Wei Wang

Hefei Normal University

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i-10 index

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Yan Zhang

Hefei Normal University

Ming Geng

Hefei Normal University

Zhongdong Xu

Hefei Normal University

Yajun Chen

Tianjin Medical University Cancer Institute and Hospital

Guilan Zhu

Hefei Normal University

Guoao Ding

Anhui University

Li‐Long Pan

Jiangnan University

Jinwu Chen

Hefei Normal University

Yajun Chen

Chinese Academy of Sciences

Maozhen Han

Anhui Provincial Hospital

Cooperative Institutions

Chinese Academy of Sciences

Hefei Normal University

Tongji University

Chinese Academy of Medical Sciences & Peking Union Medical College

Sun Yat-sen University

Chongqing Medical University

Anhui University

Sichuan University

Nanjing Medical University

Chinese Academy of Agricultural Sciences

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Nutritional Biomarkers in Alzheimer's Disease: The Association between Carotenoids, n-3 Fatty Acids, and Dementia Severity

Journal of Alzheimer s Disease (2008)

Wei Wang Lynne Shinto William E. Connor Joseph F. Quinn

Carotenoids are fat-soluble antioxidants that may protect polyunsaturated fatty acids, such as n-3 fatty acids from oxidation, and are potentially important for Alzheimer's disease (AD) prevention and treatment. Fasting plasma carotenoids were measur

beta-Carotene

10.3233/jad-2008-13103

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Citations (116)

A Reloadable Self‐Healing Hydrogel Enabling Diffusive Transport of C‐Dots Across Gel–Gel Interface for Scavenging Reactive Oxygen Species

Advanced Healthcare Materials (2017)

Jing Chen Shuya Li Ye Zhang Wei Wang Xiang Zhang

Abstract While reloadable drug delivery platforms are highly prized for the treatment of a broad spectrum of diseases, the gel–gel interface between hydrogels hinders the intergel diffusive transport of drugs and thus limits the application of hydrogels as reloadable depots. Here, this study reports the circumvention of this barrier by employing a self‐healing hydrogel prepared from N ‐carboxyethyl chitosan and sodium alginate dialdehyde, which are cross‐linked via a reversible Schiff base linkage. The injectable and bioadhesive hydrogel shows a rapid gelation time of 47 s. The dynamic self‐healing process enables the efficient diffusive transport of carbon quantum dots (C‐dots) into an adjacent hydrogel, and thus, the C‐dots can be used to scavenge reactive oxygen species from a remote inflammation site. Specifically, the diffusive transport of the C‐dots in the self‐healing hydrogel after three sequential reloading steps is sevenfold greater than that in the non‐self‐healing counterpart. In vivo, hematoxylin and eosin staining of the murine skin at the injection site shows no apparent symptoms of inflammation in the group treated with the reloadable self‐healing hydrogel. The current strategy represents a promising and straightforward route for the design of a reloadable drug delivery system for future use in clinical application.

10.1002/adhm.201700746

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Citations (43)

Comparative genomic analysis of five coprinoid mushrooms species

Functional & Integrative Genomics (2023)

Jingjing Wang Ran Zhang Guoao Ding Lingling Wang Wei Wang

Although coprinoid mushrooms are widely known for the phenomenon of deliquescence and production of fungal laccases and extracellular peroxygenases, the genome structure and genetic diversity of coprinoid mushroom species have not been extensively studied. To reveal the genomic structure and diversity in coprinoid mushroom species, the genomes of five coprinoid mushroom species were compared and analyzed. A total of 24,303 orthologous gene families, including 89,462 genes, were identified in the five species. The numbers of core, softcore, dispensable, and private genes were 5617 (25.6%), 1628 (7.4%), 2083 (9.5%), and 12,574 (57.4%), respectively. Differentiation time analysis revealed that Coprinellus micaceus and Coprinellus angulatus differentiated approximately 181.0 million years ago. Coprinopsis cinerea and Coprinopsis marcescibilis differentiated approximately 131.0 million years ago, and they were differentiated from Candolleomyces aberdarensis approximately 176.0 million years ago. Gene family contraction and expansion analyses showed that 1465 genes and 532 gene families were expanded, and 95 genes and 134 gene families were contracted. Ninety-five laccase-coding genes were detected in the five species, and the distribution of the laccase-coding genes in the five species was not uniform. These data provide a reference for a deeper understanding of the genetic structure of the genomes of coprinoid mushroom species. Furthermore, this study provides a reference for follow-up studies on the genome structure of coprinoid mushroom species and the diversity of specific functional genes.

