Qingqing Zhang

Zhongda Hospital Southeast University

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Jie Zhang

Hunan Provincial Maternal and Child Health Hospital

Xiaoyan Pan

Xi'an Jiaotong University

Ru Si

Xi'an Jiaotong University

Huanan Luo

Second Affiliated Hospital of Xi'an Jiaotong University

Nanxin Liu

First Affiliated Hospital of Xi'an Jiaotong University

Ruixin Guo

Tianjin University of Science and Technology

Jin Wang

Xi'an Jiaotong University

Meng Xie

Second Affiliated Hospital of Xi'an Jiaotong University

Sijing Ma

Hunan Academy of Traditional Chinese Medicine

Pan Huang

Central South University of Forestry and Technology

Cooperative Institutions

Xi'an Jiaotong University

Shanghai Jiao Tong University

Chinese Academy of Sciences

Nanjing Medical University

Chinese Academy of Medical Sciences & Peking Union Medical College

Harbin Medical University

Capital Medical University

Peking University

Second Affiliated Hospital of Xi'an Jiaotong University

Sun Yat-sen University

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Rescue of cAMP Response Element‐Binding Protein Signaling Reversed Spatial Memory Retention Impairments Induced by Subanesthetic Dose of Propofol

CNS Neuroscience & Therapeutics (2013)

Hao Zhang Shao‐Bo Zhang Qingqing Zhang Meng Liu Xingying He

Summary Aims The intravenous anesthetic propofol caused episodic memory impairments in human. We hypothesized propofol caused episodic‐like spatial memory retention but not acquisition impairments in rats and rescuing c AMP response element‐binding protein ( CREB ) signaling using selective type IV phosphodiesterase (PDEIV) inhibitor rolipram reversed these effects. Methods Male S prague‐ D awley rats were randomized into four groups: control; propofol (25 mg/kg, intraperitoneal); rolipram; and rolipram + propofol (pretreatment of rolipram 25 min before propofol, 0.3 mg/kg, intraperitoneal). Sedation and motor coordination were evaluated 5, 15, and 25 min after propofol injection. Invisible Morris water maze ( MWM ) acquisition and probe test (memory retention) were performed 5 min and 24 h after propofol injection. Visible MWM training was simultaneously performed to resist nonspatial effects. Hippocampal CREB signaling was detected 5 min, 50 min, and 24 h after propofol administration. Results Rolipram did not change propofol‐induced anesthetic/sedative states or impair motor skills. No difference was found on the latency to the platform during the visible MWM . Propofol impaired spatial memory retention but not acquisition. R olipram reversed propofol‐induced spatial memory impairments and suppression on c AMP levels, C a MKII α and CREB phosphorylation, brain‐derived neurotropic factor ( BDNF ) and Arc protein expression. Conclusions Propofol caused spatial memory retention impairments but not acquisition inability possibly by inhibiting CREB signaling.

Rolipram

Intraperitoneal injection

10.1111/cns.12088

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Citations (18)

The Development of Digital Financial Inclusion in China

Academic Journal of Business & Management (2023)

Anni Hu Qingqing Zhang Jianan Sui Yongkang Zhang Chen Yang

"The development of China's digital financial inclusion" is an important research field that has attracted much attention in recent years. Digital financial inclusion refers to the use of emerging technologies such as the Internet, big data, and artificial intelligence to provide the general public with more convenient, efficient, and low-cost financial services. Digital financial inclusion has become an important means to promote financial inclusion. In recent years, the development of my country's digital financial inclusion has achieved world-renowned achievements. However, there are still many issues and challenges to be resolved. For example, information asymmetry, difficulty in risk control, and imperfect regulatory policies are still the main obstacles to the development of digital financial inclusion. This article will discuss the background, development, problems and challenges, and future development directions of China's digital financial inclusion, aiming to give readers a comprehensive understanding of the development status and future trends of China's digital financial inclusion.

Digital Inclusion

10.25236/ajbm.2023.050815

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Citations (1)

3D transient CFD modelling of a scroll-type hydrogen pump used in FCVs

International Journal of Hydrogen Energy (2018)

Qingqing Zhang Jianmei Feng Wen Jie Xueyuan Peng

Scroll compressor

Volumetric efficiency

Leakage (economics)

Transient (computer programming)

Hydrogen vehicle

Positive displacement meter

10.1016/j.ijhydene.2018.08.158

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Citations (73)

Design, synthesis, and biological evaluation of trizole-based heteroaromatic derivatives as Bcr-Abl kinase inhibitors

European Journal of Medicinal Chemistry (2022)

Xiaoyan Pan Nanxin Liu Yuying Liu Qingqing Zhang Kai Wang

K562 cells

ABL

ADME

IC50

breakpoint cluster region

Docking (animal)

Chronic myelogenous leukemia

10.1016/j.ejmech.2022.114425

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Citations (6)

Research on the Interpretability Analysis Method of Transient Stability Assessment in Power Systems Based on Deep Learning

Qinfeng Ma Qingqing Zhang Mingshun Liu Jie Zhang Yihua Zhu

Interpretability

Transient (computer programming)

10.2991/978-94-6463-490-7_44

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Citations (0)

Iron-Catalyzed Photoredox Functionalization of Methane and Heavier Gaseous Alkanes: Scope, Kinetics, and Computational Studies

Organic Letters (2022)

Qingqing Zhang Shuyang Liu Jinglan Lei Yongqiang Zhang Changgong Meng

Herein, we report the development of the photocatalytic C-H functionalization of methane, ethane, and heavier gaseous alkanes with good yields and selectivity, broad scope (57 examples), mild conditions, and low cost. Kinetics and density functional theory calculations were investigated for the key photoinduced ligand-to-metal charge transfer and hydrogen atom transfer processes to reveal the detailed mechanism of iron photocatalysis. This work may bring novel ideas for feedstock upgrading and catalyst design.

