Ziyi Li

Wuhan University

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i-10 index

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Co-Authors

Guowei Li

St. Joseph’s Healthcare Hamilton

Xuejiao Chen

Nanjing Medical University

Junzhang Tian

Hunan Agricultural University

Junguo Zhang

Sun Yat-sen University

Zebing Ye

Jinan University

Li Liu

Yibin University

Yanhui Gao

Chinese Center For Disease Control and Prevention

Jie Zeng

University of Electronic Science and Technology of China

Xiaojie Wang

Macau University of Science and Technology

Cheng Li

Xiaomi (China)

Cooperative Institutions

Peking University

Cairo University

Chinese Academy of Sciences

Sun Yat-sen University

Chinese Academy of Medical Sciences & Peking Union Medical College

Shanghai Jiao Tong University

Fudan University

University of Chinese Academy of Sciences

Chinese PLA General Hospital

Capital Medical University

Author Statistics

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Fraxetin inhibits the growth of colon adenocarcinoma cells via the Janus kinase 2/signal transducer and activator of transcription 3 signalling pathway

The International Journal of Biochemistry & Cell Biology (2020)

Shuo Ren Yanwei Xing Chengbo Wang Fengqi Jiang Guangyu Liu

Janus kinase 2

10.1016/j.biocel.2020.105777

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Citations (19)

Detecting the Influencing Factors of Maize Production in China during 2009-2019

Advances in economics, business and management research/Advances in Economics, Business and Management Research (2022)

Yuqiao Sheng Ziyi Li

The maize market in China has improved and the productivity of maize in China has increased through the past decade.We studied the influencing factors of maize production in China during 2009-2019 by multiple regression, including mechanization, planting area, drone application amount and price change.The result shows that among the four factors, only planting area has a significantly positive impact on maize production.We then made some prediction and offered some suggestion to the future development and researches of maize production based on our outcomes.

10.2991/aebmr.k.220307.397

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Citations (1)

Delineating the Spatial Patterns of Cell Type–Specific Stemness Using a Statistical Deconvolution Model

bioRxiv (Cold Spring Harbor Laboratory) (2024)

E. Li Liang Li Ziyi Li

Cellular stemness is a cell's ability to self-renew and differentiate into specialized cell types. In spatial transcriptomics (ST), researchers can use gene activity to quantify stemness and the associated spatial locations, allowing for the investigation of cellular profiles in their natural context. However, many ST platforms provide data with low resolution, and each data spot (i.e., spatial location) contains multiple cell types, which hinders the investigation of cell type specific (CTS) behaviors, such as cell stemness, at different spatial locations. We developed a bivariate kernel-weighted regression method with constrained optimization to estimate CTS stemness as a function of spatial location and developed accompanying visualization tools. Through simulation studies and an application to real breast cancer ST data from the 10x Genomics Visium platform, we demonstrated that our method can accurately estimate CTS stemness and help shed light on the interplay among cell type, tissue structure, and stemness.

10.1101/2024.12.29.630672

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Ecological spatial network optimization of carbon sink patches for enhanced carbon sink in Wuhan Metropolitan Area, China

Ecological Indicators (2024)

Junyi Zhao Ziyi Li Wu Jing Zaicheng Xu Bingyao Jia

Achieving carbon neutrality through increasing carbon sinks is a crucial strategy for reaching long-term climate objectives. During rapid urbanization, the degradation of vegetation structure and quantity in fragmented patches leads to the reduction of the carbon sink capacity. Establishing the well-design ecological spatial network is crucial for improving the carbon sink capacity. This study focuses on enhancing the carbon sink capacity in the Wuhan Metropolitan Area (WMA) through a four-step approach–identification, construction, assessment, and optimization–to improve the ecological spatial structure of carbon sink patches and increase carbon sink capacity. The results show that we initially built 27 carbon sink patches and 52 networks, prioritizing 15 core networks. Due to the low connectivity between the Western and other regions, we added 18 steppingstones and 12 networks to enhance overall connectivity and stability of spatial network. Verification shows that our scheme benefits the connectivity and stability of whole ecological network of WMA, and increases the total carbon sink by 11.17 Mt CO2. This research enriches methods for increasing carbon sinks in urban areas and provides theoretical support for achieving carbon neutrality.

