Through the redesign of the dryer,the improvement on the drainage of the dryer and on the rotary joint in the steam systemsin two set of 3150mm paper machines,the speed of the paper machines has been increased from 420 m/min to 560 m/min,thetransmission load has been reduced by more than 80% and the steam consumption has been saved by more than 60%,thus the greateconomic benefits have been achieved.
Stroke is one of the most common causes of death and long-term disability worldwide. People with motor disabilities caused by stroke experience limitations in performing daily tasks independently, and traditional rehabilitation programs have tediousness and accessibility problems for the patients. It is essential to develop novel and convenient rehabilitation systems to help people with motor impairment overcome these deficiencies. In this paper, we present a Microsoft Kinect sensor (Kinect) based virtual rehabilitation system, which allows a human operator to transmit his gesture information to the virtual environment by performing specified actions designed for our verification tasks. We verify the effectiveness and applicability of the proposed system in two user studies. In the first study, we carried out a left hand and right hand dexterity comparison experiment, in which the characteristic data of normal individuals have been obtained as assessment criteria during their accomplishing designed tasks such as upper limb raising and elbow bending. In the second study, we presented a six-level recovery assessment criterion through a body parts motion monitoring based recovery assessment method. Results suggest that it is effective for our proposed virtual rehabilitation system to assist patients in conducting home-based rehabilitation without physician's supervision.
In this paper, we investigate the state-feedback $H$∞ control problem for the autonomous vehicle path-following system in the presence of periodic denial of service (DoS) attacks. First, a new switched system model is presented, which is related to the parameters of DoS attacks. Second, an attack parameter dependent time-varying Lyapunov function is introduced. Conditions for the switched system to analyze exponential stability and $H$∞ performance are established. In the meantime, the state-feedback controller is also developed by applying linear matrix inequality (LMI) techniques. An autonomous vehicle system is eventually used to prove the validity of the proposed theorem results.
Acute leukemias of ambiguous lineage (ALAL) is a rare type of acute leukemia, referring to a group of disorders characterized by a combination of myeloid, lymphoid, or more lineages, whose incidence is significantly lower in children than adults. Here, we summarized the clinical features and outcomes of 36 pediatric ALAL patients in past 16 years. The patients diagnosed as ALAL based on the criteria of EGIL scoring system in 1998 (EGIL 1998) and/or the 2016 revisions to the WHO classification (WHO 2016) from January 1, 2005 to December 1, 2021 were included, respectively. During follow-up for a median 22 months, the median leukemia-free survival (LFS) was 18 months (0 to 172 mo) and the median overall survival (OS) was 22 months (1 to 173 mo), with a 5-year LFS rate of 67.3±9.2% and a 5-year OS rate of 66.0±10.7%. Patients who sustained negative minimal residual disease after 2 courses of standardized chemotherapy contributed to better 5-year OS (100% vs. 37.2±22.0%, P =0.028) and LFS (100% vs. 46.7±16.6%, P =0.028).
