Pengfei Wang

Inner Mongolia People's Hospital

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Ping Zhang

Affiliated Hospital of Hebei University

Suzanne M. Michalek

University of Alabama at Birmingham

Xiong Ding

Southeast University

Dattatray A. Devalankar

University of Alabama at Birmingham

Huayou Hu

Huaiyin Normal University

Wen‐Ya Lu

Shenzhen University

Yun Wang

Chengdu University of Traditional Chinese Medicine

Lei Zhou

Institute of Soil Science

Haishen Yang

Shanghai University of Electric Power

ĐŠ

Đani Škalamera

University of Zagreb

Cooperative Institutions

Chinese Academy of Sciences

University of Alabama at Birmingham

Chinese Academy of Medical Sciences & Peking Union Medical College

Sun Yat-sen University

Wenzhou Medical University

Ministry of Agriculture and Rural Affairs

Zhejiang University

Xuzhou Medical College

Army Medical University

University of Chinese Academy of Sciences

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Divergent Evolution of Slip Banding in Alloys

arXiv (Cornell University) (2024)

B.Q. Xie Hangman Chen Pengfei Wang Cheng Zhang Bin Xing

Metallic materials under high stress often exhibit deformation localization, manifesting as slip banding. Over seven decades ago, Frank and Read introduced the well-known model of dislocation multiplication at a source, explaining slip band formation. Here, we reveal two distinct types of slip bands (confined and extended) in alloys through multi-scale testing and modeling from microscopic to atomic scales. The confined slip band, characterized by a thin glide zone, arises from the conventional process of repetitive full dislocation emissions at Frank-Read source. Contrary to the classical model, the extended band stems from slip-induced deactivation of dislocation sources, followed by consequent generation of new sources on adjacent planes, leading to rapid band thickening. Our findings provide critical insights into atomic-scale collective dislocation motion and microscopic deformation instability in advanced structural materials, marking a pivotal advancement in our fundamental understanding of deformation dynamics.

10.48550/arxiv.2410.17582

Cite

Citations (0)

Natural and Synthetic Saponins as Vaccine Adjuvants

Vaccines (2021)

Pengfei Wang

Saponin adjuvants have been extensively studied for their use in veterinary and human vaccines. Among them, QS-21 stands out owing to its unique profile of immunostimulating activity, inducing a balanced Th1/Th2 immunity, which is valuable to a broad scope of applications in combating various microbial pathogens, cancers, and other diseases. It has recently been approved for use in human vaccines as a key component of combination adjuvants, e.g., AS01b in Shingrix® for herpes zoster. Despite its usefulness in research and clinic, the cellular and molecular mechanisms of QS-21 and other saponin adjuvants are poorly understood. Extensive efforts have been devoted to studies for understanding the mechanisms of QS-21 in different formulations and in different combinations with other adjuvants, and to medicinal chemistry studies for gaining mechanistic insights and development of practical alternatives to QS-21 that can circumvent its inherent drawbacks. In this review, we briefly summarize the current understandings of the mechanism underlying QS-21’s adjuvanticity and the encouraging results from recent structure-activity-relationship (SAR) studies.

Vaccine adjuvant

Scope (computer science)

Human use

10.3390/vaccines9030222

Cite

Citations (88)

Rare‐Earth‐Ion Doped Bi_1.5ZnNb_1.5O₇ Photochromics: A Fast Self‐Recoverable Optical Storage Medium for Dynamic Anti‐Counterfeiting with High Security

Laser & Photonics Review (2023)

Xuefeng Li Hang Lin Shisheng Lin Peng Li Pengfei Wang

Abstract Conventional inorganic photochromic (PC) anti‐counterfeiting material generally require time‐consuming identification of information or response to changes in display information, resulting in low‐level readout and decoding efficiency. In this study, a new type of inorganic PC self‐bleaching material, i.e., rare‐earth‐ion‐doped Bi 1.5 ZnNb 1.5 O 7 (BZN) ceramic and corresponding mono‐/bi‐crystalline‐phase glass ceramic (GC) composite, are developed. The as‐prepared materials reveal maximum self‐recovery levels of the PC and the PC modulated upconversion luminescence ≈96.61% and 99.55%, respectively, and the self‐bleaching times are less than 20 min to the naked eyes. Unlike conventional thoughts of electrons’ trapping/detrapping with the aid of conduction band/valence band transportation, a new PC mechanism for ferroelectric oxides, involving the state exchanges between defects and color centers via direct electron transfer, is proposed. The proof‐of‐concept experiments demonstrate the unparalleled potentials offered by the self‐driven‐recovery BZN‐based bi‐crystalline‐phase GC composite for encoding, displaying, and erasing of time‐dependent information. The brought dynamical anti‐counterfeiting based on multimode optical storage favors to achieve complexity and concealment of the encrypted information to meet high‐security standard. This finding offers unique insight for designing integrated stimuli‐responsive and time‐dependent smart devices, particularly advanced anti‐counterfeiting technology.