Carbon sink

Sink (geography)

Carbon fibers

10.1016/j.ecolind.2024.112177

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Design, Synthesis, and Mechanistic Study of 2-Pyridone-Bearing Phenylalanine Derivatives as Novel HIV Capsid Modulators

Molecules (2022)

Xujie Zhang Lin Sun Shujing Xu Xiaoyu Shao Ziyi Li

The AIDS pandemic is still of importance. HIV-1 and HIV-2 are the causative agents of this pandemic, and in the absence of a viable vaccine, drugs are continually required to provide quality of life for infected patients. The HIV capsid (CA) protein performs critical functions in the life cycle of HIV-1 and HIV-2, is broadly conserved across major strains and subtypes, and is underexploited. Therefore, it has become a therapeutic target of interest. Here, we report a novel series of 2-pyridone-bearing phenylalanine derivatives as HIV capsid modulators. Compound FTC-2 is the most potent anti-HIV-1 compound in the new series of compounds, with acceptable cytotoxicity in MT-4 cells (selectivity index HIV-1 > 49.57; HIV-2 > 17.08). However, compound TD-1a has the lowest EC50 in the anti-HIV-2 assays (EC50 = 4.86 ± 1.71 μM; CC50= 86.54 ± 29.24 μM). A water solubility test found that TD-1a showed a moderately increased water solubility compared with PF74, while the water solubility of FTC-2 was improved hundreds of times. Furthermore, we use molecular simulation studies to provide insight into the molecular contacts between the new compounds and HIV CA. We also computationally predict drug-like properties and metabolic stability for FTC-2 and TD-1a. Based on this analysis, TD-1a is predicted to have improved drug-like properties and metabolic stability over PF74. This study increases the repertoire of CA modulators and has important implications for developing anti-HIV agents with novel mechanisms, especially those that inhibit the often overlooked HIV-2.

Viral life cycle

Metabolic stability

EC50

10.3390/molecules27217640

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Citations (7)

Recent progress in SRC targeted therapy for pancreatic cancer

Shijie huaren xiaohua zazhi (2021)

Ziyi Li Xueying Sun

Targeted Therapy

10.11569/wcjd.v29.i12.621

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Birth Weight and the Risk of Cardiovascular Outcomes: A Report From the Large Population-Based UK Biobank Cohort Study

Frontiers in Cardiovascular Medicine (2022)

Xin Huang Jun Liu Lu Qi Jonathan D. Adachi Jing Wu

Birth weight has been reported to be associated with the risk of incident cardiovascular disease (CVD); however, the relationship remains inconclusive. Here, we aimed to prospectively assess the associations between birth weight and CVD risk using the data from UK Biobank, a large-scale, prospective cohort study.We included 270,297 participants who were free of CVD at baseline and reported their birth weight for analyses. The primary outcome was incident CVD. Hazard ratios (HRs) and 95% confidence intervals (CIs) for outcomes were calculated using Cox proportional hazards models adjusted for potential confounding variables.During a median follow-up of 8.07 years (IQR: 7.4-8.7 years), 10,719 incident CVD events were recorded. The HRs for low birth weight vs. normal birth weight (2.5-4.0 kg) were 1.23 (95% CI: 1.09-1.38) for risk of incident CVD, 1.52 (95% CI: 1.18-1.95) for stroke, 1.33 (95% CI: 1.07-1.64) for myocardial infarction, and 1.15 (95% CI: 1.01-1.32) for CHD. For the ones with low birth weight, the risk of CVD is reduced by 11% for every kilogram of birth weight gain. The association of low birth weight with CVD was stronger among those younger than 55 years (p = 0.001). No association between high birth weight and risk of cardiovascular outcomes was found.Low birth weight was associated with an increased risk of cardiovascular events. These findings highlight the longstanding consequence of low birth weight on cardiovascular system.

Lower risk

10.3389/fcvm.2022.827491

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Citations (11)

A Newly Identified Spike Protein Targeted Linear B‐Cell Epitope Based Dissolvable Microneedle Array Successfully Eliciting Neutralizing Activities against SARS‐CoV‐2 Wild‐Type Strain in Mice

Advanced Science (2023)

