Fengcai Wei

Peking University Third Hospital

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Shaohua Liu

Qilu Hospital of Shandong University

Xun Qu

Qilu Hospital of Shandong University

Shan-zhen Sun

Shandong University

Zuoqing Dong

Shandong University

Ketao Wang

Shandong University

Xiaobin Song

Hangzhou DAC Biotech (China)

Xiaoying Zhang

Shaanxi University of Technology

Jintang Sun

Qilu Hospital of Shandong University

Chengjun Zhou

Soochow University

Wanye Tan

Qilu Hospital of Shandong University

Cooperative Institutions

Shandong University

Qilu Hospital of Shandong University

Shanghai Jiao Tong University

Chinese Academy of Medical Sciences & Peking Union Medical College

Peking University

Chinese Academy of Sciences

Shandong First Medical University

Central South University

Shandong Provincial Hospital

Sun Yat-sen University

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Preoperative neutrophil lymphocyte ratio but not platelet lymphocyte ratio predicts survival and early relapse in patients with oral, pharyngeal, and lip cancer

Head & Neck (2019)

Wenjie Yu Yu Dou Ketao Wang Yanguo Liu Jintang Sun

Abstract Background To evaluate the prognostic value of preoperative neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) in oral, pharyngeal, and lip cancer for survival and relapse. Methods Clinic‐pathologic and hematological records were retrospectively retrieved. Patients completed follow‐up period were included for survival and relapse analysis. Results The preoperative NLR value was a prognostic factor for both overall survival and relapse‐free survival. The high NLR group demonstrated higher total relapse rate, higher local relapse rate, and higher relapse rate within 12 months. However, the preoperative PLR did not associate with survival or relapse. Conclusions The preoperative NLR, not PLR, is an independent prognostic indicator of survival. It also exhibits predictive value for relapse, particularly early relapse within 12 months. The preoperative NLR value might be recommended as a useful tool for predicting the outcomes and stratifying patients for different management strategies.

10.1002/hed.25580

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Citations (12)

[Repairing soft-tissue defection of ankle and foot by sural neurovascular pedicle fasciocutaneous reversed island flap].

Chinese journal of plastic surgery (2005)

Mingrui Chen Cun-Fu Chen Jing-long Cai Fengcai Wei Chengqi Wang

OBJECTIVE: To explore the clinical application of sural neurovascular pedicle fasciocutaneous reversed island flap to repair soft-tissue defection of the ankle and foot. METHODS: From Sep. 1994 to Oct. 2004,29 patients with soft-tissue defects in the ankle and foot were repaired by use of sural neurovascular fasciocutaneous reversed island flap, including 15 cases of traumatic defects, 11 cases of burns and 3 cases of chronic ulcer. The flap area ranged from 5 cm x 7 cm to 12 cm x 20 cm, and the length of pedicle from 5 cm to 12 cm. RESULTS: The flaps survived totally in 27 cases, the distal necrosed partially and secondary free-skin grafting were further conducted in 2 cases. Twenty-one cases were followed-up for 3 to 60 months,the circulation, color and texture of the flaps were excellent and 2-point discrimination was 10 - 15 mm. The appearance and function of ankle joints were good. CONCLUSION: This flap has sufficient blood supply and a high survival rate; It is convenient in design, dissection and without sacrifice of major arteries. So, it is an effective method for the reconstruction of soft-tissue defects in ankle and foot.

Neurovascular bundle

Sural nerve

Blood supply

Foot (prosody)

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Osteopontin’s colocalization with the adhesion molecule CEACAM5 in cytoplasm of carcinoma of tongue and its correlation with the invasion of that diease

Cancer Cell International (2012)

Fan Zhang Xu Jin Liu Xun Qu Zhen Sheng Hu Yong Yang

Abstract The purpose of this study was to investigate the expression of carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) and correlate it with OPN expression and function in squamous carcinoma of tongue. Paraffin were sections of 80 samples with squamous carcinoma of tongue and 40 samples with normal tissue of tongue for benign lesion having undergone surgery. Immunohistochemistry (IHC) was used to study the distribution of CEACAM5 and OPN, and double–labeling immunohistochemistry was used to observe the relationship between CEACAM5 and OPN expression. CEACAM5 and OPN are found in normal tissue of tongue, but with different expression pattern. CEACAM5 expression mainly with membranous staining is restricted on the superficial epithelium. However, OPN expression with mainly cytoplasmic staining is restricted on the deep epithelium. No colocalization of CEACAM5 and OPN have been observed in normal tissue of tongue. In squamous carcinoma of tongue, CEACAM5 expression with cytoplasmic staining is different from normal tongue tissue with membranous staining, and the transformation of CEACAM5 distribution from membrane to cytoplasm is an important incident for the invasion and differentiation of tumor. CEACAM5 and OPN are colocalized in cytoplasm, and a significant correlation was observed between the positive colocalization and the negative colocalization in the depth of invasion and the differentiation of the tumor.

