Zonghui Yuan

Huazhong Agricultural University

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Qinghua Wu

Yangtze University

Yulian Wang

Nanjing University

Zhenli Liu

Huazhong Agricultural University

Xu Wang

Huazhong Agricultural University

Dongmei Chen

Huazhong Agricultural University

Dapeng Peng

Huazhong Agricultural University

Menghong Dai

Huazhong Agricultural University

Haihong Hao

University of Science and Technology of China

Guyue Cheng

Huazhong Agricultural University

Yanfei Tao

Huazhong Agricultural University

Cooperative Institutions

Huazhong Agricultural University

Universidad Complutense de Madrid

Center of Hubei Cooperative Innovation for Emissions Trading System

Chinese Academy of Sciences

China Institute of Veterinary Drug Control

Chinese Academy of Agricultural Sciences

Ministry of Agriculture and Rural Affairs

State Key Laboratory of Agricultural Microbiology

Research Institute Hospital 12 de Octubre

Sun Yat-sen University

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Permethrin-induced oxidative stress and toxicity and metabolism. A review

Environmental Research (2016)

Xu Wang María‐Aránzazu Martínez Menghong Dai Dongmei Chen Irma Arés

Neurotoxicity

10.1016/j.envres.2016.05.003

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Citations (216)

DEOXYNIVALENOL: METABOLISM AND REGIONAL DIFFERENCES IN HUMAN EXPOSURE

Military Medical Science Letters (2014)

Qinghua Wu Guang-Xu Wu Yun Wang Dan Wan Xiujuan Zhang

Deoxynivalenol (DON) is one of the most abundant mycotoxins in contaminated food and feed worldwide.It is toxic to humans and inhibits DNA, RNA and protein synthesis.In this review, the metabolism of DON and its exposure in humans from different regions are summarized.Conjugated products DON-3-glucuronide, DON-15-glucuronide, and DON-7-glucuronide are found to be the major metabolites in humans.Human exposure of DON shows some regional differences due to the different DON levels in cereal-based foods and the food intake habits.C12,13-deepoxy metabolite, DOM-1 can be found in most French populations but is rarely detected in UK adults.Spanish exposes lower DON levels than the UK populations.A very high DON exposure is detected in South Africa and Linxian, China.Fetus is shown to expose to DON during pregnancy in human.This review will provide global information of DON metabolism and exposure in humans and facilitate the mycotoxin control strategies.

10.31482/mmsl.2014.021

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Citations (4)

Development of a sensitive and robust liquid chromatography coupled with tandem mass spectrometry and a pressurized liquid extraction for the determination of aflatoxins and ochratoxin A in animal derived foods

Journal of Chromatography A (2012)

Dongmei Chen Xiaoqin Cao Yanfei Tao Qinghua Wu Yuanhu Pan

Solid phase extraction

Ochratoxins

10.1016/j.chroma.2012.06.095

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Citations (62)

Impact of Physicochemical Parameters on the Decomposition of Deoxynivalenol during Extrusion Cooking of Wheat Grits

Journal of Agricultural and Food Chemistry (2011)

