Xin Chen

West China Medical Center of Sichuan University

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Yong‐Tang Zheng

Kunming Institute of Zoology

Chiyu Zhang

Shanghai Public Health Clinical Center

Erlie Jiang

Institute of Hematology & Blood Diseases Hospital

Yan-Heng Zhou

Peking University

Aiming Pang

Institute of Hematology & Blood Diseases Hospital

Ye Mei

East China Normal University

Qiaoling Ma

Institute of Hematology & Blood Diseases Hospital

Wei Pang

Tianjin University of Science and Technology

Caiyan Lu

Chinese Academy of Sciences

Weihua Zhai

Institute of Hematology & Blood Diseases Hospital

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Chinese Academy of Sciences

215

Chinese Academy of Medical Sciences & Peking Union Medical College

149

University of Chinese Academy of Sciences

115

Huazhong University of Science and Technology

Sun Yat-sen University

Peking University

Regeneron (United States)

Zhejiang University

Sichuan University

Central South University

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Additional file 1 of Letter to the Editor: An ultra-sensitive assay using cell-free DNA fragmentomics for multi-cancer early detection

Figshare (2022)

Hua Bao Zheng Wang Xiaoji Ma Wei Guo Xiangyu Zhang

Additional file 1 : Supplementary Table 1. Participant demographics and baseline characteristics. Supplementary Table 2. Performance of the first-level cancer detection model. Supplementary Table 3. Performances of the cancer detection model on different subgroups based on clinical characteristics. Supplementary Table 4. Cancer detection model robustness test using downsampled (4× to 1× coverage depths) WGS data. Each downsampled coverage depth was repeated five times. Supplementary Table 5. Performances of the cancer detection model on extra healthy volunteer and at-risk patient cohort. Supplementary Table 6. The performance of the second level cancer origin model shown in the confusion matrix table. Supplementary Table 7. Cancer origin model robustness test using downsampled (4× to 1× coverage depths) WGS data. Each downsampled coverage depth was repeated five times.

10.6084/m9.figshare.20056739

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Comparative study of SYBR Green Ireal time RT-PCR and conventional RT-PCR for detecting giant panda rotavirus

Zhongguo Shouyikexue (2016)

Zeng Yangru Yan Qigui Yang Rui Jie Huang Lu Ren

SYBR Green I

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Data from Role of Cyclin D1 as a Mediator of c-Met– and β-Catenin–Induced Hepatocarcinogenesis

Mohini A. Patil Susie A. Lee Everardo Macías Ernest T. Lam Chuanrui Xu

<div>Abstract<p>Activation of c-Met signaling and β-catenin mutations are frequent genetic events observed in liver cancer development. Recently, we demonstrated that activated β-catenin can cooperate with c-Met to induce liver cancer formation in a mouse model. Cyclin D1 (CCND1) is an important cell cycle regulator that is considered to be a downstream target of β-catenin. To determine the importance of CCND1 as a mediator of c-Met– and β-catenin–induced hepatocarcinogenesis, we investigated the genetic interactions between CCND1, β-catenin, and c-Met in liver cancer development using mouse models. We coexpressed CCND1 with c-Met in mice and found CCND1 to cooperate with c-Met to promote liver cancer formation. Tumors induced by CCND1/c-Met had a longer latency period, formed at a lower frequency, and seemed to be more benign compared with those induced by β-catenin/c-Met. In addition, when activated β-catenin and c-Met were coinjected into CCND1-null mice, liver tumors developed despite the absence of CCND1. Intriguingly, we observed a moderate accelerated tumor growth and increased tumor malignancy in these CCND1-null mice. Molecular analysis showed an up-regulation of cyclin D2 (CCND2) expression in CCND1-null tumor samples, indicating that CCND2 may replace CCND1 in hepatic tumorigenesis. Together, our results suggest that CCND1 functions as a mediator of β-catenin during HCC pathogenesis, although other molecules may be required to fully propagate β-catenin signaling. Moreover, our data suggest that CCND1 expression is not essential for liver tumor development induced by c-Met and β-catenin. [Cancer Res 2009;69(1):253–61]</p></div>

10.1158/0008-5472.c.6498158

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Insider Share Pledging and Firm Value Consequences under the COVID-19

SSRN Electronic Journal (2021)

He Xiao Xin Chen Heyang Fang Yifei Zhang

Share pledging, the practice in which shareholders secure a loan using their shares, has become a global phenomenon in recent years. In this paper, we investigate the effect of such corporate insider actions on outsider wealth during the pandemic. Concretely, we examine how firms' market value change when corporate insiders pledge their shareholdings during China's COVID-19 outbreak. It is found that market investors responded adversely to share pledging announcements by firms in the high pandemic-affected regions. Besides, the state ownership and better corporate governance structures of the pledged firms could mitigate such adverse impacts. Our study highlights a specific externality generated by corporate insiders to outside shareholders during a crisis period.

