Lung cancer has always a cancer that threatens human health. Quality of life also has been an important research topic. psychological state in patients can influence their quality of life, and perceived social support and coping styles are relevant facilitators of Quality of life, but this specific relationship has not been adequately studied. The purpose of this study is focus on discussing the correlation of these four and understanding their potential mediating pathways. This is a cross-sectional study. A total of 300 Lung Cancer patients from a cancer hospital in Suzhou were surveyed. The Data was collected using the scales. The collected data was analyzed using SPSS and AMOS software. The study revealed a significant serial mediation model between perceived social support and coping style: Psychological state regulates patients' coping styles by influencing their perceived social support which ultimately has comprehensive impacts on their quality of life. Based on the empirical results discussed, this study proposes the following suggestion: Provide good online support to form a related social media intervention matrix. meanwhile, expand the patients' social network offline, provide channels for patients to express their troubles outwardly, and regularly assess the patients' psychological status to improve their level of psychosocial adaptation. This will in turn enhance their negative coping strategies towards the disease and strengthen their ability to buffer against it, ultimately promoting a better quality of life for the patients.
White matter (WM) damage is the main target of hereditary spastic paraplegia (HSP), but mounting evidence indicates that genotype-specific grey matter (GM) damage is not uncommon. Our aim was to identify and compare brain GM and WM damage patterns in HSP subtypes and investigate how gene expression contributes to these patterns, and explore the relationship between GM and WM damage.
We present two analog front-end circuits for acquiring ElectroCorticoGraphic (ECoG) signals from the brain for Brain-Computer Interfaces (BCIs). They exploit a priori knowledge of ECoG characteristics to reduce resolution requirements for digitization and transmission and thus power. The first saves 2 bits with a power overhead of 127 nW; the second theoretically saves up to 8.3 bits with overhead of 0.85 μW. Both are in 130 nm CMOS using a 1.2 V supply.
Objective
To explore the gender difference in Chinese version of autism spectrum rating scale (ASRS)-in terms of parents and teacher rating.
Methods
A total of 701 children (380 boys, 321 girls; 6-11 years old) were recruited from one Primary School in Minhang District of Shanghai.The parents and teachers of the children completed the ASRS.While the data were imput into the database, the software automatically calculated T-standard score according to the formula for the raw score of screening scale, treatment scale, and Diagnostic and Statistical Manual of Mental Disorders-Ⅳ-Turning Reversion scale.In the end, the gender differences in Chinese version of ASRS for both parents and teacher ratings were analyzed.
Results
A total of 671 parents rating scale were retrieved (response rate was 95.7%), involving 368 boys (54.8%); 685 for teacher rating scale (response rate was 97.7%), involving 381 boys (55.6%). No significant difference was observed in the distribution of gender(P>0.05). Minor influence of age was found among ASRS sub-scales for both parents and teacher ratings in boys and girls (parent rating scale r=-0.219 1 to -0.124 4, teacher rating scale r=-0.328 0 to -0.120 0). In parent and teacher version of ASRS, boys had higher T-standard scores in all subscales by 1-3 and 2-4 points than those in girls, respectively, and apart from abnormal behavior, adult socialization, behavioral rigidity, and sensory sensitivity there was no significant difference(all P>0.05) in parents rating scale while others had significant differences(all P<0.05), and all sub-scales had significant difference in teacher rating scale(all P<0.01).
Conclusions
The T-standard scores of both ASRS questionnaire has the gender differences in ASRS subscales, so it is necessary for researchers to understand the Chinese version of ASRS questionnaire from different angles.
Key words:
Autism spectrum disorder; Screening; Questionnaire; Child
Advancements in brain–machine interfaces and neurological treatments urgently require the development of improved brain electrodes applied for long-term implantation, where traditional and polymer options face challenges like size, tissue damage, and signal quality. Carbon nanotubes are emerging as a promising alternative, combining excellent electronic properties and biocompatibility, which ensure better neuron coupling and stable signal acquisition. In this study, a new flexible brain electrode array based on 99.99% purity of single-walled carbon nanotubes (SWCNTs) was developed, which has 30 um × 40 um size, about 5.1 kΩ impedance, and 14.01 dB signal-to-noise ratio (SNR). The long-term implantation experiment in vivo in mice shows the proposed brain electrode can maintain stable LFP signal acquisition over 12 weeks while still achieving an SNR of 3.52 dB. The histological analysis results show that SWCNT-based brain electrodes induced minimal tissue damage and showed significantly reduced glial cell responses compared to platinum wire electrodes. Long-term stability comes from SWCNT’s biocompatibility and chemical inertness, the electrode’s flexible and fine structure. Furthermore, the new brain electrode array can function effectively during 7-Tesla magnetic resonance imaging, enabling the collection of local field potential and even epileptic discharges during the magnetic scan. This study provides a comprehensive study of carbon nanotubes as invasive brain electrodes, providing a new path to address the challenge of long-term brain electrode implantation.
Children with Autism Spectrum Disorder (ASD) have social communication difficulties partly due to unusual visual processing strategy on human faces. However, their strategies are similar on cartoon faces as normal chilren. In this paper, we present Toon-Chat, a video chat system with virtual cartoon masks to help ASD children enhance communication and emotion comprehension skills. The system is tested in a series of ABA training lessons and the results are promising.
Intraoperative hemorrhage represents a major risk during endoscopic intraventricular surgery. There are very few publications describing the maintenance of hemostasis during conventional endoscopic intraventricular surgery. Here, we designed a new mini-tubular port to combine intra- and extra-endoscopic techniques for endoscopic intraventricular surgery. With this new methodology, complicated techniques can be performed more efficiently with improved bleeding control.The new mini-tubular port consists of an outer sheath and an obturator. The sheath is a thin-walled transparent cylinder that is 0.35 mm thick, 10 mm in diameter, and 90 mm in length. In this report, we describe the use of the mini-tubular port on 36 patients receiving endoscopic intraventricular surgery.The study enrolled 36 patients, with a median age of 45 years (range: 0-72 years), of which 19 were male and 17 were female. Pure ETV (endoscopic third ventriculostomy) was performed in 20 patients and pure biopsy was performed in 2. ETV and biopsy were performed in five patients, ETV and the removal of cysticerci were performed in five, cyst fenestration was performed in one, ETV and cyst fenestration were performed in two, and ETV and shunt removal were performed in one patient. Two patients received microscopic surgery following endoscopic surgery during the same operation. A total of 17 patients (47%) underwent extra-endoscopic techniques. The median Karnofsky Performance Status (KPS) score of the patients prior to surgery was 50, while the median KPS score of the patients after one month of surgery was 80; these scores were significantly different (P < 0.05), as determined by Wilcoxon's test. In total, 27 patients had a KPS score ≥70% and 75% of patients had a favorable prognosis one month after surgery. None of the patients experienced seizure.The new mini-tubular port can conveniently combine intra- and extra-endoscopic techniques for endoscopic intraventricular surgery. The application of these techniques can efficiently control bleeding during surgery, help improve the confidence of the surgeons involved, and provide a highly efficient approach for performing complicated procedures.
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