Surface Modification

Hydrogen atom

Scope (computer science)

10.1021/acs.orglett.2c00224

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Citations (61)

Adaptive coloured noise multirate Kalman filter and its application in coseismic deformations

Geophysical Journal International (2023)

Changxin Chen Xu Lin Wei Li Lin Cheng Hongyue Wang

SUMMARY The accuracy and sampling rate of a coseismic displacement and velocity waveform can be improved by fusing Global Navigation Satellite System (GNSS) and strong motion (SM) sensor data with a multirate Kalman filter. However, many studies have shown that the noise in GNSS coseismic waveforms includes coloured noise, and it is challenging to obtain proper GNSS and SM fusion results if the GNSS coloured noise is not accurately represented. In this paper, we propose a coloured noise multirate Kalman filter, which uses a stochastic model for modelling the GNSS coloured noise to achieve an accurate fusion of data from GNSS and SM for different sampling rates. In addition, we also propose an estimation method for the multirate Kalman filter stochastic model under coloured noise to achieve the optimal adaptive fusion of GNSS and SM data. After the reliability of the proposed method was confirmed using Monte Carlo simulations and earthquake engineering data tests, the proposed method was applied to data collected from the 2019 Mw 7.1 Ridgecrest earthquake and 2016 Mw 7.8 Kaikoura earthquake. The test results show that the proposed method can effectively fuse GNSS and SM data and accurately obtain broadband coseismic displacement and velocity waveforms.

Sensor Fusion

10.1093/gji/ggad117

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Citations (1)

A Potential Molecular Inhibitor of the SARS-COV-2 Main Protease Obtained by Virtual Screening

Research Square (Research Square) (2023)

Nanxin Liu Zeyu Yang Yuying Liu Xintao Dang Qingqing Zhang

Abstract SARS-CoV-2 has been out breaking around the world for more than three years and continues to evolve variants, which has become a major global health threat. Main protease (M pro , also called 3CL pro ) plays a key role in viral replication and proliferation, making it an attractive drug target. Here, we have identified novel potential inhibitor of M pro by applying a virtual screening of hundreds Nilotinib structure-like compounds we designed and synthesized. The screened compounds were followed for the SP docking, XP docking, MM-GBSA analysis, IFD docking, MD simulation, ADME/T prediction and then enzymatic assay in vitro . We finally identified compound V291 as a potential SARS-COV-2 M pro inhibitor with high docking affinity and enzyme inhibitory activity. Moreover, the docking results indicate that His41 is a favorable amino acid for pi-pi inter-actions, while Glu166 can participate in salt bridge formation with protonated primary or secondary amines in the screened molecules. Thus, compounds reported here are capable of engaging the key amino acids His41 and Glu166 in ligand-receptor interactions. Pharmacophore analysis further validates this assertion.

ADME

Docking (animal)

10.21203/rs.3.rs-2826336/v1

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Hydronidone ameliorates liver fibrosis by inhibiting activation of hepatic stellate cells via Smad7‐mediated degradation of TGFβRI

Liver International (2023)

Xianjun Xu Yuecheng Guo Xin Luo Zhenyang Shen Zhongshang Sun

Abstract Background and Purpose Liver fibrosis is a wound‐healing reaction that eventually leads to cirrhosis. Hydronidone is a new pyridine derivative with the potential to treat liver fibrosis. In this study, we explored the antifibrotic effects of hydronidone and its potential mode of action. Methods The anti‐hepatic fibrosis effects of hydronidone were studied in carbon tetrachloride (CCl 4 )‐ and 3,5‐diethoxycarbonyl‐1,4‐dihydrocollidine (DDC)‐ induced animal liver fibrosis. The antifibrotic mechanisms of hydronidone were investigated in hepatic stellate cells (HSCs). The antifibrotic effect of hydronidone was further tested after Smad7 knockdown in HSCs in mouse models of fibrosis. Results In animal models, hydronidone attenuated liver damage and collagen accumulation, and reduced the expression of fibrosis‐related genes. Hydronidone decreased the expression of fibrotic genes in HSCs. Impressively, hydronidone significantly upregulated Smad7 expression and promoted the degradation of transforming growth factor β receptor I (TGFβRI) in HSCs and thus inhibited the TGFβ‐Smad signalling pathway. Specific knockdown of Smad7 in HSCs in vivo blocked the antifibrotic effect of hydronidone. Conclusion Hydronidone ameliorates liver fibrosis by inhibiting HSCs activation via Smad7‐mediated TGFβRI degradation. Hydronidone is a potential drug candidate for the treatment of liver fibrosis.

Hepatic stellate cell

Hepatic fibrosis

Degradation

10.1111/liv.15715

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Citations (6)

Organizational Culture Status and Building Strategies of Business Health Clubs from the Concept of Value

Shenyang Tiyu Xueyuan xuebao (2011)

Qingqing Zhang

This paper defines and explains the concept of organizational values,meaning and the relationship between them and the culture of organization.By the tool of CTT culture conversion,it measures and analyzes the organizational culture status of part of the commercial health clubs in Nanjing,and sums up the current cultural advantages and disadvantages of fitness clubs.Drawing on the existing research findings,it proposes the building strategies of organizational culture of the health clubs,in order to put forward reference for promoting the sustainable development of our country's health clubs.

Value (mathematics)

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