Colocalization

Osteopontin

10.1186/1475-2867-12-33

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Citations (2)

Studies of the role of SODD in the cytotoxicity mediated by the two forms of TNF--#alpha#

Jun Zhu Fang Zheng Linyun Li Fengcai Wei Xiaodan Jiang

Objective To study the correlation between the silencer of death domain (SODD) expression and the cytotoxicity mediated by transmembrane TNF-α (TM-TNF-α) and by secreted TNF-α (S-TNF-α). Methods The cytotoxicity of S-TNF-α and TM-TNF-α to the two kinds of tumor cell lines HL60 and U937 was explored and compared by MTT assay. The expressions of SODD and TNFR1 in cells and the effects of S-TNF-α and TM-TNF-α on the expressions were examined by RT-PCR. Results The expression of SODD was higher than that of TNFR1 in HL60 cell, which was susceptive to TM-TNF-α but not to S-TNF-α. But the expression of SODD was lower than that of TNFR1 in U937 cell, which susceptive to both forms of TNF-α. S-TNF-α had no effect on the expression of SODD in HL60 and U937 cells, while TM-TNF-α was able to down-regulate the expression of SODD in HL60 and U937 cells. Conclusion The results suggest that the expression of SODD in tumor cells is negatively correlated with the cytotoxity of TNF-α. TM-TNF-α, which could down-regulate the SODD expression, has a broader tumorcidal spectrum than S-TNF-α, which could not down-regulate the SODD expression. This may be one of the reasons why TM-TNF-α and S-TNF-α have different antitumor effects.

U937 cell

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Study of the expression of integrin alphaV beta3 in mandibular distraction osteogenesis

Fengcai Wei Dong Zhang Shaohua Liu Shan-zhen Sun

OBJECTIVE To investigate the expression and distribution pattern of Integrin alphaV beta3 (ItgalphaV beta3) in course of distraction 44 adults New Zealand white osteogenesis and to quest for the function of ItgalphaV beta3 in distraction osteogenesis (DO). METHODS rabbits were selected and divided randomly into 3 groups: DO, bone fracture and normal group. There were 20, 20 and 4 rabbits in each group separately. Animal models were established and animals were killed at different time points. Sections were stained by IHC method. Distribution and expression pattern of ItgalphaV beta3 were observed by semi-quantitative technique, and the results were managed with statistic methods. RESULTS The expression of ItgalphaV beta3 was found both in the DO and bone fracture groups. The positive staining was seen mainly in vascular endothelial cells on cytomembrane and in cytoplasm. The staining intensity of group of DO was higher than that of the bone fracture group. CONCLUSION ItgalphaV beta3 plays an important role in promoting the process of DO.

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Correction of middle facial depression deformity of unilateral cleft lip and palate with expanded polytetrafluoroethylene filling

Chinese Journal of Aesthetic Medicine (2006)

Fengcai Wei

Objective To study the feasibility and the effect of expanded polytetrafluoroethylene (e-PTFE) filling to correct the middle facial deformity of unilateral cleft lip and palate. Methods Fifteen unilateral cleft lip and palate patients with serious middle facial deformity and nasal deformation,who could not afford the treatment of orthodontics and orthognathic surgery, were retrospectively reviewed from Jun 2002 to Jun 2005. All the patients underwent surgical procedures which included correction of secondary cleft lip deformity, e-PTFE filling to augment the middle facial depression and alar cartilage suspending of the cleft side. The following-up period was from 6 months to 2 years and the photographs of facial state were taken and compared preoperatively and postoperatively. Results After surgery, the middle facial depression was augmented and the nasal base was put up, the nose became quite symmetrical and the face looked much improved and natural. Conclusion E-PTFE filling was a simple and effective method to augment the middle facial depression of unilateral cleft lip and palate who could not afford the systemic treatment to correct the dento-maxillofacial deformities.

Facial symmetry

Depression

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Genotyping of Five Chinese Patients with 17α-Hydroxylase Deficiency Diagnosed through High-Performance Liquid Chromatography Serum Adrenal Profile: Identification of Two Novel CYP17 Mutations

The Journal of Clinical Endocrinology & Metabolism (2006)

