Heng Zhang

Huazhong University of Science and Technology

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Jiamin Cheng

Chinese Academy of Sciences

Xuejiao Chen

Nanjing Medical University

Chungang Liu

Chongqing Medical University

Junjie Shen

Shanghai Sixth People's Hospital

Juanjuan Shan

Chongqing Cancer Hospital

Cheng Qian

Hua Medicine (China)

Hui Wang

Longhua Hospital Shanghai University of Traditional Chinese Medicine

Limei Liu

Chongqing University

Hao Yan

Third Affiliated Hospital of Guangzhou Medical University

Junling Zhang

Chinese Academy of Medical Sciences & Peking Union Medical College

Cooperative Institutions

Chinese Academy of Medical Sciences & Peking Union Medical College

Peking Union Medical College Hospital

Central South University

Army Medical University

Peking University

Huazhong University of Science and Technology

Southwest Hospital

Tianjin Medical University

Tianjin People's Hospital

Shanghai University of Traditional Chinese Medicine

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Supplementary Figure S1 from LSD1 Stimulates Cancer-Associated Fibroblasts to Drive Notch3-Dependent Self-Renewal of Liver Cancer Stem–like Cells

Chungang Liu Limei Liu Xuejiao Chen Jiamin Cheng Heng Zhang

LSD1 regulates liver CSCs tumour growth.

Liver Cancer

10.1158/0008-5472.22417449

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Citations (0)

The Gene Variants of Maternal/Fetal Renin-Angiotensin System in Preeclampsia: A Hybrid Case-Parent/Mother-Control Study

Scientific Reports (2017)

Heng Zhang Yingxue Li Weijun Peng Zhiwei Li Chunhua Zhang

Abstract Preeclampsia (PE) is a common pregnancy-related complication, and polymorphisms in angiotensinogen ( AGT ), angiotensin-converting enzyme ( ACE ), and angiotensin II type 1 receptor ( AT1R ) are believed to contribute to PE development. We implemented a hybrid study to investigate the influence of maternal and fetal ACE I/D, ACE G2350A, AGT M235T, AGT T174M, and AT1R A1166C polymorphisms on PE in Han Chinese women. Polymorphisms were genotyped in 1,488 subjects (256 patients experiencing PE, along with their fetuses and partners, and 360 normotensive controls with their fetuses). Transmission disequilibrium tests revealed that ACE I/D ( P = 0.041), ACE G2350A ( P = 0.035), and AT1R A1166C ( P = 0.018) were associated with maternal PE. The log-linear analyses revealed that mothers whose offspring carried the MM genotype of AGT M235T had a higher risk of PE (OR = 1.54, P = 0.010), whereas mothers whose offspring carried the II genotype of ACE I/D or the GG genotype of ACE G2350A had a reduced risk (OR = 0.58, P = 0.039; OR = 0.47, P = 0.045, respectively). Our findings demonstrate that fetal ACE I/D, ACE G2350A, AGT M235T, and AT1R A1166C polymorphisms may play significant roles in PE development among pregnant Han Chinese women.

10.1038/s41598-017-05411-z

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Citations (13)

Supplementary Figure S2 from LSD1 Stimulates Cancer-Associated Fibroblasts to Drive Notch3-Dependent Self-Renewal of Liver Cancer Stem–like Cells

Chungang Liu Limei Liu Xuejiao Chen Jiamin Cheng Heng Zhang

Control of stem transcript factor expression by LSD1.

Liver Cancer

10.1158/0008-5472.22417446

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Supplementary Figure S2 from LSD1 Stimulates Cancer-Associated Fibroblasts to Drive Notch3-Dependent Self-Renewal of Liver Cancer Stem–like Cells

Chungang Liu Limei Liu Xuejiao Chen Jiamin Cheng Heng Zhang

Control of stem transcript factor expression by LSD1.

Liver Cancer

10.1158/0008-5472.22417446.v1

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Resveratrol ameliorates ionizing irradiation-induced long-term immunosuppression in mice

International Journal of Radiation Biology (2017)

Heng Zhang Hao Yan Jianzi Ying Liqing Du Chunze Zhang

Ionizing radiation has been associated with adverse effects on the immune system. Currently, there are no effective treatment options to ameliorate these effects. The aim of the present study was to investigate the protective effects of resveratrol against radiation-induced long-term immunosuppression in mice.Mice were exposed to total body irradiation and treated with resveratrol or vehicle. Several immune parameters were measured, including thymus and spleen weights, T-lymphocyte and B-lymphocyte count in peripheral blood, concanavalin A and lipopolysaccharide induced lymphocyte proliferation. To explore the mechanism, we investigated intracellular ROS level of lymphocytes and mice plasma cytokine levels.Treatment with resveratrol ameliorated TBI-induced atrophy of the thymus and spleen, reduction of lymphocyte count and decline of lymphocyte proliferation. TBI exhibited significantly reduced level of IL-2, IL-4, IL-7 and IFN-γ compared with the control mice and treatment with resveratrol attenuated the reduction.The results of the present study suggest that treatment with resveratrol could ameliorate irradiation induced long-term immune malfunction at least partly via modulation of plasma cytokine.

Immunosuppression

10.1080/09553002.2018.1408976

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Giant Intravenous Leiomyomatosis With Intracardiac Extension

The Annals of Thoracic Surgery (2012)

Heng Zhang Qi Miao Jianzhou Liu Chao Wang Chaoji Zhang

Leiomyomatosis

10.1016/j.athoracsur.2012.02.047

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Citations (4)

Supplementary Figure S1 from LSD1 Stimulates Cancer-Associated Fibroblasts to Drive Notch3-Dependent Self-Renewal of Liver Cancer Stem–like Cells

Chungang Liu Limei Liu Xuejiao Chen Jiamin Cheng Heng Zhang

LSD1 regulates liver CSCs tumour growth.

Liver Cancer

10.1158/0008-5472.22417449.v1

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Citations (0)

Administration of the Resveratrol Analogues Isorhapontigenin and Heyneanol-A Protects Mice Hematopoietic Cells against Irradiation Injuries

BioMed Research International (2014)

Hui Wang Yiling Yang Heng Zhang Hao Yan Xiaojing Wu

Ionizing radiation (IR) is known not only to cause acute bone marrow (BM) suppression but also to lead to long-term residual hematopoietic injury. These effects have been attributed to IR inducing the generation of reactive oxygen species (ROS) in hematopoietic cells. In this study, we examined if isorhapontigenin and heyneanol-A, two analogues of resveratrol, could mitigate IR-induced BM suppression. The results of cell viability assays, clonogenic assays, and competitive repopulation assays revealed that treatment with these compounds could protect mice BM mononuclear cells (BMMNC), hematopoietic progenitor cells, and hematopoietic stem cells from IR-induced BM suppression. Moreover, the expression of genes related to the endogenous cellular antioxidant system in hematopoietic cells was analyzed. The expression and activity of SOD2 and GPX1 were found to be decreased in irradiated BMMNC, and the application of the resveratrol analogues could ameliorate this damage. Our results suggest that in comparison with resveratrol and isorhapontigenin, treatment with heyneanol-A can protect hematopoietic cells from IR-induced damage to a greater degree; the protective effects of these compounds are probably the result of their antioxidant properties.

Clonogenic assay

Hematopoietic stem cell

SOD2

Viability assay

10.1155/2014/282657

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Citations (16)

Resveratrol ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice

Free Radical Biology and Medicine (2012)

Heng Zhang Zhibin Zhai Yueying Wang Junling Zhang Hongying Wu

SOD2

Sirtuin 1