Optical storage

10.1002/lpor.202200734

Cite

Citations (27)

Characterization of the Enzymes Encoded by the Anthrose Biosynthetic Operon of Bacillus anthracis

Journal of Bacteriology (2010)

Shengli Dong Sylvia A. McPherson Yun Wang Mei Li Pengfei Wang

ABSTRACT Bacillus anthracis spores, the etiological agents of anthrax, possess a loosely fitting outer layer called the exosporium that is composed of a basal layer and an external hairlike nap. The filaments of the nap are formed by trimers of the collagenlike glycoprotein BclA. Multiple pentasaccharide and trisaccharide side chains are O linked to BclA. The nonreducing terminal residue of the pentasaccharide side chain is the unusual sugar anthrose. A plausible biosynthetic pathway for anthrose biosynthesis has been proposed, and an antABCD operon encoding four putative anthrose biosynthetic enzymes has been identified. In this study, we genetically and biochemically characterized the activities of these enzymes. We also used mutant B. anthracis strains to determine the effects on BclA glycosylation of individually inactivating the genes of the anthrose operon. The inactivation of antA resulted in the appearance of BclA pentasaccharides containing anthrose analogs possessing shorter side chains linked to the amino group of the sugar. The inactivation of antB resulted in BclA being replaced with only trisaccharides, suggesting that the enzyme encoded by the gene is a dTDP-β- l -rhamnose α-1,3- l -rhamnosyl transferase that attaches the fourth residue of the pentasaccharide side chain. The inactivation of antC and antD resulted in the disappearance of BclA pentasaccharides and the appearance of a tetrasaccharide lacking anthrose. These phenotypes are entirely consistent with the proposed roles for the antABCD -encoded enzymes in anthrose biosynthesis. Purified AntA was then shown to exhibit β-methylcrotonyl-coenzyme A (CoA) hydratase activity, as we predicted. Similarly, we confirmed that purified AntC had aminotransferase activity and that purified AntD displayed N -acyltransferase activity.

Bacillus anthracis

Bacillus (shape)

Bacillaceae

10.1128/jb.00568-10

Cite

Citations (40)

Synthesis and Evaluation of a QS-17/18-Based Vaccine Adjuvant

Journal of Medicinal Chemistry (2019)

Pengfei Wang Đani Škalamera Xianwei Sui Ping Zhang Suzanne M. Michalek

We have synthesized a QS-17/18 analogue (7) and evaluated its adjuvant activity in the formulation with rHagB antigen. Compound 7 and QS-21 analogues 5 and 6 are presumably the major components of GPI-0100, a widely used complex mixture of semisynthetic derivatives of Quillaja saponaria (QS) Molina saponins. The QS-17/18 analogue 7 shows an adjuvant activity profile similar to that of GPI-0100, potentiating mixed Th-1/Th-2 immune responses, which is different from those of QS-21 analogues 5 and 6 that probably only induce a Th2-like immunity. The combination of QS-17/18 and QS-21 analogues does not show a synergistic effect. These results suggest that QS-17/18 analogue 7 might be the active component of GPI-0100 responsible for its immunostimulant property. Therefore, compound 7 can not only be a structurally defined alternative to GPI-0100 but also provide a valuable clue for rational design of new QS-based vaccine adjuvants with better adjuvant properties.

