An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc1mqkkg

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CCDC 1047356: Experimental Crystal Structure Determination

The Cambridge Structural Database (2016)

Rongrong Zhang Jia Liu Yu Zhang Meng-Qing Hou Ming‐Zhi Zhang

10.5517/ccdc.csd.cc144vpt

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Photodegradation of malachite green by Bi<inf>2</inf>WO<inf>6</inf> photocatalyst

Yijie Chen Yaqin Zhang Chen Liu Aiming Lu Weihua Zhang

Bi ₂ WO ₆ photocatalyst was first utilized to degrade malachite green. The effects of malachite green's initial concentration, pH, and Bi ₂ WO ₆ dosage on the photocatalytic degradation efficiency were investigated. This study presents a solution to eliminate highly toxic and persistent dyes such as malachite green.

Malachite green

Photodegradation

Degradation

10.1109/cecnet.2011.5768390

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Novel Fluorinated 7-Hydroxycoumarin Derivatives Containing an Oxime Ether Moiety: Design, Synthesis, Crystal Structure and Biological Evaluation

Molecules (2021)

Qingqing Wang Shuguang Zhang Jian Jiao Peng Dai Weihua Zhang

A series of fluorinated 7-hydroxycoumarin derivatives containing an oxime ether moiety have been designed, synthesized and evaluated for their antifungal activity. All the target compounds were determined by 1H-NMR, 13C-NMR, FTIR and HR-MS spectra. The single-crystal structures of compounds 4e, 4h, 5h and 6c were further confirmed using X-ray diffraction. The antifungal activities against Botrytis cinerea (B. cinerea), Alternariasolani (A. solani), Gibberella zeae (G. zeae), Rhizoctorzia solani (R. solani), Colletotrichum orbiculare (C. orbiculare) and Alternaria alternata (A. alternata) were evaluated in vitro. The preliminary bioassays showed that some of the designed compounds displayed the promising antifungal activities against the above tested fungi. Strikingly, the target compounds 5f and 6h exhibited outstanding antifungal activity against B. cinerea at 100 μg/mL, with the corresponding inhibition rates reached 90.1 and 85.0%, which were better than the positive control Osthole (83.6%) and Azoxystrobin (46.5%). The compound 5f was identified as the promising fungicide candidate against B. cinerea with the EC50 values of 5.75 μg/mL, which was obviously better than Osthole (33.20 μg/mL) and Azoxystrobin (64.95 μg/mL). Meanwhile, the compound 5f showed remarkable antifungal activities against R. solani with the EC50 values of 28.96 μg/mL, which was better than Osthole (67.18 μg/mL) and equivalent to Azoxystrobin (21.34 μg/mL). The results provide a significant foundation for the search of novel fluorinated 7-hydroxycoumarin derivatives with good antifungal activity.

Alternaria solani

Moiety

EC50

10.3390/molecules26020372

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Automatic segmentation and visualization of cortical and marrow bone in mandibular condyle on CBCT: a preliminary exploration of clinical application

Oral Radiology (2024)

Qinxin Wu Bin Feng Wenxuan Li Weihua Zhang Jun Wang

10.1007/s11282-024-00780-4

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Validated hydrophilic interaction LC–MS/MS method for simultaneous quantification of dacarbazine and 5-amino-4-imidazole-carboxamide in human plasma

Talanta (2008)

Yanhong Liu Weihua Zhang Yuhui Yang

Amide

Monolithic HPLC column

Carboxamide

10.1016/j.talanta.2008.07.004

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Rational design and discovery of novel hydrazide derivatives as potent succinate dehydrogenase inhibitors inspired by natural d/l‐camphor

Pest Management Science (2024)

Peng Dai Zihua Ma Guangfu Yi Yufei Li Kaili Xie

Abstract BACKGROUND Succinate dehydrogenase inhibitors (SDHIs) have rapidly become one of the fastest‐growing categories of fungicides used against plant pathogenic fungi. Recent research advancements have emphasized that structural modifications of SDHIs using naturally sourced scaffolds represent an innovative strategy for developing new, highly effective, broad‐spectrum fungicides. A novel series of d/l ‐camphorhydrazide derivatives potentially targeting fungal succinate dehydrogenase (SDH) were designed, synthesized and evaluated for their antifungal effects against Rhizoctonia solani , Fusarium graminearum , Valsa mali and Botrytis cinerea . RESULTS Amongst them, compounds A1‐7 ( d ‐camphor) and A2‐7 ( l ‐camphor) displayed excellent in vitro activity against R. solani with median effective concentration (EC 50 ) values of 0.38 and 0.48 μg mL −1 , which were obviously superior to that of boscalid (0.87 μg mL −1 ). A2‐5 ( l ‐camphor, EC 50 = 3.27 μg mL −1 ) exhibited good activity against V. mali . A2‐7 (2.13 μg mL − 1), A2‐21 (5.2 μg mL −1 ) and A1‐5 (5.15 μg mL −1 ) showed good antifungal activity against F. graminearum with EC 50 values below that of boscalid (5.85 μg mL −1 ). Preliminary mechanistic studies, using scanning and transmission electron microscopy, indicated that compound A1‐7 induced disordered entanglement of hyphae, shrinkage of hyphal surfaces, and vacuole swelling and rupture, which disrupted normal hyphal growth. Additionally, compound A1‐7 induced the production and accumulation of reactive oxygen species, disrupted mitochondrial membrane potential, and effectively inhibited the germination and formation of sclerotia in R. solani . Moreover, the molecular docking results and SDH enzyme assays yielded promising outcomes. CONCLUSION In this study, the designed and optimized compounds A1‐7 and A2‐7 emerged as promising candidates for SDH‐targeting fungicides, demonstrating strong antifungal activity. These compounds hold potential as new antifungal agents for further research. © 2024 Society of Chemical Industry.

Camphor

10.1002/ps.8481

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Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

WOS (2019)

Paul S. de Vries Michael R. Brown Amy R. Bentley Yan V. Sun Thomas W. Winkler

Genome-wide Association Study

Source

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