Background Oxidative stress refers to the imbalance between oxidants and antioxidants in organisms and often induces hepatic inflammation. Supplementing exogenous superoxide dismutase is an effective way to alleviate oxidative stress; however, the effects and mechanisms by which superoxide dismutase alleviates hepatic inflammation remain unclear. Methods This study established a Kunming mouse model to verify and investigate the oxidative stress and hepatic inflammation-alleviating effects of the superoxide dismutase oral supplement that was prepared by our research group in a previous study. Results The superoxide dismutase product significantly restored the body weight and liver alanine transaminase, aspartate aminotransferase, superoxide dismutase, catalase, glutathione, and glutathione peroxidase levels of oxidative stress induced mice. Moreover, exogenous superoxide dismutase significantly inhibited interleukin 1 β and interleukin 6 mRNA expression in the livers of mice with hepatic inflammation. Transcriptomic analysis indicated that superoxide dismutase had a significant inhibitory effect on Endog expression, alleviating oxidative stress damage, and mediating liver cell apoptosis by regulating the expression of Rab5if , Hnrnpab , and Ifit1 . Conclusion Our research verified the oxidative stress remediation effects of superoxide dismutase and its therapeutic role against hepatic inflammation. This study can lay a foundation for investigating the mechanism by which superoxide dismutase alleviates hepatic disease.
Tuberculous sacroiliitis with abscess accounts for approximately 50 % of all sacroiliac joint tuberculosis cases. Tuberculous abscesses spread into the sacroiliac joint capsule, subcutaneous tissue, and the skin, and finally becomes a skin sinus. As there are no previous reports about sacroiliac joint tuberculosis with a chronic sinus, we evaluated its clinical characteristics and management by negative pressure wound therapy.
The aim of this research was to study the factors influencing the formation of intracranial aneurysms with irregular morphology by observing the dynamic volume change rate of intracranial unruptured aneurysms and other aneurysm characteristics.Sixty-five unruptured intracranial aneurysms of 51 consecutive patients from 1 center were included in this study. All patients underwent a dual-source computed tomography electrocardiogram-gated 4-dimensional computed tomography angiography examination. The original data at the end of the scan were reconstructed, and 20 sets of data packages through a cardiac cycle with 5% interval were obtained. Data packages were processed by a 3-dimensional software workstation to obtain 20 sets of images and dynamic diagrams. The volume of each aneurysm in the 20 sets of images was measured, and the volume change was calculated by a specific formula. The other data features of the aneurysm such as aneurysm neck, aneurysm height, aspect ratio (AR), location at bifurcation, and clinical features such as age, sex, hypertension history, type 2 diabetes history, smoking history, family history, multiple aneurysm history, and subarachnoid hemorrhage history, were documented in detail. After single factor analysis data, logistic regression analysis of the meaningful indicator was conducted to study the predictive factors of irregular aneurysms.Of the 65 aneurysms, 25 possessed an irregular shape and 40 were of regular shape; 51 were anterior circulatory aneurysms and 14 were posterior circulatory aneurysms. Single factor analysis showed that AR (P = 0.001), volume change rate (P = 0.002), and location of aneurysm at the bifurcation (P = 0.038) of the vessel were significantly correlated with irregular aneurysms, but not correlated with age, sex, hypertension history, type 2 diabetes history, smoking history, family history, multiple aneurysm history, and subarachnoid hemorrhage history. Multifactor analysis showed that volume change rate greater than 30% (P = 0.008; odds ratio, 6.934) and AR greater than 1.4 (P = 0.004; odds ratio, 8.258) were independent correlative factors of the formation of intracranial aneurysm with irregular shape.The volume change rate and AR are independent correlative factors of the formation of intracranial aneurysm with irregular shape.
Ubiquitin-specific peptidase 10 (USP10), a typical de-ubiquitinase, has been found to play a double-edged role in human cancers. Previously, we reported that the expression of USP10 was negatively correlated with the depth of gastric wall invasion, lymph node metastasis, and prognosis in gastric cancer (GC) patients. However, it remains unclear whether USP10 can regulate the metastasis of GC cells through its de-ubiquitination function.
Objective:To evaluate the safety and technique of free hand pedicle screw implantation in the thoracic spine.Method:A total of 372 patients were subjected to thoracic pedicle screw fixation and their perioperative complication were reviewed,of which computed tomography(CT) were used in 37 patients to determine the instruments malposition.Result:A total of 2261 thoracic pedicle screws were placed by free hand technique,with every patient of avarage 6.08 screws.There was no neurovascular and visceral injury expect 6 cases of cerebrospinal fluid leaking from the initial pedicle tract during the preparation of the screw holes.37 patients were scanned with computed tomography to determine the screw′s position,in which 124 screws(30.62%) violated the cortical wall,and only 1 screw(0.02%) with penetrated distance beyond 4mm was documented.Conclusion:Although thoracic pedicle screw placement can cause cortical perforation frequently,this process can be managed accurately,safely and reliably based on individulized instrumentation.
Landslides and geological disasters occur frequently in the mountainous areas of northwest China, seriously threatening people’s life and property of the region. In this study, we investigated the Lijie Beishan landslide as a typical case and combines the results of on-site geological surveys to conduct two-dimensional and three-dimensional numerical simulations of the landslide, evaluating its stability under self-weight, rainfall, and earthquake action. By analyzing the generalized shear strain, displacement, and stability coefficient of the landslide, it is determined that the stability of the landslide shows a decreasing trend under static, rainfall, and earthquake conditions. Landslides exhibit tension controlled failure modes under normal static and rainfall conditions, and translational failure modes under earthquake conditions. Compared with static and rainfall conditions, landslides have the largest volume and sliding distance under earthquake conditions. By combining the transfer coefficient method and the simplified Bishop method, a comparative analysis was conducted on the stability of the landslide. It was found that the stability coefficients under different working conditions were consistent with the simulation results, which verified the reliability of the simulation results. The research results of this paper will assist in clarifying the development mechanism of this type of landslides and provide valuable references for the stability evaluation of landslides in the northwest mountainous areas.
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