Non-muscle invasive bladder cancer (NMIBC) is one of the most common type of bladder cancer. Here, we have utilized an integrated transcriptomic-computational approach to identify alternate treatments to the NMIBC. In this study, we have performed the comprehensive comparative analysis between three groups of 36 patients with non-relapsed (NR), recurrence and progressive symptoms. Differentially expressed genes involved in the pathways associated with the NMIBC were identified. In silico protein–protein interaction (PPI) network was performed to create the network of the hub genes associated with NMIBC. Further, we compared NR individuals with two cohorts of patients with recurrent and progressive symptoms that lead to the identification of three major biomarkers CD34, FLT1 and WHSC1 genes. Concurrently, PPI also suggests that they are significant hub genes responsible for disease recurrence and progression. Furthermore, targeted genes WHSC-1 and FLT-1 were subjected to virtual screening for identification phytochemical inhibitors. Docking and molecular dynamics simulations concluded that the phytochemicals anonymously named ‘UNK’ and ‘6-hydroxycyanidin’ are suitable for the inhibition of the proteins causing the NMIBC. In the future, this study will help for strengthening the strategies development at the molecular level for the control of carcinomas at early as well as detection of active and binding site, receptor–ligand interaction and also make drug designing for the early treatment of the carcinomas. Communicated by Ramaswamy H. Sarma
Objective
To understand the coverage of iodized salt and the iodine nutritional status of schoolchildren in Hongkou District of City and to provide a basis for adjusting corresponding intervention measures.
Methods
From 2012 to 2016, according to the Shanghai Iodine Deficiency Disease Surveillance Program, a street was chosen from five directions as east, west, south, north and centre in Hongkou District. According to the annual monitoring plan, a certain amount of residents or schoolchildren aged 8- 10 were chosen for monitoring, collecting salt samples from residents or children's home to detect salt iodine, and collecting urine samples of children to detect urinary iodine level (which was not tested in 2013). of iodine salt was based on Determination of Iodine by the General Test Method for the Salt Industry (GB/T 13025.7-2012), urinary iodine determination was based on Arsenic and Cerium Catalytic Spectrophotometric of Iodine in Urine (WS/T 107-2006).
Results
From 2012 to 2016, a total of 1 550 edible salt samples were tested, including 847 qualified iodized salts, 299 unqualified iodized salts and 404 non-iodized salts, the coverage of iodized salt was 73.9%, and the consumption rate of qualified iodized salt was 54.6%. A total of 591 urine samples were tested in 2012, 2014- 2016. The median of urinary iodine was 177.2 μg/L; of which < 100 μg/L was 103, accounting for 17.4%; 100 - 199 μg/L was 248, accounting for 42.0%; and ≥300 μg/L was 91, accounting for 15.4%.
Conclusions
The residents in Hongkou District of City do not meet the target of iodized salt coverage and consumption rates of qualified iodized salt. The average urinary iodine level of schoolchildren aged 8 - 10 years has reached the national standard for eliminating iodine deficiency disorders; we should further improve the consumption rate of qualified iodized salt.
Key words:
Iodine; Salts; Urine; Child
Objective To compare the growth of preterm infants fed standard protein-fortified human milk with that containing human milk fortifier (HMF) with a higher-than-standard protein content. Methods Published articles reporting randomized controlled trials and prospective observational intervention studies listed on the PubMed®, Embase®, CINAHL and Cochrane Library databases were searched using the keywords ‘fortifier’, ‘human milk’, ‘breastfeeding’, ‘breast milk’ and ‘human milk fortifier’. The mean difference with 95% confidence intervals was used to compare the effect of HMF with a higher-than-standard protein content on infant growth characteristics. Results Five studies with 352 infants with birth weight ≤1750 g and a gestational age ≤34 weeks who were fed human milk were included in this meta-analysis. Infants in the experimental groups given human milk with higher-than-standard protein fortifier achieved significantly greater weight and length at the end of the study, and greater weight gain, length gain, and head circumference gain, compared with control groups fed human milk with the standard HMF. Conclusions HMF with a higher-than-standard protein content can improve preterm infant growth compared with standard HMF.
To explore the effects of several prebiotics that polydextrose,polyxylose,inulin,arabinogalactan(AG) on the level of blood lipid in hamsters.The animal model of hyperlipidemia in healthy male hamsters was established by feeding diets riched in high cholesterol,in the meantime the four prebiotics were given at a level of 5 % in the diets.Observe the effects of four prebiotics on the total cholesterol(TC),triglycerides(TG) and high density lipoprotein cholesterol(HDL-C) in serm and liver of hamsters.Results showed: 1) the prebiotics could reduce the levels of serum TC and Non-HDL-C of hamsters fed on a lipid rich diet obviously,while the level of TG and HDL-C in serum did not changed in all groups during the experiment.2) the prebiotics could reduce the total cholesterol levels in liver tissue of hamsters obviously except for arabinogalactan.And all prebiotics could decrease triglyceride in liver tissue obviously.Therefore the four prebiotics could regulate the lipid of blood observably.
The pathology of sepsis is extremely complex. Pathogen invasion, inflammatory factors secretion, coagulation disorder and microcirculation disturbance lead to metabolic disorder and organ dysfunction. In recent years, immunometabolism has aroused continuous attention in aspect of nutrition therapy and immune intervention for sepsis. Nutrition metabolites include amino acids, fatty acids, and glucose metabolites, which are not only the nutritional ingredients, but also the regulators of innate immune and adaptive immune. Fatty acids and glucose metabolites are involved in regulation of immune response mainly via free fatty acid receptors and AMP-activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) signaling pathway. Here, we summarized the research progress on the roles of nutrition metabolites in nutrition therapy and immune regulation during sepsis, which could provide a new direction for the development of metabolic therapy for sepsis.
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