To evaluate the feasibility and the therapeutic effect of orthognathic surgical procedures combined distraction osteogenesis and scapular flap for correction of progressive hemifacial atrophy.5 cases with progressive hemifacial atrophy were treated. 1 mild case was treated with microsurgical de-epithelia scapular flap (MDSF) and genioplasty in one stage. The 2 moderate cases were treated with Le Fort 1 osteotomy following by sagittal split ramus osteotomy and genioplasty at the first stage. 3 - 6 months later, the MDSFs were used for augmentation. 2 sever cases were treated with bimaxillary distraction osteogenesis on the affected side. 3 - 4 months later, the distraction devices were removed and MDSFs were transplanted.The facial asymmetry was obviously improved. The orthognathic procedures and distraction osteogenesis achieved good therapeutic effect. All the MDSFs were survived.The progressive hemifacial atrophy can result in very severe deformity when it occurs in very young age. The combined deformity of bone and soft tissue can be effectively corrected by orthognathic procedures combined with distraction osteogenesis and scapular flap transplantation.
Abstract The acylation of Se-nucleophiles with N-acylbenzotriazoles was investigated. Samarium phenylselenolate and benzylselenolate (RSeSmI2) reacted with N-aroyl and N-alkanoylbenzotriazoles smoothly and afforded the corresponding selenol esters in good yields. Treatment of the RSeSmI2 with α,β-unsaturated N-acylbenzotriazoles afforded the anticipated α,β-unsaturated selenol esters in moderate yields, due mainly to the side reaction of conjugate addition. GRAPHICAL ABSTRACT
Improving the accuracy and stability of daily runoff prediction is crucial for effective water resource management and flood control. This study proposed a novel stacking ensemble learning model based on attention mechanism for the daily runoff prediction. The proposed model has a two-layer structure with the base model and the meta model. Three machine learning models, namely random forest (RF), adaptive boosting (AdaBoost), and extreme gradient boosting (XGB) are used as the base models. The attention mechanism is used as the meta model to integrate the output of the base model to obtain predictions. The proposed model is applied to predict the daily inflow to Fuchun River Reservoir in the Qiantang River basin. The results show that the proposed model outperforms the base models and other ensemble models in terms of prediction accuracy. Compared with the XGB and weighted averaging ensemble (WAE) models, the proposed model has a 10.22% and 8.54% increase in Nash–Sutcliffe efficiency (NSE), an 18.52% and 16.38% reduction in root mean square error (RMSE), a 28.17% and 18.66% reduction in mean absolute error (MAE), and a 4.54% and 4.19% increase in correlation coefficient (r). The proposed model significantly outperforms the base model and simple stacking model indicated by both the Friedman test and the Nemenyi test. Thus, the proposed model can produce reasonable and accurate prediction of the reservoir inflow, which is of great strategic significance and application value in formulating the rational allocation and optimal operation of water resources and improving the breadth and depth of hydrological forecasting integrated services.
Intake of a high dosage of baicalin has previously been shown to attenuate hyperlipidemia induced by a high-fat diet. Baicalin functions as an activator of peroxisome proliferator-activated receptor-γ (PPAR-γ), which is the key regulator of reverse cholesterol transport (RCT). The present study aimed to test the hypothesis that baicalin could promote cholesterol efflux in macrophages through activating PPAR-γ. Phorbol 12-myristate 13-acetate-stimulated THP-1 cells were treated with oxidized low-density lipoprotein and (3H)-cholesterol for 24 h, and the effects of baicalin on cholesterol efflux were evaluated in the presence of apolipoprotein A-1 (ApoA-1), or high-density lipoprotein subfraction 2 (HDL2) or subfraction 3 (HDL3). The expression levels of scavenger receptor class B type I (SR-BI), PPAR-γ and liver X receptor-α (LXRα) were detected and specific inhibitors or activators of SR-BI, PPAR-γ and LXRα were applied to investigate the mechanism. Treatment of THP-1 macrophages with baicalin significantly accelerated HDL-mediated, but not ApoA-1-mediated cholesterol efflux. However, baicalin treatment increased the expression of SR-BI at the mRNA and protein levels in a dose- and time-dependent manner, and pre-treatment with the SR-BI inhibitor BLT-1 and SR-BI small interfering RNA significantly inhibited baicalin-induced cholesterol efflux. Furthermore, baicalin increased the expression of PPAR-γ and LXRα, and the application of specific agonists and inhibitors of PPAR-γ and LXRα changed the expression of SR-BI, as well as cholesterol efflux. It may be concluded that baicalin induced cholesterol efflux from THP-1 macrophages via the PPAR-γ/LXRα/SR-BI pathway.
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
To observe the clinical results in correction of unilateral temporomandibular joint(TMJ) ankylosis accompanying with mandibular micrognathia using internal distraction osteogenesis simultaneously.Seven adult patients of unilateral TMJ ankylosis accompanying with mandibular micrognathia (13 sides of mandibular body) were treated simultaneously with internal distraction osteogenesis. Obstructive sleep apnea and hypopnea syndrome(OSAHS) was diagnosed in all patients preoperatively. The treatment includes distraction osteogenesis of mandibular body and transport distraction osteogenesis for TMJ arthroplasty at the same time. Distraction was started on the 6th to 8th day after operation. The distraction rhythm and rate was one mm a day operated in 4 separate times. The patients underwent active mouth opening postoperatively. Distractors were kept in place for 3-5 months after completion of distraction and then removed. Mean distraction distance of the 13 sides of mandibular body was 17.1mm(ranged from 14 to 20 mm) and that of the 7 sides of TMJ was 16.4mm(ranged from 15 to 20mm).After treatment, micrognathia of the 7 patients was corrected. OSAHS was cured in 6 patients. The mean range of mouth opening was increased from 8.1 mm to 39.9 mm and bone formation in the distraction gaps was observed. The mean following-up period was 34.3 months(ranged from 18 to 51 months). No recurrence of TMJ ankylosis or micrognathia was occurred.Unilateral TMJ ankylosis accompanying with micrognathia and OSAHS can be treated effectively by distraction osteogenesis simultaneously. The operation is simple with low risk. The course of treatment can be simplified and the operation times can be reduced.
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