogeographic and demographic dynamics of the CRF85_BC.HIV-1 CRF85_BC (68/1291, 5.27%) became the fourth most prevalent strain revealing a significant increase in local population. CRF85_BC were only found in heterosexually infected individuals and the majority of CRF85_BC (95.45%) were circulating among the people living with HIV aged 50 years and over (PLHIV50+), suggesting a unique prevalent pattern. The founder lineages of CRF85_BC were likely to have first emerged in Yunnan, a province of Southwest China bordering Sichuan, in the early 2000s. It then spread exponentially to various places (including Guangxi, Sichuan, et al) and became endemic around 2008.6 (2006.7-2010.2) in Sichuan.Taken together, our findings on HIV-1 subtype CRF85_BC infections provided new insights into the spread of this virus and extended the understanding of the HIV epidemic in China.
The objective of this study was to investigate the immunophenotypic subtype profiles of 207 pediatric patients with acute lymphoblastic leukemia (ALL) and its correlation with cytogenetics and clinical features. 207 children with ALL were immunophenotyped by four color flow cytometry using a panel of monoclonal antibodies. 207 patients were enrolled in this study, out of which 146 cases were subjected to karyotype analysis by R-banding technology. The results showed that 11.6% out of 207 children with ALL were identified as T-ALL, 88.4% as B-ALL. Myeloid antigen (MyAg) expression was documented in 42.5% out of 207 cases analyzed and CD13 was the most commonly expressed MyAg (31.4%). No difference was observed in the expression of MyAg between the groups of patients with T-ALL (41.7%) and B-ALL (42.6%). Abnormal karyotypes were detected in 84 out of 146 (57.5%) children. The clinical and biological characteristics of ALL patients between MyAg(+) and MyAg(-) groups showed that higher percentage of patients with high WBC count (> 50 × 10(9)/L) and higher CD34 positivity were found to be correlated with MyAg(+) ALL. It is concluded that immunophenotype analysis is useful for ALL diagnosis and classification, and the immunophenotypes are in relevance to the abnormal cytogenetic changes as well as clinical features in childhood ALL.
Caliber-focused education was rooted in the three layers of culture: spiritual,material,institution,so caliber-focused education of Chinese-style socialism composed by new-human education of socialism,the skill education in the marketing economy,the virtue education of Chinese tradition.These three aspects could built into a organic unity in which the special deficiency of every aspect could be compensated by advantage of the two other aspects.
Fertilization requires sperm migration toward oocytes and subsequent fusion. Sperm chemotaxis, a process in which motile sperm are attracted by factors released from oocytes or associated structures, plays a key role in sperm migration to oocytes. Here, we studied sperm chemotaxis in the nematode Ascaris suum. Our data show that uterus-derived factor (UDF), the protein fraction of uterine extracts, can attract spermatozoa. UDF is heat resistant, but its activity is attenuated by certain proteinases. UDF binds to the surface of spermatozoa but not spermatids, and this process is mediated by membranous organelles that fuse with the plasma membrane. UDF induces spermatozoa to release ATP from intracellular storage sites to the extracellular milieu, and extracellular ATP modulates sperm chemotaxis. Moreover, UDF increases protein serine phosphorylation (pS) levels in sperm, which facilitates sperm chemotaxis. Taken together, we revealed that both extracellular ATP and intracellular pS signaling are involved in Ascaris sperm chemotaxis. Our data provide insights into the mechanism of sperm chemotaxis in Ascaris suum.
Objective To study the imaging findings of eosinophilic hepatic infiltration on multi-slice spiral CT. Methods A retrospective analysis was performed to assess the multi-slice spiral CT imaging findings of 10 cases of pathologically confirmed eosinophilic hepatic infiltration. Evaluations were made regarding the lesions' number, site, shape, margin, size, density, enhancement pattern and the relationship between lesions and portal veins. Results CT demonstrated a single lesion in 2 cases, multiple lesions in 5 and diffuse infiltrative lesions in 3. All lesions were located in subcapsular parenchyma or surrounding the portal vein. Most subcapsular lesions were wedge-shapod, and lesions in the deep parenchyma were irregular. Larger lesions were wedge-shaped or irregular while smaller ones were round or oval. Their size ranged from 4 to 48 ram. On pre-contrast images, these lesions showed slightly low density or isodensity with fuzzy edge. During the arterial phase of post-contrast CT, these lesions exhibited slight enhancement or no enhancement. All lesions were notable and showed relatively low density with homogeneous enhancement and well-defined margin, while centrally heterogeneous enhancement was found in 2 cases during portal venous phase. Isodensity was found in 8 cases during delayed phase, and slightly low density for minor lesions in 2 cases with diffuse lesions. Branches of portal vein was found infiltrated by all lesions, without filling defect or obstruction;low-attenuated stripes surrounding branches of portal vein were found in 3 cases. Conclusion The multi-slice spiral CT findings of eosinophilie hepatic infiltration are relatively specific, and three-phase dynamic CT studies can be a valuable tool for the diagnosis of this disease.
Key words:
Liver diseases; Tomography; X-ray computed
Objective To evaluate the clinical effect of bipolar femoral head prosthetic replacement for the treatment of intertrochanteric fractures in the elderly.Methods Forty - three cases of intertrochanteric fractures in elderly,Type Ⅲ of the fracture by Evans classification was in 32 cases,Ⅳ in 11 cases.Obtain cemented bipolar femoral head prosthetic replacement with retain trochanter.Results All the cases were followed up for 6 to 36 months ( averagely 24 mouths),post - operative infection in 1 case and the fracture of around the prosthesis in 1 case.According to Harris score,excellent in 32 cases,good cases in 6 cases,the excellent rate was 88.4％.Conclusions The merits of bipolar prosthetic with retainted trochanter for the treatment of intertrochanteric fractures in the elderly are reducing bedridden time and complications.It's a satisfactory and safe choice.
Key words:
Intertrochanteric fracture; Bipolar femoral head prosthesis; Elderly; Osteoporosis ; Joint replacement
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