10.1007/s10142-023-01094-0

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Citations (2)

Corrigendum: (-)-Epigallocatechin-3-Gallate Ameliorates Atherosclerosis and Modulates Hepatic Lipid Metabolic Gene Expression in Apolipoprotein E Knockout Mice: Involvement of TTC39B

Frontiers in Pharmacology (2018)

Wei Wang Zhengzhu Zhang Yan Wu Ru-Qing Wang Jinwu Chen

The authorship of this article should be correctly ordered to protect the right ownership of this paper. In addition, Dr. Li-Long Pan has contributed significantly to this study, such that Dr. Pan should be the co-corresponding author in this study. The authorship order should be considered as follows:Wei Wang1*, Zheng-Zhu Zhang2*, Yan Wu1, Ru-Qing Wang1, Jin-Wu Chen1, Jing Chen1, Yan Zhang1, Ya-Jun Chen1, Ming Geng1, Zhong-Dong Xu1, Min Dai3, Jin-Hua Li1, Li-Long Pan4*1School of Life Science, Hefei Normal University, Hefei, China2State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, China3Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui Key Laboratory for Research and Development of Traditional Chinese Medicine, School of Pharmacy, Anhui University of Chinese Medicine, Hefei, China4School of Medicine, Jiangnan University, Wuxi, ChinaThe authors regret the error.

Knockout mouse

Gene knockout

Apolipoprotein E

Gallate

10.3389/fphar.2018.00459

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Citations (26)

Response surface methodology optimization for the synthesis of N, S-codoped carbon dots and its application for tetracyclines detection

Chemosphere (2022)

Wei Wang Shaoqing Li Pengyuan Yin Jiaxiong Li Yi Tang

Quantum yield

Carbon fibers

Carbon Quantum Dots

10.1016/j.chemosphere.2022.135145

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Citations (25)

Adsorption Equilibrium and Thermodynamics of Tea Theasinensins on HP20—A High-Efficiency Macroporous Adsorption Resin

Foods (2021)

Jianyong Zhang Hongchun Cui Jinjin Xue Wei Wang Jing Wang

The separation and preparation of theasinensins have been hot spots in the field of tea chemistry in recent years. However, information about the mechanism of efficient adsorption of tea theasinensins by resin has been limited. In this study, the adsorption equilibrium and thermodynamics of tea theasinensins by a high-efficiency macroporous adsorption HP20 resin were evaluated. The adsorption of theasinensin A, theasinensin B, and theasinensin C on HP20 resin were spontaneous physical reaction processes. Adsorption processes were exothermic processes, and lowering the temperature was beneficial to the adsorption. The Freundlich model was more suitable to describe the adsorption of tea theasinensins. The adsorption equilibrium constant and maximum adsorption capacity of theasinensin A were significantly higher than theasinensin B and theasinensin C, which indicated that the adsorption affinity of theasinensin A was stronger than that of theasinensin B and theasinensin C. The phenolic hydroxyl groups and intramolecular hydrogen bonds of theasinensin A were more than those of theasinensin B and theasinensin C, which might be the key to the resin's higher adsorption capacity for theasinensin A. The HP20 resin was very suitable for efficient adsorption of theasinensin A.

Exothermic reaction

10.3390/foods10122971

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Citations (9)

Pterostilbene Attenuates Experimental Atherosclerosis through Restoring Catalase-Mediated Redox Balance in Vascular Smooth Muscle Cells

Journal of Agricultural and Food Chemistry (2019)

Wei Wang Yaru Wang Jing Chen Yajun Chen Zhao-xia Wang

Atherosclerosis, the major risk of cardiovascular events, is a chronic vascular inflammatory disease. Pterostilbene is a naturally occurring dimethylated analogue of resveratrol and has recently been demonstrated to be beneficial against cardiovascular diseases. However, the underlying mechanisms of pterostilbene on atherosclerosis remain elusive. Experimental atherosclerosis was induced by a high-fat diet (HFD) in apolipoprotein E knockout (ApoE–/–) mice. Pterostilbene was administered intragastrically for 16 weeks. We found that pterostilbene significantly attenuated thoracic and abdominal atherosclerotic plaque formation in HFD-fed ApoE–/–mice, accompanied by modulated lipid profiles and reduced production of proinflammatory cytokines (including IL-6, IFN-γ, and TNF-α). In addition, pterostilbene restored vascular redox balance in thoracic and abdominal aorta, evidenced by enhanced catalase (CAT) expression and activities, and decreased malondialdehyde and H2O2 production. Notably, pterostilbene specifically induced CAT expression and activities in the vascular smooth muscle cells (VSMCs) of thoracic and abdominal aorta. In vitro, pterostilbene markedly promoted the expression and activity of CAT and decreased ox-low-density lipoprotein (LDL)-mediated VSMC proliferation and intracellular H2O2 production, which was abolished by CAT siRNA knockdown or inhibition. Pterostilbene-induced CAT expression was associated with inhibition of Akt, PRAS40, and GSK-3β signaling activation and upregulation of PTEN. Our data clearly demonstrated that pterostilbene exerted an antiatherosclerotic effect by inducing CAT and modulating the VSMC function.

