Zhibin Zhang

Nanjing University

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Judy Lieberman

Harvard University

Xing Liu

Institute of Zoology

Hao Wu

Southwest Medical University

Qing Kong

Ocean University of China

Shiyu Xia

Xiamen University

Yuelin Zhang

University of British Columbia

Ying Zhang

Center for Life Sciences

Du Zhu

Jiangxi Science and Technology Normal University

Youdong Pan

Brigham and Women's Hospital

Minghui Gao

Guangzhou Institutes of Biomedicine and Health

Cooperative Institutions

Harvard University

Chinese Academy of Sciences

Boston Children's Hospital

University of Chinese Academy of Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

Northeast Normal University

National Institute of Biological Sciences, Beijing

China Agricultural University

University of British Columbia

Peking University

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Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis

Nature (2022)

Wanyan Deng Yang Bai Fan Deng Youdong Pan Shenglin Mei

Pyroptosis

Streptococcus Pyogenes

Virulence factor

Exotoxin

Cysteine protease

10.1038/s41586-021-04384-4

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Citations (232)

Two redundant receptor-like cytoplasmic kinases function downstream of pattern recognition receptors to regulate activation of SA biosynthesis in Arabidopsis

PLANT PHYSIOLOGY (2016)

Qing Kong Tongjun Sun Na Qu Junling Ma Meng Li

Salicylic acid (SA) serves as a critical signaling molecule in plant defense. Two transcription factors, SARD1 and CBP60g, control SA biosynthesis through regulating pathogen-induced expression of Isochorismate Synthase1, which encodes a key enzyme for SA biosynthesis. Here, we report that Pattern-Triggered Immunity Compromised Receptor-like Cytoplasmic Kinase1 (PCRK1) and PCRK2 function as key regulators of SA biosynthesis. In the pcrk1 pcrk2 double mutant, pathogen-induced expression of SARD1, CBP60g, and ICS1 is greatly reduced. The pcrk1 pcrk2 double mutant, but neither of the single mutants, exhibits reduced accumulation of SA and enhanced disease susceptibility to bacterial pathogens. Both PCRK1 and PCRK2 interact with the pattern recognition receptor FLS2, and treatment with pathogen-associated molecular patterns leads to rapid phosphorylation of PCRK2. Our data suggest that PCRK1 and PCRK2 function downstream of pattern recognition receptor in a signal relay leading to the activation of SA biosynthesis.

WRKY protein domain

10.1104/pp.15.01954

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Citations (53)

Expression patterns of long non-coding RNAs in peripheral blood mononuclear cells of non-segmental vitiligo

Medicine (2021)

Shulan Zhang Xinyue Yang Zhibin Zhang Yifeng Xiong Yingpeng Zhang

We explored the patterns of long non-coding RNA (lncRNA) expression in peripheral blood mononuclear cells (PBMCs) from patients with non-segmental vitiligo.We used high-throughput RNA sequencing technology to generate sequence data from five patients with non-segmental vitiligo alongside five normal healthy individuals, and then performed bioinformatics analyses to detect the differential expression of lncRNA in PBMCs. Gene Ontology (GO) and pathway analyses were performed for functional annotation, and quantitative real-time polymerase chain reaction (qRT-PCR) was used to verify gene expression. Target miRNAs and mRNAs of differentially expressed lncRNAs were predicted using bioinformatics analysis.A total of 292 lncRNAs were differentially expressed in non-segmental vitiligo (fold change ≥ 2.0, P < .05), of which 171 were upregulated and 121 were downregulated. Six differentially expressed lncRNAs were selected, namely ENST00000460164.1, ENST00000393264.2, NR-046211.1, NR-135491.1, NR-135320.1, and ENST00000381108.3, for validation by qRT-PCR. The results showed that ENST00000460164.1 and NR-046211.1 were highly expressed in PBMCs of non-segmental vitiligo. An lncRNA-miRNA-mRNA network containing two lncRNAs, 17 miRNAs, and 223 mRNAs was constructed.Our results revealed patterns of differentially expressed lncRNAs in the PBMCs of non-segmental vitiligo individuals. ENST00000460164.1, and NR-046211.1 may be potential biomarkers and drug targets for the treatment of non-segmental vitiligo.

Vitiligo

10.1097/md.0000000000028399

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Citations (4)

Cytisine: State of the art in pharmacological activities and pharmacokinetics

Biomedicine & Pharmacotherapy (2024)

Xuezhen Wang Jiaming Yang Peifeng Huang Dong Wang Zhibin Zhang

Cytisine is a naturally occurring bioactive compound, an alkaloid mainly isolated from legume plants. In recent years, various biological activities of cytisine have been explored, showing certain effects in smoking cessation, reducing drinking behavior, anti-tumor, cardiovascular protection, blood sugar regulation, neuroprotection, osteoporosis prevention and treatment, etc. At the same time, cytisine has the advantages of high efficiency, safety, and low cost, has broad development prospects, and is a drug of great application value. However, a summary of cytisine's biological activities is currently lacking. Therefore, this paper summarizes the pharmacological action, mechanism, and pharmacokinetics of cytisine by referring to numerous databases, and analyzes the new and core targets of cytisine with the help of computer simulation technology, to provide reference for doctors.