Lin Li Zhongpeng Zhao Xiaolan Yang Zhongyi Su Wendong Li

Vaccination is a cost-effective medical intervention. Inactivated whole virusor large protein fragments-based severe acute respiratory syndrome coronavirus (SARS-CoV-2) vaccines have high unnecessary antigenic load to induce allergenicity and/orreactogenicity, which can be avoided by peptide vaccines of short peptide fragments that may induce highly targeted immune response. However, epitope identification and peptide delivery remain the major obstacles in developing peptide vaccines. Here, a multi-source data integrated linear B-cell epitope screening strategy is presented and a linear B-cell epitope enriched hotspot region is identified in Spike protein, from which a monomeric peptide vaccine (Epitope25) is developed and applied to subcutaneously immunize wildtype BALB/c mice. Indirect ELISA assay reveals specific and dose-dependent binding between Epitope25 and serum IgG antibodies from immunized mice. The neutralizing activity of sera from vaccinated mice is validated by pseudo and live SARS-CoV-2 wild-type strain neutralization assays. Then a dissolvable microneedle array (DMNA) is developed to pain-freely deliver Epitope25. Compared with intramuscular injection, DMNA and subcutaneous injection elicit neutralizing activities against SARS-CoV-2 wild-type strain as demonstrated by live SARS-CoV-2 virus neutralization assay. No obvious damages are found in major organs of immunized mice. This study may lay the foundation for developing linear B-cell epitope-based vaccines against SARS-CoV-2.

Peptide vaccine

Epitope mapping

10.1002/advs.202207474

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Citations (7)

An Analysis of Clinical and Pathologic Features, RecurIndex Genomic Profiles, and Survival Outcomes in HER2-Low Breast Cancer

The Oncologist (2023)

Tianli Hui Sainan Li Huimin Wang Xuejiao Ma Furong Du

Abstract Background In recent years, breast cancer has become the most common cancer in the world, increasing women’s health risks. Approximately 60% of breast cancers are categorized as human epidermal growth factor receptor 2 (HER2)-low tumors. Recently, antibody-drug conjugates have been found to have positive anticancer efficacy in patients with HER2-low breast cancer, but more studies are required to comprehend their clinical and molecular characteristics. Methods In this study, we retrospectively analyzed the data of 165 early breast cancer patients with pT1-2N1M0 who had undergone the RecurIndex testing. To better understand HER2-low tumors, we investigated the RecurIndex genomic profiles, clinicopathologic features, and survival outcomes of breast cancers according to HER2 status. Results First, there were significantly more hormone receptor (HR)-positive tumors, luminal-type tumors, and low Ki67 levels in the HER2-low than in the HER2-zero. Second, RI-LR (P = .0294) and RI-DR (P = .001) scores for HER2-low and HER2-zero were statistically significant. Third, within HER2-negative disease, HR-positive/HER2-low tumors showed highest ESR1, NFATC2IP, PTI1, ERBB2, and OBSL1 expressions. Fourth, results of the survival analysis showed that lower expression of HER2 was associated with improved relapse-free survival for HR-positive tumors, but not for HR-negative tumors. Conclusions The present study highlights the unique features of HER2-low tumors in terms of their clinical characteristics as well as their gene expression profiles. HR status may influence the prognosis of patients with HER2-low expression, and patients with HR-positive/HER2-low expression may have a favorable outcome.

10.1093/oncolo/oyad159

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Citations (2)

Abstract 3779: Clonal tracing reveals different mechanisms of resistance to immune checkpoint blockade

Tumor Biology (2019)

Shengqing Gu Xihao Hu Xiaoqing Wang Peng Jiang Ziyi Li

Immune checkpoint blockade (ICB) therapy has improved patient survival in a variety of cancers, but its resistance presents a major clinical challenge. It remains unclear whether therapeutic resistance is driven predominantly by refractory clones of cancer cells or by immunosuppressive microenvironment. To address this, we utilized syngeneic transplantation model and performed clonal tracing of cancer cells to monitor the response to ICB. Different cancer clones displayed variable sensitivity to ICB treatment, reflecting intratumoral heterogeneity in therapy response. Furthermore, different recipients manifested distinct resistance mechanisms. ICB-responders developed resistance through selection and expansion of pre-existing ICB-resistant cancer clones, whereas non-responders presented with irresponsive microenvironment rather than dominance of resistant cancer clones. Extrapolation of the tumor-infiltrating immune repertoire revealed that higher IgG and lower IgA strongly correlated with better ICB response. This biomarker was further validated in multiple clinical cohorts. Our approach discriminates different sources of resistance to ICB, and identifies humoral immunity as biomarker of ICB response.Citation Format: Shengqing Gu, Xihao Hu, Xiaoqing Wang, Peng Jiang, Ziyi Li, Nicole Traugh, Xia Bu, Xiaofang Xing, Gordon J. Freeman, Myles Brown, Xiaole S. Liu. Clonal tracing reveals different mechanisms of resistance to immune checkpoint blockade [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3779.

Immune checkpoint

10.1158/1538-7445.sabcs18-3779

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