Kai Liu

Chinese Academy of Sciences

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Hongjie Zhang

Changchun Institute of Applied Chemistry

109

Jingjing Li

Beijing University of Technology

Chao Ma

Chinese Academy of Sciences

Fan Wang

Chinese Academy of Sciences

Jing Sun

East China Normal University

Dong Chen

Institute of Process Engineering

Andreas Herrmann

RWTH Aachen University

Juanjuan Su

University of Chinese Academy of Sciences

Hongpeng You

Chinese Academy of Sciences

Yawei Liu

Fudan University

Cooperative Institutions

Institute of High Energy Physics

1,296

Chinese Academy of Sciences

922

University of Chinese Academy of Sciences

627

China Center of Advanced Science and Technology

454

COMSATS University Islamabad

436

University of Science and Technology of China

Beihang University

Tsinghua University

Peking University

Central China Normal University

277

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Bioinspired and Mechanically Strong Fibers Based on Engineered Non‐Spider Chimeric Proteins

Angewandte Chemie (2020)

Yuanxin Li Jingjing Li Jing Sun Haonan He Bo Li

Abstract Silk‐protein‐based fibers have attracted considerable interest due to their low weight and extraordinary mechanical properties. Most studies on fibrous proteins focus on the recombinant spidroins, but these fibers exhibit moderate mechanical performance. Thus, the development of alternative structural proteins for the construction of robust fibers is an attractive goal. Herein, we report a class of biological fibers produced using a designed chimeric protein, which consists of the sequences of a cationic elastin‐like polypeptide and a squid ring teeth protein. Remarkably, the chimeric protein fibers exhibit a breaking strength up to about 630 MPa and a corresponding toughness as high as about 130 MJ m −3 , making them superior to many recombinant spider silks and even comparable to some native counterparts. Therefore, this strategy is a novel concept for exploring bioinspired ultrastrong protein materials through the development of new types of structural chimeric proteins.

Spider Silk

Protein Engineering

10.1002/ange.202002399

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Citations (19)

Contact-Piezoelectric Bi-Catalysis of an Electrospun ZnO@PVDF Composite Membrane for Dye Decomposition

Molecules (2022)

Buwen Jiang Xiaoxuan Xue Zuxiang Mu Haoyuan Zhang Feng Li

The treatment of organic pollutants in wastewater is becoming a great challenge for social development. Herein, a novel contact-piezoelectric bi-catalysis of a ZnO@ PVDF composite membrane was prepared by electrospinning technology. The obtained ZnO@PVDF composite membranes is superior to the pure PVDF membrane in decomposing methyl orange (MO) under ultrasonication at room temperature, which is mainly attributed to the synergy effect of the contact-electro-catalysis of dielectric PVDF, as well as the piezoelectric catalysis of tetrapodal ZnO and the β-phase of PVDF. The heterostructure of the piezoelectric-ZnO@dielectric-PVDF composite is beneficial in reducing the electron/hole pair recombination. As compared to the pure PVDF membrane, the catalytic degradation efficiency of the ZnO@PVDF composite membrane was improved by 444.23% under ultrasonication. Moreover, the reusability and stability of the composite membrane are comparable to those of the traditional powdered catalyst. This work offers a promising strategy for improving the pollutant degradation by combining contact-electro-catalysis with piezoelectric catalysis.

Electrospinning

Methyl orange

Sonication

10.3390/molecules27238579

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Citations (18)

An Artificial Phase‐Transitional Underwater Bioglue with Robust and Switchable Adhesion Performance

Angewandte Chemie (2021)

Lingling Xiao Zili Wang Yao Sun Bo Li Baiheng Wu

Abstract Complex coacervation enables important wet adhesion processes in natural and artificial systems. However, existed synthetic coacervate adhesives show limited wet adhesion properties, non‐thermoresponsiveness, and inferior biodegradability, greatly hampering their translations. Herein, by harnessing supramolecular assembly and rational protein design, we present a temperature‐sensitive wet bioadhesive fabricated through recombinant protein and surfactant. Mechanical performance of the bioglue system is actively tunable with thermal triggers. In cold condition, adhesion strength of the bioadhesive was only about 50 kPa. By increasing temperature, the strength presented up to 600 kPa, which is remarkably stronger than other biological counterparts. This is probably due to the thermally triggered phase transition of the engineered protein and the formation of coacervate, thus leading to the enhanced wet adhesion bonding.