Cytisine

10.1016/j.biopha.2024.116210

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Citations (3)

MEKK1, MKK1/MKK2 and MPK4 function together in a mitogen-activated protein kinase cascade to regulate innate immunity in plants

Cell Research (2008)

Minghui Gao Jinman Liu Dongling Bi Zhibin Zhang Fang Cheng

Bimolecular fluorescence complementation

Genetic screen

10.1038/cr.2008.300

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Citations (406)

<p>Circular RNA Circ_0016760 Modulates Non-Small-Cell Lung Cancer Growth Through the miR-577/ZBTB7A Axis</p>

Cancer Management and Research (2020)

Yanhong Hao Junfeng Xi Peng Yancai Burong Bian Guangjun Hao

Patients with locally advanced or metastatic non-small-cell lung cancer (NSCLC) have a poor prognosis. Circular RNA circ_0016760 (circ_0016760) is associated with the development of NSCLC. At present, the role and regulatory mechanism of circ_0016760 in NSCLC have not been well explained.Quantitative real-time polymerase chain reaction (qRT-PCR) was executed to detect the expression of circ_0016760, miR-577, and Zinc finger and BTB domain containing 7A (ZBTB7A) mRNA in NSCLC tissues and cells. The colony formation, migration, invasion, and extracellular acidification rate (ECAR) of NSCLC cells were determined through colony formation, transwell, or ECAR assays. The relationship between circ_0016760 or ZBTB7A and miR-577 was analyzed via dual-luciferase reporter and RNA pull-down or RNA immunoprecipitation (RIP) assays. Protein level of ZBTB7A was evaluated with Western blot analysis. Xenograft assay was conducted to confirm the role of circ_0016760 in vivo.Circ_0016760 and ZBTB7A were upregulated and miR-577 was downregulated in NSCLC tissues and cells. Circ_0016760 exhaustion curbed the colony formation, migration, invasion, and ECAR of NSCLC cells in vitro and impeded tumor growth in vivo. Mechanically, circ_0016760 modulated ZBTB7A expression via sponging miR-577 in NSCLC cells. MiR-577 downregulation abolished the repressive effects of circ_0016760 silencing on colony formation, migration, invasion, and ECAR of NSCLC cells. Also, ZBTB7A upregulation overturned the repressive impacts of miR-577 elevation on colony formation, migration, invasion, and ECAR of NSCLC cells.Circ_0016760 silencing impeded NSCLC advancement through regulation of the miR-577/ZBTB7A axis.

Circular RNA

10.2147/cmar.s243675

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Citations (15)

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

Nature (2016)

Xing Liu Zhibin Zhang Jianbin Ruan Youdong Pan Venkat Giri Magupalli

Pyroptosis

Cleavage (geology)

10.1038/nature18629

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Citations (2,533)

PNPT1 Release from Mitochondria during Apoptosis Triggers Decay of Poly(A) RNAs

Cell (2018)

Xing Liu Rui Fu Youdong Pan Karla F. Meza‐Sosa Zhibin Zhang

Exoribonuclease

Intermembrane space

10.1016/j.cell.2018.04.017

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Citations (79)

Inhibition of Transmural Inflammation in Crohn’s Disease by Orally Administered Tumor Necrosis Factor-Alpha Deoxyribozymes-Loaded Pyroptosis Nanoinhibitors

ACS Applied Materials & Interfaces (2024)

Zhun Li Zhenxing Zhu Dongtao Zhou Yusheng Chen Yi Yin

Crohn's disease (CD) is a refractory chronic inflammatory bowel disease (IBD) with unknown etiology. Transmural inflammation, involving the intestine and mesentery, represents a characteristic pathological feature of CD and serves as a critical contributor to its intractability. Here, this study describes an oral pyroptosis nanoinhibitor loaded with tumor necrosis factor-α (TNF-α) deoxyribozymes (DNAzymes) (DNAzymes@degradable silicon nanoparticles@Mannose, Dz@MDSN), which can target macrophages at the site of inflammation and respond to reactive oxygen species (ROS) to release drugs. Dz@MDSN can not only break the inflammatory cycle in macrophages by degrading TNF-α mRNA but also reduce the production of ROS mainly from macrophages. Moreover, Dz@MDSN inhibits excessive pyroptosis in epithelial cells through ROS clearance, thereby repairing the intestinal barrier and reducing the translocation of intestinal bacteria to the mesentery. Consequently, these combined actions synergistically contribute to the suppression of inflammation within both the intestine and the mesentery. This study likely represents the first successful attempt in the field of utilizing nanomaterials to achieve transmural healing for CD, which also provides a promising treatment strategy for CD patients.

Pyroptosis

10.1021/acsami.4c05921

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Citations (0)

The lysosomal Rag-Ragulator complex licenses RIPK1– and caspase-8–mediated pyroptosis by Yersinia

Science (2021)

Zengzhang Zheng Wanyan Deng Yang Bai Rui Miao Shenglin Mei

Cell death limits pathogens During infection, Yersinia inhibition of the protein kinase TAK1 triggers cleavage of the pore-forming protein gasdermin D (GSDMD), which leads to a kind of inflammatory cell death called pyroptosis. In a genome-wide screen, Zheng et al. identified a lysosome-tethered regulatory supercomplex as being a critical driver of Yersinia -induced pyroptosis. The activity of the GTPase Rag and lysosomal tethering of Rag-Ragulator were required to recruit and activate the kinase RIPK1 and protease caspase-8 to cleave GSDMD, which causes cell death and limits infection. By contrast, Rag-Ragulator was not required for inflammasome-mediated pyroptosis. Thus, metabolic signaling on lysosomes can regulate cell death during pathogenic bacterial infection. Science , abg0269, this issue p. eabg0269

Pyroptosis

RIPK1

NLRP1

10.1126/science.abg0269

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Citations (131)