Value (mathematics)

2019-20 coronavirus outbreak

10.2139/ssrn.3996640

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Optimization of Speed Control System for Distribution Network Power Supply Vehicle Operation

2022 4th International Conference on Electrical Engineering and Control Technologies (CEECT) (2023)

Xin Chen Dongdong Huang Xiaocheng Meng Kun Jiang

Distribution network non-stop operation is an important means to improve the reliability of power supply to customers. Power supply vehicle is an important equipment to realize non-stop operation. In order to improve the anti-interference ability of the speed control system, a fuzzy adaptive PID speed control algorithm is designed for the power supply vehicle. The existing control method and the new method are compared through simulation, and the results show that the adaptive ability and anti-interference ability of the speed control system of the mobile power generator are effectively improved by introducing the fuzzy control idea.

Electronic speed control

10.1109/ceect59667.2023.10420719

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Polishing mechanism analysis of silicon carbide ceramics combined ultrasonic vibration and hydroxyl

Tribology International (2022)

Xin Chen Chao Zhang Fanwei Meng Tianbiao Yu Ji Zhao

Chemical Mechanical Planarization

10.1016/j.triboint.2022.108187

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Citations (16)

Identification of two novel HIV-1 circulating recombinant forms of CRF111_01C and CRF116_0108 in southwestern Yunnan, China

Virulence (2021)

Mei Ye Xin Chen Lin Duo Jin Ma Le Cao

Yunnan, the region hardest hit by HIV/AIDS in China, is also an area with the most abundant HIV-1 genetic diversity. A large number of novel HIV-1 circulating recombinant forms (CRFs) and unique recombinants were identified among injection drug users in Yunnan; however, few were found among sexual contacts. Here, we obtained 15 near full-length genome sequences (NFLGs) from HIV-1 seropositive heterosexual contacts in Yunnan who received antiretroviral therapy during the period from 2014 to 2016. Phylogenetic analysis showed that six NFLGs belonged to CRF01_AE (n = 3) and CRF106_cpx (n = 3), and the other nine sequences were novel inter-subtype recombinants. Of the recombinants, two novel CRFs (CRF111_01 C (n = 4) and CRF116_0108 (n = 4)) and one CRF106_cpx variant (n = 1) were identified. CRF111_01 C had a CRF01_AE backbone with seven subtype C fragments inserted into the gag, pol, vif, env, nef and 3ʹLTR regions. CRF116_0108 had a CRF08_BC backbone with a CRF01_AE fragment inserted into the pol, tat, rev, vif, vpr, vpu and env regions. Phylogeographic analyses estimated that CRF111_01 C and CRF116_0108 originated approximately 1995.7–1998.6 and 1991.7–1993.7, respectively. These identifications of two novel HIV-1 CRFs highlighted the importance of continuous surveillance in heterosexual contacts and other high-risk groups in this region and the surrounding regions.

Identification

10.1080/21505594.2021.2010399

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College English listening teaching reform based on the concept of metacognitive strategies training

Journal of Wuhan Institute of Technology (2010)

Xin Chen

College English

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Genetic Characteristics of Three Unique Recombinant Forms of HIV-1 in Yunnan, China

AIDS Research and Human Retroviruses (2020)

Ying-Na Xie Si-Le Li Rongrong Yang Jin Huang Peng Xia

To explore the molecular epidemiological status of human immunodeficiency virus type 1 (HIV-1) in Yunnan, China, three HIV-1 near full-length genomes were amplified and sequenced from plasma samples that were collected from Burmese patients newly diagnosed with HIV-1 in Dehong Prefecture in Yunnan Province in 2017. Phylogenetic and bootscanning analyses revealed that all the sequences might be HIV-1 second-generation recombinant forms of circulating recombinant forms (CRF07_BC and CRF83_cpx) and unique recombinant forms. One of the sequences contained six CRF01_AE fragments, five subtype C fragments, and two subtype B fragments, which were separated by 12 breakpoints. These results revealed that the second-generation recombination of HIV-1 within different strains is still ongoing in Dehong, China. Systematic surveys and immediate interventions are urgently needed to prevent the formation of increasingly complex HIV-1 recombinant forms.

Recombinant virus

Breakpoint

Molecular Epidemiology

10.1089/aid.2020.0234

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Total-Factor Energy Efficiency and Influence Factors Analysis in Regions of China

Applied Mechanics and Materials (2014)

Han Zhao Hai Lin Mu Xin Chen Xiao Han

This paper builds an input-output framework based on a data envelopment analysis (DEA) window aimed at exploring total-factor energy efficiency (TFEE) in 30 administrative regions and 6 areas across China from 2006 to 2012. In this framework, labor force, capital stock, energy consumption, CO2 emission are regarded as inputs, while gross domestic product (GDP) as the single output. The result indicates regions in East China and Mid South perform relatively higher TFEE especially Jiangsu, Guangdong which both obtain optimal efficiencies, while regions in Northwest have lower TFEE like Ningxia and Qinghai which TFEE lower than 0.55. But on the whole, 6 areas of China show increasing trends of TFEE during this period. Additionally, we conduct a regression analysis aimed at revealing influence factors of energy efficiency. We find properly adjusting industrial construction contributes the best for lifting TFEE, meanwhile, technology and economy size also have marked influences in raising TFEE.

Stock (firearms)

10.4028/www.scientific.net/amm.672-674.2158

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Citations (5)