Objective In January 2023, China implemented the “Class B Management” policy, marking a new phase in COVID-19 control. As new SARS-CoV-2 variants continue to emerge, some have shown significant immune evasion, posing challenges to epidemic control efforts. To manage the pandemic effectively, Henan Province launched a surveillance program for SARS-CoV-2 variants, systematically analyzing their clinical characteristics and epidemiological patterns. Methods This study collected genomic sequence data from 5,965 COVID-19 cases between January 1, 2023, and March 17, 2024, using the Henan Province SARS-CoV-2 variant surveillance system. Genome sequence analysis was performed with CLC Genomics Workbench, and genotyping and sequence alignment were carried out using the Nextclade platform. The clinical severity of different variants was assessed in relation to patient sex, age, clinical classification, and vaccination status. Results Between Week 1 of 2023 and Week 11 of 2024, a total of 5,965 complete SARS-CoV-2 genome sequences were obtained, including 3,004 male (50.36%) and 2,961 female (49.64%) cases. The majority of cases were mild (5,451 cases, 91.38%), followed by moderate (311 cases, 5.21%) and severe or critical cases (203 cases, 3.4%). The predominant variants included BA.5.2, XBB, and BA.2.86. BA.5.2 was dominant until April 2023, after which it was gradually replaced by XBB. From December 2023, BA.2.86 began to increase and became the predominant variant by January 2024. The XBB variant exhibited a significantly lower rate of severe cases, with most infections being mild ( P < 0.05). Male patients, the elderly, and certain variants (e.g., BA.5.2) were associated with more severe outcomes, while XBB and BA.2.86 showed lower pathogenicity, with a marked reduction in severe and fatal cases ( P < 0.05). Conclusion As SARS-CoV-2 variants evolve, the incidence of severe cases has progressively decreased. Both XBB and BA.2.86 variants exhibit lower pathogenicity. This study provides vital scientific evidence on the epidemiological features, clinical manifestations, and control strategies of SARS-CoV-2 variants. It underscores the importance of continuous viral surveillance and genomic sequencing to guide public health decision-making.
The hepatitis B vaccine was first introduced into the routine immunization program in Henan Province, China in 1992. In 2012, a survey was conducted to evaluate the protective effects of hepatitis B vaccination for the populations born during the preceding 15 years.A multistage stratified random cluster sampling method was used to collect samples. The participants were interviewed and relevant information was obtained for the population aged 1 to 14 years using a standardized questionnaire; a 2- or 3-ml serum sample was taken from each participant to measure hepatitis B surface antigen (HBsAg) and hepatitis B core antibody (anti-HBc). Association and logistic regression analyses were conducted to determine relationships between these parameters.A total of 13,207 residents aged 1 to 14 years residing in 60 villages or communities in Henan, China were surveyed and had their blood collected. Serological analysis revealed that the HBsAg and anti-HBc prevalences were 0.8% and 2.6%, respectively. The HBsAg prevalence among children under 5 years of age was 0.5%, showing a decline of 96% compared to the average national HBsAg prevalence in 1992. Children had a higher likelihood of HBsAg positivity if they had an HBsAg-positive family member (odds ratio (OR) 4.26), no history of vaccination (OR 2.06), were born in a smaller township hospital or at home (OR 1.61), were aged 10-14 years (OR 2.07), or were living in a rural area (OR 2.01).The HBsAg prevalence rate in persons under 15 years of age has dropped significantly in Henan Province after two decades of vaccination. Thus millions of chronic HBV infections have been prevented.
Type I interferon is widely used for antiviral therapy, yet has yielded disappointing results toward chronic HBV infection. Here we identify that PEG-IFNα-2b therapy toward persistent infection in humans is a double-edged sword of both immunostimulation and immunomodulation. Our studies of this randomised trial showed persistent PEG-IFNα-2b therapy induced large number of CD24 + CD38 hi B cells and launched a CD24 + CD38 hi B cells centered immunosuppressive response, including downregulating functions of T cells and NK cells. Patients with low induced CD24 + CD38 hi B cells have achieved an improved therapeutic effect. Specifically, using the anti-CD24 antibody to deplete CD24 + CD38 hi B cells without harming other B cell subsets suggest a promising strategy to improve the therapeutic effects. Our findings show that PEG-IFNα-2b therapy toward persistent infection constitutes an immunomodulation effect, and strategies to identifying the molecular basis for the antiviral versus immunomodulatory effects of PEG-IFNα-2b to selectively manipulate these opposing activities provide an opportunity to ameliorate anti-virus immunity and control viral infection.
