Jing Liu

Hebei Medical University

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Qi Zhou

Zhejiang University

Yu Jiang

Northwest A&F University

Luohao Xu

Southwest University

Valentina Peona

Swiss Ornithological Institute

Alexander Suh

Institute for Biodiversity

Martin Irestedt

Swedish Museum of Natural History

Knud A. Jønsson

Natural History Museum Aarhus

Patric Jern

Uppsala University

Sheng‐Hua Ying

Zhejiang University

Julie Blommaert

Plant & Food Research

Cooperative Institutions

Chinese Academy of Sciences

185

Ministry of Agriculture and Rural Affairs

129

Northwest A&F University

125

Zhejiang University

National Research Institute of Brewing

University of Chinese Academy of Sciences

Chinese Academy of Agricultural Sciences

John Wiley & Sons (United States)

Chinese Academy of Medical Sciences & Peking Union Medical College

Peking University

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Distribution, expression and methylation analysis of positively selected genes provides insights into the evolution in Brassica rapa

PLoS ONE (2021)

Yue Guo Jing Liu Xingna Wang Ying Li Xilin Hou

It is believed that positive selection is one of the major evolutionary forces underlying organism phenotypic diversification. Nevertheless, the characteristics of positively selected genes (PSGs), have not been well investigated. In this study, we performed a genome-wide analysis of orthologous genes between Brassica rapa (B. rapa) and Brassica oleracea (B. oleracea), and identified 468 putative PSGs. Our data show that, (1) PSGs are enriched in plant hormone signal transduction pathway and the transcription factor family; (2) PSGs are significantly lower expressed than randomly selected non-PSGs; (3) PSGs with tissue specificity are significantly higher expressed in the callus and reproductive tissues (flower and silique) than in vegetable tissues (root, stem and leaf); (4) the proportion of PSGs is positively correlated with the number of retained triplication gene copies, but the expression level of PSGs decay with the increasing of triplication gene copies; (5) the CG and CHG methylation levels of PSGs are significantly higher in introns and UTRs than in the promoter and exon regions; (6) the percent of transposable element is in proportion to the methylation level, and DNA methylation (especially in the CG content) has the tendency to reduce the expression of PSGs. This study provides insights into the characteristics, evolution, function, expression and methylation of PSGs in B. rapa.

Brassica rapa

10.1371/journal.pone.0256120

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Citations (1)

TOC

Gastrointestinal Endoscopy (2004)

B Petersen Alan Barkun Steven Carpenter Perapa Chotiprasidhi Ram Chuttani

10.1016/s0016-5107(04)02003-6

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Citations (0)

A novel PCV2 ORF5-interacting host factor YWHAB inhibits virus replication and alleviates PCV2-induced cellular response

Veterinary Microbiology (2020)

Kangkang Guo Xiuping Zhang Yufeng Hou Jing Liu Quanwen Feng

Host factors

Circovirus

10.1016/j.vetmic.2020.108893

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Citations (7)

Research progress of GABAergic system in drug addiction

Chin J Psychiatry (2019)

Jing Liu Xu Wenjin Qingxiao Hong

药物成瘾是一种慢性和复发性的脑部疾病。长期药物滥用影响脑部诸多神经系统，尤其是与奖赏、动机、学习记忆和自控等行为有关的神经环路，导致强烈、不可控的药物渴求和与之相关的强迫性觅药行为。γ-氨基丁酸（γ-amino-butylic acid，GABA）能系统是脑内主要中枢神经系统，参与生物体多种生理功能，其功能失调可能与精神分裂症、抑郁症、癫痫、痴呆及其他记忆障碍等神经精神疾病有关。目前越来越多的研究表明，GABA能系统在药物成瘾和复吸过程中有重要作用，其不仅可以调节多巴胺系统还可以调节谷氨酸能系统功能。本文中较系统地阐述了GABA能系统在药物成瘾过程中的作用研究进展，为临床药物成瘾和复吸的治疗提供重要的理论依据和新思路。

10.3760/cma.j.issn.1006-7884.2019.02.009

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Ochratoxin A induces DNA damage and G2 phase arrest in human esophageal epithelium Het-1A cells <i>in vitro </i>

The Journal of Toxicological Sciences (2015)

Jing Liu Sha Wu Haitao Shen Jinfeng Cui Yuan Wang

Ochratoxin A (OTA), a toxin produced by several species of Aspergillus and Penicillium, is one of the most abundant food-contaminating mycotoxins. The International Agency for Research on Cancer (IARC) has classified OTA as a possible human carcinogen. Our previous study showed that there were high levels of OTA contaminations in wheat in the areas with high incidence of esophageal cancer in north China. This finding suggests that exposure to low levels of OTA may be a critical etiological factor for esophageal cancer in these areas. However, up to now, the potential biological effects of OTA on human esophageal epithelial cells have not been fully elucidated. In the present study, we explored the cytotoxicity of OTA in human esophageal epithelium immortalized cells (Het-1A). We found that OTA could induce DNA strand breaks and chromosome aberrations in Het-1A cells. OTA-induced DNA damage was followed by G2 cell cycle arrest, and down-regulation of Cdc2 and cyclinB1 contributed to the OTA-induced G2 arrest in Het-1A cells. Additionally, OTA induced apoptosis in Het-1A cells by activating caspase-3. In conclusion, our results indicated that OTA could induce DNA damage, G2 arrest and apoptosis in Het-1A cells, which may be involved in the esophageal toxicity of OTA.

