Objective To evaluate the safety of Qingdou Xiufu Jinghua Ye,a skin care product containing the extract of Chinese manyleaf paris rhizome,purslane and sodium hyaluronate,in the improvement of acne vulgaris.Methods A multicenter,randomized,open-label,controlled study was conducted.Totally,160 patients with acne vulgaris were equally classified into two groups to topically apply the modified Qingdou Xiufu Jinghua Ye containing the extract of Chinese manyleaf paris rhizome,purslane and sodium hyaluronate (experiment group) or the original Qingdou Xiufu Jinghua Ye containing papain,vitamin B3,extract of purslane,and salicylic acid derivate (control group),twice a day after face washing with a commercial foaming face wash.The number of acne lesions was calculated at the baseline,on day 7,14 and 28 after the start of intervention.Results Finally,11 patients were lost to follow-up,and 149 patients completed the trial,including 73 patients in the experiment group and 76 patients in the control group.The number of inflammatory lesions and total lesions significantly decreased in both groups on day 14 and 28 compared with that before intervention (all P ＜ 0.05).No statistical difference was observed in the response rate between the two groups at any of the three time points after treatment (all P ＞0.05).Conclusion The topical application of modified Qingdou Xiufu Jinghua Ye containing the extract of Chinese manyleaf paris rhizome,purslane and sodium hyaluronate is beneficial to the improvement of acne vulgaris.
To investigate the clinical pathological features of tracheobronchial foreign bodies and to improve the diagnosis and treatment.A retrospective study was conducted on 1050 cases with suspected tracheobronchial foreign bodies. Each patient was analyzed for age, sex, history, complication and location of the foreign body. Nine hundred and forty-nine out of 1050 cases were diagnosed as tracheobronchial foreign body, in which 13 patients coughed out the foreign bodies before operation and the rest 936 cases were given operation by bronchoscope under general anesthesia.Among the 949 cases, 936 cases were given operation, with successful removal of foreign bodies in 932 cases (99.6%). One patient suffered from complication (0.1%).For the diagnosis of tracheobronchial foreign bodies, it is very important to collect the detailed history of foreign body inhalation, physical examination and chest roentgenoscopy. Spiral CT with 3-D reconstruction of trachea and bronchus is performed in patients with suspected foreign bodies. Complete surface anesthesia of respiratory tract mucosa is the key procedure in the removal of foreign bodies from respiratory tract by bronchoscope.
To explore the effect of Qiwei Baizhu Powder on the intestinal flora of splenoasthenic diarrhea mice and its mechanism. The splenoasthenic diarrhea mouse model established by different modeling methods (antibiotics and traditional Chinese medicine compound prescription) was used as the experimental group, and a blank control group was set up at the same time. Qiwei Baizhu Powder was used to treat the splenoasthenic diarrhea model mice. The splenoasthenic diarrhea mouse model established by taking Dachenqi Tang (Traditional Chinese medicine Group) had the most severe splenoasthenic diarrhea and poor mental state, while without significant effect on intestinal flora (p>0.05). The splenoasthenic diarrhea mouse model constructed by gentamicin sulfate and cefradine (Antibiotic combination group) had the best effect. The results of the antimicrobial spectrum showed that the gentamicin sulfate and cefradine could form the maximum complementary effect and the effect was long-lasting. After the intragastric administration of Qiwei Baizhu Powder, the mice in the Traditional Chinese medicine Group were quickly cured and the syndrome of splenoasthenic diarrhea disappeared. The number of intestinal lactic acid bacteria and fungi in the antibiotic combination group was significantly higher than that in the normal group (p<0.01). In Qiwei Baizhu Powder, there are probiotics that promote the growth of lactic acid bacteria and fungi, which can cure the imbalance of intestinal flora.
To investigate liver fibrosis, TGF-?1 levels and curative effects on hepatocellular carcinoma (HCC) with small and conventional dose perfusion chemotherapy by transcatheter arterial chemo embolization (TACE).Thirty-six hepatocellular carcinoma patients not indicated for surgical resection underwent super- selective transcatheter arterial chemoembolization, divided into small dose (n=15) and conventional dose (n=21) chemotherapy groups.With conventional doses, four indices of liver fibrosis focusing on hyaluronate acide (HA), human procollagen type-III (hPC-III), collagen type-IV (IV-C) and transforming growth factor-βl (TGF-β1) were obviously increased postoperative compared with preoperative (P<0.01); in contrast, with small doses there were no significant differences except for TGF-β1. Five year survival demonstrated no significant differences between the two groups (P>0.05).To hepatocellular carcinoma patients treated by TACE, reducing doses of chemotherapy drugs can reduce progress of liver fibrosis, without impacting on five year survival.