Objective: To evaluate the value of CT in the differential diagnosis of Pseudomonas aeruginosa sinusitis and fungal ball in paranasal sinus caused by Aspergilus flavus. Methods: In this retrospective study, CT results of 74 cases of Pseudomonas aeruginosa sinusitis including 31 male cases and 43 female cases with age onset from 15 to 74 years old (mean±SD was 50±13) and 72 cases of fungal ball in paranasal sinus caused by Aspergilus flavus including 28 male cases and 44 female cases with age onset from 25 to 78 years old (mean±SD was 53±15) at Beijing Tongren Hospital confirmed by histopathology were enrolled from January 2013 to May 2017. The CT characteristics of the two groups of cases were compared using χ(2) test, and P<0.05 was considered statistically significant. Results: Soft tissue opacification of the involved paranasal sinus was found on CT in each case of the two groups. There were significant differences in the rate of single sinus involvement (44.6% and 90.3% respectively), the incidence of lesion associated with maxillary sinus (91.9% and 70.8% respectively), ethmoid sinus (41.9% and 2.8% respectively), frontal sinus (29.7% and 0 respectively), calcification (50.0% and 72.2% respectively), and the enlargement of maxillary sinus opening (13.2% and 35.3% respectively), in addition to the central calcification (83.8% and 59.6% respectively) between the two groups (all P<0.05). However, the incidence of sphenoid sinus involvement (32.4% and 34.7% respectively), bone sclerosis (56.8% and 62.5% respectively) or destruction(18.9% and 16.7% respectively) were not found different between the two groups (P>0.05). Conclusion: Though the CT findings are similar between the two diseases such as soft tissue opacification of the involved paranasal sinus with calcification and bone sclerosis or destruction, there are still a few characteristics on CT in differentiating the one from the other. The involvement of multi-sinuses, maxillary sinus, ethmoid sinus and frontal sinus, the central calcification are more common in the Pseudomonas aeruginosa sinusitis. However, the CT features including single sinus involvement, calcification and enlargement of maxillary sinus opening, can be seen more often in the fungal ball in paranasal sinus caused by Aspergilus flavus.目的： 通过比较绿脓杆菌所致鼻窦炎和黄曲霉菌所致鼻窦真菌球CT特征，探讨CT鉴别诊断价值。 方法： 收集2013年1月至2017年5月北京同仁医院确诊的74例绿脓杆菌所致鼻窦炎[男31例、女43例，年龄15~74（50±13）岁]和72例黄曲霉菌所致鼻窦真菌球[男28例、女44例，年龄25~78（53±15）岁]患者的CT资料。回顾性比较二者CT特征，统计学方法用χ(2)检验，P<0.05为差异有统计学意义。 结果： 二者CT均表现为鼻窦内软组织密度影（100%），病变范围累及单窦（44.6%和90.3%）、上颌窦（91.9%和70.8%）、筛窦（41.9%和2.8%）、额窦（29.7%和0）、伴钙化（50.0%和72.2%）、上颌窦口扩大（13.2%和35.3%）、中央钙化（83.8%和59.6%）的差异有统计学意义（均P<0.05），而在累及蝶窦（32.4%和34.7%）、窦壁增生硬化（56.8%和62.5%）或破坏吸收（18.9%和16.7%）上差异无统计学意义（均P>0.05）。 结论： 绿脓杆菌所致鼻窦炎和黄曲霉菌所致鼻窦真菌球均可表现为窦腔软组织影伴钙化、窦壁增生硬化或破坏吸收，但前者常多窦受累，易累及上颌窦、筛窦、额窦，钙化相对少见且多位于受累鼻窦的中央；而后者多累及单窦，上颌窦受累最多见，其次为蝶窦，而额窦及筛窦受累少见，钙化更常见且易发生于受累鼻窦的窦口，多伴窦口扩大。.
ABSTRACT Background Although cryosurgery has been proved to be an effective treatment to extend the survival time of unresectable liver cancer patients and improve their quality of life, few surgeons actually treat unresectable pancreatic cancer with this method because of its safety risks. This study aims to evaluate the safety and efficacy of cryosurgical ablation in the treatment for unresectable pancreatic cancer. Methods A retrospective study was conducted on 142 patients who underwent palliative bypass with cryoablation (PBC group: 68) or without cryoablation (PB group: 74) for unresectable pancreatic cancer from 1995 to 2002. The morbidity and 5 year survival rates of the two groups were compared. Carbohydrate antigen 19–9 (CA19-9) level and tumour size were evaluated in PBC group. Results There was no significant difference in the rate of overall complications between the two groups (p=0.809), except for a higher delayed gastric emptying rate observed in the PBC group (36.8% vs 16.2%, p=0.005). In the PBC group, the median preoperative CA19-9 concentration decreased from 690 U/ml to 56 U/ml (p=0.000). CT scan results of 55 patients indicated that tumour mass shrinkage occurred in 36 of them, from 4.3 cm to 2.4 cm (pre-ablation to 3 months after ablation). Kaplan–Meier analysis showed no significant difference in 5 year survival rates between the two groups (p=0.124). Conclusions Cryosurgery combined with palliative bypass surgery can be considered a safe and effective treatment for unresectable pancreatic cancer. Though this technique remains only palliative, it may be further employed to improve advanced stage pancreatic cancer.
