Xia Wang

Sichuan University

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Ting Deng

Hunan University

Yi Ba

Tianjin Medical University Cancer Institute and Hospital

Anwen Liu

Nanchang University

Zhimin Zeng

Nanchang University

Jing Cai

Second Affiliated Hospital of Nanchang University

Tao Ning

Tianjin Medical University Cancer Institute and Hospital

Haiyang Zhang

Central Hospital of Zibo

Likun Zhou

Chinese Academy of Medical Sciences & Peking Union Medical College

Shaohua Ge

Tianjin Medical University Cancer Institute and Hospital

Xiang Fei

Army Medical University

Cooperative Institutions

Sichuan University

182

Chinese Academy of Medical Sciences & Peking Union Medical College

149

West China Hospital of Sichuan University

106

Sun Yat-sen University

103

Central South University

102

Shanghai Jiao Tong University

100

Chinese Academy of Sciences

Zhejiang University

Fudan University

Nanjing Medical University

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MicroRNA‑320 inhibits cell proliferation and invasion in breast cancer cells by targeting SOX4

Oncology Letters (2017)

Junwen Bai Xia Wang Yafeng Zhang Guo‐Dong Yao Hong Liu

Dysregulation of microRNAs (miRs) can contribute to cancer development and progression. In the present study, the function and underlying molecular mechanisms of miR-320 in breast cancer tumorigenesis and progression were investigated. The results of a reverse transcription-quantitative polymerase chain reaction analysis demonstrated that miR-320 was frequently downregulated in breast cancer tissues compared with adjacent normal tissues. In addition, knockdown of miR-320 in breast cancer cell lines promoted cell proliferation and invasion in vitro, whereas miR-320 overexpression had the opposite effect. Furthermore, a Dual-Luciferase reporter assay indicated that SRY-box 4 (SOX4) is a direct target of miR-320, and the restoration of SOX4 in miR-320-overexpressing cells attenuated the tumor-suppressive effects of miR-320. Collectively, these results indicated that miR-320 acts as a tumor suppressor in breast cancer tumorigenesis and progression.

SOX4

10.3892/ol.2017.7087

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Citations (16)

Comparison of ciprofol (HSK3486) versus propofol for the induction of deep sedation during gastroscopy and colonoscopy procedures: A multi‐centre, non‐inferiority, randomized, controlled phase 3 clinical trial

Basic & Clinical Pharmacology & Toxicology (2022)

Jun-Xiang Li Xiao Wang Jin Liu Xia Wang Xiangkui Li

Ciprofol is a propofol analogue with improved pharmacokinetic properties. A multi-centre, non-inferiority trial was conducted to compare the deep sedation properties of ciprofol and propofol with a non-inferiority margin of 8% in patients undergoing gastroscopy and colonoscopy. In total, 289 patients were randomly allocated for surgery (259 colonoscopy and 30 gastroscopy) at a 1:1 ratio to be given intravenous injections of ciprofol (0.4 mg/kg) or propofol (1.5 mg/kg). The primary outcome was the success rate of colonoscopy defined as colonoscopy completion with no need for an alternative sedative or >5 ciprofol or propofol top up doses within any 15-min time period. The success rate of colonoscopy was 100% in the ciprofol group vs. 99.2% in the propofol group (mean difference 0.8%, 95% CI: -2.2% to 4.2%). Except for the gastrointestinal lesions found during the gastroscopy and colonoscopy procedures, the occurrence rates of adverse drug reactions in the ciprofol and propofol groups were 31.3% and 62.8%, respectively (P < 0.001). Pain on injection was less common in the ciprofol group (4.9% vs. 52.4%, P < 0.001). The outcomes demonstrated that ciprofol was non-inferior to propofol with regard to successful sedation for gastroscopy or colonoscopy procedures and no obvious important adverse events occurred.

10.1111/bcpt.13761

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Citations (87)

A multimodal machine learning model for the stratification of breast cancer risk

Nature Biomedical Engineering (2024)

Xuejun Qian Jing Pei Chunguang Han Zhiying Liang Gaosong Zhang

Risk Stratification

Breast imaging

10.1038/s41551-024-01302-7

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Citations (0)

Supplementary Fig. from IKKβ-mediated nuclear factor-κB activation attenuates smac mimetic–induced apoptosis in cancer cells

Lang Bai Wenshu Chen Wenjie Chen Xia Wang Tang Hong

Supplementary Fig. from IKKβ-mediated nuclear factor-κB activation attenuates smac mimetic–induced apoptosis in cancer cells

IκB kinase

10.1158/1535-7163.22485032.v1

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Hypoxia stimulates invasion and migration of human cervical cancer cell lines HeLa/SiHa through the Rab11 trafficking of integrin αvβ3/FAK/PI3K pathway-mediated Rac1 activation

Journal of Biosciences (2017)

Hao Xu Yuan Yuan Wenqian Wu Min Zhou Qian Jiang

HeLa

Hypoxia

10.1007/s12038-017-9699-0

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Citations (16)

Supplementary Figure S2 from miR-211-5p Suppresses Metastatic Behavior by Targeting SNAI1 in Renal Cancer

Kefeng Wang Wei Jin Peng Jin Xiang Fei Xia Wang

<p>Supplementary Figure S2</p>

SNAI1

Kidney cancer

10.1158/1541-7786.22511322.v1

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A hybrid protein of the amino-terminal fragment of urokinase and mutant plasminogen activator inhibitor-2 efficiently inhibits tumor cell invasion and metastasis

Journal of Cancer Research and Clinical Oncology (2004)

Xia Wang Min Hou Li Tan Xinghui Sun Yuqing Zhang

Matrigel

Plasminogen activator inhibitor-1

10.1007/s00432-004-0623-2

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Citations (5)

Bcl-3, induced by Tax and HTLV-1, inhibits NF-κB activation and promotes autophagy

Cellular Signalling (2013)

Jinheng Wang Zhiguo Niu Ying Shi Cai Gao Xia Wang

10.1016/j.cellsig.2013.09.010

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Citations (14)

Asperuloside Promotes Apoptosis of Cervical Cancer Cells through Endoplasmic Reticulum Stress-Mitochondrial Pathway

Chinese Journal of Integrative Medicine (2023)

QI Zhi-min Xia Wang Xia Liu Juan Zhao

HeLa

10.1007/s11655-023-3695-z

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Citations (5)

Absence of Association Between CD86 +1057G/A Polymorphism and Coronary Artery Disease

DNA and Cell Biology (2010)

Xiaona Ma Xia Wang Youyi Yan Lin Yang Dalei Zhang

CD86, one of the key costimulatory molecules, is not only involved in the initiation of T-cell immunity but also plays important roles in the development of cardiovascular diseases. The purpose of this study was to investigate the association between the CD86 polymorphism and the risk of coronary artery disease (CAD) in a Chinese population. We analyzed single-nucleotide polymorphism of CD86 +1057G/A (rs1129055) in 164 patients with CAD and 299 healthy controls by performing polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing assay. No significant association was observed in the genotype and allele frequencies of +1057G/A polymorphism between cases and controls, indicating that CD86 +1057G/A polymorphism may not be associated with CAD in the Chinese population.

CD86

10.1089/dna.2009.0987

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Citations (3)