Immunostimulant

Vaccine adjuvant

Immunoadjuvant

10.1021/acs.jmedchem.8b01997

Cite

Citations (20)

1-[3-(Diethylamino)phenyl]ethyl (DEAPE): A Photolabile Protecting Group for Hydroxyl and Carboxyl Groups

The Journal of Organic Chemistry (2018)

Xiong Ding Pengfei Wang

Herein we demonstrate that the photolabile protecting group (PPG), the 1-[3-(diethylamino)-phenyl]ethyl (DEAPE) group, has dramatically different photochemical properties from the parent 3-(diethylamino)benzyl (DEABn) PPG. The new PPG, derived from DEABn by adding a methyl group to the benzylic carbon, has similar reactivity as DEABn in releasing alcohol in MeCN/water; however, it is more efficient than DEABn in releasing carboxylic acid. In particular, it can release carboxylic acid efficiently in aprotic solvents and the PPG itself converts to 3-diethylaminostyrene. Photochemical removal of DEAPE can also be conveniently carried out with sunlight. The results in this work suggest that there probably exist multiple reaction pathways in cleaving the benzylic C–O bond and they can be affected by the benzylic substitution and the reaction conditions.

Protecting group

10.1021/acs.joc.8b01137

Cite

Citations (10)

Facile glycosylation strategy with two-stage activation of allyl glycosyl donors. Application to concise synthesis of Shigella flexneri serotype Y O-antigen

Organic & Biomolecular Chemistry (2010)

Yun Wang Xin Zhang Pengfei Wang

A practical, useful glycosylation method employing only allyl glycoside building blocks has been developed. The donor's glycosylation reactivity is turned on via isomerization of its anomeric allyl protecting group into the corresponding prop-1-enyl moiety. Subsequent chemoselective activation with NIS/TfOH achieves high yields in glycosidic bond construction at room temperature. The efficacy and efficiency of this approach in carbohydrate synthesis is demonstrated in the concise synthesis of the fully protected Shigella flexneri serotype Y O-antigen.

Carbohydrate synthesis

Glycosidic bond

Moiety

Glycosyl donor

Carbohydrate chemistry

10.1039/c002865g

Cite

Citations (15)

Synthesis and characterization of poly (Itaconic Acid-m-Phen- ylenediamine)

Chuanxing Wang Pengfei Wang Xu Qinhong Zhe Wei Yu-Min Wu

With Itaconyl chloride and m-phenylenediamine as raw materials, poly(itaconic acid-m-phenylenediamine) was synthesized by the low temperature solution polycondensation we reported.The effects of initial temperature and reaction time on polycondensation were investigated.And the product was characterized by 1 H-NMR, FT-IR and TGA.The results showed that the polycondensation should carry out at a low temperature.The initial temperature should be lower 0 ºC.The polycondensation time was 90-100 minutes.Under these conditions, the thermal stability was good and its inherent viscosity was about 1.4.The spectra of FT-IR and 1 H-NMR confirmed its structure.

Itaconic acid

Characterization

10.2991/imst-16.2016.3

Cite

Citations (1)

Enhancing Protective Antibodies against Opioids through Antigen Display on Virus-like Particles

Bioconjugate Chemistry (2023)

Fatemeh Shafieichaharberoud Shuyao Lang Connor Whalen Cristina Rivera Quiles L. J. Purcell

Opioid use disorder (OUD) has become a public health crisis, with recent significant increases in the number of deaths due to overdose. Vaccination can provide an attractive complementary strategy to combat OUD. A key for high vaccine efficacy is the induction of high levels of antibodies specific to the drug of abuse. Herein, a powerful immunogenic carrier, virus-like particle mutant bacteriophage Qβ (mQβ), has been investigated as a carrier of a small molecule hapten 6-AmHap mimicking heroin. The mQβ-6-AmHap conjugate was able to induce significantly higher levels of IgG antibodies against 6-AmHap than mice immunized with the corresponding tetanus toxoid-6-AmHap conjugate in head-to-head comparison studies in multiple strains of mice. The IgG antibody responses were persistent with high anti-6-AmHap titers 600 days after being immunized with mQβ-6-AmHap. The antibodies induced exhibited strong binding toward multiple heroin/morphine derivatives that have the potential to be abused, while binding weakly to medications used for OUD treatment and pain relief. Furthermore, vaccination effectively reduced the impacts of morphine on mice in both ambulation and antinociception assays, highlighting the translational potential of the mQβ-6-AmHap conjugate to mitigate the harmful effects of drugs of abuse.

Toxoid

Conjugate

Hapten

10.1021/acs.bioconjchem.3c00415

Cite

Citations (3)

Meta-analysis of the effect of positive thyroid peroxidase antibody on spontaneous abortion in pregnant women

Yang Zhisen Liang Xinke Pengfei Wang Geng Li

Thyroid peroxidase

Source

Cite

Citations (0)