Coacervate

10.1002/ange.202102158

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Citations (17)

Photonic Fibrous Liquid Crystal Elastomer Actuators

Chinese Journal of Polymer Science (2025)

Yunlong Li Kai Liu Huimin Wu Jiu‐an Lv

10.1007/s10118-025-3286-x

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Injectable In Situ Induced Robust Hydrogel for Photothermal Therapy and Bone Fracture Repair

Advanced Functional Materials (2021)

Bin Liu Xinquan Gu Qiannan Sun Shengjie Jiang Jing Sun

Abstract Malignant bone tumors are often accompanied by osteolytic destruction and severe pathological fractures. Current therapeutic strategies can largely inhibit tumor proliferation, but the high recurrence rate of tumors and related bone defects remain a significant challenge. This study aims to address these issues by developing a novel near‐infrared (NIR) light‐responsive and a mechanically strong hydrogel that offers excellent photothermal tumor therapy and bone fracture repair capabilities. The as‐prepared hydrogel exhibits good biocompatibility and an ultra‐strong photothermal effect due to the formation of a complex network with up‐conversion lanthanide‐Au hybrid nanoparticles and alginate molecules. A subcutaneous tumor model is used to demonstrate that tumors can be efficiently eradicated via local photothermal treatment, where there is no tumor recurrence within the observation period. Moreover, the injected hydrogel becomes mechanically strong due to in situ Ca 2+ crosslinking, which provides a supportive matrix to promote the repair of bone defects via stabilization of the fractured bone structure. The high photothermal effect and robust support offered by this single material demonstrate the potential of using the proposed hydrogel for the simultaneous treatment of bone tumor removal and bone healing.

Biocompatibility

Photothermal effect

10.1002/adfm.202010779

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Citations (53)

Highly Plasticized Lanthanide Luminescence for Information Storage and Encryption Applications

Advanced Science (2022)

Yawei Liu Kelu Zhao Yubin Ren Sikang Wan Chenjing Yang

Abstract The development of new storage media to meet the demands for diverse information storage scenarios is a great challenge. Here, a series of lanthanide‐based luminescent organogels with ultrastrong mechanical performance and outstanding plasticity are developed for patterned information storage and encryption applications. The organogels possessing outstanding mechanical properties and tunable luminescent colors are prepared by electrostatic and coordinative interactions between natural DNA, synthetic ligands, and rare earth (RE) ions. The organogel‐REs can be stretched by 180 times and show an ultrastrong breaking strength of 80 MPa. A series of applications with both information storage and encryption, such as self‐information pattern, quick response (QR) code, and barcode, are successfully demonstrated by the organogel‐REs. The developed information storage systems have various advantages of good processability, high stretchability, excellent stability, and versatile design of information patterns. Therefore, the organogel‐RE‐based information storage systems are suitable for applications under different scenarios, such as flexible devices under repeating rude operations. The advancements will enable the design and development of luminescent organogel‐REs as information storage and encryption media for various scenarios.

Information storage

10.1002/advs.202105108

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Citations (51)

Pharmacological targeting of NLRP3 deubiquitination for treatment of NLRP3-associated inflammatory diseases

Science Immunology (2021)

Guang‐Ming Ren Jian Li Xiaochun Zhang Yu Wang Yang Xiao

Thiolutin, an inhibitor of the BRISC deubiquitinating enzyme complex, specifically and potently inhibits NLRP3 inflammasome activation.