Background Colorectal polyps refer to all neoplasms that protrude into the intestinal cavity. Researchers believe that 50%-70% of colorectal cancers originate from adenomatous polyps. Aim To investigate the endoscopic morphologic features, pathologic types, and clinical situation; evaluate the efficacy and safety of endoscopic mucosal resection (EMR); and guide clinicians in their daily practice. Methods Two hundred thirty-four patients who underwent EMR in our hospital from January 1, 2018 to December 31, 2019 were recruited. Data including sex, age, endoscopic morphology of the polyps, and pathological characteristics were analyzed among groups. Results A total of 295 polyps were resected from the 234 subjects enrolled in the study, of which 4 (1.36%) were Yamada type I. There were 75 (25.42%) type II, 101 (34.24%) type III, and 115 (38.98%) type IV adenomas. Among them, 41 were non-adenomas, 110 were low-risk adenomas, 139 were high-risk adenomas, and 5 were carcinomas. The differences in distribution were not statistically significant, with P values greater than 0.05. The risk of cancer significantly increased for polyps ≥ 1 cm in diameter (c2 = 199.825, P = 0.00). Regarding the endoscopic morphological features, congestion, erosion, and lobulation were more common on the surface morphology of high-risk adenomas and cancerous polyps (c2 = 75.257, P = 0.00), and most of them were Yamada types III and IV. In all, 6 of the 295 polyps could not be removed completely, with a one-time resection rate of 97.97%. There were two cases of postoperative bleeding and no cases of perforation, with an overall complication rate of 0.09%. Conclusion Colorectal polyps ranging from non-adenomatous polyps, low-risk adenomas, and high-risk adenomas to adenocarcinomas each has their own endoscopic features, while EMR, as a mature intervention, has good safety and operability and should be promoted clinically, especially at the primary care level.
This study was designed to investigate the effect of laparoscopic gastrectomy on adjuvant chemotherapy in patients with gastric cancer. Patients with gastric cancer who underwent radical gastrectomy at our institution from January 2008 to January 2015 with R0 resection, as determined by a pathological examination, were included in this study. According to the surgical approach, patients were divided into the laparoscopic gastrectomy (LG) group and open gastrectomy (OG) group. Short-term and long-term outcomes were compared between the 2 groups. Of the 206 patients enrolled in the study, 114 patients were included in the LG group and 92 patients were included in the OG group. There was no significant difference in patients' general data, including age, sex, medical comorbidities, and pathological staging, between the 2 groups. However, patients in the LG group had less intraoperative blood loss, fewer postoperative complications, and a shorter hospital stay compared with patients in the OG group. There was no significant difference in the start time of adjuvant chemotherapy between the groups. However, compared with OG, LG had the following advantages: patients received more cycles of adjuvant chemotherapy, more patients received a full dose of on-schedule adjuvant chemotherapy, and more patients completed ≥75% of the planned dose. Long-term survival and disease-free survival rates were higher in the LG than in the OG. In summary, LG can improve compliance with adjuvant chemotherapy and long-term outcomes in patients with gastric cancer.
Objective
To evaluate the efficacy of L-Arabinose for bowel preparation before colonoscopy.
Methods
A total of 170 patients who underwent colonoscopy were randomized into 2 groups. The experimental group (n=85) used L-Arabinose for bowel preparation, while the control group (n=85) used polyethylene glycol electrolyte solution (PEG-ELS). The degree of comfort, adverse effects, and the visibility during colonoscopy were observed.
Results
Premedication of L-Arabinose for bowel preparation yielded to more comfort (U=-4.349, P=0.000), less adverse effects (χ2=29.27, P=0.000), and similar visibility during colonoscopy (U=-0.875, P=0.381) compared with PEG-ELS.
Conclusion
L-Arabinose is safe, comfortable, and effective for bowel preparation before colonoscopy.
Key words:
Arabinose; Colonoscopy; Bowel preparation
Histological discrepancies between biopsy and resection specimens are common. In this study, we aimed to analyze the risk factors predicting histological upgrade or downgrade of biopsy-diagnosed gastric low-grade dysplasia (LGD).The medical records of patients with 104 biopsy-diagnosed gastric LGD from January 2011 to December 2017 were collected. The association of endoscopic characteristics with histological discrepancies between the biopsy and resection specimens was analyzed. The risk factors for histological upgrade were studied using the multivariate analysis.Among the 104 lesions, 88 were removed by endoscopic resection and 16 were monitored. The upgrade and downgrade rates of the pathological diagnosis were 48.9% and 12.5%, respectively. Lesion size >20 mm, surface redness and positive results in magnifying endoscopy with narrow band imaging (ME-NBI) were risk factors for histological upgrade. Compared with the negative ME-NBI group, the positive ME-NBI group had a higher upgrade rate (56.8% vs 7.1%) but a lower downgrade rate (2.7% vs 64.3%). In addition, 11 of the 16 the gastric LGD with negative ME-NBI findings were monitored, and all 11 lesions regressed to gastritis during follow-up.Endoscopic resection should be recommended in cases of LGD showing surface redness, with a lesion size of >20 mm or positive ME-NBI result, whereas regular follow-up may be an option for LGD with negative ME-NBI result.
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