Ji‐Qing Wei Ji‐Lu Wei Weichun Li BI Yun-sheng Fengcai Wei

17alpha-Hydroxylase deficiency is a rare form of congenital adrenal hyperplasia caused by CYP17 gene mutations.Five Chinese patients with 17alpha-hydroxylase deficiency were genotyped.The five patients derived from four families living in Shandong Province, China. The diagnosis of 17alpha-hydroxylase deficiency was initially established through HPLC serum adrenal profiles in Qilu Hospital, China, from 1983-1993.Three CYP17 gene mutations were identified from these patients. Among them, V311fs and Y329fs are two novel frame-shifting mutations. V311fs is an 8-bp nucleotide (TTAAATGG) deletion in exon 5. Y329fs is a deletion-insertion combined mutation (TAC-->AA) at codon 329 in exon 6. Two homozygotes for Y329fs and one compound heterozygote for Y329fs and V311fs were identified from three different families. Two homozygous sisters for the D487_S488_F489 deletion were identified.The results confirmed the diagnostic value of the HPLC serum adrenal profile for 17alpha-hydroxylase deficiency. The D487_S488_F489 deletion had been identified in two previously genotyped Chinese families. In our present study, a third Chinese family with this mutation was identified, suggesting that this mutation is a prevalent CYP17 mutation in the Chinese population. The identification of Y329fs mutation in addition to three previously identified mutations at codon 329 suggests that codon 329 is an unstable point of the CYP17 gene. The mutations identified from our five patients appear to be random, but the recurrence of the Y329fs mutation may be attributed to a founder effect. Our studies suggest that 17alpha-hydroxylase deficiency may not be rare in the Chinese population.

21-Hydroxylase

Compound heterozygosity

10.1210/jc.2006-0153

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Citations (44)

Fucoidan reduced the invasion of oral squamous cell carcinoma cells and modified their effects to macrophages

Medical Oncology (2016)

Junda Lin Ketao Wang Huayang Wang Qianqian Shao Y. Luan

Fucoidan

CCL3

10.1007/s12032-016-0858-1

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Citations (21)

Octreotide Inhibits Choroidal Neovascularization in Rats

Ophthalmic Research (2009)

Yi Qu Shuihua Zhang Xiaoyi Xu Hong Wang Jinghai Li

Aims: Octreotide exhibits anti-angiogenic activity in animal models of retinopathy of prematurity and in clinical cases of proliferative diabetic retinopathy. In this study, we tested the applicability of using octreotide for inhibiting experimental choroidal neovascularization (CNV) in rats. Methods: Of 15 adult rats used, 3 served as non-laser-treated controls. CNV was induced in the right eye of the remaining 12 rats by laser photocoagulation. These 12 rats were divided into two groups (n = 6 each) which were retrobulbarly injected with octreotide (50 μg/kg) or phosphate-buffered saline (PBS) (0.15 ml) immediately and on day 3 after the first injection. Fluorescein angiography and quantitative analysis of the retinal pigment epithelium (RPE)-choroidal flat mounts were performed 14 days after the operation to evaluate the changes in the CNV lesions. Quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR) was used to compare the changes shown by the octreotide-, PBS-, and non-laser-treated rats (n = 3 each) with regard to mRNA levels of the vascular endothelial growth factor (VEGF) and insulin-like growth factor (IGF)-1 in the RPE-choroidal complex. Results: Octreotide treatment significantly inhibited fluorescein leakage and the extent of neovascularization as was observed in the flat mounts of choroidal tissue derived from the rats with induced CNV. The VEGF and IGF-1 mRNA levels were reduced following treatment with octreotide. Conclusion: The retrobulbar administration of octreotide may be an effective new therapeutic strategy for CNV.

10.1159/000219683

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Citations (10)

In situ expression and serum level of thymic stromal lymphopoietin in oral lichen planus

Journal of Oral Pathology and Medicine (2014)

Mingxia Sun Wanye Tan Shaohua Liu Guixiang Liu Xiaoying Zhang

Background Oral lichen planus ( OLP ) is a chronic inflammatory disease of oral mucosa in which the CD 8 + T cell‐mediated cytotoxicity is regarded as a major mechanism of pathogenesis. The main objective of this study is to investigate in situ expression and secretion of thymic stromal lymphopoietin ( TSLP ) in specimens and sera from patients with oral lichen planus. Methods Thirty‐six patients with OLP and 35 donors enrolled in specimen and serum collection. Immunohistochemical method and immunofluorescence double‐staining method were used to detect the expression of thymic stromal lymphopoietin and its receptor ( TSLPR ) together with CD 8 in OLP specimens. Enzyme‐linked immunosorbent assay ( ELISA ) was used to detect TSLP secretion. Results More TSLP ‐ or TSLPR ‐positive cells showed in OLP specimens than in normal controls, and TSLP ‐positive cells were mainly in the epithelium, while TSLPR ‐positive cells mainly in the lamina propria. Furthermore, the number of TSLP ‐positive cells in the stratum basal was associated with the amount of mononuclear cells infiltrating in the lamina propria of OLP specimens. Among infiltrating mononuclear cells in the lamina propria, some CD 8‐positive cells also expressed TSLPR . The TSLP serum level of patients with OLP was significantly higher than of healthy donors, but there was no statistically difference between two clinical subtypes of OLP . Conclusions Our findings provided the first evidence that TSLP may enroll in the pathology of OLP and the TSLP – TSLPR interaction may play an important role in it.

Thymic stromal lymphopoietin

Oral Lichen Planus

Lamina propria

Pathogenesis

Stratum spinosum

10.1111/jop.12196

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Citations (4)