Qinghua Wu Lilia Lohrey Benedikt Cramer Zonghui Yuan Hans‐Ulrich Humpf

Deoxynivalenol (DON) is a toxic secondary metabolite produced by molds of the Fusarium genus and is known to cause a spectrum of diseases in animals such as vomiting and gastroenteritis. It is found in cereals and cereal products as most processing techniques lead only to a partial reduction of deoxynivalenol levels. One technique with a reported relatively high impact on deoxynivaleol decomposition is extrusion cooking. In the current work, systematic studies of a range of physicochemical parameters, such as temperature, moisture, compression, residence time in the extruder, pH value, and protein content, on their impact on deoxynivalenol decomposition during extrusion cooking were performed. The analysis of deoxynivalenol was made by high-performance liquid chromatography--tandem mass spectrometry using a quick, easy, cheap, effective, rugged, and safe-based cleanup with 15-d(1)-deoxynivalenol as an internal standard. It could be shown that the reduction of deoxynivalenol levels is dependent on a set of parameters partially interacting with each other. Especially the moisture content and compression are key factors for the reduction of deoxynivalenol levels. A correlation between residence time of the mycotoxin in the extruder and deoxynivalenol degradation was also observed when screws without a compression factor were used. Generally, the reduction of deoxynivalenol levels was increased by the use of screws with a high compression factor. As known from cooking, deoxynivalenol could also be easily degraded by extrusion under alkaline conditions. Furthermore, an increase of the protein content of the starting material resulted in higher reduction rates of deoxynivalenol.

Extrusion cooking

10.1021/jf2038604

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Citations (59)

Development of Monoclonal Antibodies and Indirect Competitive Enzyme-Linked Immunosorbent Assay Kits for the Detection of Clenbuterol and Salbutamol in the Tissues and Products of Food-Producing Animals

Food Analytical Methods (2017)

Dapeng Peng Lingyan Zhang Chen Situ Yuanhu Pan Yanfei Tao

Clenbuterol

Hapten

Ractopamine

Isotype

10.1007/s12161-017-0925-z

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Citations (21)

Metabolic pathways of trichothecenes

Drug Metabolism Reviews (2010)

Qinghua Wu Vlastimil Dohnal Lingli Huang Kamil Kuča Zonghui Yuan

Trichothecenes are a group of mycotoxins mainly produced by the fungi of Fusarium genus. Consumers are particularly concerned over the toxicity and food safety of trichothecenes and their metabolites from food-producing animals. The metabolism of T-2 toxin, deoxynivalenol (DON), nivalenol (NIV), fusarenon-X (FX), diacetoxyscirpenol (DAS), 3-acetyldeoxy-nivalenol (3-aDON), and 15-acetyldeoxynivalenol (15-aDON) in rodents, swine, ruminants, poultry, and humans are reviewed in this article. Metabolic pathways of these mycotoxins are very different. The major metabolic pathways of T-2 toxin in animals are hydrolysis, hydroxylation, de-epoxidation, and conjugation. After being transformed to HT-2 toxin, it undergoes further hydroxylation at C-3' to yield 3'-hydroxy-HT-2 toxin, which is considered as an activation pathway, whereas transformation from T-2 to T-2 tetraol is an inactivation pathway in animals. The typical metabolites of T-2 toxin in animals are HT-2 toxin, T-2 triol, T-2 tetraol, neosolaniol (NEO), 3'-hydroxy-HT-2, and 3'-hydroxy-T-2, whereas HT-2 toxin is the main metabolite in humans. De-epoxidation is an important pathway for detoxification in animals. De-epoxy products, DOM-1, and de-epoxy-NIV are the main metabolites of DON and NIV in most animals, respectively. However, the two metabolites are not found in humans. Deacetyl can occur rapidly on the acetyl derivatives, 3-aDON, 15-aDON, and FX. DAS is metabolized in animals to 15-monoacetoxyscirpenol (15-MAS) via C-4 deacetylation and then transformed to scirpentriol (SCP) via C-15 deacetylation. Finally, the epoxy is lost, yielding de-epoxy-SCP. De-epoxy-15-MAS is also the main metabolite of DAS. 15-MAS is the main metabolite in human skin. The review on the metabolism of trichothecenes will help one to well understand the fate of these toxins' future in animals and humans, as well as provide basic information for the risk assessment of them for food safety.