Pterostilbene

Proinflammatory cytokine

Apolipoprotein E

10.1021/acs.jafc.9b05373

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Citations (16)

The Effect of Long-Term Moderate Static Magnetic Field Exposure on Adult Female Mice

Biology (2022)

Xingxing Yang Biao Yu Chao Song Chuanlin Feng Jing Zhang

Because of the high cost and safety of ultra-high magnetic resonance imaging (MRI), its application has certain limitations. Whereas 0.5−3 T MRI has been widely applied in hospitals, static magnetic fields (SMFs) have been shown to improve mice mental health and have anti-tumor potentials. Here, we compared the effects of the upward and downward 150 mT SMF groups with the sham group on C57BL/6J adult female mice. Locomotor and exploratory activity were also measured by behavioral tests, including the open field and elevated plus test. Additionally, physiology, pathology indicators and gut microbiota were examined. We found that 150 mT SMFs long-term exposure enhanced locomotive and exploratory activity of mice, especially the downward 150 mT SMF. Compared with the downward 150 mT SMF group, the movement speed and distance in the center area of the sham group were increased by 65.99% (p < 0.0001) and 68.58% (p = 0.0038), respectively. Moreover, compared to the sham group, downward 150 mT SMF increased the number of entrances to the center area by 67.0% (p = 0.0082) and time in the center area by 77.12% (p = 0.0054). Additionally, we observed that upward 150 mT SMF improved the number of follicles (~2.5 times, p = 0.0325) and uterine glands through increasing the total antioxidant capacity and reducing lipid peroxidation level in mice. Gut microbiome analysis showed that 150 mT SMFs long-term exposure improved the microbiota abundance (Clostridium, Bifidobacterium, Ralstonia and Yaniella) in the genus level, which may affect metabolism, anxiety and behavior in adult female mice. Our results demonstrated that 150 mT SMFs long-term exposure not only had good biosafety, but also improved athletic performance, emotion and the function of ovarian, uterine and gut microbiota abundance in adult female mice, which unraveled the potential of moderate long-term SMF exposure in clinical applications.

10.3390/biology11111585

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Citations (6)

The selective retention of lutein, meso-zeaxanthin and zeaxanthin in the retina of chicks fed a xanthophyll-free diet

Experimental Eye Research (2007)

Yingming Wang Sonja L. Connor Wei Wang Elizabeth J. Johnson William E. Connor

10.1016/j.exer.2006.11.013

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Citations (37)

Matrix-valued Allen-Cahn equation and the Keller-Rubinstein-Sternberg problem

arXiv (Cornell University) (2021)

Mingwen Fei Fanghua Lin Wei Wang Zhifei Zhang

In this paper, we consider the sharp interface limit of a matrix-valued Allen-Cahn equation, which takes the form: $$\partial_t A=\Delta A-\varepsilon^{-2}( A A^{\mathrm{T}}A- A)~~\text{with}~~A:\Omega\subset\mathbb{R}^m\to\mathbb{R}^{n\times n}.$$ We show that the sharp interface system is a two-phases flow system: the interface evolves according to the motion by mean curvature; in the two bulk phase regions, the solution obeys the heat flow of harmonic maps with values in $O^+(n)$ and $O^-(n)$ (represent the sets of $n\times n$ orthogonal matrices with determinant $+1$ and $-1$ respectively); on the interface, the phase matrices in two sides satisfy a novel mixed boundary condition. The above result provides a solution to the Keller-Rubinstein-Sternberg's (conjecture) problem in this $O(n)$ setting. Our proof relies on two key ingredients. First, in order to construct the approximate solution by matched asymptotic expansions as the standard approach does not seem to work, we introduce the notion of quasi-minimal connecting orbits. They satisfy the usual leading order equations up to some small higher order terms. In addition, the linearized systems around these quasi-minimal orbits needs to be solvable up to some good remainders. These flexibilities are needed for the possible "degenerations" or higher dimensional kernels for the linearized operators due to intriguing boundary conditions at the sharp interface. The second key point is to establish a spectral uniform lower bound estimate for the linearized operator around approximate solutions. To this end, we introduce additional decompositions to reduce the problem into the coercive estimates of several linearized operators for scalar functions and some singular product estimates which is accomplished by exploring special cancellation structures between eigenfunctions of these linearized operators.

Matrix (chemical analysis)

Operator (biology)

10.48550/arxiv.2106.08293

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Citations (1)