BACKGROUND Obtaining comprehensive epidemic information for specific global infectious diseases is crucial to travel health. However, different infectious disease information websites may have different purposes, which may lead to misunderstanding by travelers and travel health staff when making accurate epidemic control and management decisions. OBJECTIVE The objective of this study was to develop a Global Infectious Diseases Epidemic Information Monitoring System (GIDEIMS) in order to provide comprehensive and timely global epidemic information. METHODS Distributed web crawler and cloud agent acceleration technologies were used to automatically collect epidemic information about more than 200 infectious diseases from 26 established epidemic websites and Baidu News. Natural language processing and in-depth learning technologies have been utilized to intelligently process epidemic information collected in 28 languages. Currently, the GIDEIMS presents world epidemic information using a geographical map, including date, disease name, reported cases in different countries, and the epidemic situation in China. In order to make a practical assessment of the GIDEIMS, we compared infectious disease data collected from the GIDEIMS and other websites on July 16, 2019. RESULTS Compared with the Global Incident Map and Outbreak News Today, the GIDEIMS provided more comprehensive information on human infectious diseases. The GIDEIMS is currently used in the Health Quarantine Department of Shenzhen Customs District (Shenzhen, China) and was recommended to the Health Quarantine Administrative Department of the General Administration of Customs (China) and travel health–related departments. CONCLUSIONS The GIDEIMS is one of the most intelligent tools that contributes to safeguarding the health of travelers, controlling infectious disease epidemics, and effectively managing public health in China.
As a national regional development strategy and a vital region of the Belt and Road Initiative, the sustainable development of the Pan-Pearl River Delta (Pan-PRD) region is of great importance. The national development plan emphasizes improving total factor productivity (TFP) and promoting high-quality economic development. This paper uses the DEA-Malmquist index model to measure the TFP of nine provinces in the Pan-PRD region based on inter-provincial panel data from 2003 to 2020. Furthermore, it analyzes its growth trend and heterogeneity characteristics in the inter-provincial spatial, industrial, and city dimensions. The results show that in the time dimension, TFP shows a W-shaped fluctuation trend, technical efficiency grows slowly, and technical progress is the pillar of TFP improvement. The spatial dimension shows a high distribution in the center and low distribution in the south. On the industry dimension, the TFP is in descending order as follows: tertiary industry—secondary industry—primary industry. The spatial distribution is heterogeneous, exacerbating the uneven economic development within the region, and the regional industrial structure needs urgent optimization. The spatial development of city TFP is uneven, and the number of cities with a TFP below 1 is increasing. Finally, we suggest policies to accelerate regional collaborative innovation, cultivate advantageous industrial clusters, create an advantageous industrial ecosystem, and achieve sustainable development in the Pan-PRD region.
Objective
To evaluate the immunogenicity and safety of an immunization strategy with two doses of live attenuated varicella vaccine.
Methods
A total of 958 children aged 1.5 to 7 years were recruited from Henan province and divided into four groups based on the length of interval between two injections (3 months, 1 year, 3 years and 5 years). Serum samples were collected from each individual before and 35 to 42 days after the second immunization for the detection of antibodies against varicella-zoster virus by antibody membrane immune-fluorescence assay.
Results
The levels of antibodies in serum samples from all groups declined over time since the first dose immunization of varicella vaccine. Significant differences with the geometric mean titers (GMT) of antibodies were found among different groups by statistical analysis of variance (F=39.690, P<0.05). Results of the Wilcoxon signed-rank test showed that there were significant differences with the GMT of antibodies in all subjects before and after the second dose immunization with varicella vaccine (all P<0.01). The adverse events were observed in 10.4% (100/958) of immunized children within 14 days after the second vaccination. Of the adverse events, fever accounted for 6.99% and local swelling took 1.15%, no other adverse events were observed.
Conclusion
Immunization of children with two doses of live attenuated varicella vaccine showed the advantages of good immunogenicity and safety. The immunization strategy with two doses of varicella vaccine should be proposed in our country as soon as possible.
Key words:
Live attenuated varicella vaccine; Two-dose; Immunogenicity; Safety
Background Obtaining comprehensive epidemic information for specific global infectious diseases is crucial to travel health. However, different infectious disease information websites may have different purposes, which may lead to misunderstanding by travelers and travel health staff when making accurate epidemic control and management decisions. Objective The objective of this study was to develop a Global Infectious Diseases Epidemic Information Monitoring System (GIDEIMS) in order to provide comprehensive and timely global epidemic information. Methods Distributed web crawler and cloud agent acceleration technologies were used to automatically collect epidemic information about more than 200 infectious diseases from 26 established epidemic websites and Baidu News. Natural language processing and in-depth learning technologies have been utilized to intelligently process epidemic information collected in 28 languages. Currently, the GIDEIMS presents world epidemic information using a geographical map, including date, disease name, reported cases in different countries, and the epidemic situation in China. In order to make a practical assessment of the GIDEIMS, we compared infectious disease data collected from the GIDEIMS and other websites on July 16, 2019. Results Compared with the Global Incident Map and Outbreak News Today, the GIDEIMS provided more comprehensive information on human infectious diseases. The GIDEIMS is currently used in the Health Quarantine Department of Shenzhen Customs District (Shenzhen, China) and was recommended to the Health Quarantine Administrative Department of the General Administration of Customs (China) and travel health–related departments. Conclusions The GIDEIMS is one of the most intelligent tools that contributes to safeguarding the health of travelers, controlling infectious disease epidemics, and effectively managing public health in China.
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