Deubiquitinating enzyme

10.1126/sciimmunol.abe2933

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Citations (61)

Flexible Sono–Piezo Patch for Functional Sweat Gland Repair through Endogenous Microenvironmental Remodeling

ACS Nano (2024)

Wei Pi Huating Chen Yawei Liu Jiangbing Xiang Hongliang Zhang

Remodeling the endogenous regenerative microenvironment in wounds is crucial for achieving scarless, functional tissue regeneration, especially the functional recovery of skin appendages such as sweat glands in burn patients. However, current approaches mostly rely on the use of exogenous materials or chemicals to stimulate cell proliferation and migration, while the remodeling of a pro-regenerative microenvironment remains challenging. Herein, we developed a flexible sono-piezo patch (fSPP) that aims to create an endogenous regenerative microenvironment to promote the repair of sweat glands in burn wounds. This patch, composed of multifunctional fibers with embedded piezoelectric nanoparticles, utilized low-intensity pulsed ultrasound (LIPUS) to activate electrical stimulation of the target tissue, resulting in enhanced pro-regenerative behaviors of niche tissues and cells, including peripheral nerves, fibroblasts, and vasculatures. We further demonstrated the effective wound healing and regeneration of functional sweat glands in burn injuries solely through such physical stimulation. This noninvasive and drug-free therapeutic approach holds significant potential for the clinical treatment of burn injuries.

Regenerative Medicine

Low-intensity pulsed ultrasound

10.1021/acsnano.4c03974

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Citations (2)

Correlation Between the MTHFR C677T Genotype and Coronary Heart Disease in Populations from Gansu, China

DNA and Cell Biology (2022)

Xue Wu Kai Liu Xinke Zhao Xiaowei Zhang Huan Guo

This study was designed to evaluate the relationship between polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and coronary heart disease (CHD) in populations from the Gansu region of China. The MTHFR C677T polymorphism genotypes from 209 patients with CHD, as confirmed by coronary angiography, and 212 non-CHD control patients were identified using PCR gold magnetic particle chromatography. We simultaneously evaluated homocysteine (Hcy) and folate levels in these samples using biochemical methods. The TT genotype of the MTHFR C677T locus was significantly more frequent in the CHD group than in the control, while the CC genotype was significantly less frequent in CHD patients than in non-CHD patients (p < 0.05). In addition, biochemical analysis revealed that the serum Hcy levels increased, and folate levels decreased in the TT genotype. Logistic regression analysis showed that this correlation was independent of nationality, sex, age, body mass index, medical history, and blood lipid level (p < 0.05). The occurrence of the TT genotype at the MTHFR C677T locus was closely associated with CHD in the Gansu population and may serve as a biomarker of increased risk for this disease.

10.1089/dna.2022.0329

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Search for eta and eta ' -> pi(+)e(-)(v)over-bar(e) + c.c. decays in J/psi -> phi eta and phi eta '

Physical Review D (2013)

F. De Mori М. Н. Ачасов O. Albayrak D. Ambrose F. F. An

Using a sample of 225.3 million J/psi events collected with the BESIII detector at the BEPCII e(+)e(-) collider in 2009, searches for the decays of eta and eta' -> pi(+)e(-)(v) over bar (e) + c.c. in J/psi -> phi eta and phi eta' are performed. The phi signals, which are reconstructed in K+K- final states, are used to tag eta and eta' semileptonic decays. No signals are observed for either eta or eta', and upper limits at the 90% confidence level are determined to be 7.3 x 10(-4) and 5.0 x 10(-4) for the ratios B(eta ->pi(+)e(-)(v) over bar (e) + c.c)/B(eta ->pi(+)pi(-)pi(0)) and B(eta'->pi(+)e(-)(v) over bar (e) + c.c)/B(eta'->pi(+)pi(-)eta) respectively. These are the first upper- limit values determined for eta and eta' semileptonic weak decays. DOI: 10.1103/PhysRevD.87.032006

Electron–positron annihilation

Bar (unit)

Semileptonic decay

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Citations (9)