Comet Assay

10.2131/jts.40.657

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Citations (30)

De novo assembly of a Chinese soybean genome

Science China Life Sciences (2018)

Yanting Shen Jing Liu Haiying Geng Jixiang Zhang Yucheng Liu

Sequence assembly

Genome size

10.1007/s11427-018-9360-0

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Citations (140)

Research Progress of the Role of Purple Acid Phosphatase in Plant Response to low Phosphorus Stress

Molecular Soil Biology (2021)

Mengyan Zhou Dongmei He Yachao Li Jing Liu Xiangqing Ma

10.5376/msb.2021.12.0002

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Genetic Diversity and Prevalence of Porcine Circovirus Type 2 in China During 2000-2019

Frontiers in Veterinary Science (2021)

Ning Li Jing Liu Jiali Qi Hao Feng Lei Xu

As the major pathogen for porcine circovirus-associated disease (PCVAD), porcine circovirus type 2 (PCV2) is no longer treated as an emerging virus anymore. The wide distribution of PCV2 infection in China causes huge economic losses in the swine industry. Currently, it is generally believed that PCV2 has eight genotypes (PCV2a to PCV2h), with PCV2a, PCV2b, and PCV2d being widely distributed. To comprehensively explore the genetic diversity and prevalence of PCV2 in China, PCV-2 sequences submitted from China in the GenBank database were retrieved. With a total of 714 PCV2 strains were retrieved, we found that early-submitted PCV2 sequences were mainly collected from coastal provinces in the southeast part of China, which may indicate PCV2 was initially circulating in those regions. From 2002 to 2008, PCV2b was the dominant prevalent genotype in those retrieved sequences. From 2009, PCV2d became the dominant genotype in those sequences, dropping a hint that a potential shift of PCV2b to PCV2d might occur in 2009, which is similar to the patterns at the global level. In addition to the PCV2a, PCV2b, and PCV2d genotypes, novel strains were also characterized. We further revealed that the amino acid sequences consistency of PCV2a Cap is higher than those in other genotypes. Together, this study provided clues for the possible prevalent genotypes and dynamics of genetic diversity in China from 2000 to 2019.

10.3389/fvets.2021.788172

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Citations (11)

Characterization of the Hog1 MAPK pathway in the entomopathogenic fungus Beauveria bassiana

Environmental Microbiology (2017)

Jing Liu Zhikang Wang Huanhuan Sun Sheng‐Hua Ying Ming‐Guang Feng

High-osmolarity glycerol (HOG) pathway required for yeast osmoregulation relies upon the mitogen-activated protein kinase (MAPK) Hog1 cascade that comprise the MAPKKKs Ssk2/Ssk22 and Ste11 converging on the MAPKK Pbs2. Here we show a Hog1 cascade with the unique MAPKKK Ssk2 acting in Beauveria bassiana. Hypersensitivity to high osmolarity and high resistance to fludioxonil fungicide appeared in Δssk2, Δpbs2 and Δhog1 mutants whereas the two hallmark phenotypes were reversed in Δste11. Increased sensitivity to heat shock and decreased sensitivity to cell wall perturbation also occurred in the three mutants but not in Δste11 although antioxidant phenotypes were different in all deletion mutants. Intriguingly, signals of Hog1 phosphorylation induced by osmotic, oxidative and thermal cues were present in Δste11 but absent in Δssk2 and Δpbs2. Moreover, vegetative growth on minimal media with different carbon/nitrogen sources was much more suppressed in Δste11 and Δssk2 than in Δpbs2 and Δhog1 although all mutants suffered similar, but severe, conidiation defects on a standard medium. Normal host infection was abolished in Δste11 while virulence was differentially attenuated in other mutants. Our findings exclude Ste11 from the Hog1 cascade that regulates multiple stress responses and environmental adaptation of B. bassiana and perhaps other filamentous fungi.

Conidiation

10.1111/1462-2920.13671

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Citations (70)

A new species of the Asian leaf litter toad genus Leptobrachella (Amphibia, Anura, Megophryidae) from southwest China

ZooKeys (2020)

Shize Li Jing Liu Gang Wei Bin Wang

A new species of the Asian leaf litter toad genus Leptobrachella from Guizhou Province, China is described based on molecular phylogenetic analyses, morphological comparisons, and bioacoustics data. Phylogenetic analyses based on the mitochondrial 16S rRNA gene sequences supported the new species as an independent clade nested into the Leptobrachella clade and sister to L. bijie . The new species could be distinguished from its congeners by a combination of the following characters: small body size (SVL 30.8–33.4 mm in seven adult males, and 34.2 mm in one adult female); dorsal skin shagreened, some of the granules forming longitudinal short skin ridges; tympanum distinctly discernible, slightly concave; internasal distance longer than interorbital distance; supra-axillary, femoral, pectoral and ventrolateral glands distinctly visible; absence of webbing and lateral fringes on fingers; toes with rudimentary webbing and shallow lateral fringes, relative finger lengths II < IV < I < III; heels overlapped when thighs are positioned at right angles to the body; and tibia-tarsal articulation reaches the tympanum.

Tympanum (architecture)

Sister group

10.3897/zookeys.943.51572

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Citations (15)