Metabolic pathway

10.3109/03602530903125807

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Citations (165)

The crossability ofTriticum turgidumwithAegilops tauschii

Cereal Research Communications (2008)

Li Zhang Zehong Yan Seping Dai Qiang Chen Zonghui Yuan

Aegilops tauschii

Triticum turgidum

Subspecies

Common wheat

10.1556/crc.36.2008.3.6

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Citations (21)

Paracetamol: overdose-induced oxidative stress toxicity, metabolism, and protective effects of various compoundsin vivo and in vitro

Drug Metabolism Reviews (2017)

Xu Wang Qinghua Wu Aimei Liu Arturo Anadón José-Luis Rodríguez

Paracetamol (APAP) is one of the most widely used and popular over-the-counter analgesic and antipyretic drugs in the world when used at therapeutic doses. APAP overdose can cause severe liver injury, liver necrosis and kidney damage in human beings and animals. Many studies indicate that oxidative stress is involved in the various toxicities associated with APAP, and various antioxidants were evaluated to investigate their protective roles against APAP-induced liver and kidney toxicities. To date, almost no review has addressed the APAP toxicity in relation to oxidative stress. This review updates the research conducted over the past decades into the production of reactive oxygen species (ROS), reactive nitrogen species (RNS), and oxidative stress as a result of APAP treatments, and ultimately their correlation with the toxicity and metabolism of APAP. The metabolism of APAP involves various CYP450 enzymes, through which oxidative stress might occur, and such metabolic factors are reviewed within. The therapeutics of a variety of compounds against APAP-induced organ damage based on their anti-oxidative effects is also discussed, in order to further understand the role of oxidative stress in APAP-induced toxicity. This review will throw new light on the critical roles of oxidative stress in APAP-induced toxicity, as well as on the contradictions and blind spots that still exist in the understanding of APAP toxicity, the cellular effects in terms of organ injury and cell signaling pathways, and finally strategies to help remedy such against oxidative damage.

Acetaminophen

10.1080/03602532.2017.1354014

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Citations (87)

Crosstalk of JNK1-STAT3 is critical for RAW264.7 cell survival

Cellular Signalling (2014)

Qinghua Wu Xu Wang Dan Wan Juan Li Zonghui Yuan

Crosstalk

10.1016/j.cellsig.2014.09.013

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Citations (40)

Development of an Indirect Competitive ELISA for the Detection of Furazolidone Marker Residue in Animal Edible Tissues

Journal of Agricultural and Food Chemistry (2008)

Chao Chang Da-peng Peng Jine Wu Yulian Wang Zonghui Yuan

Due to its carcinogenicity and mutagenicity, furazolidone has been prohibited completely from being used in food animal production in the world since 1995. To monitor the illegal abuse of furazolidone, a polyclonal antibody-based indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) was developed for the determination of tissue-bound furazolidone metabolite 3-amino-2-oxazolidone (AOZ). The highly specific antibody was targeted for PAOZ, the benzaldehyde derivative of AOZ. The 50% inhibition values (IC50) of 0.91 µg/L for AOZ was achieved with the most sensitive antibody Ab-B1 by altering ELISA conditions. In the ELISA, sample extraction and cleanup were performed by an is MAX cartridge following combined hydrolysis of the tissue-bound AOZ and derivatization of the homogenized tissues with benzaldehyde. The limitsof detection (LOD) calculated from the analysis of 20 known negative tissue samples (swine liver, swine muscle, chicken liver, chicken muscle,and fish muscle) were 0.3−0.4 µg/kg (mean + 3 SD). Recoveries of AOZ fortified at the levels of 0.4, 1, and 5 μg/kg ranged from 55.8 to 96.6% in the tissues. The coefficients of variation were less than 20% over the range of AOZ concentrations studied. The linear detection range was between 0.1 and 25.6 µg/L. Validation of the ELISA method with swine muscle and liver from furazolidone-treated pigs was carried out using HPLC, resulting in a similar correlation in swine muscle (r = 0.99) and in swine liver (r = 0.98). The results suggest that this ELISA is a specific, accurate, and sensitive method of detecting AOZ residues in animal edible tissues.

Furazolidone

Polyclonal antibodies

Residue (chemistry)

10.1021/jf0726684

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Citations (43)