The aim of this study was to investigate the effects of 131I gelatin microspheres (131I-GMS) on human breast cancer cells (MCF-7) in nude mice and the biodistribution of 131I-GMSs following intratumoral injections. A total of 20 tumor-bearing mice were divided into a treatment group and control group and received intratumoral injections of 2.5 mci 131I-GMSs and nonradioactive GMSs, respectively. Tumor size was measured once per week. Another 16 mice received intratumoral injections of 0.4 mci 131I-GMSs and were subjected to single photon emission computed tomography (SPECT) scans and tissue radioactivity concentration measurements on day 1, 4, 8 and 16 postinjection. The 20 tumor-bearing mice received intratumoral injections of 0.4 mci [131I] sodium iodide solution and were subjected to SPECT scans and intratumoral radioactivity measurements at 1, 6, 24, 48 and 72 h postinjection. The tumors were collected for histological examination. The average tumor volume in the 131I-GMSs group on post-treatment day 21 decreased to 86.82 ± 63.6%, while it increased to 893.37 ± 158.12% in the control group (P < 0.01 vs. the 131I-GMSs group). 131I-GMSs provided much higher intratumoral retention of radioactivity, resulting in 19.93 ± 5.24% of the injected radioactivity after 16 days, whereas the control group retained only 1.83 ± 0.46% of the injected radioactivity within the tumors at 1 h postinjection. 131I-GMSs suppressed the growth of MCF-7 in nude mice and provided sustained intratumoral radioactivity retention. The results suggest the potential of 131I-GMSs for clinical applications in radiotherapy for breast cancer.
Abstract (1) Background: The colonization characteristics of infant gut microbiota are influenced by many factors at various stages, but few studies have explored the longitudinal effects of environmental tobacco exposure and quantitative weaning time on young children’ intestinal flora. The purpose of this study was to characterize the evolution of intestinal microflora in young children aged 0-2 years and the longitudinal effects of environmental tobacco exposure and weaning time on young children aged 6, 12, and 24 months.(2) Methods: A total of 37 maternal and children pairs were included in a tertiary general hospital in China and followed up for 2 years. General demographic information was collected on mothers (after delivery, 6 months, 12 months) and young children (6 months, 12 months, 24 months), including frequency of exposure and time of weaning, through self-made questionnaires. Fecal samples were collected from mothers in the third trimester of pregnancy and infants at 6, 12 and 24 months, and analyze the microbiota results using the V3-V4 gene sequence of 16S rRNA.(3) Results: the diversity of intestinal microflora in young children was the highest at 24 months and most similar to that in mothers. Weaning time was positively correlated with Lactobacillus in the intestines of infants aged 0 to 12 months. The diversity of microbiota exposed to environmental tobacco smoke at 6 months was lower than that of the non-exposed group, and the higher the exposure at 6-12 months, the lower the abundance of Blautia.(4) Conclusion: The gut microbiota of young children becomes more mature and complicated with age. The extension of complete weaning time to about 12 months is conducive to the colonization of beneficial bacteria. And the long-term exposure of children and the environment of tobacco smoke will affect the dysbiosis of gut microbiota.
'/%3e%3cuse xlink:href='%23a' transform='rotate(23.036 .093 25.536)'/%3e%3cuse xlink:href='%23a' transform='rotate(45.87 1.273 16.18)'/%3e%3cuse xlink:href='%23a' transform='rotate(69.945 .996 12.078)'/%3e%3cuse xlink:href='%23a' transform='rotate(20.66 -19.689 31.932)'/%3e%3c/svg%3e)